Childhood obesity: Behavioral aberration or biochemical drive? Reinterpreting the First Law of Thermodynamics

Nature Clinical Practice Endocrinology and Metabolism

Volumn 2, Issue 8, 2006, Pages 447-458

  Lustig, Robert H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Addiction; Insulin; Leptin resistance; Obesity; Starvation

Indexed keywords

DOPAMINE; LEPTIN;

ADIPOSE TISSUE; AUTONOMIC DYSFUNCTION; BEHAVIOR DISORDER; CALORIC INTAKE; CHILDHOOD DISEASE; ENERGY EXPENDITURE; HUMAN; HYPERINSULINEMIA; LIFESTYLE; OBESITY; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; REWARD; SIGNAL TRANSDUCTION; THERMODYNAMICS; WEIGHT GAIN; WEIGHT REDUCTION;

CHILD; ENERGY METABOLISM; HUMANS; HYPERINSULINISM; OBESITY; THERMODYNAMICS;

EID: 33747052261     PISSN: 17458366     EISSN: 17458374     Source Type: Journal    
DOI: 10.1038/ncpendmet0220     Document Type: Review

References (80)

1. Ogden CL et al. (2002) Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA 288: 1728-1732
2. Hill JO et al. (2003) Obesity and the environment: where do we go from here? Science 299: 853-855
3. Ebbeling CB et al. (2002) Childhood obesity: public-health crisis, common sense cure. Lancet 360: 473-482
4. Troiano RP et al. (2000) Energy and fat intakes of children and adolescents in the United States: data from the National Health and Nutrition Examination Surveys. Am J Clin Nutr 72 (Suppl): 1343S-1353S
5. Kimm SYS et al. (2002) Decline in physical activity in black girls and white girls in adolescence. N Engl J Med 347: 709-715
6. Schwimmer JB et al. (2003) Health-related quality of life of severely obese children and adolescents. JAMA 289: 1813-1819
7. Epstein LH et al. (2001) Behavioral therapy in the treatment of pediatric obesity. Pediatr Clin North Am 48: 981-993
8. Ritchie L et al. (2001) Pediatric overweight: a review of the literature [http://www.cnr.berkeley.edu/cwh/PDFs/Full_COPI_secure.pdf] (accessed 17 May 2006)
9. Lustig RH (2001) The neuroendocrinology of childhood obesity. Pediatr Clin North Am 48: 909-930
10. Balthasar N et al. (2005) Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123: 493-505
11. Lustig RH The efferent arm of the energy balance regulatory pathway: neuroendocrinology and pathology. In Obesity and Energy Metabolism: Research and Clinical Applications (Ed Donahoue PA) New Jersey: Humana, in press
12. Porte D et al. (2005) Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans. Diabetes 54: 1264-1276
13. Flier JS (1998) What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab 83: 1407-1413
14. Mark AL et al. (2003) A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat. Acta Physiol Scand 177: 345-349
15. Baskin DG et al. (1988) Insulin and insulin-like growth factors in the CNS. Trends Neurosci 11: 107-111
16. Schwartz MW et al. (1990) Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats. Peptides 11: 467-472
17. Muntzel MS et al. (1994) Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity. Am J Physiol 267 (Pt 2): R1350-R1355
18. Niswender KD et al. (2001) Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 413: 794-795
19. Brüning JC et al. (2000) Role of brain insulin receptor in control of body weight and reproduction. Science 289: 2122-2125
20. Kubota N et al. (2004) Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus. J Clin Invest 114: 917-927
21. Choudhury AI et al. (2005) The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115: 940-950
22. Niswender KD and Schwartz MW (2003) Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol 24: 1-10
23. Lowell BB and Spiegelman BM (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404: 652-660
24. Collins S et al. (1996) Role of leptin in fat regulation [letter]. Nature 380: 677
25. Haynes WG et al. (1997) Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 100: 270-278
26. Blaak EE et al. (1993) Adrenoceptor subtypes mediating catecholamine-induced thermogenesis in man. Int J Obes Relat Metab Disord 17 (Suppl 3): S78-S81
27. Kreier F et al. (2002) Selective parasympathetic innervation of subcutaneous and intra-abdominal fat-functional implications. J Clin Invest 110: 1243-1250
28. Lustig RH (2003) Autonomic dysfunction of the β-cell and the pathogenesis of obesity. Rev Endocr Metab Disord 4: 23-32
29. Yamada M et al. (2001) Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature 410: 207-212
30. Bray GA and Greenway FL (1999) Current and potential drugs for treatment of obesity. Endocr Rev 20: 805-875
31. Leibel RL et al. (1995) Changes in energy expenditure resulting from altered body weight. N Engl J Med 332: 621-628
32. Rosenbaum M et al. (1997) Effects of weight change on plasma leptin concentrations and energy expenditure. J Clin Endocrinol Metab 82: 3647-3654
33. Rosenbaum M et al. (2003) Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol 285: R183-R192
34. Smit HJ et al. (2004) Mood and cognitive performance effects of "energy" drink constituents: caffeine, glucose, and carbonation. Nutr Neurosci 7: 127-139
35. Belza A and Jessen AB (2005) Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation. Eur J Clin Nutr 59: 733-741
36. Boden G et al. (1996) Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 81: 454-458
37. Aronne LJ et al. (1995) Autonomic nervous system activity in weight gain and weight loss. Am J Physiol 269: R222-R225
38. Farooqi IS et al. (2002) Beneficial effects of leptin on obesity, T-cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110: 1093-1103
39. Lee HC et al. (1989) Direct effect of CNS on insulin hypersecretion in obese Zucker rats: involvement of vagus nerve. Am J Physiol 256: E439-E444
40. van Dijk G et al. (2005) Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats. Endocrinology 146: 5247-5256
41. Heymsfield SB et al. (1999) Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282: 1568-1575
42. Poretti A et al. (2004) Outcome of craniopharyngioma in children: long-term complications and quality of life. Dev Med Child Neurol 46: 220-229
43. Lustig RH et al. (2003) Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab 88: 611-616
44. Schofl C et al. (2002) Sympathoadrenal counterregulation in patients with hypothalamic craniopharyngioma. J Clin Endocrinol Metab 87: 624-629
45. Harz KJ et al. (2003) Obesity in patients with craniopharyngioma: assessment of food intake and movement counts indicating physical activity. J Clin Endocrinol Metab 88: 5227-5231
46. Rosenbaum M et al. (2002) Low dose leptin administration reverses effects of sustained weight reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 87: 2391-2394
47. Bray GA and Gallagher TF (1975) Manifestations of hypothalamic obesity in man: a comprehensive investigation of eight patients and a review of the literature. Medicine (Baltimore) 54: 301-333
48. Lustig RH et al. (1999) Hypothalamic obesity in children caused by cranial insult: altered glucose and insulin dynamics, and reversal by a somatostatin agonist. J Pediatr 135: 162-168
49. Lustig RH et al. (2003) Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial. J Clin Endocrinol Metab 88: 2586-2592
50. Velasquez-Mieyer PA et al. (2003) Suppression of insulin secretion promotes weight loss and alters macronutrient preference in a subset of obese adults. Int J Obesity 27: 219-226
51. Lustig RH et al. (2004) Obesity, leptin resistance, and the effects of insulin suppression. Int J Obesity 28: 1344-1348
52. Lustig RH et al. (2006) A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion. Int J Obes 30: 331-341
53. El-Haschimi K et al. (2000) Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105: 1827-1832
54. Clegg DJ et al. (2005) Reduced anorexic effects of insulin in obesity-prone rats fed a moderate fat diet. Am J Physiol Regul Integr Comp Physiol 288: R981-R986
55. Mori H et al. (2004) Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 10: 739-743
56. Munzberg H and Myers MG (2005) Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 8: 566-570
57. Emanuelli B et al. (2000) SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem 275: 15985-15991
58. Banks W et al. (1999) Impaired transport of leptin across the blood-brain barrier in obesity. Peptides 20: 1341-1345
59. Ishihara Y et al. (2004) Effects of diet and time of the day on serum and CSF leptin levels in Osborne-Mendel and S5B/Pl rats. Obes Res 12: 1067-1076
60. Nam SY et al. (2001) Cerebrospinal fluid and plasma concentrations of leptin, NPY, and α-MSH in obese women and their relationship to negative energy balance. J Clin Endocrinol Metab 86: 4849-4853
61. Figlewicz DP et al. (1996) Review article: endocrine regulation of food intake and body weight. J Lab Clin Med 127: 328-332
62. Zabolotny JM et al. (2002) PTP1B regulates leptin signal transduction in vivo. Dev Cell 2: 489-495
63. Flier JS (2004) Obesity wars: molecular progress confronts an expanding epidemic. Cell 116: 337-350
64. Li HJ et al. (2005) A twin study for serum leptin, soluble leptin receptor, and free insulin-like growth factor-1 in pubertal females. J Clin Endocrinol Metab 90: 3659-3664
65. McLachlan KA et al. (2006) Do adiponectin, TNFα, leptin, and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy. Diab Metab Res Rev 22: 131-138
66. Castracane VD et al. (2005) Serum leptin in nonpregnant and pregnant women and in old and new world nonhuman primates. Exp Biol Med 230: 251-254
67. Kelley AE et al. (2002) Opioid modulation of taste hedonics within the ventral striatum. Physiol Behav 76: 365-377
68. Shalev U et al. (2001) Leptin attenuates food deprivation-induced relapse to heroin seeking. J Neurosci 21: RC129
69. Carr KD et al. (2003) Evidence of increased dopamine receptor signaling in food-restricted rats. Neuroscience 119: 1157-1167
70. Wang GJ et al. (2001) Brain dopamine and obesity. Lancet 357: 354-357
71. Figlewicz DP et al. (1994) Intraventricular insulin increases dopaminergic transporter mRNA in rat VTA/substantia nigra. Brain Res 644: 331-334
72. Sipols AJ et al. (2002) Intraventricular insulin decreases kappa opioid-mediated sucrose intake in rats. Peptides 23: 2181-2187
73. Figlewicz DP (2003) Adiposity signals and food reward: expanding the CNS roles of insulin and leptin. Am J Phyisol Regul Integ Comp Physiol 284: R882-R892
74. Arslanian SA et al. (2002) Hyperinsulinemia in African-American children. Decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity. Diabetes 51: 3014-3019
75. Preeyasombat C et al. (2005) Racial and etiopathologic dichotomies in insulin secretion and resistance in obese children. J Pediatr 146: 474-481
76. Stocker CJ et al. (2005) Fetal origins of insulin resistance and obesity. Proc Nutr Soc 64: 143-151
77. Yajnik CS et al. (2002) Adiposity and hyperinsulinemia in Indians are present at birth. J Clin Endocrinol Metab 87: 5575-5580
78. Hofman PL et al. (2004) Premature birth and later insulin resistance. N Engl J Med 351: 2179-2186
79. Cettour-Rose P et al. (2005) Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: a link between catch-up growth and later metabolic syndrome. Diabetes 54: 751-756
80. Isganaitis E and Lustig RH (2005) Fast food, central nervous system insulin resistance, and obesity. Arterioscler Thromb Vasc Biol 25: 2451-2462