The spontaneously hypertensive rat as a model of human cardiovascular disease: Evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled emission particulate matter

Toxicology and Applied Pharmacology

Volumn 164, Issue 3, 2000, Pages 250-263

  Kodavanti, Urmila P ^a   Schladweiler, Mette C ^a   Ledbetter, Allen D ^a   Watkinson, William P ^a   Campen, Matthew J ^b   Winsett, Darrell W ^a   Richards, Judy R ^a   Crissman, Kay M ^a   Hatch, Gary E ^a   Costa, Daniel L ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ASCORBIC ACID; BETA ACTIN; CYTOKINE; FIBRONECTIN; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; INTERLEUKIN 6; M PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 2; METAL; THIOBARBITURIC ACID REACTIVE SUBSTANCE; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRONCHUS HYPERREACTIVITY; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; ELECTROCARDIOGRAPHY; FLY ASH; HISTOPATHOLOGY; INHALATION; LUNG INJURY; LUNG LAVAGE; MALE; NONHUMAN; OXIDATIVE STRESS; PARTICULATE MATTER; PATHOGENESIS; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALIA; BRONCHUS;

EID: 0034192641     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2000.8899     Document Type: Article

References (67)

1. Aharinejad S., Schraufnagel D. E., Bock P., MacKay C. A., Larson E. K., Miksovsky A., Marks S. C. Jr. Spontaneously hypertensive rats develop pulmonary hypertension and hypertrophy of pulmonary venous sphincters. Am. J. Pathol. 148:1996;281-290.
2. Alexander R. W. Atherosclerosis as disease of redox-sensitive genes. Trans. Am. Clin. Climatol. Assoc. 109:1998;129-146.
3. Anderson M. E. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113:1985;548-555.
4. Arndt H., Smith C. W., Granger D. N. Leukocyte-endothelial cell adhesion in spontaneously hypertensive and normotensive rats. Hypertension. 21:1993;667-673.
5. Bouthillier L., Vincent R., Goegan P., Adamson I. Y., Bjarnason S., Stewart M., Guenette J., Potvin M., Kumarathasan P. Acute effects of inhaled urban particles and ozone: Lung morphology, macrophage activity, and plasma endothelin-1. Am. J. Pathol. 153:1998;1873-1884.
6. Burke-Wolin T., Pino P., Itani M., Talerico M., Pucci M., Benson D., Fayngersh R. Peripheral hypertension and alteration in pulmonary vascular regulation. Am. J. Physiol. 273:1997;L113-L118.
7. ILAR News. XIX:1976;G1-G20.
8. Conrad C. H., Brooks W. W., Hayes J. A., Sen S., Robinson K. G., Bing O. H. L. Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat. Circulation. 91:1995;161-170.
9. Cui Z. H., Sjostrand M., Pullerits T., Andius P., Skoogh B. E., Lotvall J. Bronchial hyperresponsiveness, epithelial damage, and airway eosinophilia after single and repeated allergen exposure in a rat model of anhydride-induced asthma. Allergy. 52:1997;739-746.
10. Daffonchio A., Franzelli C., Di Rienzo M., Castiglioni P., Mancia G., Ferrari A. U. Sympathetic, parasympathetic and non-autonomic contributions to cardiovascular spectral powers in unanesthetized spontaneously hypertensive rats. J. Hypertens. 13:1995;1636-1642.
11. Debreczeni L. A., Vertes K., Barat E., Huszar E. Breathing pattern of spontaneously hypertensive rats. Acta Physiol. Hung. 74:1989;33-36.
12. Dockery D. W., Pope A. III, Xu X., Spengler J. D., Ware J. H., Fay M. E., Ferris B. G. Jr., Speizer F. E. An association between air pollution and mortality in six U.S. cities. N. Engl. J. Med. 329:1993;1753-1759.
13. Dreher K. L., Jaskot R. H., Lehmann J. R., Richards J. H., McGee J. K., Ghio A. J., Costa D. L. Soluble transition metals mediate residual oil fly ash induced acute lung injury. J. Toxicol. Environ. Health. 50:1997;285-305.
14. Driscoll K. E., Hassenbein D. G., Carter J., Poynter J., Asquith T. N., Grant R. A., Whitten J., Purdon M. P., Takigiku R. Macrophage inflammatory proteins 1 and 2: Expression by rat alveolar macrophages, fibroblasts, and epithelial cells and in rat lung after mineral dust exposure. Am. J. Respir. Cell Mol. Biol. 8:1993;311-318.
15. Fort P., Marty L., Piechaczyk M., El Sabrouty S., Dani C., Jeanteur P., Blanchard J. M. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res. 13:1985;1431-1442.
16. Haller H., Behrend M., Park J. K., Schaberg T., Luft F. C., Distler A. Monocyte infiltration and c-fos expression in hearts of spontaneously hypertensive rats. Hypertension. 25:1995;132-138.
17. Hartroft P. M., Kuhn C. C. III, Freeman S. V., Tansuvan C., Gregory R. O., Gardner R. A. Effects of chronic, continuous exposure to simulated urban Air pollution on laboratory animals with cardiovascular and respiratory diseases. Inst. Elect. Electron. Eng. USA Ann. 75CH1004-I34-5:1976;1-5.
18. Iannini J. P., Spinale F. G. Medical management of heart failure and candidate selection: The identification of contributory mechanisms for the development and progression of congestive heart failure in animal models. J. Heart Lung Transplant. 15:1996;1138-1150.
19. Itani M. M., Talerico M. G., Pino P. A., Burke-Wolin T. Early regulatory changes in rat pulmonary artery of rennin-dependent systemic hypertension models. Am. J. Respir. Cell Mol. Biol. 15:1996;467-472.
20. Ito H., Torii M., Suzuki T. Comparative study on free radical injury in the endothelium of SHR and WKY aorta. Clin. Exp. Pharmacol. Physiol. 22:1995;S157-S159.
21. Jaskot R. H., Costa D. L., Kodavanti U. P., Lehmann J. R., Winsett D., Dreher K. L. Comparison of lung inflammation and airway reactivity in three strains of rats exposed to residual oil fly ash particles. Am. J. Respir. Crit. Care Med. 151:1995;A264.
22. Killingsworth C. R., Alessandrini F., Krishna Murthy G. G., Catalano P. J., Paulauskis J. D., Godleski J. J. Inflammation, chemokine expression, and death in monocrotaline-treated rats following fuel oil fly ash inhalation. Inhal. Toxicol. 9:1997;541-565.
23. Kodavanti U. P., Costa D. L., Dreher K. L., Crissman K., Hatch G. E. Ozone-induced tissue injury and changes in antioxidant homeostasis in normal and ascorbate-deficient guinea pigs. Biochem. Pharmacol. 50:1995;243-251.
24. Kodavanti U. P., Jaskot R. H., Bonner J., Badgett A., Dreher K. L. Eosinophilic lung inflammation in particulate-induced lung injury: Technical consideration in isolating RNA for gene expression studies. Exp. Lung Res. 22:1996;541-554.
25. Kodavanti U. P., Jaskot R. H., Su W. Y., Costa D. L., Ghio A. J., Dreher K. L. Genetic variability in combustion particle-induced chronic lung injury. Am. J. Physiol. 272:1997a;L521-L532.
26. Kodavanti U. P., Jaskot R. H., Costa D. L., Dreher K. L. Pulmonary proinflammatory gene induction following acute exposure to residual oil fly ash: Roles of particle-associated metals. Inhal. Toxicol. 9:1997b;679-701.
27. Kodavanti U. P., Costa D. L., Bromberg P. A. Rodent models of cardiopulmonary disease: Their potential applicability in studies of air pollutant susceptibility. Environ. Health Perspect. 106:1998a;111-130.
28. Kodavanti U. P., Hauser R., Christiani D. C., Meng Z. H., McGee J., Ledbetter A., Richards J., Costa D. L. Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicol. Sci. 43:1998b;204-212.
29. Kodavanti U. P., Jackson M. C., Ledbetter A. D., Richards J. R., Gardner S. Y., Watkinson W. P., Campen M. J., Costa D. L. Lung injury from intratracheal and inhalation exposures to residual oil fly ash in a rat model of monocrotaline-induced pulmonary hypertension. J. Toxicol. Environ. Health. 57:1999;101-121.
30. Kristal B., Shurtz-Swirski R., Chezar J., Manaster J., Levy R., Shapiro G., Weissman I., Shasha S. M., Sela S. Participation of peripheral polymorphonuclear leukocytes in the oxidative stress and inflammation in patients with essential hypertension. Am. J. Hypertens. 11:1998;921-928.
31. Kutnink M. A., Skala J. H., Sauberlich H. E., Omaye S. T. Simultaneous determination of ascorbic acid (erythorbic acid) and uric acid in human plasma by high performance liquid chromatography with amperometric detection. J. Liquid Chromatogr. 8:1985;31-46.
32. Lacolley P., Poitevin P., Koen R., Levy B. I. Different effects of calcium antagonists on fluid filtration of large arteries and albumin permeability in spontaneously hypertensive rats. J. Hypertens. 16:1998;349-355.
33. Ledbetter A. D., Killough P., Hudson G. F. A low-sample-consumption dry-particulate aerosol generator for use in nose-only inhalation exposures. Inhal. Toxicol. 10:1998;239-251.
34. Lominadze D., Joshua I. G., Catalfamo J. L., Schulschke D. A. Platelet thrombus formation in micro vessels of young spontaneously hypertensive rats. Clin. Exp. Hypertens. 20:1998;917-937.
35. Long N. C., Martin J. G., Pantano R., Shore S. A. Airway hyperresponsiveness in a rat model of chronic bronchitis: Role of C fibers. Am. J. Respir. Crit. Care Med. 155:1997;1222-1229.
36. Mamuya W., Chobanian A., Brecher P. Age-related changes in fibronectin expression in spontaneously hypertensive, Wistar-Kyoto, and Wistar rat hearts. Circ. Res. 71:1992;1341-1350.
37. Michel M. C., Wang X. L., Schlicker E., Gothert M., Beckeringh J. J., Brodde O. E. Increased beta 2-adrenoreceptor density in heart, kidney and lung of spontaneously hypertensive rats. J. Auton. Pharmacol. 7:1987;41-51.
38. Minami M., Kuraishi Y., Satoh M. Effects of kainic acid on messenger RNA levels of IL-1β, IL-6, TNF-α and LIF in the rat brain. Biochem. Biophys. Res. Commun. 176:1991;593-598.
39. Morris R. D., Naumova E. N., Munasinghe R. L. Ambient air pollution and hospitalization for congestive heart failure among elderly people in seven large US cities. Am. J. Public Health. 85:1995;1361-1365.
40. Mulheron G. W., Mulheron J. G., Danielpour D., Schomberg D. W. Porcine granulosa cells do not express transforming growth factor-b2 (TGF-β2) messenger ribonucleic acid: Molecular basis for their inability to produce TGF-β activity comparable to that of rat granulosa cells. Endocrinology. 131:1992;2609-2614.
41. Nudel U., Jahut R., Shani M., Neuman S., Levy Z., Yaffe D. The nucleotide sequence of the rat cytoplasmic beta-actin gene. Nucleic Acids Res. 11:1983;1759-1771.
42. Ofosu-Appiah W., Sfeir G., Smith D., Richard T. Neutrophil-mediated damage to vascular endothelium in the spontaneously hypertensive rat. Clin. Immunol. Immunopathol. 83:1997;293-301.
43. Peters A., Doring A., Wichmann H.-E., Koenig W. Increased plasma viscosity during an air pollution episode: A link to mortality? Lancet. 349:1997;1582-1587.
44. Philips N., Bashey R. I., Jimenez S. A. Collagen and fibronectin expression in cardiac fibroblasts from hypertensive rats. Cardiovasc. Res. 28:1994;1342-1347.
45. Piano M. R., Bondmass M., Schwertz D. W. The molecular and cellular pathophysiology of the heart failure. Heart Lung. 27:1998;3-21.
46. Piechaczyk M., Blanchard J. M., Riaad-El Sabouty S., Dani C., Marty L., Jeanteur P. Unusual abundance of vertebrate 3-phosphate dehydrogenase pseudogenes. Nature. 312:1984;469-471.
47. Pope C. A. III, Dockery D. W., Kanner R. E., Villegas G. M., Schwartz J. Oxygen saturation, pulse rate, and particulate air pollution: A daily time-series panel study. Am. J. Respir. Crit. Care Med. 159:1999;365-372.
48. Quay J. L., Reed W., Samet J., Devlin R. B. Air pollution particles induce IL-6 gene expression in human airway epithelial cells via NF-kappaβ activation. Am. J. Respir. Cell Mol. Biol. 19:1998;98-106.
49. Repine J. E., Bast A., Lankhorst I. Oxidative stress in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 156:1997;341-357.
50. Rogers W. R., Carey K. D., McMahan C. A., Montiel M. M., Mott G. E., Wigodsky H. S., McGill H. C. Jr. Cigarette smoking, dietary hyperlipidemia, and experimental atherosclerosis in the baboon. Exp. Mol. Pathol. 48:1988;135-151.
51. Russo C., Olivieri O., Girelli D., Faccini G., Zenari M. L., Lombardi S., Corrocher R. Anti-oxidant status and lipid peroxidation in patients with essential hypertension. J. Hypertens. 16:1998;1267-1271.
52. Samani N. J., Brammar W. J., Swales J. D. A major structural abnormality in the renin gene of the spontaneously hypertensive rat. J. Hypertens. 7:1989;249-254.
53. Samet J. M., Silbajoris R., Wu W., Graves L. M. Tyrosine phosphatases as targets in metal-induced signaling in human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 21:1999;357-364.
54. Schmid-Schonbein G. W., Seiffge D., DeLano F. A., Shen K., Zweifach B. W. Leukocyte counts and activation in spontaneously hypertensive and normotensive rats. Hypertension. 17:1991;323-330.
55. Shen K., DeLano F. A., Zweifach B. W., Schmid-Schonbein G. W. Circulating leukocyte counts, activation, and degranulation in Dahl hypertensive rats. Circ. Res. 76:1995;276-283.
56. Sjogren B., Wang Z., Larsson B. M., Larsson K., Larsson P. H., Westerholm P. Increase in interleukin-6 and fibrinogen in peripheral blood after swine dust inhalation. Scand. J. Work Environ. Health. 25:1999;39-41.
57. Sugiyama S., Kugiyama K., Ohgushi M., Matsumura T., Ota Y., Doi H., Ogata N., Oka H., Yasue H. Super sensitivity of atherosclerotic artery to constrictor effect of cigarette smoke extract. Cardiovasc. Res. 38:1998;508-515.
58. Suzuki H., Swei A., Zweifach B. W., Schmid-Schonbein G. W. In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats. Hydroethidine microfluorography. Hypertension. 25:1995;1083-1089.
59. Swei A., Lacy F., DeLano F. A., Schmid-Schonbein G. W. Oxidative stress in the Dahl hypertensive rat. Hypertension. 30:1997;1628-1633.
60. Vedal S. Ambient particles and health: lines that divide. J. Air Waste Manag. Assoc. 47:1997;551-581.
61. Watkinson W. P., Brice M. A., Robinson K. S. A computer-assisted electrocardiographic analysis system: Methodology and potential application to cardiovascular toxicology. J. Toxicol. Environ. Health. 15:1985;713-727.
62. Watkinson W. P., Campen M. J., Costa D. L. Cardiac arrhythmia induction after exposure to residual oil fly ash particles in a rat model of pulmonary hypertension. Toxicol. Sci. 41:1998;209-216.
63. Watkinson W. P., Campen M. J., Dreher K. L., Su W-Y., Kodavanti U. P., Highfill J. W., Costa D. L. Thermoregulatory effects following exposure to particulate matter in healthy and cardiopulmonary-compromised rats. J. Thermal Biol. 25:2000;131-137.
64. Watkinson W. P., Campen M. J., Nolan J. P., Kodavanti U. P., Dreher K. L., Su W-Y., Highfill J. W., Costa D. L. Cardiovascular effects following exposure to particulate matter in healthy and cardiopulmonary-compromised rats. Mohr U. Relationships Between Acute and Chronic Effects of Air Pollution. 2000;ILSI Press, Washington.
65. Yoshioka A., Kishino Y. Vascular changes involved in pulmonary hemorrhage of stroke-prone spontaneously hypertensive rats. Tokushima J. Exp. Med. 36:1989;1-10.
66. Yuan Y. V., Kitts D. D., Godin D. V. Heart and red blood cell antioxidant status and plasma lipid levels in the spontaneously hypertensive and normotensive Wistar-Kyoto rat. Can. J. Physiol. Pharmacol. 74:1996;290-297.
67. Zerrouk A., Champeroux P., Safar M., Brisac A. M. Role of endothelium in the endothelin-1-mediated potentiation of the norepinephrine response in the aorta of hypertensive rats. J. Hypertens. 15:1997;1101-1111.