Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independently of changes in nitric oxide and inducible nitric-oxide synthase dimerization

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 3, 2009, Pages 890-899

  Pieper, Galen M ^a,b   Ionova, Irina A ^a   Cooley, Brian C ^a   Migrino, Raymond Q ^a   Khanna, Ashwani K ^c   Whitsett, Jennifer ^a   Vásquez Vivar, Jeannette ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b FREE RADICAL RESEARCH CENTER   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 2; NITRIC OXIDE; SEPIAPTERIN; TETRAHYDROBIOPTERIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIAC GRAFT REJECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GRAFT REJECTION; HEART TRANSPLANTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; LEWIS RAT; NITRATION; NONHUMAN; OXIDATIVE STRESS; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WISTAR RAT;

ALDEHYDES; ANIMALS; APOPTOSIS; ARGINASE; BIOPTERIN; CYCLOSPORINE; CYTOKINES; ECHOCARDIOGRAPHY; GENE EXPRESSION; GRAFT REJECTION; GTP CYCLOHYDROLASE; HEART TRANSPLANTATION; HEART VENTRICLES; IMMUNOSUPPRESSIVE AGENTS; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN PROCESSING, POST-TRANSLATIONAL; PTERINS; RATS; RATS, INBRED LEW; RATS, INBRED WF; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC; TYROSINE;

EID: 66749102277     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.148569     Document Type: Article

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