Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation

Circulation Research

Volumn 111, Issue 6, 2012, Pages 718-727

  Carnicer, Ricardo ^a   Hale, Ashley B ^a   Suffredini, Silvia ^a   Liu, Xing ^a   Reilly, Svetlana ^a   Zhang, Mei Hua ^a   Surdo, Nicoletta C ^a   Bendall, Jennifer K ^a   Crabtree, Mark J ^a   Lim, Gregory B S ^a   Alp, Nicholas J ^a   Channon, Keith M ^a   Casadei, Barbara ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

neuronal NOS; nitric oxide; phospholamban; relaxation; tetrahydrobiopterin

Indexed keywords

BIOPTERIN; CALCIUM ION; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MYOSIN HEAVY CHAIN ALPHA; NEURONAL NITRIC OXIDE SYNTHASE; SUPEROXIDE; TETRAHYDROBIOPTERIN; XANTHINE OXIDASE;

ARTICLE; BIOSYNTHESIS; GENOTYPE; HEART FUNCTION; HEART MUSCLE; HUMAN; MALE; MOUSE; MUSCLE CELL; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; BIOPTERIN; CALCIUM; CELLS, CULTURED; ENZYME ACTIVATION; FEMALE; GTP CYCLOHYDROLASE; HEART; HUMANS; IMMUNOBLOTTING; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; NITRIC OXIDE SYNTHASE TYPE I; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SUPEROXIDES;

EID: 84865861379     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.274464     Document Type: Article

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