Synthesis and antiproliferative evaluation of some new amidino-substituted bis-benzothiazolyl-pyridines and pyrazine

European Journal of Medicinal Chemistry

Volumn 55, Issue , 2012, Pages 108-116

  Racané, Livio ^a   Kraljević Pavelić, Sandra ^b   Ratkaj, Ivana ^b   Stepanić, Višnja ^c   Pavelić, Krešimir ^b   Tralić Kulenović, Vesna ^a   Karminski Zamola, Grace ^d  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b University of Rijeka   (Croatia)

^c RUDER BO KOVI INSTITUTE   (Croatia)

^d UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

Amidines; Anticancer evaluation; Bis benzothiazolyl substituted pyridines and pyrazine

Indexed keywords

2,2' (PYRIDINE 2,3 DIYL) BIS [6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 1,3 BENZOTHIAZOLE] DIHYDROCHLORIDE; 2,2' (PYRIDINE 2,4 DIYL) BIS (1,3 BENZOTHIAZOLE 6 CARBOXIMIDAMID) DIHYDROCHLORIDE; 2,2' (PYRIDINE 2,4 DIYL) BIS [6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 1,3 BENZOTHIAZOLE] DIHYDROCHLORIDE; 2,2' (PYRIDINE 2,5 DIYL) BIS [6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 1,3 BENZOTHIAZOLE] DIHYDROCHLORIDE; 2,2' (PYRIDINE 2,6 DIYL) BIS (1,3 BENZOTHIAZOLE 6 CARBOXIMIDAMIDE) DIHYDROCHLORIDE; 2,2' (PYRIDINE 2,6 DIYL) BIS [6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 1,3 BENZOTHIAZOLE] DIHYDROCHLORIDE; 2,2' (PYRIDINE 3,4 DIYL) BIS (1,3 BENZOTHIAZOLE 6 CARBOXIMIDAMIDE) DIHYDROCHLORIDE; 2,2' (PYRIDINE 3,4 DIYL) BIS [6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 1,3 BENZOTHIAZOLE] DIHYDROCHLORIDE; 2,2' (PYRIDINE 3,5 DIYL) BIS (1,3 BENZOTHIAZOLE 6 CARBOXIMIDAMIDE) DIHYDROCHLORIDE; 2,2' (PYRIDINE 3,5 DIYL) BIS [6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 1,3 BENZOTHIAZOLE] DIHYDROCHLORIDE; 2,5 BIS [6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 1,3 BENZOTHIAZOL 2 YL] PYRAZINE DIHYDROCHLORIDE; ACETIC ACID; ALCOHOL; ANTINEOPLASTIC AGENT; CHLORIDE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; PYRAZINE DERIVATIVE; PYRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; DRUG SYNTHESIS; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; OXIDATIVE STRESS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; COMPUTATIONAL BIOLOGY; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; PYRAZINES; PYRIDINES;

EID: 84865793206     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.005     Document Type: Article

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