Obesity and energy balance: Is the tail wagging the dog

European Journal of Clinical Nutrition

Volumn 65, Issue 11, 2011, Pages 1173-1189

  Wells, J C K ^a   Siervo, M ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

energy balance; fructose; metabolic flexibility; metabolism; obesity

Indexed keywords

FRUCTOSE; INSULIN;

CELL METABOLISM; CHILD GROWTH; DISEASE ASSOCIATION; ENERGY BALANCE; ENERGY EXPENDITURE; FRUCTOSE METABOLISM; HUMAN; HYPERINSULINEMIA; LIPID STORAGE; METABOLIC REGULATION; OBESITY; PATHOPHYSIOLOGY; PUBLIC HEALTH; REVIEW; SLEEP TIME; SUGAR INTAKE; THERMODYNAMICS; WEIGHT GAIN;

ADOLESCENT; ADULT; ANIMALS; CHILD; CHILD DEVELOPMENT; DIETARY SUCROSE; ENERGY INTAKE; ENERGY METABOLISM; FRUCTOSE; HEALTH PROMOTION; HUMANS; INFANT; INSULIN; MODELS, BIOLOGICAL; MOTOR ACTIVITY; OBESITY; SLEEP; WEIGHT GAIN;

CANIS FAMILIARIS; SLOTHS; ZEA MAYS;

EID: 80455155113     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2011.132     Document Type: Review

References (171)

1. Ainsworth BE, Haskell WL, Leon AS, Jacobs Jr DR, Montoye HJ, Sallis JF et al. (1993). Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 25, 71-80. (Pubitemid 23027685)
2. American Dietetic Association (2004). Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners. J Am Dietet Assoc 104, 255-275.
3. Astrup A (2001). The role of dietary fat in the prevention and treatment of obesity. Efficacy and safety of low-fat diets. Int J Obes Relat Metab Disord 25 (Suppl 1), S46-S50. (Pubitemid 32565156)
4. Augustine RA, Ladyman SR, Grattan DR (2008). From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy. J Physiol 586, 387-397.
5. Axelsson I (2006). Effects of high protein intakes. Nestle Nutr Workshop Ser Pediatr Program 58, 121-129; discussion 129-131.
6. Baird J, Fisher D, Lucas P, Kleijnen J, Roberts H, Law C (2005). Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ 331, 929-92.
7. Bandini LG, Schoeller DA, Dietz WH (1990). Energy expenditure in obese and nonobese adolescents. Pediatr Res 27, 198-203. (Pubitemid 20044542)
8. Bar-Or O, Foreyt J, Bouchard C, Brownell KD, Dietz WH, Ravussin E et al. (1998). Physical activity, genetic, and nutritional considerations in childhood weight management. Med Sci Sports Exerc 30, 2-10. (Pubitemid 28071377)
9. Barker DJ, Osmond C, Kajantie E, Eriksson JG (2009). Growth and chronic disease: findings in the Helsinki Birth Cohort. Ann Hum Biol 36, 445-458.
10. Basciano H, Federico L, Adeli K (2005). Fructose, insulin resistance, and metabolic dyslipidemia. Nutr Metab (Lond) 2, 5.
11. Bell SJ, Sears B (2003). Low-glycemic diets: impact on obesity and chronic diseases. Crit Rev Food Sci Nutr 43, 357-377. (Pubitemid 38552297)
12. Berson SA, Yalow RS (1965). Some current controversies in diabetes research. Diabetes 14, 549-572.
13. Bickel PE (2004). Metabolic fuel selection: the importance of being flexible. J Clin Invest 114, 1547-1549. (Pubitemid 40385545)
14. Bleich SN, Wang YC, Wang Y, Gortmaker SL (2009). Increasing consumption of sugar-sweetened beverages among US adults: 1988-1994 to 1999-2004. Am J Clin Nutr 89, 372-381.
15. Blundell JE, Lawton CL, Cotton JR, Macdiarmid JI (1996). Control of human appetite: implications for the intake of dietary fat. Annu Rev Nutr 16, 285-319. (Pubitemid 26286856)
16. Bogin B (1999). Patterns of Human Growth 2nd edn. Cambridge University Press: Cambridge.
17. Botton J, Heude B, Maccario J, Ducimetiere P, Charles MA (2008). Postnatal weight and height growth velocities at different ages between birth and 5 y and body composition in adolescent boys and girls. Am J Clin Nutr 87, 1760-1768. (Pubitemid 351872640)
18. Bray GA (2010). Soft drink consumption and obesity: it is all about fructose. Curr Opin Lipidol 21, 51-57.
19. Bray GA, Nielsen SJ, Popkin BM (2004). Consumption of highfructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79, 537-543. (Pubitemid 41103894)
20. Bray MS, Young ME (2006). Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte. Obes Rev 8, 169-181.
21. Briefel RR, Johnson CL (2004). Secular trends in dietary intake in the United States. Annu Rev Nutr 24, 401-431. (Pubitemid 38938798)
22. Cappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, Stranges S. et al. (2008). Meta-analysis of short sleep duration and obesity in children and adults. Sleep 31, 619-626. (Pubitemid 351694250)
23. Caton PW, Nayuni NK, Khan N, Wood EG, Corder R (2011). Fructose induces gluconeogenesis and lipogenesis through a Sirt1-dependent mechanism. J Endocrinol 208, 273-283.
24. Cha SH, Wolfgang M, Tokutake Y, Chohnan S, Lane MD (2008). Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci USA 105, 16871-16875.
25. Chan SJ, Cao QP, Steiner DF (1990). Evolution of the insulin superfamily: cloning of a hybrid insulin/insulin-like growth factor cDNA from amphioxus. Proc Natl Acad Sci USA 87, 9319-9323. (Pubitemid 120030617)
26. Chaput JP, Brunet M, Tremblay A (2006). Relationship between short sleeping hours and childhood overweight/obesity: results from the Quebec en Forme Project. Int J Obes (Lond) 30, 1080-1085. (Pubitemid 43980575)
27. Chellakooty M, Juul A, Boisen KA, Damgaard IN, Kai CM, Schmidt IM et al. (2006). A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding. J Clin Endocrinol Metab 91, 820-826. (Pubitemid 43357745)
28. chi-Mejia AM, Longacre MR, Gibson JJ, Beach ML, Titus-Ernstoff LT, Dalton MA (2007). Children with a TV in their bedroom at higher risk for being overweight. Int J Obes (Lond) 31, 644-651. (Pubitemid 46482346)
29. Chomtho S, Wells JC, Williams JE, Davies PS, Lucas A, Fewtrell MS (2008). Infant growth and later body composition: evidence from the 4-component model. Am J Clin Nutr 87, 1776-1784. (Pubitemid 351872642)
30. Commerford SR, Ferniza JB, Bizeau ME, Thresher JS, Willis WT, Pagliassotti MJ (2002). Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats. Am J Physiol Endocrinol Metab 283, E545-E555. (Pubitemid 35230492)
31. Corpeleijn E, Saris WH, Blaak EE (2009). Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle. Obes Rev 10, 178-193.
32. Cunha MC, Zanetti ML, Hass VJ (2008). Sleep quality in type 2 diabetics. Rev Lat Am Enfermagem 16, 850-855.
33. Danguir J, Nicolaidis S (1979). Dependence of sleep on nutrients availability. Physiol Behav 22, 735-740.
34. Danguir J, Nicolaidis S (1980a). Circadian sleep and feeding patterns in the rat: possible dependence on lipogenesis and lipolysis. Am J Physiol 238, E223-E230. (Pubitemid 10118452)
35. Danguir J, Nicolaidis S (1980b). Intravenous infusions of nutrients and sleep in the rat: an ischymetric sleep regulation hypothesis. Am J Physiol 238, E307-E312.
36. De Meyts P, Wallach B, Christoffersen CT, Urso B, Gronskov K, Latus LJ et al. (1994). The insulin-like growth factor-I receptor. Structure, ligandbinding mechanism and signal transduction. Horm Res 42, 152-169. (Pubitemid 24336143)
37. Dennison BA, Edmunds LS, Stratton HH, Pruzek RM (2006). Rapid infant weight gain predicts childhood overweight. Obesity (Silver Spring) 14, 491-499. (Pubitemid 46219769)
38. Dewey KG, Heinig MJ, Nommsen LA, Peerson JM, Lonnerdal B (1993). Breast-fed infants are leaner than formula-fed infants at 1 y of age: the DARLING study. Am J Clin Nutr 57, 140-145. (Pubitemid 23039883)
39. Di LL, De PG, Zocchetti C, LAbbate N, Basso A, Pannacciulli N et al. (2003). Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry. Int J Obes Relat Metab Disord 27, 1353-1358. (Pubitemid 37386484)
40. Dietz WH (1994). Critical periods in childhood for the development of obesity. Am J Clin Nutr 59, 955-959. (Pubitemid 24138364)
41. Dirlewanger M, Schneiter P, Jequier E, Tappy L (2000). Effects of fructose on hepatic glucose metabolism in humans. Am J Physiol Endocrinol Metab 279, E907-E911.
42. Doak CM, Adair LS, Bentley M, Monteiro C, Popkin BM (2005). The dual burden household and the nutrition transition paradox. Int J Obes (Lond) 29, 129-136. (Pubitemid 40065475)
43. Duffey KJ, Popkin BM (2008). High-fructose corn syrup: is this whats for dinner? Am J Clin Nutr 88, 1722S-1732S.
44. Dzamko NL, Steinberg GR (2009). AMPK-dependent hormonal regulation of whole-body energy metabolism. Acta Physiol (Oxf) 196, 115-127.
45. Eisenmann JC, Ekkekakis P, Holmes M (2006). Sleep duration and overweight among Australian children and adolescents. Acta Paediatr 95, 956-963. (Pubitemid 44181216)
46. Ekelund U, Aman J, Yngve A, Renman C, Westerterp K, Sjostrom M (2002). Physical activity but not energy expenditure is reduced in obese adolescents: a case-control study. Am J Clin Nutr 76, 935-941. (Pubitemid 35244662)
47. Ekelund U, Brage S, Froberg K, Harro M, Anderssen SA, Sardinha LB et al. (2006a). TV viewing and physical activity are independently associated with metabolic risk in children: the European Youth Heart Study. PLoS Med 3, e488-e48.
48. Ekelund U, Ong K, Linne Y, Neovius M, Brage S, Dunger DB et al. (2006b). Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm Weight Development Study (SWEDES). Am J Clin Nutr 83, 324-330. (Pubitemid 44713194)
49. Ferro-Luzzi A, Martino L (1996). Obesity and physical activity. Ciba Found Symp 201, 207-221; discussion 221-207.
50. Foster-Powell K, Holt SH, Brand-Miller JC (2002). International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76, 5-56. (Pubitemid 34686548)
51. Ganong WF (1999). Review of Medical Physiology, 19th edn. Appleton and Lange: Stamford, CT.
52. Garby L, Garrow JS, Jorgensen B, Lammert O, Madsen K, Sorensen P. et al. (1988). Relation between energy expenditure and body composition in man: specific energy expenditure in vivo of fat and fat-free tissue. Eur J Clin Nutr 42, 301-305.
53. Gohlke BC, Schreiner F, Fimmers R, Bartmann P, Woelfle J (2010). Insulin-like growth factor-I in cord blood is predictive of catch-up growth in monozygotic twins with discordant growth. J Clin Endocrinol Metab 95, 5375-5381.
54. Goodell LS, Wakefield DB, Ferris AM (2009). Rapid weight gain during the first year of life predicts obesity in 2-3 year olds from a low-income, minority population. J Community Health 34, 370-375.
55. Goran MI, Treuth MS (2001). Energy expenditure, physical activity, and obesity in children. Pediatr Clin North Am 48, 931-953. (Pubitemid 32718103)
56. Goris AH, Westerterp-Plantenga MS, Westerterp KR (2000). Undereating and underrecording of habitual food intake in obese men: selective underreporting of fat intake. Am J Clin Nutr 71, 130-134. (Pubitemid 30033595)
57. Gross LS, Li L, Ford ES, Liu S (2004). Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment. Am J Clin Nutr 79, 774-779. (Pubitemid 41103877)
58. Gupta NK, Mueller WH, Chan W, Meininger JC (2002). Is obesity associated with poor sleep quality in adolescents? Am J Hum Biol 14, 762-768. (Pubitemid 35256218)
59. Haig D, Wharton R (2003). Prader-Willi syndrome and the evolution of human childhood. Am J Hum Biol 15, 320-329. (Pubitemid 36546294)
60. Haroun D, Wells JC, Williams JE, Fuller NJ, Fewtrell MS, Lawson MS (2005). Composition of the fat-free mass in obese and nonobese children: matched case-control analyses. Int J Obes (Lond) 29, 29-36. (Pubitemid 40065462)
61. Hess GH (1838). The evolution of heat in multiple proportions. Poggendorf Ann Chemie Physik 47, 210-212.
62. Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ et al. (2009). Insulin resistance is a cellular antioxidant defense mechanism. Proc Natl Acad Sci USA 106, 17787-17792.
63. Hoffman DJ, Sawaya AL, Verreschi I, Tucker KL, Roberts SB (2000). Why are nutritionally stunted children at increased risk of obesity? Studies of metabolic rate and fat oxidation in shantytown children from Sao Paulo, Brazil. Am J Clin Nutr 72, 702-707. (Pubitemid 30667090)
64. Hoffmans M, Pfeifer WA, Gundlach BL, Nijkrake HG, Oude Ophuis AJ, Hautvast JG (1979). Resting metabolic rate in obese and normal weight women. Int J Obes 3, 111-118. (Pubitemid 9212370)
65. Hopkins M, King NA, Blundell JE (2010). Acute and long-term effects of exercise on appetite control: is there any benefit for weight control? Curr Opin Clin Nutr Metab Care 13, 635-640.
66. Horne J (2008). Too weighty a link between short sleep and obesity? Sleep 31, 595-596. (Pubitemid 351694247)
67. Ibanez L, Lopez-Bermejo A, Diaz M, Marcos MV, Casano P, de Zegher F (2009). Abdominal fat partitioning and high-molecular-weight adiponectin in short children born small for gestational age. J Clin Endocrinol Metab 94, 1049-1052.
68. Ibanez L, Ong K, Dunger DB, de ZF (2006). Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children. J Clin Endocrinol Metab 91, 2153-2158. (Pubitemid 43854998)
69. Iniguez G, Gonzalez CA, Argandona F, Kakarieka E, Johnson MC, Cassorla F (2010). Expression and protein content of IGF-I and IGF-I receptor in placentas from small, adequate and large for gestational age newborns. Horm Res Paediatr 73, 320-327.
70. Iniguez G, Ong K, Bazaes R, Avila A, Salazar T, Dunger D et al. (2006). Longitudinal changes in insulin-like growth factor-I, insulin sensitivity, and secretion from birth to age three years in small-forgestational- age children. J Clin Endocrinol Metab 91, 4645-4649. (Pubitemid 44833451)
71. Jiang F, Zhu S, Yan C, Jin X, Bandla H, Shen X (2009). Sleep and obesity in preschool children. J Pediatr 154, 814-818.
72. Johnson MA, Tekkanat K, Schmaltz SP, Fox IH (1989). Adenosine triphosphate turnover in humans. Decreased degradation during relative hyperphosphatemia. J Clin Invest 84, 990-995. (Pubitemid 19228374)
73. Johnstone AM, Horgan GW, Murison SD, Bremner DM, Lobley GE (2008). Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum. Am J Clin Nutr 87, 44-55.
74. Karlsson B, Knutsson A, Lindahl B (2001). Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 people. Occup Environ Med 58, 747-752. (Pubitemid 33010493)
75. Karlsson BH, Knutsson AK, Lindahl BO, Alfredsson LS (2003). Metabolic disturbances in male workers with rotating three-shift work. Results of the WOLF study. Int Arch Occup Environ Health 76, 424-430. (Pubitemid 37038168)
76. Kasik JW, Lu C, Menon RK (2000). The expanding insulin family: structural, genomic, and functional considerations. Pediatr Diabetes 1, 169-177.
77. Keys A, Brozek J, Henschel A, Mickelsen O, Taylor HL (1950). The Biology of Human Starvation.. University of Minnesota Press: Minneapolis.
78. Knutson KL (2010). Sleep duration and cardiometabolic risk: a review of the epidemiologic evidence. Best Pract Res Clin Endocrinol Metab 24, 731-743.
79. Laessle RG, Platte P, Schweiger U, Pirke KM (1996). Biological and psychological correlates of intermittent dieting behavior in young women. A model for bulimia nervosa. Physiol Behav 60, 1-5. (Pubitemid 126335844)
80. Larnkjaer A, Hoppe C, Molgaard C, Michaelsen KF (2009). The effects of whole milk and infant formula on growth and IGF-I in late infancy. Eur J Clin Nutr 63, 956-963.
81. Laron Z (2004). IGF-1 and insulin as growth hormones. Novartis Found Symp 262, 56-77; discussion 77-83, 265-268.
82. Leclerc I, Kahn A, Doiron B (1998). The 50-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex. FEBS Lett 431, 180-184. (Pubitemid 28334212)
83. Ley RE, Turnbaugh PJ, Klein S, Gordon JI (2006). Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022-1023. (Pubitemid 46018512)
84. Li H, Stein AD, Barnhart HX, Ramakrishnan U, Martorell R (2003). Associations between prenatal and postnatal growth and adult body size and composition. Am J Clin Nutr 77, 1498-1505. (Pubitemid 39655286)
85. Ludwig DS, Peterson KE, Gortmaker SL (2001). Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet 357, 505-508. (Pubitemid 32173586)
86. Lustig RH (2006a). Childhood obesity: behavioral aberration or biochemical drive? Reinterpreting the First Law of Thermodynamics. Nat Clin Pract Endocrinol Metab 2, 447-458. (Pubitemid 44214067)
87. Lustig RH (2006b). The skinny on childhood obesity: how our western environment starves kids brains. Pediatr Ann 35, 898-897.
88. Lustig RH (2008). Which comes first? The obesity or the insulin? The behavior or the biochemistry? J Pediatr 152, 601-602. (Pubitemid 351503540)
89. Maggard MA, Shugarman LR, Suttorp M, Maglione M, Sugerman HJ, Livingston EH et al. (2005). Meta-analysis: surgical treatment of obesity. Ann Intern Med 142, 547-559.
90. Malik VS, Schulze MB, Hu FB (2006). Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr 84, 274-288. (Pubitemid 44699135)
91. Marshall NS, Glozier N, Grunstein RR (2008). Is sleep duration related to obesity? A critical review of the epidemiological evidence. Sleep Med Rev 12, 289-298.
92. Matsuzaka T, Shimano H, Yahagi N, memiya-Kudo M, Okazaki H, Tamura Y et al. (2004). Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice. Diabetes 53, 560-569. (Pubitemid 38270623)
93. Mayes PA (1993). Intermediary metabolism of fructose. Am J Clin Nutr 58(5 Suppl), 754S-765S. (Pubitemid 23319973)
94. Mericq V, Ong KK, Bazaes R, Pena V, Avila A, Salazar T et al. (2005). Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestationalage children. Diabetologia 48, 2609-2614. (Pubitemid 41738229)
95. Metcalf B, Hosking J, Frémeaux AE, Jeffery AN, Voss LD, Wilkin TJ (2011). BMI was right all along-taller children really are fatter 3 (implications of making childhood BMI independent of height) EarlyBird 48. Int J Obes (Lond) 35, 541-547.
96. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ et al. (1997). Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908. (Pubitemid 27289591)
97. Monteiro PO, Victora CG (2005). Rapid growth in infancy and childhood and obesity in later life-a systematic review. Obes Rev 6, 143-154. (Pubitemid 40604423)
98. Morrison CD, Berthoud HR (2007). Neurobiology of nutrition and obesity. Nutr Rev 65 (12 Part 1), 517-534. (Pubitemid 351804334)
99. Muoio DM, Seefeld K, Witters LA, Coleman RA (1999). AMPactivated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 338 (Part 3), 783-791. (Pubitemid 29140087)
100. Myers Jr MG, Leibel RL, Seeley RJ, Schwartz MW (2010). Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab 21, 643-651.
101. Nestle M (2007). Food Politics: How the Food Industry Influences Nutrition and Health. University of California Press: Berkeley.
102. Nixon GM, Thompson JM, Han DY, Becroft DM, Clark PM, Robinson E et al. (2008). Short sleep duration in middle childhood: risk factors and consequences. Sleep 31, 71-78.
103. Noguchi T, Tanaka T (1995). Insulin resistance in obesity and its molecular control. Obes Res 3 (Suppl 2), 195S-198S.
104. ORahilly S, Farooqi IS, Yeo GS, Challis BG (2003). Minireview: human obesity-lessons from monogenic disorders. Endocrinology 144, 3757-3764. (Pubitemid 37088726)
105. Ong KK, Ahmed ML, Emmett PM, Preece MA, Dunger DB (2000). Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ 320, 967-971. (Pubitemid 30192864)
106. Ong KK, Emmett P, Northstone K, Golding J, Rogers I, Ness AR et al. (2009a). Infancy weight gain predicts childhood body fat and age at menarche in girls. J Clin Endocrinol Metab 94, 1527-1532.
107. Ong KK, Langkamp M, Ranke MB, Whitehead K, Hughes IA, Acerini CL et al. (2009b). Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study. Am J Clin Nutr 90, 156-161.
108. Padez C, Mourao I, Moreira P, Rosado V (2009). Long sleep duration and childhood overweight/obesity and body fat. Am J Hum Biol 21, 371-376.
109. Padwal RS, Majumdar SR (2007). Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet 369, 71-77. (Pubitemid 46027230)
110. Pagliassotti MJ, Prach PA (1995). Quantity of sucrose alters the tissue pattern and time course of insulin resistance in young rats. Am J Physiol 269 (3 Part 2), R641-R646.
111. Pagliassotti MJ, Prach PA, Koppenhafer TA, Pan DA (1996). Changes in insulin action, triglycerides, and lipid composition during sucrose feeding in rats. Am J Physiol 271 (5 Part 2), R1319-R1326.
112. Patel SR, Hu FB (2008). Short sleep duration and weight gain: a systematic review. Obesity (Silver Spring) 16, 643-653. (Pubitemid 351328014)
113. Polychronakos C, Kukuvitis A (2002). Parental genomic imprinting in endocrinopathies. Eur J Endocrinol 147, 561-569. (Pubitemid 35414552)
114. Popkin BM (2003). The nutrition transition in the developing world. Dev Policy Rev 21, 581-597. (Pubitemid 37172408)
115. Popkin BM (2007). The world is fat. Sci Am 297, 88-95. (Pubitemid 47506845)
116. Popkin BM (2009). Global changes in diet and activity patterns as drivers of the nutrition transition. Nestle Nutr Workshop Ser Pediatr Program 63, 1-10; discussion 10-14, 259-268.
117. Prentice AM, Black AE, Coward WA, Davies HL, Goldberg GR, Murgatroyd PR et al. (1986). High levels of energy expenditure in obese women. BMJ (Clin Res Ed) 292, 983-987. (Pubitemid 16137062)
118. Prentice AM, Jebb SA (1995). Obesity in Britain: gluttony or sloth? BMJ 311, 437-439.
119. Prentice AM, Jebb SA (2003). Fast foods, energy density and obesity: a possible mechanistic link. Obes Rev 4, 187-194. (Pubitemid 37444213)
120. Randhawa R, Cohen P (2005). The role of the insulin-like growth factor system in prenatal growth. Mol Genet Metab 86, 84-90. (Pubitemid 41412163)
121. Reinehr T (2010). Obesity and thyroid function. Mol Cell Endocrinol 316, 165-171.
122. Repaci A, Gambineri A, Pasquali R (2011). The role of low-grade inflammation in the polycystic ovary syndrome. Mol Cell Endocrinol 335, 30-41.
123. Robinson TN (1999). Reducing childrens television viewing to prevent obesity: a randomized controlled trial. JAMA 282, 1561-1567. (Pubitemid 29504370)
124. Sachdev HS, Fall CH, Osmond C, Lakshmy R, Dey Biswas SK, Leary SD et al. (2005). Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohort. Am J Clin Nutr 82, 456-466.
125. Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD et al. (2009). Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 360, 859-873.
126. Sahebjami H, Scalettar R (1971). Effects of fructose infusion on lactate and uric acid metabolism. Lancet 1, 366-369.
127. Saltiel AR, Kahn CR (2001). Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806. (Pubitemid 34000783)
128. Schwartz MW, Morton GJ (2002). Obesity: keeping hunger at bay. Nature 418, 595-597.
129. Sekine M, Yamagami T, Handa K, Saito T, Nanri S, Kawaminami K et al. (2002). A dose-response relationship between short sleeping hours and childhood obesity: results of the Toyama Birth Cohort Study. Child Care Health Dev 28, 163-170. (Pubitemid 34812335)
130. Sesti G, Federici M, Lauro D, Sbraccia P, Lauro R (2001). Molecular mechanism of insulin resistance in type 2 diabetesmellitus: role of the insulin receptor variant forms. Diabetes Metab Res Rev 17, 363-373. (Pubitemid 33040309)
131. Singhal A, Cole TJ, Fewtrell M, Deanfield J, Lucas A (2004). Is slower early growth beneficial for long-term cardiovascular health? Circulation 109, 1108-1113. (Pubitemid 38332614)
132. Singhal A, Lucas A (2004). Early origins of cardiovascular disease: is there a unifying hypothesis? Lancet 363, 1642-1645. (Pubitemid 38625670)
133. Skomro RP, Ludwig S, Salamon E, Kryger MH (2001). Sleep complaints and restless legs syndrome in adult type 2 diabetics. Sleep Med 2, 417-422. (Pubitemid 32952345)
134. Soto N, Bazaes RA, Pena V, Salazar T, Avila A, Iniguez G et al. (2003). Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: results from a prospective cohort. J Clin Endocrinol Metab 88, 3645-3650. (Pubitemid 37034508)
135. Speakman JR, Rance KA, Johnstone AM (2008). Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 16, 1961-1965.
136. Spiegel K, Leproult R, Van CE (1999). Impact of sleep debt on metabolic and endocrine function. Lancet 354, 1435-1439. (Pubitemid 29494756)
137. Spiegel K, Tasali E, Penev P, Van CE (2004). Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 141, 846-850. (Pubitemid 39601178)
138. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL et al. (2009). Consuming fructose-sweetened, not glucosesweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 119, 1322-1334.
139. Stanner SA, Yudkin JS (2001). Fetal programming and the Leningrad Siege study. Twin Res 4, 287-292. (Pubitemid 34151390)
140. Stettler N, Kumanyika SK, Katz SH, Zemel BS, Stallings VA (2003). Rapid weight gain during infancy and obesity in young adulthood in a cohort of African Americans. Am J Clin Nutr 77, 1374-1378. (Pubitemid 39655268)
141. Stettler N, Stallings VA, Troxel AB, Zhao J, Schinnar R, Nelson SE et al. (2005). Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula. Circulation 111, 1897-1903. (Pubitemid 40570209)
142. Storlien L, Oakes ND, Kelley DE (2004). Metabolic flexibility. Proc Nutr Soc 63, 363-368. (Pubitemid 38787491)
143. Swinburn BA, Sacks G, Lo SK,Westerterp KR, Rush EC, Rosenbaum M et al. (2009). Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr 89, 1723-1728.
144. Taheri S, Lin L, Austin D, Young T, Mignot E (2004). Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med 1, e62.
145. Tappy L, Le KA (2010). Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 90, 23-46.
146. Tate AR, Dezateux C, Cole TJ (2006). Is infant growth changing? Int J Obes (Lond) 30, 1094-1096. (Pubitemid 43980578)
147. Taubes G (2008). The Diet Delusion. Vermillion: London.
148. Treuth MS, Figueroa-Colon R, Hunter GR, Weinsier RL, Butte NF, Goran MI (1998). Energy expenditure and physical fitness in overweight vs non-overweight prepubertal girls. Int J Obes Relat Metab Disord 22, 440-447. (Pubitemid 28211972)
149. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006). An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031. (Pubitemid 46018515)
150. Underwood AH, Newsholme EA (1965). Properties of phosphofructokinase from rat liver and their relation to the control of glycolysis and gluconeogenesis. Biochem J 95, 868-875.
151. VanSchaftingen E, Veiga-da-Cunha M, Niculescu L (1997). The regulatory protein of glucokinase. Biochem Soc Trans 25, 136-140. (Pubitemid 27092565)
152. Victora CG, Adair L, Fall C, Hallal PC, Martorell R, Richter L et al. (2008). Maternal and child undernutrition: consequences for adult health and human capital. Lancet 371, 340-357.
153. von Helmholtz H (1847). Uber Die Warmeenwicklung Bei Der Muskelaction. G Reiner: Berlin.
154. vonKries R, Toschke AM,Wurmser H, Sauerwald T, Koletzko B (2002). Reduced risk for overweight and obesity in 5- and 6-y-old children by duration of sleep-a cross-sectional study. Int J Obes Relat Metab Disord 26, 710-716. (Pubitemid 34499292)
155. Walter J, Paulsen M (2003). Imprinting and disease. Semin Cell Dev Biol 14, 101-110. (Pubitemid 36259941)
156. Wells JC (1998). Is obesity really due to high energy intake or low energy expenditure? Int J Obes Relat Metab Disord 22, 1139-1140. (Pubitemid 28486611)
157. Wells JC (2009). Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms. Int J Obes (Lond) 33, 1331-1338.
158. Wells JC, Chomtho S, Fewtrell MS (2007). Programming of body composition by early growth and nutrition. Proc Nutr Soc 66, 423-434. (Pubitemid 47076239)
159. Wells JC, Fewtrell MS, Williams JE, Haroun D, Lawson MS, Cole TJ (2006). Body composition in normal weight, overweight and obese children: matched case-control analyses of total and regional tissue masses, and body composition trends in relation to relative weight. Int J Obes 30, 1506-1513. (Pubitemid 44470199)
160. Wells JC, Hallal PC, Reichert FF, Menezes AM, Araujo CL, Victora CG (2008). Sleep patterns and television viewing in relation to obesity and blood pressure: evidence from an adolescent Brazilian birth cohort. Int J Obes (Lond).
161. Wells JC, Hallal PC, Wright A, Singhal A, Victora CG (2005). Fetal, infant and childhood growth: relationships with body composition in Brazilian boys aged 9 years. Int J Obes (Lond) 29, 1192-1198. (Pubitemid 43080297)
162. Westerterp KR, Speakman JR (2008). Physical activity energy expenditure has not declined since the 1980s and matches energy expenditures of wild mammals. Int J Obes (Lond) 32, 1256-1263.
163. White MF, Kahn CR (1994). The insulin signaling system. J Biol Chem 269, 1-4. (Pubitemid 24026607)
164. Wishnofsky M (1958). Caloric equivalent of gained or lost weight. Am J Clin Nutr 6, 542-546.
165. Wolfgang MJ, Cha SH, Sidhaye A, Chohnan S, Cline G, Shulman GI et al. (2007). Regulation of hypothalamic malonyl-CoA by central glucose and leptin. Proc Natl Acad Sci USA 104, 19285-19290.
166. Woods SC, DAlessio DA (2008). Central control of body weight and appetite. J Clin Endocrinol Metab 93 (11 Suppl 1), S37-S50.
167. Woods SC, Seeley RJ (2000). Adiposity signals and the control of energy homeostasis. Nutrition 16, 894-902.
168. Wronka I (2010). Association between BMI and age at menarche in girls fromdifferent socio-economic groups. Anthropol Anz 68, 43-52.
169. Young T (2008). Increasing sleep duration for a healthier (and less obese?) population tomorrow. Sleep 31, 593-594.
170. Zepelin H, Rechtschaffen A (1974). Mammalian sleep, longevity, and energy metabolism. Brain Behav Evol 10, 425-470.
171. Ziegler EE (2006). Growth of breast-fed and formula-fed infants. Nestle NutrWorkshop Ser Pediatr Program 58, 51-59; discussion 59-63.