Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: Implications for the antiarrhythmic effect of statins

Circulation

Volumn 124, Issue 10, 2011, Pages 1107-1117

  Reilly, Svetlana N ^a   Jayaram, Raja ^a   Nahar, Keshav ^a   Antoniades, Charalambos ^a,b   Verheule, Sander ^c   Channon, Keith M ^a   Alp, Nicholas J ^a   Schotten, Ulrich ^c   Casadei, Barbara ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF ATHENS   (Greece)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

atrial fibrillation; free radicals; nitric oxide synthase; oxidative stress; statins

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ARGINASE; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIOPTERIN; CALCIUM ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; MITOCHONDRIAL OXIDASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; P22PHOX PROTEIN; PROTEIN P22; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; ATRIOVENTRICULAR BLOCK; CELL INFILTRATION; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DISEASE ACTIVITY; DISEASE DURATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GOAT; HEART ATRIUM FIBRILLATION; HEART LEFT ATRIUM; HEART MUSCLE; HEART PACING; HEART RIGHT ATRIUM; HEART SURGERY; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SECONDARY PREVENTION; SINUS RHYTHM;

AGED; AGED, 80 AND OVER; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARGINASE; ATRIAL FIBRILLATION; ATRIOVENTRICULAR BLOCK; DISEASE MODELS, ANIMAL; FEMALE; GOATS; HEART ATRIA; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MITOCHONDRIA; NADPH OXIDASE; OXIDOREDUCTASES; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES;

EID: 80052602720     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.029223     Document Type: Article

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