Oscillatory expression of the BHLH factor Hes1 regulated by a negative feedback loop

Science

Volumn 298, Issue 5594, 2002, Pages 840-843

  Hirata, Hiromi ^a   Yoshiura, Shigeki ^a   Ohtsuka, Toshiyuki ^a   Bessho, Yasumasa ^a   Harada, Takahiro ^a   Yoshikawa, Kenichi ^a   Kageyama, Ryoichiro ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEGRADATION; FEEDBACK; PROTEINS; RNA;

SOMITE SEGMENTATION;

NATURAL SCIENCES;

HELIX LOOP HELIX PROTEIN; MESSENGER RNA; NOTCH RECEPTOR; PROTEASOME; TRANSCRIPTION FACTOR HES 1; UBIQUITIN; UNCLASSIFIED DRUG;

FEEDBACK MECHANISM; RNA;

ANIMAL CELL; ARTICLE; BIOLOGICAL RHYTHM; CELL CULTURE; CIRCADIAN RHYTHM; GENE EXPRESSION; NEGATIVE FEEDBACK; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ACETYLCYSTEINE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL CLOCKS; BLOOD; CELL LINE; CYCLOHEXIMIDE; CYSTEINE ENDOPEPTIDASES; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION; GLYCOSYLTRANSFERASES; HALF-LIFE; HOMEODOMAIN PROTEINS; LEUPEPTINS; MESODERM; MICE; MULTIENZYME COMPLEXES; PC12 CELLS; PERIODICITY; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RATS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFECTION; UBIQUITIN;

ANIMALIA;

EID: 0037174669     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1074560     Document Type: Article

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30. We thank D. Ish-Horowicz and O. Pourquié for critical reading of an earlier version of the manuscript and communicating their results before publication, G. Huang for technical help, T. Sudo for Hes1 antibody, T. Honjo for Delta-expressing cells (D10) and S. Nagata for pEF-BOS. Supported by research grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan and the Japan Society for the Promotion of Science.