Notch signalling pathway in tooth development and adult dental cells

Cell Proliferation

Volumn 44, Issue 6, 2011, Pages 495-507

  Cai, X ^a   Gong, P ^a   Huang, Y ^b   Lin, Y ^a  

^a SICHUAN UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; I KAPPA B; NOTCH RECEPTOR; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMAN; NONHUMAN; ODONTOBLAST; OSTEOBLAST; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL; TISSUE INJURY; TOOTH DEVELOPMENT; ANIMAL; CYTOLOGY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; REVIEW; TOOTH;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMANS; ODONTOBLASTS; OSTEOBLASTS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TOOTH;

EID: 84866004198     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2011.00780.x     Document Type: Article

References (128)

1. Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1998) Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation. Dev. Biol. 204, 420-431.
2. Souilhol C, Cormier S, Tanigaki K, Babinet C, Cohen-Tannoudji M (2006) RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development. Mol. Cell. Biol. 26, 4769-4774.
3. Conlon RA, Reaume AG, Rossant J (1995) Notch1 is required for the coordinate segmentation of somites. Development 121, 1533-1545.
4. Crowe R, Niswander L (1998) Disruption of scale development by Delta-1 misexpression. Dev. Biol. 195, 70-74.
5. de la Pompa JL, Wakeham A, Correia KM, Samper E, Brown S, Aguilera RJ et al. (1997) Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 124, 1139-1148.
6. Dorsky RI, Chang WS, Rapaport DH, Harris WA (1997) Regulation of neuronal diversity in the Xenopus retina by Delta signalling. Nature 385, 67-70.
7. Henrique D, Adam J, Myat A, Chitnis A, Lewis J, Ish-Horowicz D (1995) Expression of a Delta homologue in prospective neurons in the chick. Nature 375, 787-790.
8. Henrique D, Hirsinger E, Adam J, Le Roux I, Pourquie O, IshHorowicz D et al. (1997) Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina. Curr. Biol. 7, 661-670.
9. Kopan R, Nye JS, Weintraub H (1994) The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 120, 2385-2396.
10. Kopan R, Weintraub H (1993) Mouse notch: expression in hair follicles correlates with cell fate determination. J. Cell Biol. 121, 631-641.
11. Artavanis-Tsakonas S, Simpson P (1991) Choosing a cell fate: a view from the Notch locus. Trends Genet. 7, 403-408.
12. Greenwald I (1994) Structure/function studies of lin-12/Notch proteins. Curr. Opin. Genet. Dev. 4, 556-562.
13. Mitsiadis TA, Lardelli M, Lendahl U, Thesleff I (1995a) Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. J. Cell Biol. 130, 407-418.
14. Rebay I, Fehon RG, Artavanis-Tsakonas S (1993) Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74, 319-329.
15. Struhl G, Fitzgerald K, Greenwald I (1993) Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74, 331-345.
16. Grottkau BE, Chen XR, Friedrich CC, Yang XM, Jing W, Wu Y et al. (2009) DAPT enhances the apoptosis of human tongue carcinoma cells. Int. J. Oral Sci. 1, 81-89.
17. Katoh M, Katoh M (2007) Notch signaling in gastrointestinal tract (review). Int. J. Oncol. 30, 247-251.
18. Fehon RG, Kooh PJ, Rebay I, Regan CL, Xu T, Muskavitch MA et al. (1990) Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61, 523-534.
19. Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A et al. (1999) Human ligands of the Notch receptor. Am. J. Pathol. 154, 785-794.
20. Leong KG, Karsan A (2006) Recent insights into the role of Notch signaling in tumorigenesis. Blood 107, 2223-2233.
21. Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis- Tsakonas S (1991) Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 67, 687-699.
22. Katoh M, Katoh M (2006a) Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells. Int. J. Mol. Med. 17, 681-685.
23. Lindsell CE, Shawber CJ, Boulter J, Weinmaster G (1995). Jagged: a mammalian ligand that activates Notch1. Cell 80, 909-917.
24. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (1997) Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol. Cell. Biol. 17, 6057-6067.
25. Mitsiadis TA, Regaudiat L, Gridley T (2005) Role of the Notch signalling pathway in tooth morphogenesis. Arch. Oral Biol. 50, 137-140.
26. Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M (2002) Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. J. Biol. Chem. 277, 25400-25407.
27. Cui XY, Hu QD, Tekaya M, Shimoda Y, Ang BT, Nie DY et al. (2004) NB-3 / Notch1 pathway via Deltex1 promotes neural progen- itor cell differentiation into oligodendrocytes. J. Biol. Chem. 279, 25858-25865.
28. Kluppel M, Wrana JL (2005) Turning it up a Notch: cross-talk between TGF beta and Notch signaling. Bioessays 27, 115-118.
29. Miele L (2006) Notch signaling. Clin. Cancer Res. 12, 1074-1079.
30. Miele L, Golde T, Osborne B (2006) Notch signaling in cancer. Curr. Mol. Med. 6, 905-918.
31. Osipo C, Golde TE, Osborne BA, Miele LA (2008) Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Lab. Invest. 88, 11-17.
32. Oswald F, Tauber B, Dobner T, Bourteele S, Kostezka U, Adler G et al. (2001) p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol. Cell. Biol. 21, 7761-7774.
33. Wallberg AE, Pedersen K, Lendahl U, Roeder RG (2002) p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol. Cell. Biol. 22, 7812-7819.
34. Baron M (2003) An overview of the Notch signalling pathway. Semin. Cell Dev. Biol. 14, 113-119.
35. Kojika S, Griffin JD (2001) Notch receptors and hematopoiesis. Exp. Hematol. 29, 1041-1052.
36. Oka C, Nakano T, Wakeham A, de la Pompa JL, Mori C, Sakai T et al. (1995) Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development 121, 3291-3301.
37. Sullivan DC, Bicknell R (2003) New molecular pathways in angiogenesis. Br. J. Cancer 89, 228-231.
38. Iso T, Kedes L, Hamamori Y (2003) HES and HERP families: multiple effectors of the Notch signaling pathway. J. Cell. Physiol. 194, 237-255.
39. Hirata H, Yoshiura S, Ohtsuka T, Bessho Y, Harada T, Yoshikawa K et al. (2002) Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science 298, 840-843.
40. Ronchini C, Capobianco AJ (2001) Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol. Cell. Biol. 21, 5925-5934.
41. Rangarajan A, Talora C, Okuyama R, Nicolas M, Mammucari C, Oh H et al. (2001) Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 20, 3427-3436.
42. Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G et al. (2002) Notch signaling promotes astrogliogenesis via direct CSL- mediated glial gene activation. J. Neurosci. Res. 69, 848-860.
43. Krebs LT, Iwai N, Nonaka S, Welsh IC, Lan Y, Jiang R et al. (2003) Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev. 17, 1207-1212.
44. Oakley F, Mann J, Ruddell RG, Pickford J, Weinmaster G, Mann DA (2003) Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1. J. Biol. Chem. 278, 24359-24370.
45. Cheng P, Zlobin A, Volgina V, Gottipati S, Osborne B, Simel EJ et al. (2001) Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells. J. Immunol. 167, 4458-4467.
46. Oswald F, Liptay S, Adler G, Schmid RM (1998) NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. Mol. Cell. Biol. 18, 2077-2088.
47. Lecourtois M, Schweisguth F (1995) The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes Dev. 9, 2598-2608.
48. Bush G, diSibio G, Miyamoto A, Denault JB, Leduc R, Weinmaster G (2001) Ligand-induced signaling in the absence of furin process- ing of Notch1. Dev. Biol. 229, 494-502.
49. Shawber C, Nofziger D, Hsieh JJ, Lindsell C, Bogler O, Hayward D et al. (1996) Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development 122, 3765-3773.
50. Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, Golde TE et al. (2006) Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J. 25, 129-138.
51. Sriuranpong V, Borges MW, Strock CL, Nakakura EK, Watkins DN, Blaumueller CM et al. (2002) Notch signaling induces rapid degradation of achaete-scute homolog 1. Mol. Cell. Biol. 22, 3129-3139.
52. Lovschall H, Tummers M, Thesleff I, Fuchtbauer EM, Poulsen K (2005) Activation of the Notch signaling pathway in response to pulp capping of rat molars. Eur. J. Oral Sci. 113, 312-317.
53. Mitsiadis TA, Fried K, Goridis C (1999) Reactivation of Delta-Notch signaling after injury: complementary expression patterns of ligand and receptor in dental pulp. Exp. Cell Res. 246, 312-318.
54. Mucchielli ML, Mitsiadis TA (2000) Correlation of asymmetric Notch2 expression and mouse incisor rotation. Mech. Dev. 91, 379-382.
55. Pouyet L, Mitsiadis TA (2000) Dynamic Lunatic fringe expression is correlated with boundaries formation in developing mouse teeth. Mech. Dev. 91, 399-402.
56. Thesleff I, Aberg T (1997) Tooth morphogenesis and the differentiation of ameloblasts. Ciba Found. Symp. 205, 3-12; discussion 12-17.
57. Lumsden AG (1988) Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ. Development 103(Suppl), 155-169.
58. Mina M, Kollar EJ (1987) The induction of odontogenesis in nondental mesenchyme combined with early murine mandibular arch epithelium. Arch. Oral Biol. 32, 123-127.
59. Jernvall J, Keranen SV, Thesleff I (2000) Evolutionary modification of development in mammalian teeth: quantifying gene expression patterns and topography. Proc. Natl. Acad. Sci. USA 97, 14444-14448.
60. Laurikkala J, Mikkola M, Mustonen T, Aberg T, Koppinen P, Pispa J et al. (2001) TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis. Dev. Biol. 229, 443-455.
61. Vaahtokari A, Aberg T, Jernvall J, Keranen S, Thesleff I (1996) The enamel knot as a signaling center in the developing mouse tooth. Mech. Dev. 54, 39-43.
62. Jernvall J, Kettunen P, Karavanova I, Martin LB, Thesleff I (1994) Evidence for the role of the enamel knot as a control center in mam- malian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene. Int. J. Dev. Biol. 38, 463-469.
63. Mustonen T, Tummers M, Mikami T, Itoh N, Zhang N, Gridley T et al. (2002) Lunatic fringe FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth. Dev. Biol. 248, 281-293.
64. Harada H, Ichimori Y, Yokohama-Tamaki T, Ohshima H, Kawano S, Katsube K et al. (2006) Stratum intermedium lineage diverges from ameloblast lineage via Notch signaling. Biochem. Biophys. Res. Commun. 340, 611-616.
65. Gridley T (2003). Notch signaling and inherited disease syndromes. Hum. Mol. Genet. 12 Spec No 1, R9-R13.
66. Lewis J (1998) Notch signalling and the control of cell fate choices in vertebrates. Semin. Cell Dev. Biol. 9, 583-589.
67. Harada H, Kettunen P, Jung HS, Mustonen T, Wang YA, Thesleff I (1999) Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. J. Cell Biol. 147, 105-120.
68. Mitsiadis TA, Henrique D, Thesleff I, Lendahl U (1997). Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor- 4. Development 124, 1473-1483.
69. Weinmaster G (1997) The ins and outs of notch signaling. Mol. Cell. Neurosci. 9, 91-102.
70. About I, Mitsiadis TA (2001) Molecular aspects of tooth pathogenesis and repair: in vivo and in vitro models. Adv. Dent. Res. 15, 59-62.
71. Mitsiadis TA, Romeas A, Lendahl U, Sharpe PT, Farges JC (2003) Notch2 protein distribution in human teeth under normal and pathological conditions. Exp. Cell Res. 282, 101-109.
72. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S (2000) Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc. Natl. Acad. Sci. USA 97, 13625-13630.
73. Honda MJ, Shinohara Y, Sumita Y, Tonomura A, Kagami H, Ueda M (2006) Shear stress facilitates tissue-engineered odontogenesis. Bone 39, 125-133.
74. Young CS, Terada S, Vacanti JP, Honda M, Bartlett JD, Yelick PC (2002) Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J. Dent. Res. 81, 695-700.
75. Bray S (1998) A Notch affair. Cell 93, 499-503.
76. Carlesso N, Aster JC, Sklar J, Scadden DT (1999) Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics. Blood 93, 838-848.
77. Fortini ME, Artavanis-Tsakonas S (1993) Notch: neurogenesis is only part of the picture. Cell 75, 1245-1247.
78. Morsczeck C, Moehl C, Gotz W, Heredia A, Schaffer TE, Eckstein N et al. (2005) In vitro differentiation of human dental follicle cells with dexamethasone and insulin. Cell Biol. Int. 29, 567-575.
79. Grottkau BE, Purudappa PP, Lin YF (2010) Multilineage differentiation of dental pulp stem cells from green fluorescent protein transgenic mice. Int. J. Oral Sci. 2, 21-27.
80. Peng L, Ye L, Zhou XD (2009) Mesenchymal stem cells and tooth engineering. Int. J. Oral Sci. 1, 6-12.
81. Lovschall H, Mitsiadis TA, Poulsen K, Jensen KH, Kjeldsen AL (2007) Coexpression of Notch3 and Rgs5 in the pericyte-vascular smooth muscle cell axis in response to pulp injury. Int. J. Dev. Biol. 51, 715-721.
82. Iohara K, Zheng L, Ito M, Tomokiyo A, Matsushita K, Nakashima M (2006) Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis. Stem Cells 24, 2493- 2503.
83. Kawanabe N, Murakami K, Takano-Yamamoto T (2006) The presence of ABCG2-dependent side population cells in human periodontal ligaments. Biochem. Biophys. Res. Commun. 344, 1278- 1283.
84. Matsuzaki Y, Kinjo K, Mulligan RC, Okano H (2004) Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity 20, 87-93.
85. Honda MJ, Nakashima F, Satomura K, Shinohara Y, Tsuchiya S, Watanabe N et al. (2007) Side population cells expressing ABCG2 in human adult dental pulp tissue. Int. Endod. J. 40, 949-958.
86. Kumano K, Chiba S, Shimizu K, Yamagata T, Hosoya N, Saito T et al. (2001). Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression. Blood 98, 3283-3289.
87. Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT (2002) Notch 1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood 99, 2369-2378.
88. Aberg T, Wozney J, Thesleff I (1997) Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation. Dev. Dyn. 210, 383-396.
89. Adams JC, Watt FM (1993) Regulation of development and differentiation by the extracellular matrix. Development 117, 1183-1198.
90. Mitsiadis TA, Muramatsu T, Muramatsu H, Thesleff I (1995b) Midkine (MK), a heparin-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis. J. Cell Biol. 129, 267-281.
91. Mitsiadis TA, Salmivirta M, Muramatsu T, Muramatsu H, Rauvala H, Lehtonen E et al. (1995c) Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis. Development 121, 37-51.
92. Ruch JV, Lesot H, Begue-Kirn C (1995) Odontoblast differentiation. Int. J. Dev. Biol. 39, 51-68.
93. Vaahtokari A, Vainio S, Thesleff I (1991) Associations between transforming growth factor beta 1 RNA expression and epithelial-mesenchymal interactions during tooth morphogenesis. Development 113, 985-994.
94. Vainio S, Karavanova I, Jowett A, Thesleff I (1993) Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75, 45-58.
95. Nakashima M (1994) Induction of dentine in amputated pulp of dogs by recombinant human bone morphogenetic proteins-2 and -4 with collagen matrix. Arch. Oral Biol. 39, 1085-1089.
96. Tziafas D, Smith AJ, Lesot H (2000) Designing new treatment strategies in vital pulp therapy. J. Dent. 28, 77-92.
97. van Mullem PJ (1991) Healing of the guinea pig incisor after partial pulp removal. Endod. Dent. Traumatol. 7, 164-176.
98. Begue-Kirn C, Smith AJ, Ruch JV, Wozney JM, Purchio A, Hartmann D et al. (1992) Effects of dentin proteins, transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblast in vitro. Int. J. Dev. Biol. 36, 491-503.
99. Melin M, Joffre-Romeas A, Farges JC, Couble ML, Magloire H, Bleicher F (2000) Effects of TGFbeta1 on dental pulp cells in cultured human tooth slices. J. Dent. Res. 79, 1689-1696.
100. Faux CH, Turnley AM, Epa R, Cappai R, Bartlett PF (2001) Interactions between fibroblast growth factors and Notch regulate neuronal differentiation. J. Neurosci. 21, 5587-5596.
101. Uyttendaele H, Soriano JV, Montesano R, Kitajewski J (1998) Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion. Dev. Biol. 196, 204-217.
102. Hansson EM, Lendahl U, Chapman G (2004) Notch signaling in development and disease. Semin. Cancer Biol. 14, 320-328.
103. Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U et al. (2003) Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J. Cell Biol. 163, 723-728.
104. Dahlqvist C, Blokzijl A, Chapman G, Falk A, Dannaeus K, Ibanez CF et al. (2003) Functional Notch signaling is required for BMP4- induced inhibition of myogenic differentiation. Development 130, 6089-6099.
105. Itoh F, Itoh S, Goumans MJ, Valdimarsdottir G, Iso T, Dotto GP et al. (2004) Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J. 23, 541-551.
106. Henderson AM, Wang SJ, Taylor AC, Aitkenhead M, Hughes CC (2001) The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation. J. Biol. Chem. 276, 6169-6176.
107. Campbell KJ, Perkins ND (2006) Regulation of NF-kappaB function. Biochem. Soc. Symp. 73, 165-180.
108. Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M et al. (2004) A dual role for Ikk alpha in tooth development. Dev. Cell 6, 219-227.
109. Bash J, Zong WX, Banga S, Rivera A, Ballard DW, Ron Y et al. (1999) Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J. 18, 2803-2811.
110. Moran ST, Cariappa A, Liu H, Muir B, Sgroi D, Boboila C et al. (2007) Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. J. Immunol. 179, 195-200.
111. Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA, Hoffman T (1996) T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells. J. Exp. Med. 183, 2025-2032.
112. Wang J, Shelly L, Miele L, Boykins R, Norcross MA, Guan E (2001) Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain. J. Immunol. 167, 289-295.
113. Kratochwil K, Galceran J, Tontsch S, Roth W, Grosschedl R (2002) FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev. 16, 3173-3185.
114. Sarkar L, Sharpe PT (1999) Expression of Wnt signalling pathway genes during tooth development. Mech. Dev. 85, 197-200.
115. Katoh M (2005a) Epithelial-mesenchymal transition in gastric cancer (Review). Int. J. Oncol. 27, 1677-1683.
116. Katoh M (2005b) WNT2B: comparative integromics and clinical applications (Review). Int. J. Mol. Med. 16, 1103-1108.
117. Swain RK, Katoh M, Medina A, Steinbeisser H (2005) Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt / beta-catenin signaling. Cell Commun. Signal. 3, 12.
118. Katoh M, Katoh M (2006b) NUMB is a break of WNT-Notch signaling cycle. Int. J. Mol. Med. 18, 517-521.
119. Strutt D, Johnson R, Cooper K, Bray S (2002) Asymmetric localization of frizzled and the determination of notch-dependent cell fate in the Drosophila eye. Curr. Biol. 12, 813-824.
120. Ross DA, Kadesch T (2001) The notch intracellular domain can function as a coactivator for LEF-1. Mol. Cell. Biol. 21, 7537-7544.
121. Foltz DR, Santiago MC, Berechid BE, Nye JS (2002) Glycogen synthase kinase-3beta modulates notch signaling and stability. Curr. Biol. 12, 1006-1011.
122. Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort M et al. (2003) Notch1 functions as a tumor suppressor in mouse skin. Nat. Genet. 33, 416-421.
123. Bitgood MJ, McMahon AP (1995) Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 172, 126-138.
124. Dassule HR, McMahon AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol. 202, 215-227.
125. Hardcastle Z, Mo R, Hui CC, Sharpe PT (1998). The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125, 2803-2811.
126. Zhang Y, Zhao X, Hu Y, St Amand T, Zhang M, Ramamurthy R et al. (1999) Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev. Dyn. 215, 45-53.
127. Dassule HR, Lewis P, Bei M, Maas R, McMahon AP (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127, 4775-4785.
128. Ingram WJ, McCue KI, Tran TH, Hallahan AR, Wainwright BJ (2008) Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling. Oncogene 27, 1489-1500.