Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites

Journal of Molecular Biology

Volumn 279, Issue 1, 1998, Pages 189-199

  Steinmetz, Michel O ^a   Plüss, Christoph ^b   Christen, Urs ^c   Wolpensinger, Bettina ^a   Lustig, Ariel ^a   Werner, Ernst R ^d   Wachter, Helmut ^d   Engel, Andreas ^a   Aebi, Ueli ^a   Pfeilschifter, Josef ^b,e   Kammerer, Richard A ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d UNIVERSITY OF INNSBRUCK   (Austria)

^e Zentrum PharmakologieKlinikum J   (Germany)

Author keywords

Digital image processing; Dopa responsive dystonia; EF hand like calcium binding loop motif; Electron microscopy; Homodecameric enzyme complex

Indexed keywords

DOPA; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; LIVER ENZYME;

AMINO ACID SEQUENCE; ARTICLE; CALCIUM BINDING; DYSTONIA; ELECTRON MICROSCOPY; ESCHERICHIA COLI; FLUORESCENCE; GENE MUTATION; HUMAN; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY; ULTRACENTRIFUGATION;

ESCHERICHIA COLI; EUKARYOTA;

EID: 13144282701     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.1649     Document Type: Article

References (48)

1. Bremer A., Aebi U. Negative staining. Celis J.E. Cell Biology A Laboratory Handbook. Volume 2:1994;126-133 Academic Press Inc, London, U.K
2. Cha K.W., Jacobson K.B., Yim J.J. Isolation and characterization of GTP cyclohydrolase I from mouse liver. Comparison of normal and the hph-I mutant. J. Biol. Chem. 266:1991;12294-12300
3. Chen Y.-H., Yang J.T., Chau K.H. Determination of the helix and β-form of proteins in aqueous solution by circular dichroism. Biochemistry. 13:1974;3350-3359
4. Cone J.E., Plowman J., Guroff G. Purification and properties of guanosine triphosphate cyclohydrolase and a stimulating protein from Comamonas Sp. (ATCC 11299a). J. Biol. Chem. 249:1974;5551-5558
5. De Saizieu A., Vankan P., Van Loon A.P.G.M. Enzymatic characterization of Bacillus subtilis GTP cyclohydrolase I. Evidence for a chemical dephosphorylation of dihyroneopterin triphosphate. Biochem. J. 306:1995;371-377
6. Duch D.S., Smith G.K. Biosynthesis and function of tetrahydrobiopterin. J. Nutr. Biochem. 2:1991;411-423
7. Eason R. Analytical ultracentrifugation. Rickwood D. Centrifugation A Practical Approach. 1986;251-286 IRL press, Oxford and Washington, DC
8. Engel A., Colliex C. Application of scanning transmission electron microscopy to the study of biological structure. Curr. Opin. Biotechnol. 4:1993;403-411
9. Engel J., Schalch W. Antibody binding constants from Farr test and other radioimmunoassays. A theoretical and experimental analysis. Mol. Immun. 17:1980;675-680
10. Fujishiro K., Hagihara M., Takahashi A., Nagatsu T. Concentrations of neopterin and biopterin in the cerebrosial fluid of patients with Parkinson's disease. Biochem. Med. Metab. Biol. 44:1990;97-100
11. Haiech J., Derancourt J., Pechère J.-F., Demaille J.G. Magnesium and calcium binding to parvalbumins evidence for differences between parvalbumins and an explanation of their relaxing function. Biochemistry. 18:1979;2752-2758
12. Harada T., Kagamiyama H., Hatakeyama K. Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity. Science. 260:1993;1507-1510
13. Hatakeyama K., Harada T., Suzuki S., Watanabe Y., Kagamiyama H. Purification and characterization of rat liver GTP cyclohydrolase I. Cooperative binding of GTP to the enzyme. J. Biol. Chem. 264:1989;21660-21664
14. Hatakeyama K., Inoue Y., Harada T., Kagamiyama H. Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydropterin biosynthetic pathway. J. Biol. Chem. 266:1991;765-769
15. Hatakeyama K., Harada T., Kagamiyama H. IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels. Indications of the regulation of GTP cyclohydrolase I activity by restriction of GTP availability in the cells. J. Biol. Chem. 267:1992;20734-20739
16. Ho S.N., Hunt H.D., Horton R.M., Pullen J.K., Pease L.R. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene. 77:1989;51-59
17. Ichinose H., Ohye T., Takahashi E., Seki N., Hori T., Segawa M., Nomura Y., Endo K., Tanaka H., Tsuji S., Fujita K., Nagatsu T. Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene. Nature Genetics. 8:1994;236-242
18. Imazumi K., Sasaki T., Takahasi K., Takai Y. Identification of a Rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells. Biochem. Biophys. Res. Commun. 205:1994;1409-1416
19. Kammerer R.A., Antonsson P., Schulthess T., Fauser C., Engel J. Selective chain recognition in the C-terminal α-helical coiled-coil region of laminin. J. Mol. Biol. 250:1995;64-73
20. Kaufman S. New tetrahydrobiopterin-dependent systems. Annu. Rev. Nutr. 13:1993;261-286
21. Kohashi M., Itadani T., Iwai K. Purification and characterization of guanosine triphosphate cyclohydrolase from Serratia indica. Agric. Biol. Chem. 44:1980;271-278
22. Kretzinger R.H., Tolbert D., Nakayama S., Pearson W. The EF-hand, homologs and analogs. Heizmann C.W. Novel Calcium-Binding Proteins. 1991;17-37 Springer-Verlag, Berlin Heidelberg, D
23. Maier J., Witter K., Gütlich M., Ziegler I., Werner T., Ninnemann H. Homology cloning of GTP-cyclohydrolase I from various unrelated eukaryotes by reverse-transcription polymerase chain reaction using a general set of degenerate primers. Biochem. Biophys. Res. Commun. 212:1995;705-711
24. 45Ca autoradiography on nitrocellulose membrane after sodium dodecyl sulfate gel electrophoresis. J. Biochem. 95:1984;511-519
25. Meining W., Bacher A., Bachmann L., Schmid C., Weinkauf S., Huber R., Nar H. Elucidation of crystal packing by X-ray diffraction and freeze-etching electron microscopy. Studies on GTP cyclohydrolase I of Escherichia coli. J. Mol. Biol. 253:1995;207-218
26. Milstien S., Jaffe H., Kowlessur D., Bonner T.I. Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP. J. Biol. Chem. 271:1996;19743-19751
27. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide physiology, pathophysiology & pharmacology. Pharmacol. Rev. 43:1991;109-142
28. Müller S.A., Goldie K.N., Bürki R., Häring R., Engel A. Factors influencing the precision of quantitative scanning transmission electron microscopy. Ultramicroscopy. 46:1992;317-334
29. Nar H., Huber R., Meining W., Schmid C., Weinkauf S., Bacher A. Atomic structure of GTP cyclohydrolase I. Structure. 3:1995;459-466
30. Nichol C.A., Smith G.K., Duch D.S. Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin. Annu. Rev. Biochem. 54:1985;729-764
31. Niedwieser A., Blau N., Wang M., Joller P., Atarés M., Cardesa-Garcia J. GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine and serotonin deficiencies and muscular hypotonia. Eur. J. Pediatr. 141:1984;208-214
32. Plüss C., Werner E.R., Blau N., Wachter H., Pfeilschifter J. Interleukin 1β and cAMP trigger the expression of GTP cyclohydrolase I in rat renal mesangial cells. Biochem. J. 318:1996;665-671
33. Pottgiesser J., Maurer P., Mayer U., Nischt R., Mann K., Timpl R., Krieg T., Engel J. Changes in calcium and collagen IV binding caused by mutations in the EF hand and other domains of extracellular matrix protein BM-40 (SPARC, osteonectin). J. Mol. Biol. 238:1994;563-574
34. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning A Laboratory Manual. 2nd edn:1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
35. Sawada M., Hirata Y., Arai H., Iizuka R., Nagatsu T. Tyrosine hydroxylase, tryptophan hydroxylase, bioptrin and neopterin in the brains of normal controls and patients with senile dementia of Alzheimer type. J. Neurochem. 58:1987;760-764
36. Saxton O.W. Semper distortion compensation, selective averaging, 3-D reconstruction and transfer function correction in a highly programmable system. J. Struct. Biol. 16:1996;230-236
37. Schägger H., von Jagow G. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range of 1-100 kDa. Anal. Biochem. 166:1987;368-379
38. Schoedon G., Redweik U., Curtius H.-C. Purification of GTP cyclohydrolase I from human liver and production of specific monoclonal antibodies. Eur. J. Biochem. 178:1989;627-634
39. Schoedon G., Redweik U., Frank G., Cotton R.G.H., Blau N. Allosteric characteristics of GTP cyclohydrolase I from Escherichia coli. Eur. J. Biochem. 210:1992;561-568
40. Strynadka N.C.J., James M.N.G. Crystal structures of helix-loop-helix calcium-binding proteins. Annu. Rev. Biochem. 58:1989;951-998
41. Tanaka K., Kaufman S., Milstein S. Tetrahydrobiopterin, the co-factor for aromatic amino acid hydroxylases, is synthesized by and regulates proliferation of erythroid cells. Proc. Natl Acad. Sci. USA. 86:1989;5864-5867
42. van Heel M. Multivariate statistical classification of noisy images (randomly orientated biological macromolecules). Ultramicroscopy. 13:1984;165-183
43. Weisberg E.P., O'Donnell J.M. Purification and characterization of GTP cyclohydrolase I from Drosophila melanogaster. J. Biol. Chem. 261:1986;1453-1458
44. Werner E.R., Werner-Felmayer G., Fuchs D., Hausen A., Reibnegger G., Yim J.J., Pfleiderer W., Wachter H. Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T24 cells. GTP-cyclohydrolase I is stimulated by interferon-γ, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present. J. Biol. Chem. 265:1990;3189-3192
45. Werner E.R., Werner-Feldmayer G., Wachter H., Mayer B. Biosynthesis of nitric oxide dependence on pteridine metabolism. Rev. Physiol. Biochem. Pharmacol. 127:1996;97-135
46. Wojcik J., Góral J., Pawlowski K., Bierzynsky A. Isolated calcium-binding loops of EF-hand proteins can dimerize to form a native-like structure. Biochemistry. 36:1997;680-687
47. Yim J.J., Brown G.M. Characteristics of guanosine triphosphate cyclohydrolase I purified from Escherichia coli. J. Biol. Chem. 251:1976;5087-5094
48. Ziegler I. Production of pteridines during hematopoiesis and T-lymphocyte proliferation potential participation in the control of cytokine signal transmission. Med. Res. Rev. 10:1990;95-114