Induction of apoptosis by 11-dehydrosinulariolide via mitochondrial dysregulation and ER stress pathways in human melanoma cells

Marine Drugs

Volumn 10, Issue 8, 2012, Pages 1883-1898

  Su, Tzu Rong ^a   Tsai, Feng Jen ^b   Lin, Jen Jie ^c   Huang, Han Hsiang ^b   Chiu, Chien Chih ^d   Su, Jui Hsin ^e   Yang, Ya Ting ^f   Chen, Jeff Yi Fu ^d   Wong, Bing Sang ^a   Wu, Yu Jen ^b  

^a TIAN SHENG MEMORIAL HOSPITAL   (Taiwan)

^b MEIHO UNIVERSITY   (Taiwan)

^c NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

^f NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

11 Dehydrosinulariolide; ER stress; Melanoma; Mitochondrial dysregulation

Indexed keywords

11 DEHYDROSINULARIOLIDE; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; CALNEXIN; CALRETICULIN; CASPASE 3; CASPASE 9; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; NATURAL PRODUCT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG;

ANTIMIGRATORY ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL GROWTH; CELL MIGRATION; CONTROLLED STUDY; CORAL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE RESPONSE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; MELANOMA CELL; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; SINULARIA LEPTOCLADOS; UPREGULATION;

ALCYONACEA; SINULARIA LEPTOCLADOS;

EID: 84865963073     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md10081883     Document Type: Article

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