Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/β-catenin signaling

Cell Communication and Signaling

Volumn 3, Issue , 2005, Pages

  Swain, Rajeeb Kumar ^a   Katoh, Masaru ^c   Medina, Araceli ^b   Steinbeisser, Herbert ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; FRIZZLED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; PROTEIN XFZ4; WNT PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN SECRETION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; XENOPUS;

EID: 33646007215     PISSN: 1478811X     EISSN: None     Source Type: Journal    
DOI: 10.1186/1478-811X-3-12     Document Type: Article

References (41)

1. Wodarz A, Nusse R: Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 1998, 14:59-88.
2. van de Wetering M, de Lau W, Clevers H: WNT signaling and lymphocyte development. Cell 2002, 109(Suppl):S13-S19.
3. Alonso L, Fuchs E: Stem cells in the skin: waste not, Wnt not. Genes Dev 2003, 17:1189-1200.
4. Veeman MT, Axelrod JD, Moon RT: A second canon. Functions and mechanisms of beta-catenin-independent Wnt signalling. Dev Cell 2003, 5:367-377.
5. Bhanot P, Brink M, Samos CH, Hsieh JC, Wang Y, Macke JP, Andrew D, Nathans J, Nusse R: A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 1996, 382:225-230.
6. Yang-Snyder J, Miller JR, Brown JD, Lai CJ, Moon RT: A frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr Biol 1996, 6:1302-1306.
7. Hecht A, Kemler R: Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression. EMBO Rep 2000, 1:24-28. 4
8. Wehrli M, Dougan ST, Caldwell K, O'Keefe L, Schwartz S, Vaizel-Ohayon D, Schejter E, Tomlinson A, DiNardo S: arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 2000, 407:527-530.
9. Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X: LDL-receptor-related proteins in Wnt signal transduction. Nature 2000, 407:530-535.
10. Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC: An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 2000, 407:535-538.
11. Mao J, Wang J, Liu B, Pan W, Farr GH 3rd, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D: Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell 2001, 7:801-809.
12. Kikuchi A: Regulation of beta-catenin signaling in the Wnt pathway. Biochem Biophys Res Commun 2000, 268:243-248.
13. Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997, 16:3797-3804.
14. Kawano Y, Kypta R: Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003, 116:2627-2634.
15. Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C: LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 2001, 411:321-325.
16. Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X: Head inducer Dickkopf-I is a ligand for Wnt coreceptor ILRP6. Curr Biol 2001, 11:951-961.
17. Sagara N, Kirikoshi H, Terasaki H, Yasuhiko Y, Toda G, Shiokawa K, Katoh M: FZD4S, a splicing variant of frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway. Biochem Biophys Res Commun 2001, 282:750-756.
18. Shi DL, Boucaut JC: Xenopus frizzled 4 is a maternal mRNA and its zygotic expression is localized to the neuroectoderm and trunk lateral plate mesoderm. Mech Dev 2000, 94:243-245.
19. He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, Varmus H: A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 1997, 275:1652-1654.
20. Itoh K, Sokol SY: Axis determination by inhibition of Wnt: signaling in Xenopus. Genes Dev 1999, 13:2328-2336.
21. Wharton KA Jr: Runnin' with the DvI: proteins that associate with Dsh/ Dvl and their significance to Wnt signal transduction. Dev Biol 2003, 253:1-17.
22. Schweizer L, Varmus H: Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC Cell Biol 2003, 4:4.
23. Yoshino K, Rubin JS, Higinbotham KG, Uren A, Anest V, Plisov SY, Perantoni AO: Secreted Frizzled-related proteins can regulate metanephric development. Mech Dev 2001, 102:45-55.
24. Wu W, Glinka A, Delius H, Niehrs C: Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling. Curr Biol 2000, 10:1611-164.
25. Brott BK, Sokol SY: Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol Cell Biol 2002, 22:6100-6110.
26. Sawyer EJ, Hanby AM, Rowan AJ, Gillett CE, Thomas RE, Poulsom R, Lakhani SR, Ellis IO, Ellis P, Tomlinson IP: The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours. J Pathol 2002, 196:437-444.
27. Ku M, Melton DA: Xwnt-II: a maternally expressed Xenopus wnt gene. Development 1993, 119:1161-1173.
28. Tao Q, Yokota C, Puck H, Kofron M, Birsoy B, Yan D, Asashima M, Wylie CC, Lin X, Heasman J: Maternal wntII activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell 2005, 120:857-871.
29. Tada M, Smith JC: XwntII is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development 2000, 127:2227-2238.
30. Kuhl M: Non-canonical Wnt: signaling in Xenopus: regulation of axis formation and gastrulation. Semin Cell Dev Biol 2002, 13:243-249.
31. Nieuwkoop PD, Faber J: Normal Table of Xenopus laevis (Daudin). Amsterdam, North Holland Publishing Company, 1967.
32. Moon RT, Campbell RM, Christian JL, McGrew LL, Shih J, Fraser S: Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. Development 1993, 119:97-111.
33. Wolda SL, Moody CJ, Moon RT: Overlapping expression of Xwt-3A and Xwnt-I in neural tissue of Xenopus laevis embryos. Dev Biol 1993, 155:46-57.
34. McGrew LL, Otte AP, Moon RT: Analysis of Xwnt-4 in embryos of Xenopus laevis: a Wnt family member expressed in the brain and floor plate. Development 1992, 115:463-473.
35. Rothbacher U, Laurent MN, Deardorff MA, Klein PS, Cho KW, Fraser SE: Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J 2000, 19:1010-1022.
36. Deardorff MA, Tan C, Conrad LJ, Klein PS: Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis. Development 1998, 125:2687-2700.
37. Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C: Dickkopf-I is a member of a new family of secreted proteins and functions in head induction. Nature 1998, 391:357-362.
38. Sokol SY: Analysis of Dishevelled signalling pathways during Xenopus development. Curr Biol 1996, 6:1456-1467.
39. Cui Y, Brown JD, Moon RT, Christian JL: Xwnt-8b: a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis. Development 1995, 121:2177-2186.
40. Christian JL, McMahon JA, McMahon AP, Moon RT: Xwnt-8, a Xenopus Wnt-I/ int-I-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development 1991, 111:1045-1055.
41. Epstein M, Pillemer G, Yelin R, Yisraeli JK, Fainsod A: Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes. Development 1997, 124:3805-3814.