The evolution of human adiposity and obesity: Where did it all go wrong?

DMM Disease Models and Mechanisms

Volumn 5, Issue 5, 2012, Pages 595-607

  Wells, Jonathan C K ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GROWTH FACTOR;

ADIPOSE TISSUE; ANTHROPOMETRIC PARAMETERS; BRAIN FUNCTION; CALORIC INTAKE; CLIMATE CHANGE; CYTOKINE RELEASE; ECONOMIC ASPECT; ENERGY EXPENDITURE; ENERGY METABOLISM; ENVIRONMENTAL CHANGE; EVOLUTION; GENETIC ASSOCIATION; GENETIC DRIFT; GENETIC VARIABILITY; HERITABILITY; HUMAN; IMMUNE RESPONSE; LIFE HISTORY TRAIT; MENTAL STRESS; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RISK MANAGEMENT; SEX DIFFERENCE; SEXUAL SELECTION; SKINFOLD THICKNESS; STARVATION; WEIGHT GAIN;

ADIPOSE TISSUE; ADIPOSITY; BIOLOGICAL EVOLUTION; ENVIRONMENT; GENETIC PREDISPOSITION TO DISEASE; HUMANS; OBESITY;

EID: 84865453864     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.009613     Document Type: Review

References (153)

1. Abi-Rached, L., Jobin, M. J., Kulkarni, S., McWhinnie, A., Dalva, K., Gragert, L., Babrzadeh, F., Gharizadeh, B., Luo, M., Plummer, F. A. et al. (2011). The shaping of modern human immune systems by multiregional admixture with archaic humans. Science 334, 89-94.
2. Adam, T. C. and Epel, E. S. (2007). Stress, eating and the reward system. Physiol. Behav. 91, 449-458.
3. Ahima, R. S. (2006). Adipose tissue as an endocrine organ. Obesity 14 Suppl. 5, 242S-249S.
4. Albritton, R. (2009). Let Them Eat Junk. London: Pluto Press.
5. Altmann, J., Schoeller, D., Altmann, S. A., Muruthi, P. and Sapolsky, R. M. (1993). Body size and fatness of free-living baboons reflect food availability and activity levels. Am. J. Primatol. 30, 149-161.
6. Alvehus, M., Buren, J., Sjostrom, M., Goedecke, J. and Olsson, T. (2010). The human visceral fat depot has a unique inflammatory profile. Obesity 18, 879-883.
7. Anderson, G. D., Blidner, I. N., McClemont, S. and Sinclair, J. C. (1984). Determinants of size at birth in a Canadian population. Am. J. Obstet. Gynecol. 150, 236-244.
8. Armitage, J. A., Poston, L. and Taylor, P. D. (2008). Developmental origins of obesity and the metabolic syndrome: the role of maternal obesity. Front. Horm. Res. 36, 73-84.
9. Atanassova, P., Tonchev, A. B., Peneva, V. N., Chaldakov, G. N., Valchanov, K. P., Fiore, M. and Aloe, L. (2007). What are subcutaneous adipocytes really good for? Viewpoint 3. Exp. Dermatol. 16, 56-59.
10. Badman, M. K. and Flier, J. S. (2007). The adipocyte as an active participant in energy balance and metabolism. Gastroenterology 132, 2103-2115.
11. Bays, H. E., Gonzalez-Campoy, J. M., Bray, G. A., Kitabchi, A. E., Bergman, D. A., Schorr, A. B., Rodbard, H. W. and Henry, R. R. (2008). Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Expert Rev. Cardiovasc. Ther. 6, 343-368.
12. Bender, N., Allemann, N., Marek, D., Vollenweider, P., Waeber, G., Mooser, V., Egger, M. and Bochud, M. (2011). Association between variants of the Leptin Receptor Gene (LEPR) and Overweight: A systematic review and an analysis of the CoLaus study. PLoS. ONE 6, e26157.
13. Berg. A. H. and Scherer, P. E. (2005). Adipose tissue, inflammation, and cardiovascular disease. Circ. Res. 96, 939-949.
14. Bouchard, C. (2007). The biological predisposition to obesity: beyond the thrifty genotype scenario. Int. J. Obes. 31, 1337-1339.
15. Briefel, R. R. and Johnson, C. L. (2004). Secular trends in dietary intake in the United States. Annu. Rev. Nutr. 24, 401-431.
16. Brunner, E. J., Chandola, T. and Marmot, M. G. (2007). Prospective effect of job strain on general and central obesity in the Whitehall II study. Am. J. Epidemiol. 165, 828-837.
17. Buchwald, H., Estok, R., Fahrbach, K., Banel, D., Jensen, M. D., Pories, W. J., Bantle, J. P. and Sledge, I. (2009). Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am. J. Med. 122, 248-256.
18. Caceres, M., Lachuer, J., Zapala, M. A., Redmond, J. C., Kudo, L., Geschwind, D. H., Lockhart, D. J., Preuss, T. M. and Barlow, C. (2003). Elevated gene expression levels distinguish human from non-human primate brains. Proc. Natl. Acad. Sci. USA 100, 13030-13035.
19. Campos, D. B., Palin, M. F., Bordignon, V. and Murphy, B. D. (2008). The 'beneficial' adipokines in reproduction and fertility. Int. J. Obes. 32, 223-231.
20. Cnattingius, S., Villamor, E., Lagerros, Y. T., Wikstrom, A. K. and Granath, F. (2011). High birth weight and obesity-a vicious circle across generations. Int. J. Obes. [Epub ahead of print].
21. Cochran, G. and Harpending, H. C. (2009). The 10,000 Year Explosion. How Civilization Accelerated Human Evolution. New York: Basic Books.
22. Cole, T. J., Bellizzi, M. C., Flegal, K. M. and Dietz, W. H. (2000). Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320, 1240-1243.
23. Coupe, B., Grit, I., Darmaun, D. and Parnet, P. (2009). The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297, R813-R824.
24. Danaei, G., Ding, E. L., Mozaffarian, D., Taylor, B., Rehm, J., Murray, C. J. and Ezzati, M. (2009). The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS. Med. 6, e1000058.
25. Dark, J. (2005). Annual lipid cycles in hibernators: integration of physiology and behavior. Ann. Rev. Nutr. 25, 469-497.
26. Diamond, J. (1998). Guns, Germs and Steel. London: Vintage.
27. Doak, C., Monteiro, C., Adai, L. S., Bentley, M. E. and Popkin, B. M. (2000). Coexisting overweight and underweight within households is related to the nutrition transition. FASEB J. 14, A792.
28. Doak, C. M., Adair, L. S., Bentley, M., Monteiro, C. and Popkin, B. M. (2005). The dual burden household and the nutrition transition paradox. Int. J. Obes. 29, 129-136.
29. Dollman, J., Norton, K. and Norton, L. (2005). Evidence for secular trends in children's physical activity behavior. Br. J. Sports. Med. 39, 892-897.
30. Drazen, D. L., Demas, G. E. and Nelson, R. J. (2001). Leptin effects on immune function and energy balance are photoperiod dependent in Siberian hamsters (Phodopus sungorus). Endocrinology 142, 2768-2775.
31. Dulloo, A. G. (2008). Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance. Best Pract. Res. Clin. Endocrinol. Metab. 22, 155-171.
32. Dunger, D. B., Ahmed, M. L. and Ong. K. K. (2006). Early and late weight gain and the timing of puberty. Mol. Cell. Endocrinol. 254-255, 140-145.
33. Elks, C. E., Loos, R. J., Sharp, S. J., Langenberg, C., Ring, S. M., Timpson, N. J., Ness, A. R., Davey Smith, G., Dunger, D. B., Wareham, N. J. et al. (2010a). Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Med. 7, e1000284.
34. Elks, C. E., Perry, J. R., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L. et al. (2010b). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat. Genet. 42, 1077-1085.
35. Epel, E, Lapidus, R., McEwen, B. and Brownell, K. (2001). Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinology 26, 37-49.
36. Fagan, B. (1999). Floods, Famines and Emperors. New York: Basic Books.
37. Fernandez-Real, J. M. and Ricart, W. (2003). Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr. Rev. 24, 278-301.
38. Ferro-Luzi, A. and Branca, F. (1993). Nutritional seasonality: the dimensions of the problem. In Seasonality and Human Ecology (ed. S. J. Ulijaszek and S. S. Strickland), pp. 149-165. Cambridge: Cambridge University Press.
39. Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine- Suner, D., Cigudosa, J. C., Urioste, M., Benitez, J. et al. (2005). Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. USA 102, 10604-10609.
40. Garrigan, D. and Hammer, M. F. (2006). Reconstructing human origins in the genomic era. Nat. Rev. Genet. 7, 669-680.
41. Garrow, J. S. and Webster, J. (1985). Quetelet's index (W/H2) as a measure of fatness. Int. J. Obes. 9, 147-153.
42. German, A. J. (2006). The growing problem of obesity in dogs and cats. J. Nutr. 136, 1940S-1946S.
43. Green, R. E., Krause, J., Briggs, A. W., Maricic, T., Stenzel, U., Kircher, M., Patterson, N., Li, H., Zhai, W., Fritz, M. H. et al. (2010). A draft sequence of the Neandertal genome. Science 328, 710-722.
44. Hales, C. N. and Barker, D. J. (1992). Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35, 595-601.
45. Hancock, A. M., Witonsky, D. B., Gordon, A. S., Eshel, G., Pritchard, J. K., Coop, G. and Di Rienzo, A. (2008). Adaptations to climate in candidate genes for common metabolic disorders. PLoS Genet. 4, e32.
46. Hankey, G. J. (2012). Nutrition and the risk of stroke. Lancet Neurol. 11, 66-81.
47. Harshman, L. G. and Zera, A. J. (2007). The cost of reproduction: the devil in the details. Trends Ecol. Evol. 22, 80-86.
48. Hattersley, A. T., Beards, F., Ballantyne, E., Appleton, M., Harvey, R. and Ellard, S. (1998). Mutations in the glucokinase gene of the fetus result in reduced birth weight. Nat. Genet. 19, 268-270.
49. Haworth, C. M., Carnell, S., Meaburn, E. L., Davis, O. S., Plomin, R. and Wardle, J. (2008). Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity 16, 2663-2668.
50. Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., Magi, R. et al. (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat. Genet. 42, 949-960.
51. Herculano-Houzel, S. (2011). Scaling of brain metabolism with a fixed energy budget per neuron: implications for neuronal activity, plasticity and evolution. PLoS ONE 6, e17514.
52. Hill, K. (1993). Life history theory and evolutionary anthropology. Evol. Anthropol. 2, 78-89.
53. Hjelmborg, J. B., Fagnani, C., Silventoinen, K., McGue, M., Korkeila, M., Christensen, K., Rissanen, A. and Kaprio, J. (2008). Genetic influences on growth traits of BMI: a longitudinal study of adult twins. Obesity 16, 847-852.
54. Holliday, M. A. (1978). Body composition and energy needs during growth. In Human Growth, Vol 2 (ed. F. Falkner and J. M. Tanner), pp. 101-117. New York: Plenum.
55. Hotamisligil, G. S. (2006). Inflammation and metabolic disorders. Nature 444, 860-867.
56. Huda, M. S., Wilding, J. P. and Pinkney, J. H. (2006). Gut peptides and the regulation of appetite. Obes. Rev. 7, 163-182.
57. Ibanez, L., Lopez-Bermejo, A., Diaz, M., Marcos, M. V., Casano, P. and de Zegher, F. (2009). Abdominal fat partitioning and high-molecular-weight adiponectin in short children born small for gestational age. J. Clin. Endocrinol. Metab. 94, 1049-1052.
58. Ivanova, M., Ruiqing, J., Kawai, S., Matsushita, M., Ochiai, N., Maruya, E. and Saji, H. (2011). IL-6 SNP diversity among four ethnic groups as revealed by bead-based liquid array profiling. Int. J. Immunogenet. 38, 17-20.
59. Kagawa, Y., Yanagisawa, Y., Hasegawa, K., Suzuki, H., Yasuda, K., Kudo, H., Abe, M., Matsuda, S., Ishikawa, Y., Tsuchiya, N. et al. (2002). Single nucleotide polymorphisms of thrifty genes for energy metabolism: evolutionary origins and prospects for intervention to prevent obesity-related diseases. Biochem. Biophys. Res. Commun. 295, 207-222.
60. Keith, S. W., Redden, D. T., Katzmarzyk, P. T., Boggiano, M. M., Hanlon, E. C., Benca, R. M., Ruden, D., Pietrobelli, A., Barger, J. L., Fontaine, K. R. et al. (2006). Putative contributors to the secular increase in obesity: exploring the roads less traveled. Int. J. Obes. 30, 1585-1594.
61. Kemnitz, J. W. and Francken, G. A. (1986). Characteristics of spontaneous obesity in male rhesus monkeys. Physiol. Behav. 38, 477-483.
62. Keys, A., Brozek, J., Henschel, A., Mickelsen, O. and Taylor, H. L. (1950). The Biology of Human Starvation. Minneapolis: University of Minnesota Press.
63. Keys, D. (1999). Catastrophe: An Investigation into the Origins of the Modern World. London: Century (Random House).
64. Kinra, S., Andersen, E., Ben-Shlomo, Y., Bowen, L., Lyngdoh, T., Prabhakaran, D., Reddy, K. S., Ramakrishnan, L., Bharathi, A., Vaz, M. et al. (2011). Association between urban life-years and cardiometabolic risk: the Indian migration study. Am. J. Epidemiol. 174, 154-164.
65. Kuzawa, C. W. (1998). Adipose tissue in human infancy and childhood: an evolutionary perspective. Am. J. Phys. Anthropol. Suppl. 27, 177-209.
66. Laclaustra, M., Corella, D. and Ordovas, J. M. (2007). Metabolic syndrome pathophysiology: the role of adipose tissue. Nutr. Metab. Cardiovasc. Dis. 17, 125-139.
67. Lango Allen, H., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., Willer, C. J., Jackson, A. U., Vedantam, S., Raychaudhuri, S. et al. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467, 832-838.
68. Lassek, W. D. and Gaulin, S. J. (2006). Changes in body fat distribution in relation to parity in American women: a covert form of maternal depletion. Am. J. Phys. Anthropol. 131, 295-302.
69. Lassek, W. D. and Gaulin, S. J. (2007). Waist-hip ratio and cognitive ability: is gluteofemoral fat a privileged store of neurodevelopmental resources? Evol. Hum. Behav. 29, 26-34.
70. Lawrence, M., Coward, W. A., Lawrence, F., Cole, T. J. and Whitehead, R. G. (1987). Fat gain during pregnancy in rural African women: the effect of season and dietary status. Am. J. Clin. Nutr. 45, 1442-1450.
71. Lee, J., Chen, L., Snieder, H., Chen da, F., Lee, L. M., Liu, G. F., Wu, T., Tang, X., Zhan, S. Y., Cao, W. H. et al. (2010). Heritability of obesity-related phenotypes and association with adiponectin gene polymorphisms in the Chinese national twin registry. Ann. Hum. Genet. 74, 146-154.
72. Lisiecki, L. E. and Raymo, M. E. (2005). A plio-pleistocene stack of 57 globally distributed benthic δ18O records. Paleoceanography 20.
73. Lustig, R. H. (2006). Childhood obesity: behavioral aberration or biochemical drive? Reinterpreting the First Law of Thermodynamics. Nat. Clin. Pract. Endocrinol. Metab. 2, 447-458.
74. Lustig, R. H. (2008). Which comes first? The obesity or the insulin? The behavior or the biochemistry? J. Pediatr. 152, 601-602.
75. Mattacks, C. A., Sadler, D. and Pond, C. M. (2004). Site-specific differences in fatty acid composition of dendritic cells and associated adipose tissue in popliteal depot, mesentery, and omentum and their modulation by chronic inflammation and dietary lipids. Lymphat. Res. Biol. 2, 107-129.
76. Michalakis, K. G. and Segars, J. H. (2010). The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction. Fertil. Steril. 94, 1949-1957.
77. Misra, A. and Khurana, L. (2008). Obesity and the metabolic syndrome in developing countries. J. Clin. Endocrinol. Metab. 93 Suppl. 1, S9-S30.
78. Mokyr, J. and O Grada, C. (2002). What do people die of during famines: the Great Irish Famine in comparative perspective. Eur. Rev. Econ. Hist. 6, 339-363.
79. Muhlhausler, B. S., Duffield, J. A., Ozanne, S. E., Pilgrim, C., Turner, N., Morrison, J. L. and McMillen, I. C. (2009). The transition from fetal growth restriction to accelerated postnatal growth: a potential role for insulin signaling in skeletal muscle. J. Physiol. 587, 4199-4211.
80. Navarrete, A., van Schaik, C. P. and Isler, K. (2011). Energetics and the evolution of human brain size. Nature 480, 91-93.
81. Neel, V. (1962). Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am. J. Hum. Genet. 14, 353-362.
82. Nestle, M. (2007). Food Politics: How the Food Industry Influences Nutrition and Health. Berkeley: University of California Press.
83. Nettle, D., Coall, D. A. and Dickins, T. E. (2010). Birthweight and paternal involvement predict early reproduction in British women: evidence from the National Child Development Study. Am. J. Hum. Biol. 22, 172-179.
84. Norgan, N. G. (1997). The beneficial effects of body fat and adipose tissue in humans. Int. J. Obes. Relat. Metab. Disord. 21, 738-746.
85. O'Rahilly, S., Farooqi, I. S., Yeo, G. S. and Challis, B. G. (2003). Minireview: human obesity-lessons from monogenic disorders. Endocrinology 144, 3757-3764.
86. Oftedal, O. T. (2000). Use of maternal reserves as a lactation strategy in large mammals. Proc. Nutr. Soc. 59, 99-106.
87. Ong, K. K., Ahmed, M. L., Emmett, P. M., Preece, M. A. and Dunger, D. B. (2000). Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ 320, 967-971.
88. Ong, K. K., Northstone, K., Wells, J. C., Rubin, C., Ness, A. R., Golding, J. and Dunger, D. B. (2007). Earlier mother's age at menarche predicts rapid infancy growth and childhood obesity. PLoS Med. 4, e132.
89. Ong, K. K., Emmett, P., Northstone, K., Golding, J., Rogers, I., Ness, A. R., Wells, J. C. and Dunger, D. B. (2009). Infancy weight gain predicts childhood body fat and age at menarche in girls. J. Clin. Endocrinol. Metab. 94, 1527-1532.
90. Paalani, M., Lee, J. W., Haddad, E. and Tonstad, S. (2011). Determinants of inflammatory markers in a bi-ethnic population. Ethn. Dis. 21, 142-149.
91. Pandey, R. M., Gupta, R., Misra, A., Misra, P., Singh, V., Agrawal, A., Dey, S., Rao, S., Menon, V. U., Kamalamma, N. et al. (2011). Determinants of urban-rural differences in cardiovascular risk factors in middle-aged women in India: A cross-sectional study. Int. J. Cardiol. [Epub ahead of print].
92. Pasquet, P., Brigant, L., Froment, A., Koppert, G. A., Bard, D., de Garine, I. and Apfelbaum, M. (1992). Massive overfeeding and energy balance in men: the Guru Walla model. Am. J. Clin. Nutr. 56, 483-490.
93. Permana, P. A. and Reardon, C. L. (2007). What are subcutaneous adipocytes really good for? Viewpoint 2. Exp. Dermatol. 16, 53-55.
94. Pickrell, J. K., Coop, G., Novembre, J., Kudaravalli, S., Li, J. Z., Absher, D., Srinivasan, B. S., Barsh, G. S., Myers, R. M., Feldman, M. W. et al. (2009). Signals of recent positive selection in a worldwide sample of human populations. Genome Res. 19, 826-837.
95. Pierce, M. B. and Leon, D. A. (2005). Age at menarche and adult BMI in the Aberdeen children of the 1950s cohort study. Am. J. Clin. Nutr. 82, 733-739.
96. Pond, C. M. (1984). Physiological and ecological importance of energy storage in the evolution of lactation: evidence for a common pattern of anatomical organisation of adipose tissue in mammals. Symp. Zool. Soc. Lond. 51, 1-32.
97. Pond, C. M. (1998). The Fats of Life. Cambridge: Cambridge University Press.
98. Pond, C. M. (2003). Paracrine interactions of mammalian adipose tissue. J. Exp. Zool. 295A, 99-110.
99. Popkin, B. M. (2007). The world is fat. Sci. Am. 297, 88-95.
100. Poppitt, S. D., Prentice, A. M., Goldberg, G. R. and Whitehead, R. G. (1994). Energy-sparing strategies to protect human fetal growth. Am. J. Obstet. Gynecol. 171, 118-125.
101. Poston, W. S. and Foreyt, J. P. (1999). Obesity is an environmental issue. Atherosclerosis 146, 201-209.
102. Potts, R. (1996). Humanity's Descent: The Consequences of Ecological Instability. New York, William Morrow & Co.
103. Potts, R. (2011). An African environmental framework for investigating the evolution of early Homo. Curr. Anthropol. in press.
104. Prasad, S., Sung, B. and Aggarwal, B. B. (2011). Age-associated chronic diseases require age-old medicine: Role of chronic inflammation. Prev. Med. 54, S29-S37.
105. Prentice, A. M. and Jebb, S. A. (1995). Obesity in Britain: gluttony or sloth? BMJ 311, 437-439.
106. Prentice, A. M., Moore, S. E., Collinson, A. C. and O'Connell, M. A. (2002). Leptin and undernutrition. Nutr. Rev. 60, S56-S67.
107. Randhawa, R. and Cohen, P. (2005). The role of the insulin-like growth factor system in prenatal growth. Mol. Genet. Metab. 86, 84-90.
108. Rebuffe-Scrive, M., Enk, L., Crona, N., Lonnroth, P., Abrahamsson, L., Smith, U. and Bjorntorp, P. (1985). Fat cell metabolism in different regions in women. Effect of menstrual cycle, pregnancy, and lactation. J. Clin. Invest. 75, 1973-1976.
109. Richerson, P. J., Boyd, R. and Bettinger, R. L. (2001). Was agriculture impossible during the pleistocene but mandatory during the holocene? Am. Anthropol. 66, 387-411.
110. Rivers, J. P. (1988). The nutritional biology of famine. In Famine (ed. G. A. Harrison), pp. 57-106. Oxford: Oxford University Press.
111. Rodgers, R. J., Tschöp, M. H. and Wilding, J. P. H. (2012). Anti-obesity drugs: past, present and future. Dis. Model. Mech. 5, 621-626.
112. Romanyukha, A. A., Rudnev, S. G. and Sidorov, I. A. (2006). Energy cost of infection burden: an approach to understanding the dynamics of host-pathogen interactions. J. Theor. Biol. 241, 1-13.
113. Roth, J., Szulc, A. L. and Danoff, A. (2011). Energy, evolution, and human diseases: an overview. Am. J. Clin. Nutr. 93, 875S-883S.
114. Schneider, J. E. (2004). Energy balance and reproduction. Physiol. Behav. 81, 289-317.
115. Schwartz, M. W. and Morton, G. J. (2002). Obesity: keeping hunger at bay. Nature 418, 595-597.
116. Shell, E. R. (2002). The Hungry Gene: The Inside Story of the Obesity Industry. New York: Grove Press.
117. Siervo, M., Wells, J. C. and Cizza, G. (2009). The contribution of psychosocial stress to the obesity epidemic: an evolutionary approach. Horm. Metab. Res. 41, 261-270.
118. Singh, J., Prentice, A. M., Diaz, E., Coward, W. A., Ashford, J., Sawyer, M. and Whitehead, R. G. (1989). Energy expenditure of Gambian women during peak agricultural activity measured by the doubly-labelled water method. Br. J. Nutr. 62, 315-329.
119. Snijder, M. B., Dekker, J. M., Visser, M., Bouter, L. M., Stehouwer, C. D., Yudkin, J. S., Heine, R. J., Nijpels, G. and Seidell, J. C. (2004a). Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study. Diabetes Care 27, 372-377.
120. Snijder, M. B., Zimmet, P. Z., Visser, M., Dekker, J. M., Seidell, J. C. and Shaw, J. E. (2004b). Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the Aus. Diab Study. Int. J. Obes. Relat. Metab. Disord. 28, 402-409.
121. Snodgrass, J. J., Sorensen, M. V., Tarskaia, L. A. and Leonard, W. R. (2007). Adaptive dimensions of health research among indigenous Siberians. Am. J. Hum. Biol. 19, 165-180.
122. Sorensen, T. I., Price, R. A., Stunkard, A. J. and Schulsinger, F. (1989). Genetics of obesity in adult adoptees and their biological siblings. BMJ 298, 87-90.
123. Speakman, J. R. (2006). Thrifty genes for obesity and the metabolic syndrome-time to call off the search? Diab. Vasc. Dis. Res. 3, 7-11.
124. Speakman, J. R. (2008). Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the 'drifty gene' hypothesis. Int. J. Obes. 32, 1611-1617.
125. Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., Luan, J., Magi, R. et al. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937-948.
126. Stearns, S. C. (1992). The Evolution of Life Histories. Oxford: Oxford University Press.
127. Stuckler, D., McKee, M., Ebrahim, S. and Basu, S. (2012). Manufacturing epidemics: the role of global producers in increased consumption of unhealthy commodities including processed foods, alcohol, and tobacco. PLoS Med. 9, e1001235.
128. Stunkard, A. J., Foch, T. T. and Hrubec, Z. (1986a). A twin study of human obesity. JAMA 256, 51-54.
129. Stunkard, A. J., Sorensen, T. I., Hanis, C., Teasdale, T. W., Chakraborty, R., Schull, W. J. and Schulsinger, F. (1986b). An adoption study of human obesity. N. Engl. J. Med. 314, 193-198.
130. Tatar, M., Bartke, A. and Antebi, A. (2003). The endocrine regulation of aging by insulin-like signals. Science 299, 1346-1351.
131. Taubes, G. (2008). The Diet Delusion. London: Vermillion.
132. Tilg, H. and Moschen, A. R. (2006). Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 6, 772-783.
133. Tovee, M. J., Swami, V., Furnham, A. and Mangalparsad, R. (2006). Changing perceptions of attractiveness as observers are exposed to a different culture. Evol. Hum. Behav. 27, 443-456.
134. Voight, B. F., Kudaravalli, S., Wen, X. and Pritchard, J. K. (2006). A map of recent positive selection in the human genome. PLoS Biol. 4, e72.
135. Wade, G. N., Schneider, J. E. and Li, H. Y. (1996). Control of fertility by metabolic cues. Am. J. Physiol. 270, E1-E19.
136. Wagner, A. (2005). Robustness and Evolvability in Living Systems. Princeton: Princeton University Press.
137. Watson, N. F., Buchwald, D., Vitiello, M. V., Noonan, C. and Goldberg, J. (2010). A twin study of sleep duration and body mass index. J. Clin. Sleep Med. 6, 11-17.
138. Wells, J. C. (2006). The evolution of human fatness and susceptibility to obesity: an ethological approach. Biol. Rev. 81, 183-205.
139. Wells, J. C. (2009a). Ethnic variability in adiposity and cardiovascular risk: the variable disease selection hypothesis. Int. J. Epidemiol. 38, 63-71.
140. Wells, J. C. (2009b). Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms. Int. J. Obes. 33, 1331-1338.
141. Wells, J. C. (2009c). The Evolutionary Biology of Human Body Fatness: Thrift and Control. Cambridge: Cambridge University Press.
142. Wells, J. C. (2010). Maternal capital and the metabolic ghetto: An evolutionary perspective on the transgenerational basis of health inequalities. Am. J. Hum. Biol. 22, 1-17.
143. Wells, J. C. (2011). An evolutionary perspective on the trans-generational basis of obesity. Ann. Hum. Biol. 38, 400-409.
144. Wells, J. C. (2012a). Obesity as malnutrition: the role of capitalism in the obesity epidemic. Am. J. Hum. Biol. 24, 261-276.
145. Wells, J. C. (2012b). Sexual dimorphism in body composition across human populations: associations with climate and proxies for short- and long-term energy supply. Am. J. Hum. Biol. 2, 411-419.
146. Wells, J. C. (2012c). Ecogeographical associations between climate and human body composition: analyses based on anthropometry and skinfolds. Am. J. Phys. Anthropol. 147, 169-186.
147. Wells, J. C. and Stock, J. T. (2007). The biology of the colonizing ape. Am. J. Phys. Anthropol. Suppl. 45, 191-222.
148. Wells, J. C. and Siervo, M. (2011). Obesity and energy balance: is the tail wagging the dog? Eur. J. Clin. Nutr. 65, 1173-1189.
149. Wilding, J. (2004). Clinical evaluation of anti-obesity drugs. Curr. Drug Targets 5, 325-332.
150. Willer, C. J., Speliotes, E. K., Loos, R. J., Li, S., Lindgren, C. M., Heid, I. M., Berndt, S. I., Elliott, A. L., Jackson, A. U., Lamina, C. et al. (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25-34.
151. Yajnik, C. S. (2004). Obesity epidemic in India: intrauterine origins? Proc. Nutr. Soc. 63, 387-396.
152. Yajnik, C. S., Janipalli, C. S., Bhaskar, S., Kulkarni, S. R., Freathy, R. M., Prakash, S., Mani, K. R., Weedon, M. N., Kale, S. D., Deshpande, J. et al. (2009). FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia 52, 247-252.
153. Yu, Z. B., Han, S. P., Zhu, G. Z., Zhu, C., Wang, X. J., Cao, X. G. and Guo, X. R. (2011). Birth weight and subsequent risk of obesity: a systematic review and meta-analysis. Obes. Rev. 12, 525-542.