Biochemical analysis of HIV-1 integrase variants resistant to strand transfer inhibitors

Journal of Biological Chemistry

Volumn 283, Issue 35, 2008, Pages 23599-23609

  Dicker, Ira B ^a   Terry, Brian ^a   Lin, Zeyu ^a   Li, Zhufang ^a   Bollini, Sagarika ^a   Samanta, Himadri K ^a   Gali, Volodymyr ^a   Walker, Michael A ^a   Krystal, Mark R ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BIOCHEMISTRY; CATALYSTS; DISSOCIATION; ENZYME ACTIVITY; MAGNESIUM; METAL IONS; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC ACIDS; PROTEINS; VIRUSES;

ACTIVE SITES; AFFINITY BINDINGS; BIOCHEMICAL ANALYSIS; CATALYTIC EFFICIENCIES; CATALYTIC TURNOVERS; DISSOCIATION RATES; ENZYMATIC ANALYSES; INTEGRASE; INTEGRASE PROTEINS; LONG TERMINAL REPEATS; MAGNESIUM IONS; MOLECULAR BASES; SECONDORDER EFFECTS; TRANSFER ACTIVITIES; TRANSFER EFFICIENCIES; WILD TYPES;

ENZYMES;

HEAT SHOCK PROTEIN 60; INTEGRASE; MAGNESIUM; INTEGRASE INHIBITOR; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VIRUS DNA;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA DETERMINATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PURIFICATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN VARIANT; VIRUS RESISTANCE; VIRUS STRAIN; AMINO ACID SUBSTITUTION; ANTIVIRAL RESISTANCE; CATALYSIS; CELL LINE; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; KINETICS; LONG TERMINAL REPEAT; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; VIRUS DNA CELL DNA INTERACTION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SUBSTITUTION; CATALYSIS; CELL LINE; DNA, VIRAL; DRUG RESISTANCE, VIRAL; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; KINETICS; MUTATION, MISSENSE; VIRUS INTEGRATION;

EID: 53049101908     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804213200     Document Type: Article

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