Novel Cyano- And amidinobenzothiazole derivatives: Synthesis, antitumor evaluation, and X-ray and quantitative structure-activity relationship (QSAR) analysis

Journal of Medicinal Chemistry

Volumn 52, Issue 6, 2009, Pages 1744-1756

  Ćaleta, Irena ^a,b   Kralj, Marijeta ^c   Marjanović, Marko ^c   Bertoŝa, Branimir ^c   Tomiĉ, Sanja ^c   Pavlović, Gordana ^d   Pavelić, Kreŝimir ^c   Karminski Zamola, Grace ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b GLAXOSMITHKLINE   (United Kingdom)

^c RUDER BO KOVI INSTITUTE   (Croatia)

^d UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N (6 (N ISOPROPYL)AMIDINOBENZOTIAZOL 2 YL)BENZAMIDE HYDROCHLORIDE; 4 (N ISOPROPYLAMIDINO) N (BENZOTHIAZOL 2 YL)BENZAMIDE HYDROCHLORIDE; 4 FLUORO N (6 (N ISOPROPYL)AMIDINOBENZOTIAZOL 2 YL)BENZAMID HYDROCHLORIDE; 6 (N ISOPROPYL)AMIDINO 2 (N (3 METHYLPYRIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 (N ISOPROPYL)AMIDINO 2 (N (4 METHYLPYRIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 (N ISOPROPYL)AMIDINO 2 (N (5 CHLOROPYRIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 (N ISOPROPYL)AMIDINO 2 (N (5 METHYLPYRIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 (N ISOPROPYL)AMIDINO 2 (N (6 METHYLPYRIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 (N ISOPROPYL)AMIDINO 2 (N (PYRIMIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 (N ISOPROPYLAMIDINO) 2 (N (4 ((N ISOPROPYLAMIDINO)PHENAMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 IMIDAZOLINYL 2 (N (3 METHYLPYRIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 IMIDAZOLINYL 2 (N (4 IMIDAZOLINYLPHENYL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 IMIDAZOLINYL 2 (N (4 METHYLPYRIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 IMIDAZOLINYL 2 (N (5 CHLOROPYRIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 IMIDAZOLINYL 2 (N (5 METHYLPYRIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 IMIDAZOLINYL 2 (N (6 METHYLPYRIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; 6 IMIDAZOLINYL 2 (N (PYRIMIDIN 2 YL)AMINO)BENZOTHIAZOLE DIHYDROCHLORIDE; ANTINEOPLASTIC AGENT; N (6 (N ISOPROPYL)AMIDINOBENZOTHIAZOL 2 YL)BENZAMIDE HYDROCHLORIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOTHIAZOLES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SOLUBILITY;

EID: 64349120832     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801566q     Document Type: Article

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