메뉴 건너뛰기




Volumn 1222, Issue 1, 2011, Pages 83-89

Raltegravir: The first HIV-1 integrase strand transfer inhibitor in the HIV armamentarium

Author keywords

AIDS; HIV 1; Integrase inhibitor; Raltegravir

Indexed keywords

ATAZANAVIR; DARUNAVIR; EFAVIRENZ; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ENFUVIRTIDE; ETRAVIRINE; INTEGRASE; LAMIVUDINE; MIDAZOLAM; PLACEBO; RALTEGRAVIR; RIFAMPICIN; RITONAVIR; TENOFOVIR; TIPRANAVIR;

EID: 79952834794     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2011.05972.x     Document Type: Article
Times cited : (46)

References (35)
  • 1
    • 79952821149 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organization (WHO). AIDS epidemic update, December 2009. Available at: Accessed December 13, 2010.
    • Joint United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organization (WHO). AIDS epidemic update, December 2009. Available at: Accessed December 13, 2010.
  • 2
    • 48949097660 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA Panel
    • Hammer, S.M., J.J. Eron, P. Reiss, et al 2008. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA Panel. JAMA 300: 555-570.
    • (2008) JAMA , vol.300 , pp. 555-570
    • Hammer, S.M.1    Eron, J.J.2    Reiss, P.3
  • 3
    • 0038162585 scopus 로고    scopus 로고
    • Decline in the AIDS and death rates in the EuroSIDA study: an observational study
    • Mocroft, A., B. Ledergerber, C. Katlama, et al 2003. Decline in the AIDS and death rates in the EuroSIDA study: an observational study. Lancet 362: 22-29.
    • (2003) Lancet , vol.362 , pp. 22-29
    • Mocroft, A.1    Ledergerber, B.2    Katlama, C.3
  • 4
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella, F.J., K.M. Delaney, A.C. Moorman, et al 1998. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N. Engl. J. Med. 338: 853-860.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 853-860
    • Palella, F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 5
    • 0037043652 scopus 로고    scopus 로고
    • Antiretroviral-drug resistance among patients recently infected with HIV
    • Little, S.J., S. Holte, J.-P. Routy, et al 2002. Antiretroviral-drug resistance among patients recently infected with HIV. N. Engl. J. Med. 347: 385-394.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 385-394
    • Little, S.J.1    Holte, S.2    Routy, J.-P.3
  • 6
    • 2942529150 scopus 로고    scopus 로고
    • The epidemiology of antiretroviral drug resistance among drug-naive HIV-1-infected persons in 10 US cities
    • Weinstock, H.S., I. Zaidi, W. Heneine, et al 2004. The epidemiology of antiretroviral drug resistance among drug-naive HIV-1-infected persons in 10 US cities. J. Infect. Dis. 189: 2174-2180.
    • (2004) J. Infect. Dis. , vol.189 , pp. 2174-2180
    • Weinstock, H.S.1    Zaidi, I.2    Heneine, W.3
  • 7
    • 24644472997 scopus 로고    scopus 로고
    • Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management
    • Wensing, A.M.J., D.A. van de Vijver, G. Angarano, et al 2005. Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management. J. Infect. Dis. 192: 958-966.
    • (2005) J. Infect. Dis. , vol.192 , pp. 958-966
    • Wensing, A.M.J.1    van de Vijver, D.A.2    Angarano, G.3
  • 8
    • 33646812239 scopus 로고    scopus 로고
    • Tracking the prevalence of transmitted antiretroviral drug-resistant HIV-1: a decade of experience
    • Shet, A., L. Berry, H. Mohri, et al 2006. Tracking the prevalence of transmitted antiretroviral drug-resistant HIV-1: a decade of experience. J. Acquir. Immune Defic. Syndr. 41: 439-446.
    • (2006) J. Acquir. Immune Defic. Syndr. , vol.41 , pp. 439-446
    • Shet, A.1    Berry, L.2    Mohri, H.3
  • 9
    • 0037055016 scopus 로고    scopus 로고
    • Time trends in primary HIV-1 drug resistance among recently infected persons
    • Grant, R.M., F.M. Hecht, M. Warmerdam, et al 2002. Time trends in primary HIV-1 drug resistance among recently infected persons. JAMA 288: 181-188.
    • (2002) JAMA , vol.288 , pp. 181-188
    • Grant, R.M.1    Hecht, F.M.2    Warmerdam, M.3
  • 10
    • 0037178323 scopus 로고    scopus 로고
    • Evolving patterns of HIV-1 resistance to antiretroviral agents in newly infected individuals
    • Simon, V., J. Vanderhoeven, A. Hurley, et al 2002. Evolving patterns of HIV-1 resistance to antiretroviral agents in newly infected individuals. AIDS 16: 1511-1519.
    • (2002) AIDS , vol.16 , pp. 1511-1519
    • Simon, V.1    Vanderhoeven, J.2    Hurley, A.3
  • 11
    • 4143093674 scopus 로고    scopus 로고
    • Persistence of multidrug-resistant HIV-1 in primary infection leading to superinfection
    • Brenner, B., J.-P. Routy, Y. Quan, et al 2004. Persistence of multidrug-resistant HIV-1 in primary infection leading to superinfection. AIDS 18: 1653-1660.
    • (2004) AIDS , vol.18 , pp. 1653-1660
    • Brenner, B.1    Routy, J.-P.2    Quan, Y.3
  • 12
    • 0036149707 scopus 로고    scopus 로고
    • Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection
    • Brenner, B.G., J.-P. Routy, M. Petrella, et al 2002. Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection. J. Virol. 76: 1753-1761.
    • (2002) J. Virol. , vol.76 , pp. 1753-1761
    • Brenner, B.G.1    Routy, J.-P.2    Petrella, M.3
  • 13
    • 13444279867 scopus 로고    scopus 로고
    • Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: implications for routine resistance screening before initiation of antiretroviral therapy
    • Novak, R.M., L. Chen, R.D. MacArthur, J.D. Baxter, et al 2005. Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: implications for routine resistance screening before initiation of antiretroviral therapy. Clin. Infect. Dis. 40: 468-474.
    • (2005) Clin. Infect. Dis. , vol.40 , pp. 468-474
    • Novak, R.M.1    Chen, L.2    MacArthur, R.D.3    Baxter, J.D.4
  • 14
    • 10744228522 scopus 로고    scopus 로고
    • Risk of failure in patients with 215 HIV-1 revertants starting their first thymidine analog-containing highly active antiretroviral therapy
    • Violin, M., A. Cozzi-Lepri, R. Velleca, et al 2004. Risk of failure in patients with 215 HIV-1 revertants starting their first thymidine analog-containing highly active antiretroviral therapy. AIDS 18: 227-235.
    • (2004) AIDS , vol.18 , pp. 227-235
    • Violin, M.1    Cozzi-Lepri, A.2    Velleca, R.3
  • 15
    • 3142660152 scopus 로고    scopus 로고
    • The prevalence of antiretroviral drug resistance in the United States
    • Richman, D.D., S.C. Morton, T. Wrin, et al 2004. The prevalence of antiretroviral drug resistance in the United States. AIDS 18: 1393-1401.
    • (2004) AIDS , vol.18 , pp. 1393-1401
    • Richman, D.D.1    Morton, S.C.2    Wrin, T.3
  • 16
    • 77949365510 scopus 로고    scopus 로고
    • Retroviral intasome assembly and inhibition of DNA strand transfer
    • Hare, S., S.S. Gupta, E. Valkov, et al 2010. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature 464: 232-236.
    • (2010) Nature , vol.464 , pp. 232-236
    • Hare, S.1    Gupta, S.S.2    Valkov, E.3
  • 17
    • 12944270496 scopus 로고    scopus 로고
    • HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
    • Espeseth, A.S., P. Felock, A. Wolfe, et al 2000. HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase. Proc. Natl. Acad. Sci. 97: 11244-11249.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 11244-11249
    • Espeseth, A.S.1    Felock, P.2    Wolfe, A.3
  • 18
    • 0037076324 scopus 로고    scopus 로고
    • Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes
    • Grobler, J.A., K. Stillmock, B. Hu, et al 2002. Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes. Proc. Natl. Acad. Sci. 99: 6661-6666.
    • (2002) Proc. Natl. Acad. Sci. , vol.99 , pp. 6661-6666
    • Grobler, J.A.1    Stillmock, K.2    Hu, B.3
  • 19
    • 79952832396 scopus 로고    scopus 로고
    • Merck & Co., Inc. ISENTRESS (raltegravir tablets) Prescribing Information.
    • Merck & Co., Inc. 2008. ISENTRESS (raltegravir tablets) Prescribing Information.
    • (2008)
  • 20
    • 38349194563 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects
    • Iwamoto, M., L.A. Wenning, A.S. Petry, et al 2008. Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects. Clin. Pharmacol. Ther. 83: 293-299.
    • (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 293-299
    • Iwamoto, M.1    Wenning, L.A.2    Petry, A.S.3
  • 21
    • 34548065793 scopus 로고    scopus 로고
    • Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme
    • Kassahun, K., I. McIntosh, D. Cui, et al 2007. Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme. Drug Metab. Dispos. 35: 1657-1663.
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 1657-1663
    • Kassahun, K.1    McIntosh, I.2    Cui, D.3
  • 22
    • 66149137187 scopus 로고    scopus 로고
    • Lack of a clinically important effect of moderate hepatic insufficiency and severe renal insufficiency on raltegravir pharmacokinetics
    • Iwamoto, M., W.D. Hanley, A.S. Petry, et al 2009. Lack of a clinically important effect of moderate hepatic insufficiency and severe renal insufficiency on raltegravir pharmacokinetics. Antimicrob. Agents Chemother. 53: 1747-1752.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 1747-1752
    • Iwamoto, M.1    Hanley, W.D.2    Petry, A.S.3
  • 23
    • 38349182976 scopus 로고    scopus 로고
    • Lack of pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation
    • Iwamoto, M., K. Kassahun, M.D. Troyer, et al 2008. Lack of pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation. J. Clin. Pharmacol. 48: 209-214.
    • (2008) J. Clin. Pharmacol. , vol.48 , pp. 209-214
    • Iwamoto, M.1    Kassahun, K.2    Troyer, M.D.3
  • 24
    • 57049123891 scopus 로고    scopus 로고
    • Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir
    • Iwamoto, M., L.A. Wenning, A.S. Petry, et al 2008. Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir. Antimicrob. Agents Chemother. 52: 4338-4343.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 4338-4343
    • Iwamoto, M.1    Wenning, L.A.2    Petry, A.S.3
  • 25
    • 46249087089 scopus 로고    scopus 로고
    • Atazanavir modestly increases plasma levels of raltegravir in healthy subjects
    • Iwamoto, M., L.A. Wenning, G.C. Mistry, et al 2008. Atazanavir modestly increases plasma levels of raltegravir in healthy subjects. Clin. Infect. Dis. 47: 137-140.
    • (2008) Clin. Infect. Dis. , vol.47 , pp. 137-140
    • Iwamoto, M.1    Wenning, L.A.2    Mistry, G.C.3
  • 26
    • 66949126977 scopus 로고    scopus 로고
    • Effect of tipranavir-ritonavir on pharmacokinetics of raltegravir
    • Hanley, W.D., L.A. Wenning, A. Moreau, et al 2009. Effect of tipranavir-ritonavir on pharmacokinetics of raltegravir. Antimicrob. Agents Chemother. 53: 2752-2755.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 2752-2755
    • Hanley, W.D.1    Wenning, L.A.2    Moreau, A.3
  • 27
    • 50949095712 scopus 로고    scopus 로고
    • Lack of a significant drug interaction between raltegravir and tenofovir
    • Wenning, L.A., E.J. Friedman, J.T. Kost, et al 2008. Lack of a significant drug interaction between raltegravir and tenofovir. Antimicrob. Agents Chemother. 52: 3253-3258.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 3253-3258
    • Wenning, L.A.1    Friedman, E.J.2    Kost, J.T.3
  • 28
    • 57049148690 scopus 로고    scopus 로고
    • Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects
    • Anderson, M.S., T.N. Kakuda, W. Hanley, et al 2008. Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects. Antimicrob. Agents Chemother. 52: 4228-4232.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 4228-4232
    • Anderson, M.S.1    Kakuda, T.N.2    Hanley, W.3
  • 29
    • 66949149605 scopus 로고    scopus 로고
    • Effect of rifampin, a potent inducer of drug metabolizing enzymes, on the pharmacokinetics of raltegravir
    • Wenning, L.A., W.D. Hanley, D.M. Brainard, et al 2009. Effect of rifampin, a potent inducer of drug metabolizing enzymes, on the pharmacokinetics of raltegravir. Antimicrob. Agents Chemother. 53: 2852-2856.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 2852-2856
    • Wenning, L.A.1    Hanley, W.D.2    Brainard, D.M.3
  • 30
    • 69449101785 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naïve patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial
    • Lennox, J.L., E. DeJesus, A. Lazzarin, et al 2009. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naïve patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial. Lancet 374: 796-806.
    • (2009) Lancet , vol.374 , pp. 796-806
    • Lennox, J.L.1    DeJesus, E.2    Lazzarin, A.3
  • 31
    • 77956646683 scopus 로고    scopus 로고
    • Raltegravir-based compared to efavirenz-based regimens in treatment-naive HIV-1 infected patients: efficacy, durability, subgroup, safety, and metabolic analyses through 96 weeks of follow-up
    • Lennox, J.L., E. DeJesus, D.S. Berger, et al 2010. Raltegravir-based compared to efavirenz-based regimens in treatment-naive HIV-1 infected patients: efficacy, durability, subgroup, safety, and metabolic analyses through 96 weeks of follow-up. J. Acquir. Immune Defic. Syndr. 55: 39-48.
    • (2010) J. Acquir. Immune Defic. Syndr. , vol.55 , pp. 39-48
    • Lennox, J.L.1    DeJesus, E.2    Berger, D.S.3
  • 32
    • 47949120697 scopus 로고    scopus 로고
    • Raltegravir with optimized background therapy for resistant HIV-1 infection
    • Steigbigel, R.T., D.A. Cooper, P.N. Kumar, et al 2008. Raltegravir with optimized background therapy for resistant HIV-1 infection. N. Engl. J. Med. 359: 339-354.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 339-354
    • Steigbigel, R.T.1    Cooper, D.A.2    Kumar, P.N.3
  • 33
    • 47949114939 scopus 로고    scopus 로고
    • Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
    • Cooper, D.A., R.T. Steigbigel, J.M. Gatell, et al 2008. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N. Engl. J. Med. 359: 355-365.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 355-365
    • Cooper, D.A.1    Steigbigel, R.T.2    Gatell, J.M.3
  • 34
    • 75749107023 scopus 로고    scopus 로고
    • Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatment-experienced patients with resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 phase III trials
    • Steigbigel, R.T., D.A. Cooper, H. Teppler, et al 2010. Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatment-experienced patients with resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 phase III trials. Clin. Infect. Dis. 50: 605-612.
    • (2010) Clin. Infect. Dis. , vol.50 , pp. 605-612
    • Steigbigel, R.T.1    Cooper, D.A.2    Teppler, H.3
  • 35
    • 79952828309 scopus 로고    scopus 로고
    • Hepatic safety & efficacy of raltegravir in patients coinfected with HIV and hepatitis B (HBV) and/or C (HCV) virus. Presented at 17th Conference on Retroviruses and Opportunistic Infections, San Francisco, CA, February 2010 [Abstract Q-125.
    • Rockstroh, J., H. Teppler, J. Zhao, et al 2010. Hepatic safety & efficacy of raltegravir in patients coinfected with HIV and hepatitis B (HBV) and/or C (HCV) virus. Presented at 17th Conference on Retroviruses and Opportunistic Infections, San Francisco, CA, February 2010 [Abstract Q-125.
    • (2010)
    • Rockstroh, J.1    Teppler, H.2    Zhao, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.