Novel amidino substituted 2-phenylbenzothiazoles: Synthesis, antitumor evaluation in vitro and acute toxicity testing in vivo

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1038-1044

  Racané, Livio ^b   Kralj, Marijeta ^c   Šuman, Lidija ^c   Stojković, Ranko ^c   Tralić Kulenović, Vesna ^b   Karminski Zamola, Grace ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Antitumor activity 'in vitro'; Nitro amidino , amino amidino and diamidino substituted 2 phenylbenzothiazoles; Toxicity testing 'in vivo'

Indexed keywords

2 (4 AMIDINOPHENYL) 6 AMIDINOBENZOTHIAZOLE; 2 (4 AMIDINOPHENYL) 6 AMINOBENZOTHIAZOLE; 2 (4 AMIDINOPHENYL) 6 NITROBENZOTHIAZOLE; 2 (4 AMINOPHENYL) 6 (IMIDAZOLIN 2 YL)BENZOTHIAZOLE; 2 (4 AMINOPHENYL) 6 AMIDINOBENZOTHIAZOLE; 2 (4 NITROPHENYL) 6 (IMIDAZOLIN 2 YL)BENZOTHIAZOLE; 2 (4 NITROPHENYL) 6 AMIDINOBENZOTHIAZOLE; 2 [4 (IMIDAZOLIN 2 YL)PHENYL] 6 (IMIDAZOLIN 2 YL)BENZOTHIAZOLE; 2 [4 (IMIDAZOLIN 2 YL)PHENYL] 6 AMINOBENZOTHIAZOLE; 2 [4 (IMIDAZOLIN 2 YL)PHENYL] 6 NITROBENZOTHIAZOLE; 6 CYANO 2 (4 NITROPHENYL)BENZOTHIAZOLE; 6 CYANO 2(4 CYANOPHENYL)BENZOTHIAZOLE; 6 NITRO 2 (4 CYANOPHENYL)BENZOTHIAZOLE; AMIDINE; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY WEIGHT; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; GASTROINTESTINAL TRACT; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LD 50; METHODOLOGY; MOUSE; NONHUMAN; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; LETHAL DOSE 50; MICE; MICE, INBRED BALB C; NEOPLASMS; THIAZOLES;

ANIMALIA; MUS;

EID: 75149117788     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.054     Document Type: Article

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