Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation

Particle and Fibre Toxicology

Volumn 9, Issue , 2012, Pages

  Wang, Ting ^a   Wang, Lichun ^a   Moreno Vinasco, Liliana ^a   Lang, Gabriel D ^a   Siegler, Jessica H ^a   Mathew, Biji ^a   Usatyuk, Peter V ^a   Samet, Jonathan M ^b   Geyh, Alison S ^c   Breysse, Patrick N ^c   Natarajan, Viswanathan ^a   Garcia, Joe G N ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Calpain; Endothelial permeability; Particulate matter; ROS; TRPM2

Indexed keywords

ACETYLCYSTEINE; BETA CATENIN; CALPAIN; INTERLEUKIN 6; PROTEIN ZO1; PROTEIN ZO2; REACTIVE OXYGEN METABOLITE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; VASCULAR ENDOTHELIAL CADHERIN;

AIR POLLUTION; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; ELECTRIC RESISTANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG LAVAGE; MALE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ACETYLCYSTEINE; AIR POLLUTANTS; CALCIUM; CALPAIN; CELLS, CULTURED; ELECTRIC IMPEDANCE; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; HUMANS; LUNG; OXIDATIVE STRESS; PARTICULATE MATTER; PERMEABILITY; REACTIVE OXYGEN SPECIES; TRPM CATION CHANNELS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84865423614     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-9-35     Document Type: Article

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