Inhibitory activities against topoisomerase I & II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 7, 2004, Pages 1669-1672

  Abdel Aziz, Mohamed ^a   Matsuda, Kazuya ^a   Otsuka, Masami ^a   Uyeda, Masaru ^a   Okawara, Tadashi ^a   Suzuki, Keitarou ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Polyhydroxybenzoyl amide; Structure activity relationship; Topoisomerase inhibitor

Indexed keywords

1,2 PHENYLENEDIAMINE; 1,3 PHENYLENEDIAMINE; 2,3,4 TRIACETYLOXYBENZOYLCHLORIDE; 3,4 DIACETYLOXYBENZOYLCHLORIDE; 4 ACETYLOXYBENZOYLCHLORIDE; ACETIC ACID; AMIDE; BENZOTHIAZOLE DERIVATIVE; BIS(TRIHYDROXYBENZOYL) 2 PHENYLENEDIAMIDE DERIVATIVE; CHLORINE DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; HYDROXYL GROUP; PHENYLENEDIAMINE; POLYHYDROXYBENZOYLAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

CELL CYCLE; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GROWTH INHIBITORS; HELA CELLS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1542613871     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.060     Document Type: Article

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