Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway

Journal of Clinical Investigation

Volumn 117, Issue 10, 2007, Pages 2952-2961

  Mutlu, Gökhan M ^a   Green, David ^a   Bellmeyer, Amy ^a   Baker, Christina M ^a   Burgess, Zach ^a   Rajamannan, Nalini ^a   Christman, John W ^b   Foiles, Nancy ^a   Kamp, David W ^a   Ghio, Andrew J ^c   Chandel, Navdeep S ^a   Dean, David A ^a   Sznajder, Jacob I ^a   Budinger, G R Scott ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; C REACTIVE PROTEIN; CLODRONIC ACID; FIBRINOGEN; INTERLEUKIN 6; PROTHROMBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; BLEEDING TIME; BLOOD CLOTTING; CARDIOVASCULAR RISK; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEMOSTASIS; LUNG ALVEOLUS MACROPHAGE; MOUSE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PARTICULATE MATTER; PRIORITY JOURNAL; PROTHROMBIN TIME; THROMBOCYTE ACTIVATION; THROMBOSIS;

ANIMALS; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; BRONCHOALVEOLAR LAVAGE FLUID; CAROTID ARTERY THROMBOSIS; CLODRONIC ACID; FERRIC COMPOUNDS; INTERLEUKIN-6; MACROPHAGES, ALVEOLAR; MICE; MICE, KNOCKOUT; PARTICULATE MATTER; PROTHROMBIN TIME; THROMBIN;

EID: 34948830244     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI30639     Document Type: Article

References (48)

1. Peters, A., Dockery, D.W., Muller, J.E., and Mittleman, M.A. 2001. Increased particulate air pollution and the triggering of myocardial infarction. Circulation. 103:2810-2815.
2. D'Ippoliti, D., et al. 2003. Air pollution and myocardial infarction in Rome: a case-crossover analysis. Epidemiology. 14:528-535.
3. Peters, A., et al. 2004. Exposure to traffic and the onset of myocardial infarction. N. Engl. J. Med. 351:1721-1730.
4. Rich, D.Q., et al. 2005. Association of short-term ambient air pollution concentrations and ventricular arrhythmias. Am. J. Epidemiol. 161:1123-1132.
5. Wellenius, G.A., Bateson, T.F., Mittleman, M.A., and Schwartz, J. 2005. Particulate air pollution and the rate of hospitalization for congestive heart failure among Medicare beneficiaries in Pittsburgh, Pennsylvania. Am. J. Epidemiol. 161:1030-1036.
6. Wellenius, G.A., Schwartz, J., and Mittleman, M.A. 2005. Air pollution and hospital admissions for ischemic and hemorrhagic stroke among Medicare beneficiaries. Stroke. 36:2549-2553.
7. Nemmar, A., Nemery, B., Hoet, P.H., Vermylen, J., and Hoylaerts, M.F. 2003. Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters: role of histamine. Am. J. Respir. Crit. Care Med. 168:1366-1372.
8. Nemmar, A., et al. 2003. Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis. Circulation. 107:1202-1208.
9. Ruckerl, R., et al. 2006. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am. J. Respir. Crit. Care Med. 173:432-441.
10. Kerr, R., Stirling, D., and Ludlam, C.A. 2001. Interleukin 6 and haemostasis. Br. J. Haematol. 115:3-12.
11. Tracy, R.P. 1999. Epidemiological evidence for inflammation in cardiovascular disease. Thromb. Haemost. 82:826-831.
12. Yudkin, J.S., Stehouwer, C.D., Emeis, J.J., and Coppack, S.W. 1999. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler. Thromb. Vasc. Biol. 19:972-978.
13. Harris, T.B., et al. 1999. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 106:506-512.
14. Yeh, E.T. 2004. CRP as a mediator of disease. Circulation. 109:II11-II14.
15. Mutlu, G.M., et al. 2006. Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation. Am. J. Respir. Cell Mol. Biol. 34:670-676.
16. Upadhyay, D., Panduri, V., Ghio, A., and Kamp, D.W. 2003. Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria. Am. J. Respir. Cell Mol. Biol. 29:180-187.
17. Brook, R.D., et al. 2004. Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation. 109:2655-2671.
18. Ghio, A.J., Hall, A., Bassett, M.A., Cascio, W.E., and Devlin, R.B. 2003. Exposure to concentrated ambient air particles alters hematologic indices in humans. Inhal. Toxicol. 15:1465-1478.
19. Baccarelli, A., et al. 2007. Effects of exposure to air pollution on blood coagulation. J. Thromb. Haemost. 5:252-260.
20. Riediker, M., et al. 2004. Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men. Am. J. Respir. Crit. Care Med. 169:934-940.
21. Nieswandt, B., Schulte, V., and Bergmeier, W. 2004. Flow-cytometric analysis of mouse platelet function. Methods Mol. Biol. 272:255-268.
22. Konstantinides, S., Schafer, K., Thinnes, T., and Loskutoff, D.J. 2001. Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice. Circulation. 103:576-583.
23. Nel, A. 2005. Atmosphere. Air pollution-related illness: effects of particles. Science. 308:804-806.
24. Li, N., et al. 2004. Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. J. Immunol. 173:3467-3481.
25. Ghio, A.J., Kim, C., and Devlin, R.B. 2000. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am. J. Respir. Crit. Care Med. 162:981-988.
26. Burstein, S.A., et al. 1996. Cytokine-induced alteration of platelet and hemostatic function. Stem Cells. 14(Suppl. 1):154-162.
27. Neumann, F.J., et al. 1997. Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity. Arterioscler. Thromb. Vasc. Biol. 17:3399-3405.
28. Niessen, R.W., et al. 1997. Antithrombin acts as a negative acute phase protein as established with studies on HepG2 cells and in baboons. Thromb. Haemost. 78:1088-1092.
29. Stouthard, J.M., et al. 1996. Interleukin-6 stimulates coagulation, not fibrinolysis, in humans. Thromb. Haemost. 76:738-742.
30. Stirling, D., Hannant, W.A., and Ludlam, C.A. 1998. Transcriptional activation of the factor VIII gene in liver cell lines by interleukin-6. Thromb. Haemost. 79:74-78.
31. Amrani, D.L. 1990. Regulation of fibrinogen biosynthesis: glucocorticoid and interleukin-6 control. Blood Coagul. Fibrinolysis. 1:443-446.
32. Kannel, W.B., Wolf, P.A., Castelli, W.P., and D'Agostino, R.B. 1987. Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA. 258:1183-1186.
33. Kraaijenhagen, R.A., et al. 2000. High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism. Thromb. Haemost. 83:5-9.
34. Kyrle, P.A., et al. 2000. High plasma levels of factor VIII and the risk of recurrent venous thromboembolism. N. Engl. J. Med. 343:457-462.
35. Jenkins, B.J., et al. 2007. Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood. 109:2380-2388.
36. Woodward, M., Rumley, A., Tunstall-Pedoe, H., and Lowe, G.D. 1999. Associations of blood rheology and interleukin-6 with cardiovascular risk factors and prevalent cardiovascular disease. Br. J. Haematol. 104:246-257.
37. Gauldie, J., Northemann, W., and Fey, G.H. 1990. IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6. J. Immunol. 144:3804-3808.
38. Heinrich, P.C., Castell, J.V., and Andus, T. 1990. Interleukin-6 and the acute phase response. Biochem. J. 265:621-636.
39. Nemmar, A., Nemery, B., Hoet, P.H., Van Rooijen, N., and Hoylaerts, M.F. 2005. Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross-talk. Am. J. Respir. Crit. Care Med. 171:872-879.
40. Brauer, M., et al. 2001. Air pollution and retained particles in the lung. Environ. Health Perspect. 109:1039-1043.
41. Imai, Y., et al. 2003. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA. 289:2104-2112.
42. Schlenker, E.H. 1984. An evaluation of ventilation in dystrophic Syrian hamsters. J. Appl. Physiol. 56:914-921.
43. [Anonymous]. 1994. Air pollution in the world's megacities: a report from the UN Environment Programme and WHO Environment. United Nations. New York, New York, USA. WHO. Geneva, Switzerland. Environment. 36:35-37.
44. de Hennezel, L., et al. 2001. Plethysmography for the assessment of pneumococcal pneumonia and passive immunotherapy in a mouse model. Eur. Respir. J. 17:94-99.
45. Mutlu, G.M., et al. 2004. Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling. Circ. Res. 94:1091-1100.
46. Gailani, D., Lasky, N.M., and Broze, G.J., Jr. 1997. A murine model of factor XI deficiency. Blood Coagul. Fibrinolysis. 8:134-144.
47. Everhart, M.B., et al. 2005. Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation. J. Leukoc. Biol. 77:173-180.
48. Garn, H., et al. 2006. Phenotypical and functional characterization of alveolar macrophage subpopulations in the lungs of NO2-exposed rats. Respir. Res. 7:4.