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Volumn 14, Issue 4, 2012, Pages 445-453

Use of corticosteroids and other adjunct therapies for acute bacterial meningitis in adults

Author keywords

Acute bacterial meningitis; Adjuvant therapy; Brain derived neurotrophic factor; Corticosteroid; Glycerol; Hypothermia; Immunoglobulin; Intracranial pressure (ICP) monitoring; Meningitis in adults; Poly ADP ribose; Tumor necrosis factor

Indexed keywords

BB 1101; CEFTRIAXONE; CORTICOSTEROID; DEXAMETHASONE; GLYCEROL; ILOMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; PLACEBO; TNF 484; UNCLASSIFIED DRUG;

EID: 84865644192     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-012-0271-7     Document Type: Article
Times cited : (9)

References (80)
  • 5
    • 0031954454 scopus 로고
    • Complications sequelae of meningococcal disease in Quebec Canada 1994-1998
    • Erickson L, De Wals P. Complications and sequelae of meningococcal disease in Quebec, Canada, 1990-1994. Clin Infect Dis. 1998;26(5):1159-64.
    • (1990) Clin Infect Dis. , vol.26 , Issue.5 , pp. 1159-1164
    • Erickson, L.1    De Wals, P.2
  • 6
    • 0031729541 scopus 로고    scopus 로고
    • Three-year multicenter surveillance of pneumococcal meningitis in children: Clinical characteristics, and outcome related to penicillin susceptibility and dexamethasone use
    • DOI 10.1542/peds.102.5.1087
    • Arditi M, Mason Jr. EO, Bradley JS, Tan TQ, Barson WJ, Schutze GE, et al. Three-year multicenter surveillance of pneumococcal meningitis in children: Clinical characteristics, and outcome related to penicillin susceptibility and dexamethasone use. Pediatrics. 1998;102(5):1087-97. (Pubitemid 28511715)
    • (1998) Pediatrics , vol.102 , Issue.5 , pp. 1087-1097
    • Arditi, M.1    Mason Jr., E.O.2    Bradley, J.S.3    Tan, T.Q.4    Barson, W.J.5    Schuze, G.E.6    Wald, E.R.7    Givner, L.B.8    Kim, K.S.9    Yogev, R.10    Kaplan, S.L.11
  • 7
    • 0033839838 scopus 로고    scopus 로고
    • Twelve year outcomes following bacterial meningitis: Further evidence for persisting effects
    • DOI 10.1136/adc.83.2.111
    • Grimwood K, Anderson P, Anderson V, Tan L, Nolan T. Twelve year outcomes following bacterial meningitis: Further evidence for persisting effects. Arch Dis Child. 2000;83(2):111-6. (Pubitemid 30670418)
    • (2000) Archives of Disease in Childhood , vol.83 , Issue.2 , pp. 111-116
    • Grimwood, K.1    Anderson, P.2    Anderson, V.3    Tan, L.4    Nolan, T.5
  • 9
    • 0027122363 scopus 로고
    • Bacterial meningitis: Pathogenesis, pathophysiology, and progress
    • Quagliarello V, Scheld WM. Bacterial meningitis: Pathogenesis, pathophysiology, and progress. N Engl J Med. 1992;327 (12):864-72.
    • (1992) N Engl J Med , vol.327 , Issue.12 , pp. 864-872
    • Quagliarello, V.1    Scheld, W.M.2
  • 10
    • 33747371683 scopus 로고    scopus 로고
    • Bacterial meningitis and inflammation
    • Nelson Jr. RP. Bacterial meningitis and inflammation. Curr Opin Neurol. 2006;19(4):369-73.
    • (2006) Curr Opin Neurol. , vol.19 , Issue.4 , pp. 369-373
    • Nelson Jr., R.P.1
  • 12
    • 33644751620 scopus 로고    scopus 로고
    • Chemotactic factors in cerebrospinal fluid during bacterial meningitis
    • DOI 10.1128/IAI.74.3.1445-1451.2006
    • Zwijnenburg PJG, van der Poll T, Roord JJ, van Furth AM. Chemotactic factors in cerebrospinal fluid during bacterial meningitis. Infect Immun. 2006;74(3):1445-51. (Pubitemid 43346776)
    • (2006) Infection and Immunity , vol.74 , Issue.3 , pp. 1445-1451
    • Zwijnenburg, P.J.G.1    Van Der Poll, T.2    Roord, J.J.3    Van Furth, A.M.4
  • 13
    • 33646527392 scopus 로고    scopus 로고
    • Strategies to prevent neuronal damage in paediatric bacterial meningitis
    • Grandgirard D, Leib SL. Strategies to prevent neuronal damage in paediatric bacterial meningitis. Curr Opin Pediatr. 2006;18(2):112-8.
    • (2006) Curr Opin Pediatr , vol.18 , Issue.2 , pp. 112-118
    • Grandgirard, D.1    Leib, S.L.2
  • 15
    • 0027165428 scopus 로고
    • Listeria meningitis: Identification of a cerebrospinal fluid inhibitor of macrophage listericidal function as interleukin 10
    • Frei K, Nadal D, Pfister HW, Fontana A. Listeria meningitis: Identification of a cerebrospinal fluid inhibitor of macrophage listericidal function as interleukin 10. J Exp Med. 1993;178(4):1255-61. (Pubitemid 23277358)
    • (1993) Journal of Experimental Medicine , vol.178 , Issue.4 , pp. 1255-1261
    • Frei, K.1    Nadal, D.2    Pfister, H.-W.3    Fontana, A.4
  • 16
    • 0029058650 scopus 로고
    • High levels of interleukin 10 and tumor necrosis factor alpha in cerebrospinal fluid during the onset of bacterial meningitis
    • van Furth AM, Seijmonsbergen EM, Langermans JA, Groeneveld PH, de Bel CE, van Furth R. High levels of interleukin 10 and tumor necrosis factor alpha in cerebrospinal fluid during the onset of bacterial meningitis. Clin Infect Dis. 1995;21(1):220-2.
    • (1995) Clin Infect Dis , vol.21 , Issue.1 , pp. 220-222
    • Van Furth, A.M.1    Seijmonsbergen, E.M.2    Langermans, J.A.3    Groeneveld, P.H.4    De Bel, C.E.5    Van Furth, R.6
  • 18
    • 34247120545 scopus 로고    scopus 로고
    • Bacterial meningitis: The role of transforming growth factor-beta in innate immunity and secondary brain damage
    • DOI 10.1159/000100358
    • Malipiero U, Koedel U, Pfister W, Fontana A. Bacterial meningitis: The role of transforming growth factor-Beta in innate immunity and secondary brain damage. Neurodegener Dis. 2007;4(1):43-50. (Pubitemid 46586559)
    • (2007) Neurodegenerative Diseases , vol.4 , Issue.1 , pp. 43-50
    • Malipiero, U.1    Koedel, U.2    Pfister, W.3    Fontana, A.4
  • 19
    • 0034845846 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinases and tumour necrosis factor α converting enzyme as adjuvant therapy in pneumococcal meningitis
    • Leib SL, Clements JM, Lindberg RL, Heimgartner C, Loeffler JM, Pfister LA, et al. Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain. 2001;124(Pt 9):1734-42. (Pubitemid 32845435)
    • (2001) Brain , vol.124 , Issue.9 , pp. 1734-1742
    • Leib, S.L.1    Clements, J.M.2    Lindberg, R.L.P.3    Heimgartner, C.4    Loeffler, J.M.5    Pfister, L.-A.6    Ta Uber, M.G.7    Leppert, D.8
  • 21
    • 34250198282 scopus 로고    scopus 로고
    • Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis
    • DOI 10.1128/AAC.01014-06
    • Grandgirard D, Schürch C, Cottagnoud P, Leib SL. Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. Antimicrob Agents Chemother. 2007;51(6):2173-8. (Pubitemid 46903110)
    • (2007) Antimicrobial Agents and Chemotherapy , vol.51 , Issue.6 , pp. 2173-2178
    • Grandgirard, D.1    Schurch, C.2    Cottagnoud, P.3    Leib, S.L.4
  • 22
    • 0023135866 scopus 로고
    • Differences in cerebrospinal fluid penetration of corticosteroids: Possible relationship to the prevention of meningeal leukemia
    • Balis FM, Lester CM, Chrousos GP, Heideman RL, Poplack DG. Differences in cerebrospinal fluid penetration of corticosteroids: Possible relationship to the prevention of meningeal leukemia. J Clin Oncol. 1987;5(2):202-7. 23. 9. (Pubitemid 17021600)
    • (1987) Journal of Clinical Oncology , vol.5 , Issue.2 , pp. 202-207
    • Balis, F.M.1    Lester, C.M.2    Chrousos, G.P.3
  • 23
    • 0037079004 scopus 로고    scopus 로고
    • Dexamethasone in adults with bacterial meningitis
    • DOI 10.1056/NEJMoa021334
    • de Gans J, van de Beek D. Dexamethasone in adults with bacterial meningitis. N Engl J Med. 2002;347(20):1549-56. This study included 301 acute bacterial meningitis patients in which dexamethasone group was associated with favourable outcome among the patients with pneumococcal meningitis. (Pubitemid 35315835)
    • (2002) New England Journal of Medicine , vol.347 , Issue.20 , pp. 1549-1556
    • De Gans, J.1    Van Beek, D.2
  • 25
    • 0001563188 scopus 로고
    • The effectiveness of hydrocortisone in the management of severe infections
    • Bennett I, Finland M, Hamburger M, et al. The effectiveness of hydrocortisone in the management of severe infections. JAMA. 1963;183(6):462-5.
    • (1963) JAMA , vol.183 , Issue.6 , pp. 462-465
    • Bennett, I.1    Finland, M.2    Hamburger, M.3
  • 26
    • 0014541486 scopus 로고
    • Corticosteroids as an adjunct to treatment in bacterial meningitis. A controlled clinical trial
    • DeLemos RA, Haggerty RJ. Corticosteroids as an adjunct to treatment in bacterial meningitis. A controlled clinical trial. Pediatrics. 1969;44(1):30-4.
    • (1969) Pediatrics , vol.44 , Issue.1 , pp. 30-34
    • DeLemos, R.A.1    Haggerty, R.J.2
  • 27
    • 0023778758 scopus 로고
    • Dexamethasone therapy for bacterial meningitis. Results of two double-blind, placebo-controlled trials
    • Lebel MH, Freij BJ, Syrogiannopoulos GA, Chrane DF, Hoyt MJ, Stewart SM, et al. Dexamethasone therapy for bacterial meningitis. Results of two double-blind, placebo-controlled trials. N Engl J Med. 1988;319(15):964-71.
    • (1988) N Engl J Med , vol.319 , Issue.15 , pp. 964-971
    • Lebel, M.H.1    Freij, B.J.2    Syrogiannopoulos, G.A.3    Chrane, D.F.4    Hoyt, M.J.5    Stewart, S.M.6
  • 29
    • 0025876403 scopus 로고
    • The beneficial effects of early dexamethasone administration in infants and children with bacterial meningitis
    • Odio CM, Faingezicht I, Paris M, Nassar M, Baltodano A, Rogers J, et al. The beneficial effects of early dexamethasone administration in infants and children with bacterial meningitis. N Engl J Med. 1991;324(22):1525-31. 30. 9.
    • (1991) N Engl J Med. , vol.324 , Issue.22 , pp. 1525-3
    • Odio, C.M.1    Faingezicht, I.2    Paris, M.3    Nassar, M.4    Baltodano, A.5    Rogers, J.6
  • 31
    • 37249060680 scopus 로고    scopus 로고
    • Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa
    • DOI 10.1056/NEJMoa065711
    • Scarborough M, Gordon SB, Whitty CJM, French N, Njalale Y, Chitani A, et al. Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa. N Engl J Med. 2007;357(24):2441-50. This study is an important RCTwas conducted in Malawi on 465 patients, most of whom were human immunodeficiency virus (HIV) positive. This trial did not support the routine use of corticosteroids in the management of adult bacterial meningitis in resource-poor areas where relatively higher proportion of population is HIV positive. 32. 9. (Pubitemid 350272783)
    • (2007) New England Journal of Medicine , vol.357 , Issue.24 , pp. 2441-2450
    • Scarborough, M.1    Gordon, S.B.2    Whitty, C.J.M.3    French, N.4    Njalale, Y.5    Chitani, A.6    Peto, T.E.A.7    Lalloo, D.G.8    Zijlstra, E.E.9
  • 32
    • 76449121189 scopus 로고    scopus 로고
    • Adjunctive dexamethasone in bacterial meningitis: A meta-Analysis of individual patient data
    • This study is a recently published individual patient data meta-Analysis included five large double blinded RCTs since 2001
    • van de Beek D, Farrar JJ, de Gans J, Mai NTH, Molyneux EM, Peltola H, et al. Adjunctive dexamethasone in bacterial meningitis: A meta-Analysis of individual patient data. Lancet Neurol. 2010;9 (3):254-63. This study is a recently published individual patient data meta-Analysis included five large double blinded RCTs since 2001.
    • (2010) Lancet Neurol. , vol.9 , Issue.3 , pp. 254-63
    • Van De Beek, D.1    Farrar, J.J.2    De Gans, J.3    Mai, N.T.H.4    Molyneux, E.M.5    Peltola, H.6
  • 33
    • 65449128065 scopus 로고    scopus 로고
    • Adjunctive dexamethasone therapy for bacterial meningitis in adults: A meta-Analysis of randomized controlled trials
    • This is a meta-Analysis article included four large trials on this toic
    • Vardakas KZ, Matthaiou DK, Falagas ME. Adjunctive dexamethasone therapy for bacterial meningitis in adults: A meta-Analysis of randomized controlled trials. Eur J Neurol. 2009;16(6):662-73. This is a meta-Analysis article included four large trials on this topic.
    • (2009) Eur J Neurol. , vol.16 , Issue.6 , pp. 662-73
    • Vardakas, K.Z.1    Matthaiou, D.K.2    Falagas, M.E.3
  • 34
    • 66149183025 scopus 로고    scopus 로고
    • Corticosteroid administration and outcome of adolescents and adults with acute bacterial meningitis: A metaanalysis
    • This is a meta-Analysis article on this topic.35.9
    • Assiri AM, Alasmari FA, Zimmerman VA, Baddour LM, Erwin PJ, Tleyjeh IM. Corticosteroid administration and outcome of adolescents and adults with acute bacterial meningitis: A metaanalysis. Mayo Clin Proc. 2009;84(5):403-9. This is a meta-Analysis article on this topic. 35. 9.
    • (2009) Mayo Clin Proc. , vol.84 , Issue.5 , pp. 403-9
    • Assiri, A.M.1    Alasmari, F.A.2    Zimmerman, V.A.3    Baddour, L.M.4    Erwin, P.J.5    Tleyjeh, I.M.6
  • 35
    • 84891675790 scopus 로고    scopus 로고
    • Corticosteroids for acute bacterial meningitis
    • This article is a Cochrane review evaluated corticosteroid versus placebo on mortality, hearing loss and neurological sequelae in patients with acute bacterial meningitis. Twenty-four randomized control studies involving 4041 patients were included in the review
    • Brouwer MC, McIntyre P, de Gans J, Prasad K, van de Beek D. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev. 2010;9:CD004405. This article is a Cochrane review evaluated corticosteroid versus placebo on mortality, hearing loss and neurological sequelae in patients with acute bacterial meningitis. Twenty-four randomized control studies involving 4041 patients were included in the review.
    • (2010) Cochrane Database Syst Rev. , Issue.9
    • Brouwer, M.C.1    McIntyre, P.2    De Gans, J.3    Prasad, K.4    Van De Beek, D.5
  • 36
    • 0033581124 scopus 로고    scopus 로고
    • Consensus statement. Global burden of tuberculosis: Estimated incidence, prevalence, and mortality by country. Who global surveillance and monitoring project
    • Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC. Consensus statement. Global burden of tuberculosis: Estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA. 1999;282(7):677-86.
    • (1999) JAMA , vol.282 , Issue.7 , pp. 677-686
    • Dye, C.1    Scheele, S.2    Dolin, P.3    Pathania, V.4    Raviglione, M.C.5
  • 37
    • 0022337692 scopus 로고
    • Acute effect of glycerol on net cerebrospinal fluid production in dogs
    • Zoghbi HY, Okumura S, Laurent JP, Fishman MA. Acute effect of glycerol on net cerebrospinal fluid production in dogs. J Neurosurg. 1985;63(5):759-62. (Pubitemid 16198966)
    • (1985) Journal of Neurosurgery , vol.63 , Issue.5 , pp. 759-762
    • Zoghbi, H.Y.1    Okumura, S.2    Laurent, J.P.3    Fishman, M.A.4
  • 38
    • 0025617685 scopus 로고
    • General principles of therapy of pyogenic meningitis
    • Täuber MG, Sande MA. General principles of therapy of pyogenic meningitis. Infect Dis Clin North Am. 1990;4(4):661-76.
    • (1990) Infect Dis Clin North Am , vol.4 , Issue.4 , pp. 661-676
    • Täuber, M.G.1    Sande, M.A.2
  • 39
    • 0021356089 scopus 로고
    • Antibacterial activity of β-lactam antibiotics in experimental meningitis due to Streptococcus pneumoniae
    • Täuber MG, Doroshow CA, Hackbarth CJ, Rusnak MG, Drake TA, Sande MA. Antibacterial activity of beta-lactam antibiotics in experimental meningitis due to Streptococcus pneumoniae. J Infect Dis. 1984;149(4):568-74. (Pubitemid 14139042)
    • (1984) Journal of Infectious Diseases , vol.149 , Issue.4 , pp. 568-574
    • Tauber, M.G.1    Doroshow, C.A.2    Hackbarth, C.J.3
  • 40
    • 0018192285 scopus 로고
    • Factors influencing the therapy of experimental Proteus mirabilis meningitis in rabbits
    • Strausbaugh LJ, Sande MA. Factors influencing the therapy of experimental Proteus mirabilis meningitis in rabbits. J Infect Dis. 1978;137(3):251-60. (Pubitemid 8309141)
    • (1978) Journal of Infectious Diseases , vol.137 , Issue.3 , pp. 251-260
    • Strausbaugh, L.J.1    Sande, M.A.2
  • 41
    • 0013912694 scopus 로고
    • Oral glycerol: The mechanism of intraocular hypotension
    • McCurdy DK, Schneider B, Scheie HG. Oral glycerol: The mechanism of intraocular hypotension. Am J Ophthalmol. 1966;61(5 Pt 2):1244-9.
    • (1966) Am J Ophthalmol. , vol.61 , Issue.5 PART 2 , pp. 1244-1249
    • McCurdy, D.K.1    Schneider, B.2    Scheie, H.G.3
  • 42
    • 30844443240 scopus 로고    scopus 로고
    • Clinical features, complications, and outcome in adults with pneumococcal meningitis: A prospective case series
    • DOI 10.1016/S1474-4422(05)70288-X, PII S147444220570288X
    • Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J. Clinical features, complications, and outcome in adults with pneumococcal meningitis: A prospective case series. Lancet Neurol. 2006;5(2):123-9. (Pubitemid 43107848)
    • (2006) Lancet Neurology , vol.5 , Issue.2 , pp. 123-129
    • Weisfelt, M.1    Van De Beek, D.2    Spanjaard, L.3    Reitsma, J.B.4    De Gans, J.5
  • 43
    • 0025096057 scopus 로고
    • Cerebral blood flow and carbon dioxide reactivity in children with bacterial meningitis
    • Ashwal S, Stringer W, Tomasi L, Schneider S, Thompson J, Perkin R. Cerebral blood flow and carbon dioxide reactivity in children with bacterial meningitis. J Pediatr. 1990;117(4):523-30. 44. 9. (Pubitemid 20332089)
    • (1990) Journal of Pediatrics , vol.117 , Issue.4 , pp. 523-530
    • Ashwal, S.1    Stringer, W.2    Tomasi, L.3    Schneider, S.4    Thompson, J.5    Perkin, R.6
  • 44
    • 79953048814 scopus 로고    scopus 로고
    • Glycerol adjuvant therapy in adults with bacterial meningitis in a high hiv seroprevalence setting in malawi: A double-blind, randomised controlled trial
    • This study is a good, high quality, placebocontrolled, double blinded randomized control trial evaluated the role of glycerol in adult bacterial meningitis
    • Ajdukiewicz KM, Cartwright KE, Scarborough M, Mwambene JB, Goodson P, Molyneux ME, Zijlstra EE, French N, Whitty CJ, Lalloo DG. Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: A double-blind, randomised controlled trial. Lancet Infect Dis. 2011;11(4):293-300. This study is a good, high quality, placebocontrolled, double blinded randomized control trial evaluated the role of glycerol in adult bacterial meningitis.
    • (2011) Lancet Infect Dis. , vol.11 , Issue.4 , pp. 293-300
    • Ajdukiewicz, K.M.1    Cartwright, K.E.2    Scarborough, M.3    Mwambene, J.B.4    Goodson, P.5    Molyneux, M.E.6    Zijlstra, E.E.7    French, N.8    Whitty, C.J.9    Lalloo, D.G.10
  • 45
    • 74049150519 scopus 로고    scopus 로고
    • Hearing impairment in childhood bacterial meningitis is little relieved by dexamethasone or glycerol
    • Peltola H, Roine I, Fernández J, González Mata A, Zavala I, Gonzalez Ayala S, et al. Hearing impairment in childhood bacterial meningitis is little relieved by dexamethasone or glycerol. Pediatrics. 2010;125(1):e1-8.
    • (2010) Pediatrics , vol.125 , Issue.1
    • Peltola, H.1    Roine, I.2    Fernández, J.3    González Mata, A.4    Zavala, I.5    Gonzalez Ayala, S.6
  • 46
    • 34948903280 scopus 로고    scopus 로고
    • Role of dexamethasone and oral glycerol in reducing hearing and neurological sequelae in children with bacterial meningitis
    • Sankar J, Singhi P, Bansal A, Ray P, Singhi S. Role of dexamethasone and oral glycerol in reducing hearing and neurological sequelae in children with bacterial meningitis. Indian Pediatr. 2007;44(9):649-56. (Pubitemid 47523298)
    • (2007) Indian Pediatrics , vol.44 , Issue.9 , pp. 649-656
    • Sankar, J.1    Singhi, P.2    Bansal, A.3    Ray, P.4    Singhi, S.5
  • 51
    • 80955180009 scopus 로고    scopus 로고
    • Neurointensive care of patients with severe community-Acquired meningitis
    • Edberg M, Furebring M, Sjölin J, Enblad P. Neurointensive care of patients with severe community-Acquired meningitis. Acta Anaesthesiol Scand. 2011;55(6):732-9.
    • (2011) Acta Anaesthesiol Scand , vol.55 , Issue.6 , pp. 732-739
    • Edberg, M.1    Furebring, M.2    Sjölin, J.3    Enblad, P.4
  • 52
    • 33750092752 scopus 로고    scopus 로고
    • Multimodal cerebral monitoring and decompressive surgery for the treatment of severe bacterial meningitis with increased intracranial pressure
    • Baussart B, Cheisson G, Compain M, Leblanc PE, Tadie M, Benhamou D, et al. Multimodal cerebral monitoring and decompressive surgery for the treatment of severe bacterial meningitis with increased intracranial pressure. Acta Anaesthesiol Scand. 2006;50(6):762-5.
    • (2006) Acta Anaesthesiol Scand. , vol.50 , Issue.6 , pp. 762-765
    • Baussart, B.1    Cheisson, G.2    Compain, M.3    Leblanc, P.E.4    Tadie, M.5    Benhamou, D.6
  • 53
    • 32744468113 scopus 로고    scopus 로고
    • Induced hypothermia in neurocatastrophes: Feeling the chill
    • Wijdicks EFM. Induced hypothermia in neurocatastrophes: Feeling the chill. Rev Neurol Dis. 2004;1(1):10-5.
    • (2004) Rev Neurol Dis. , vol.1 , Issue.1 , pp. 10-15
    • Wijdicks, E.F.M.1
  • 56
    • 0038726157 scopus 로고    scopus 로고
    • Therapeutic hypothermia for acute stroke
    • DOI 10.1016/S1474-4422(03)00436-8
    • Olsen TS, Weber UJ, Kammersgaard LP. Therapeutic hypothermia for acute stroke. Lancet Neurol. 2003;2(7):410-6. (Pubitemid 36793933)
    • (2003) Lancet Neurology , vol.2 , Issue.7 , pp. 410-416
    • Olsen, T.S.1    Weber, U.J.2    Kammersgaard, L.P.3
  • 58
    • 0141530958 scopus 로고    scopus 로고
    • Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation
    • DOI 10.1161/01.STR.0000091269.67384.E7
    • Deng H, Han HS, Cheng D, Sun GH, Yenari MA. Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation. Stroke. 2003;34(10):2495-501. (Pubitemid 37221971)
    • (2003) Stroke , vol.34 , Issue.10 , pp. 2495-2501
    • Deng, H.1    Han, H.S.2    Cheng, D.3    Sun, G.H.4    Yenari, M.A.5
  • 59
    • 0035495804 scopus 로고    scopus 로고
    • Immunotherapy of sepsis
    • DOI 10.1016/S1473-3099(01)00093-7, PII S1473309901000937
    • van der Poll T. Immunotherapy of sepsis. Lancet Infect Dis. 2001;1 (3):165-74. (Pubitemid 33586050)
    • (2001) Lancet Infectious Diseases , vol.1 , Issue.3 , pp. 165-174
    • Van Der Poll, T.1
  • 63
    • 0036900042 scopus 로고    scopus 로고
    • Pathogenesis and pathophysiology of pneumococcal meningitis
    • DOI 10.1016/S1473-3099(02)00450-4
    • Koedel U, Scheld WM, Pfister H-W. Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infect Dis. 2002;2 (12):721-36. (Pubitemid 35434557)
    • (2002) Lancet Infectious Diseases , vol.2 , Issue.12 , pp. 721-736
    • Koedel, U.1    Scheld, W.M.2    Pfister, H.-W.3
  • 64
    • 0037868085 scopus 로고    scopus 로고
    • Pathogenesis of bacterial meningitis: From bacteraemia to neuronal injury
    • DOI 10.1038/nrn1103
    • Kim KS. Pathogenesis of bacterial meningitis: From bacteraemia to neuronal injury. Nat Rev Neurosci. 2003;4(5):376-85. (Pubitemid 37280176)
    • (2003) Nature Reviews Neuroscience , vol.4 , Issue.5 , pp. 376-385
    • Kim, K.S.1
  • 65
    • 30844446454 scopus 로고    scopus 로고
    • Pneumococcal meningitis: A 21st century perspective
    • DOI 10.1016/S1474-4422(06)70329-5, PII S1474442206703295
    • Kastenbauer S. Pneumococcal meningitis: A 21st century perspective. Lancet Neurol. 2006;5(2):104-5. (Pubitemid 43107840)
    • (2006) Lancet Neurology , vol.5 , Issue.2 , pp. 104-105
    • Kastenbauer, S.1
  • 67
    • 11144321597 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor protects against multiple forms of brain injury in bacterial meningitis
    • DOI 10.1086/426399
    • Bifrare Y-D, Kummer J, Joss P, Täuber MG, Leib SL. Brain-derived neurotrophic factor protects against multiple forms of brain injury in bacterial meningitis. J Infect Dis. 2005;191(1):40-5. (Pubitemid 40041398)
    • (2005) Journal of Infectious Diseases , vol.191 , Issue.1 , pp. 40-45
    • Bifrare, Y.-D.1    Kummer, J.2    Joss, P.3    Tauber, M.G.4    Leib, S.L.5
  • 69
    • 0033984374 scopus 로고    scopus 로고
    • Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis
    • DOI 10.1128/IAI.68.2.615-620.2000
    • Leib SL, Leppert D, Clements J, Täuber MG. Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis. Infect Immun. 2000;68(2):615-20. (Pubitemid 30056514)
    • (2000) Infection and Immunity , vol.68 , Issue.2 , pp. 615-620
    • Leib, S.L.1    Leppert, D.2    Clements, J.3    Tauber, M.G.4
  • 70
    • 0037175071 scopus 로고    scopus 로고
    • Oxidant and antioxidant activities in childhood meningitis
    • DOI 10.1016/S0024-3205(02)02137-9, PII S0024320502021379
    • Tsukahara H, Haruta T, Todoroki Y, Hiraoka M, Noiri E, Maeda M, et al. Oxidant and antioxidant activities in childhood meningitis. Life Sci. 2002;71(23):2797-806. (Pubitemid 35291066)
    • (2002) Life Sciences , vol.71 , Issue.23 , pp. 2797-2806
    • Tsukahara, H.1    Haruta, T.2    Todoroki, Y.3    Hiraoka, M.4    Noiri, E.5    Maeda, M.6    Mayumi, M.7
  • 71
    • 0030901966 scopus 로고    scopus 로고
    • Protective effect of the antioxidant N-acetyl-L-cysteine in pneumococcal meningitis in the rat
    • DOI 10.1016/S0304-3940(97)00177-8, PII S0304394097001778
    • Koedel U, Pfister HW. Protective effect of the antioxidant Nacetyl-L-cysteine in pneumococcal meningitis in the rat. Neurosci Lett. 1997;225(1):33-6. (Pubitemid 27154211)
    • (1997) Neuroscience Letters , vol.225 , Issue.1 , pp. 33-36
    • Koedel, U.1    Pfister, H.-W.2
  • 72
    • 0033931132 scopus 로고    scopus 로고
    • Effects of clinically used antioxidants in experimental pneumococcal meningitis
    • DOI 10.1086/315658
    • Auer M, Pfister LA, Leppert D, Täuber MG, Leib SL. Effects of clinically used antioxidants in experimental pneumococcal meningitis. J Infect Dis. 2000;182(1):347-50. (Pubitemid 30497829)
    • (2000) Journal of Infectious Diseases , vol.182 , Issue.1 , pp. 347-350
    • Auer, M.1    Pfister, L.-A.2    Leppert, D.3    Tauber, M.G.4    Leib, S.L.5
  • 73
    • 0029852720 scopus 로고    scopus 로고
    • Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
    • Leib SL, Kim YS, Chow LL, Sheldon RA, Täuber MG. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J Clin Invest. 1996;98(11):2632-9. (Pubitemid 26415086)
    • (1996) Journal of Clinical Investigation , vol.98 , Issue.11 , pp. 2632-2639
    • Leib, S.L.1    Kim, Y.S.2    Chow, L.L.3    Sheldon, R.A.4    Tauber, M.G.5
  • 74
    • 0035863578 scopus 로고    scopus 로고
    • The free radical scavenger α-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis
    • DOI 10.1086/317921
    • Loeffler JM, Ringer R, Hablützel M, Täuber MG, Leib SL. The free radical scavenger alpha-phenyl-Tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. J Infect Dis. 2001;183(2):247-52. (Pubitemid 32066026)
    • (2001) Journal of Infectious Diseases , vol.183 , Issue.2 , pp. 247-252
    • Loeffler, J.M.1    Ringer, R.2    Hablutzel, M.3    Tauber, M.G.4    Leib, S.L.5
  • 75
    • 0035877050 scopus 로고    scopus 로고
    • Differential expression of nitric oxide synthases in bacterial meningitis: Role of the inducible isoform for blood-brain barrier breakdown
    • DOI 10.1086/320730
    • Winkler F, Koedel U, Kastenbauer S, Pfister HW. Differential expression of nitric oxide synthases in bacterial meningitis: role of the inducible isoform for blood-brain barrier breakdown. J Infect Dis. 2001;183(12):1749-59. (Pubitemid 32523237)
    • (2001) Journal of Infectious Diseases , vol.183 , Issue.12 , pp. 1749-1759
    • Winkler, F.1    Koedel, U.2    Kastenbauer, S.3    Pfister, H.W.4
  • 77
    • 0036139308 scopus 로고    scopus 로고
    • Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase
    • Koedel U, Winkler F, Angele B, Fontana A, Pfister H-W. Meningitis-Associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab. 2002;22(1):39-49. (Pubitemid 34038381)
    • (2002) Journal of Cerebral Blood Flow and Metabolism , vol.22 , Issue.1 , pp. 39-49
    • Koedel, U.1    Winkler, F.2    Angele, B.3    Fontana, A.4    Pfister, H.-W.5
  • 78
    • 0141870088 scopus 로고    scopus 로고
    • Meningitis-associated hearing loss: Protection by adjunctive antioxidant therapy
    • DOI 10.1002/ana.10684
    • Klein M, Koedel U, Pfister H-W, Kastenbauer S. Meningitisassociated hearing loss: Protection by adjunctive antioxidant therapy. Ann Neurol. 2003;54(4):451-8. (Pubitemid 37176539)
    • (2003) Annals of Neurology , vol.54 , Issue.4 , pp. 451-458
    • Klein, M.1    Koedel, U.2    Pfister, H.-W.3    Kastenbauer, S.4
  • 79
    • 0033790833 scopus 로고    scopus 로고
    • Pharmacologic interference with nf-kappab activation attenuates central nervous system complications in experimental pneumococcal meningitis
    • Koedel U, Bayerlein I, Paul R, Sporer B, Pfister HW. Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis. J Infect Dis. 2000;182(5):1437-45.
    • (2000) J Infect Dis , vol.182 , Issue.5 , pp. 1437-1445
    • Koedel, U.1    Bayerlein, I.2    Paul, R.3    Sporer, B.4    Pfister, H.W.5
  • 80
    • 34247529539 scopus 로고    scopus 로고
    • Adjuvant tace inhibitor treatment improves the outcome of tlr2-/-mice with experimental pneumococcal meningitis
    • Echchannaoui H, Leib SL, Neumann U, Landmann RMA. Adjuvant TACE inhibitor treatment improves the outcome of TLR2-/-mice with experimental pneumococcal meningitis. BMC Infect Dis. 2007;7:25.
    • (2007) BMC Infect Dis. , vol.7 , pp. 25
    • Echchannaoui, H.1    Leib, S.L.2    Neumann, U.3    Landmann, R.M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.