메뉴 건너뛰기




Volumn 88, Issue 1043, 2012, Pages 522-529

Genetics and epigenetics of Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CD33 ANTIGEN; CYTOCHROME P450 2D6; EPHRIN RECEPTOR A1; ESTROGEN RECEPTOR; INTERLEUKIN 1; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; PRESENILIN 1; PRESENILIN 2;

EID: 84865401658     PISSN: 00325473     EISSN: 14690756     Source Type: Journal    
DOI: 10.1136/postgradmedj-2011-130363     Document Type: Review
Times cited : (30)

References (91)
  • 1
    • 0034643928 scopus 로고    scopus 로고
    • Prevalence of dementia and major subtypes in Europe: A collobarative study of population-based cohorts. Neurological Diseases in the Elderly Research Group
    • Lobo A, Launer LJ, Fratiglioni L, et al. Prevalence of dementia and major subtypes in Europe: a collobarative study of population-based cohorts. Neurological Diseases in the Elderly Research Group. Neurology 2000;54(11Suppl 5):S4e9.
    • (2000) Neurology , vol.54 , Issue.11 SUPPL. 5
    • Lobo, A.1    Launer, L.J.2    Fratiglioni, L.3
  • 2
    • 84873504604 scopus 로고    scopus 로고
    • Alzheimer's disease International Consortium, (accessed 24 Jan)., Alzheimer's disease International. London
    • Alzheimer's disease International Consortium. AD International World Alzheimer Report 2009. Alzheimer's disease International. London. http://www.alz.co.uk/. (accessed 24 Jan 2012).
    • (2012) AD International World Alzheimer Report 2009
  • 3
    • 34147096369 scopus 로고    scopus 로고
    • Systemic inflammation, infection, ApoE alleles, and Alzheimer's disease: A position paper
    • Finch CE, Morgan TE. Systemic inflammation, infection, ApoE alleles, and Alzheimer's disease: a position paper. Curr Alzheimer Res 2007;4:185e9.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 185-189
    • Finch, C.E.1    Morgan, T.E.2
  • 4
    • 33847192092 scopus 로고    scopus 로고
    • Oxidative damage, protein synthesis and protein degradation in Alzheimer's disease
    • Ding Q, Dinayuga E, Keller JN. Oxidative damage, protein synthesis and protein degradation in Alzheimer's disease. Curr Alzheimer Res 2007;4:73e9.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 73-79
    • Ding, Q.1    Dinayuga, E.2    Keller, J.N.3
  • 5
    • 70349118087 scopus 로고    scopus 로고
    • Treating vascular risk factors and preventing Alzheimer's
    • Alagiakrishnan K. Treating vascular risk factors and preventing Alzheimer's. Res Pract Alzheimers Dis 2007;12:59e65.
    • (2007) Res Pract Alzheimers Dis , vol.12 , pp. 59-65
    • Alagiakrishnan, K.1
  • 6
    • 0141739322 scopus 로고    scopus 로고
    • The impact of cerebrovascular lesion in Alzheimer's disease-a comparative autopsy study
    • Jellinger KA, Mitter-Ferstl E. The impact of cerebrovascular lesion in Alzheimer's disease-a comparative autopsy study. J Neurol 2003;250:1050e5.
    • (2003) J Neurol , vol.250 , pp. 1050-1055
    • Jellinger, K.A.1    Mitter-Ferstl, E.2
  • 8
    • 55949117032 scopus 로고    scopus 로고
    • Frequent amyloid deposition without significant cognitive impairment among the elderly
    • Alzenstein HJ, Nebes RD, Saxton JA, et al. Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol 2008;65:1509e17.
    • (2008) Arch Neurol , vol.65 , pp. 1509-1517
    • Alzenstein, H.J.1    Nebes, R.D.2    Saxton, J.A.3
  • 9
    • 3042857903 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Cummings JL. Alzheimer's disease. N Engl J Med 2004;351:56e67.
    • (2004) N Engl J Med , vol.351 , pp. 56-67
    • Cummings, J.L.1
  • 10
    • 77953518555 scopus 로고    scopus 로고
    • Alzheimer's disease: Clinical trials and drug development
    • Mangialasche F, Solomon A, Winblad B, et al. Alzheimer's disease: clinical trials and drug development. Lancet Neurol 2010;9:702e16.
    • (2010) Lancet Neurol , vol.9 , pp. 702-716
    • Mangialasche, F.1    Solomon, A.2    Winblad, B.3
  • 11
    • 41149125591 scopus 로고    scopus 로고
    • Pharmacogenomics and therapeutic prospects in dementia
    • Cacabelos R. Pharmacogenomics and therapeutic prospects in dementia. Eur Arch Psychiatry Clin Neurosci 2008;258(Suppl 1):28e47.
    • (2008) Eur Arch Psychiatry Clin Neurosci , vol.258 , Issue.SUPPL. 1 , pp. 28-47
    • Cacabelos, R.1
  • 12
    • 77954407332 scopus 로고    scopus 로고
    • Genome wide association studies and assessment of the risk of disease
    • Manolio TA. Genome wide association studies and assessment of the risk of disease. N Engl J Med 2010;363:166e76.
    • (2010) N Engl J Med , vol.363 , pp. 166-176
    • Manolio, T.A.1
  • 13
    • 68949096744 scopus 로고    scopus 로고
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
    • Mastroeni D, McKee A, Grover J, et al. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One 2009;4:e6617.
    • (2009) PLoS One , vol.4
    • Mastroeni, D.1    McKee, A.2    Grover, J.3
  • 14
    • 78650179659 scopus 로고    scopus 로고
    • Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation
    • Mastroeni D, Grover A, Delvaux E, et al. Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging 2010;31:2025e37.
    • (2010) Neurobiol Aging , vol.31 , pp. 2025-2037
    • Mastroeni, D.1    Grover, A.2    Delvaux, E.3
  • 15
    • 77952298384 scopus 로고    scopus 로고
    • Reaching the limits of genome-wide significance in Alzheimer disease: Back to the environment
    • Pedersen NL. Reaching the limits of genome-wide significance in Alzheimer disease: back to the environment. JAMA 2010;303:1864e5.
    • (2010) JAMA , vol.303 , pp. 1864-1865
    • Pedersen, N.L.1
  • 16
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate A, Chartier-Hartin MC, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704e6.
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Hartin, M.C.2    Mullan, M.3
  • 17
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995;375:754e60.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 18
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995;269:973e7.
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 19
    • 29444442794 scopus 로고    scopus 로고
    • APP locus duplication causes autosomal dominant early onset Alzheimer disease with cerebral amyloid angiopathy
    • Rovelet-Lecrux A, Hannequin D, Raux G, et al. APP locus duplication causes autosomal dominant early onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 2006;38:24e6.
    • (2006) Nat Genet , vol.38 , pp. 24-26
    • Rovelet-Lecrux, A.1    Hannequin, D.2    Raux, G.3
  • 20
    • 33745028432 scopus 로고    scopus 로고
    • Neuroanatomy of Down syndrome in vivo: A model of preclinical Alzheimer's disease
    • Teipel SJ, Hampel H. Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease. Behav Genet 2006;36:405e15.
    • (2006) Behav Genet , vol.36 , pp. 405-415
    • Teipel, S.J.1    Hampel, H.2
  • 21
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database
    • Bertram L, McQueen MB, Mullin K, et al. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 2007;39:17e23.
    • (2007) Nat Genet , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3
  • 22
    • 80052600940 scopus 로고    scopus 로고
    • Panel of genetic variations as a potential non-invasive biomarker for early diagnosis of Alzheimer's disease
    • Ma SL, Lam LCW. Panel of genetic variations as a potential non-invasive biomarker for early diagnosis of Alzheimer's disease. Clinical Psychopharmacology and Neuroscience 2011;9:54e66.
    • (2011) Clinical Psychopharmacology and Neuroscience , vol.9 , pp. 54-66
    • Ma, S.L.1    Lam, L.C.W.2
  • 23
    • 2542502430 scopus 로고    scopus 로고
    • Apo E genotype accounts for the vast majority of AD risk and AD pathology
    • Raber J, Huang Y, Ashford JW. Apo E genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol Aging 2004;25:641e50.
    • (2004) Neurobiol Aging , vol.25 , pp. 641-650
    • Raber, J.1    Huang, Y.2    Ashford, J.W.3
  • 24
    • 44649197748 scopus 로고    scopus 로고
    • APOE promotes the proteolytic degradation of Abeta
    • Jiang Q, Lee CY, Mandrekar S, et al. APOE promotes the proteolytic degradation of Abeta. Neuron 2008;58:681e93.
    • (2008) Neuron , vol.58 , pp. 681-693
    • Jiang, Q.1    Lee, C.Y.2    Mandrekar, S.3
  • 25
    • 78649573450 scopus 로고    scopus 로고
    • Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease
    • Jones L, Holmans PA, Hamshere ML, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One 2010;5:e 13950.
    • (2010) PLoS One , vol.5
    • Jones, L.1    Holmans, P.A.2    Hamshere, M.L.3
  • 26
    • 48649110601 scopus 로고    scopus 로고
    • Cholesterol as a risk factor for dementia and cognitive decline; a systematic review of prospective studies with meta-analysis
    • Anstey KJ, Lipnicki DM, Low LF. Cholesterol as a risk factor for dementia and cognitive decline; a systematic review of prospective studies with meta-analysis. Am J Geriatr Psychiatry 2008;16:343e54.
    • (2008) Am J Geriatr Psychiatry , vol.16 , pp. 343-354
    • Anstey, K.J.1    Lipnicki, D.M.2    Low, L.F.3
  • 27
    • 0029018858 scopus 로고
    • Apolipoprotein E: A review of its role in lipoprotein metabolism, neuronal growth and repair as a risk for Alzheimer's disease
    • Rubensztein DC. Apolipoprotein E: a review of its role in lipoprotein metabolism, neuronal growth and repair as a risk for Alzheimer's disease. Psychol Med 1995;25:223e9.
    • (1995) Psychol Med , vol.25 , pp. 223-229
    • Rubensztein, D.C.1
  • 28
    • 77952307991 scopus 로고    scopus 로고
    • Genome-wide analysis of genetic loci associated with Alzheimer disease
    • CHARGE Consortium; GERAD1 Consortium; EADI1 Consortium
    • Seshadri S, Fitzpatrick AL, Ikram MA, et al; CHARGE Consortium; GERAD1 Consortium; EADI1 Consortium. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010;303:1832e40.
    • (2010) JAMA , vol.303 , pp. 1832-1840
    • Seshadri, S.1    Fitzpatrick, A.L.2    Ikram, M.A.3
  • 29
    • 77955463899 scopus 로고    scopus 로고
    • Replications of CLU, CR1 and PICALM associations with alzheimer's disease
    • Carrasquillo MM, Belbin O, Hunter TA, et al. Replications of CLU, CR1 and PICALM associations with alzheimer's disease. Arch Neurol 2010;67:961e4.
    • (2010) Arch Neurol , vol.67 , pp. 961-964
    • Carrasquillo, M.M.1    Belbin, O.2    Hunter, T.A.3
  • 30
    • 77957909886 scopus 로고    scopus 로고
    • Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interaction with APOE genotypes
    • Jun G, Naj AC, Beecham GW, et al. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interaction with APOE genotypes. Arch Neurol 2010;67:1473e84.
    • (2010) Arch Neurol , vol.67 , pp. 1473-1484
    • Jun, G.1    Naj, A.C.2    Beecham, G.W.3
  • 31
    • 59249097049 scopus 로고    scopus 로고
    • Complement Receptor 1: Disease associations and therapeutic implications
    • Khera R, Das N. Complement Receptor 1: disease associations and therapeutic implications. Mol Immunol 2009;46:761e72.
    • (2009) Mol Immunol , vol.46 , pp. 761-772
    • Khera, R.1    Das, N.2
  • 32
    • 33750031006 scopus 로고    scopus 로고
    • Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes
    • Rogers J, Li R, Mastroenui D, et al. Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes. Neurobiol Aging 2006;27:1733e9.
    • (2006) Neurobiol Aging , vol.27 , pp. 1733-1739
    • Rogers, J.1    Li, R.2    Mastroenui, D.3
  • 33
    • 9144224765 scopus 로고    scopus 로고
    • ApoE and clusterin cooperatively suppress A beta levels and deposition: Evidence that ApoE regulates extracellular A beta metabolism in vivo
    • DeMattos RB, Cirrito JR, Parsadanian M, et al. ApoE and clusterin cooperatively suppress A beta levels and deposition: evidence that ApoE regulates extracellular A beta metabolism in vivo. Neuron 2004;41:193e202.
    • (2004) Neuron , vol.41 , pp. 193-202
    • DeMattos, R.B.1    Cirrito, J.R.2    Parsadanian, M.3
  • 34
    • 70349557788 scopus 로고    scopus 로고
    • Clusterin: A forgotten player in Alzheimer's disease
    • Nuutinen T, Suuronen T, Kauppinen A, et al. Clusterin: a forgotten player in Alzheimer's disease. Brain Res Rev 2009;61:89e104.
    • (2009) Brain Res Rev , vol.61 , pp. 89-104
    • Nuutinen, T.1    Suuronen, T.2    Kauppinen, A.3
  • 35
    • 38849199843 scopus 로고    scopus 로고
    • Evidence for CALM in directing VAMP2 trafficking
    • Harol A, Wu F, Mattson MP, et al. Evidence for CALM in directing VAMP2 trafficking. Traffic 2008;9:417e29.
    • (2008) Traffic , vol.9 , pp. 417-429
    • Harol, A.1    Wu, F.2    Mattson, M.P.3
  • 36
    • 79960654507 scopus 로고    scopus 로고
    • Replication of EPHA1 and CD33 association with late-onset Alzheimer's disease: A multi-centre case-control study
    • Carraquillo MM, Belbin O, Hunter TA, et al. Replication of EPHA1 and CD33 association with late-onset Alzheimer's disease: a multi-centre case-control study. Mol Neurodegener 2011;6:1e9.
    • (2011) Mol Neurodegener , vol.6 , pp. 1-9
    • Carraquillo, M.M.1    Belbin, O.2    Hunter, T.A.3
  • 37
    • 34249745769 scopus 로고    scopus 로고
    • GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers
    • Reiman EM, Webster JA, Myers AJ, et al. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron 2007;54:713e20.
    • (2007) Neuron , vol.54 , pp. 713-720
    • Reiman, E.M.1    Webster, J.A.2    Myers, A.J.3
  • 38
    • 77953912200 scopus 로고    scopus 로고
    • Examination of the current top candidate genes for AD in a genome-wide association study
    • Feulner TM, Laws SM, Friedrich P, et al. Examination of the current top candidate genes for AD in a genome-wide association study. Mol Psychiatry 2010;15:756e66.
    • (2010) Mol Psychiatry , vol.15 , pp. 756-766
    • Feulner, T.M.1    Laws, S.M.2    Friedrich, P.3
  • 39
    • 79959396151 scopus 로고    scopus 로고
    • The three new pathways leading to Alzheimer's disease
    • Morgan K. The three new pathways leading to Alzheimer's disease. Neuropathol Appl Neurobiol 2011;37:353e7.
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 353-357
    • Morgan, K.1
  • 40
    • 52449089987 scopus 로고    scopus 로고
    • Thirty years of Alzheimer's disease genetics: The implications of systematic meta-analyses
    • Bertram L, Tanzi RE. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci 2008;9:768e78.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 768-778
    • Bertram, L.1    Tanzi, R.E.2
  • 41
    • 78651297619 scopus 로고    scopus 로고
    • Meta-analysis of the association between variants in SORL1 and Alzheimer's disease
    • Genetic and Environmental Risk in Alzheimer Disease 1 Consortium
    • Reitz C, Cheng R, Rogaeva E, et al; Genetic and Environmental Risk in Alzheimer Disease 1 Consortium. Meta-analysis of the association between variants in SORL1 and Alzheimer's disease. Arch Neurol 2011;68:99e106.
    • (2011) Arch Neurol , vol.68 , pp. 99-106
    • Reitz, C.1    Cheng, R.2    Rogaeva, E.3
  • 42
    • 33747876259 scopus 로고    scopus 로고
    • DAPK 1 variants are associated with Alzheimer's disease and allele-specific expression
    • Li Y, Grupe A, Rowland C, et al. DAPK 1 variants are associated with Alzheimer's disease and allele-specific expression. Hum Mol Genet 2006;15:2560e8.
    • (2006) Hum Mol Genet , vol.15 , pp. 2560-2568
    • Li, Y.1    Grupe, A.2    Rowland, C.3
  • 43
    • 20044362721 scopus 로고    scopus 로고
    • Family-based association between Alzheimer's disease and variants in UBQLN1
    • Bertram L, Hittunen M, Parkinson M, et al. Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med 2005;352:884e94.
    • (2005) N Engl J Med , vol.352 , pp. 884-894
    • Bertram, L.1    Hittunen, M.2    Parkinson, M.3
  • 44
    • 34247120141 scopus 로고    scopus 로고
    • Gender-specific association of ATP binding cassette transporter 1(ABCA 1) polymorphisms with the risk of late-onset Alzheimer's disease
    • Sundar PD, Feingold E, Minster RL, et al. Gender-specific association of ATP binding cassette transporter 1(ABCA 1) polymorphisms with the risk of late-onset Alzheimer's disease. Neurobiol Aging 2007;28:856e62.
    • (2007) Neurobiol Aging , vol.28 , pp. 856-862
    • Sundar, P.D.1    Feingold, E.2    Minster, R.L.3
  • 45
    • 34547191230 scopus 로고    scopus 로고
    • Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease
    • De Ferrari GV, Papassotiropoulos A, Biechele T, et al. Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A 2007;104:9434e9.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 9434-9439
    • De Ferrari, G.V.1    Papassotiropoulos, A.2    Biechele, T.3
  • 46
    • 33846613222 scopus 로고    scopus 로고
    • The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
    • Rogaeva E, Meng Y, Lee JH, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 2007;39:168e77.
    • (2007) Nat Genet , vol.39 , pp. 168-177
    • Rogaeva, E.1    Meng, Y.2    Lee, J.H.3
  • 47
    • 77952298384 scopus 로고    scopus 로고
    • Reaching the limits of genome-wide significance in Alzheimer disease: Back to the environment
    • Pedersen NL. Reaching the limits of genome-wide significance in Alzheimer disease: back to the environment. JAMA 2010;303:1864e5.
    • (2010) JAMA , vol.303 , pp. 1864-1865
    • Pedersen, N.L.1
  • 48
    • 67349139411 scopus 로고    scopus 로고
    • APOE, ACT and CHRNA 7 genes in the conversion from amnestic mild cognive impairment to Alzheimer's disease
    • Barabash A, Marcos A, Ancin I, et al. APOE, ACT and CHRNA 7 genes in the conversion from amnestic mild cognive impairment to Alzheimer's disease. Neurobiol Aging 2009;30:1254e64.
    • (2009) Neurobiol Aging , vol.30 , pp. 1254-1264
    • Barabash, A.1    Marcos, A.2    Ancin, I.3
  • 49
    • 0030005627 scopus 로고    scopus 로고
    • Apolipoprotein E alleles as risk factors in Alzheimer's disease
    • Roses AD. Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu Rev Med 1996;47:387e400.
    • (1996) Annu Rev Med , vol.47 , pp. 387-400
    • Roses, A.D.1
  • 50
    • 0037047458 scopus 로고    scopus 로고
    • Alpha 2 macroglobulin 11000 V polymorphism in Chinese sporadic Alzheimer's disease and Parkinson's disease
    • Tang G, Zhang M, Xie H, et al. Alpha 2 macroglobulin 11000 V polymorphism in Chinese sporadic Alzheimer's disease and Parkinson's disease. Neurosci Lett 2002;328:195e7.
    • (2002) Neurosci Lett , vol.328 , pp. 195-197
    • Tang, G.1    Zhang, M.2    Xie, H.3
  • 51
    • 0033809389 scopus 로고    scopus 로고
    • Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population
    • Hatanaka Y, Kamino K, Fukuo K, et al. Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. Clin Genet 2000;58:319e23.
    • (2000) Clin Genet , vol.58 , pp. 319-323
    • Hatanaka, Y.1    Kamino, K.2    Fukuo, K.3
  • 52
    • 33744917558 scopus 로고    scopus 로고
    • Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer's and Parkinson's diseases
    • Li YJ, Scott WK, Zhang L, et al. Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer's and Parkinson's diseases. Neurobiol Aging 2006;27:1087e93.
    • (2006) Neurobiol Aging , vol.27 , pp. 1087-1093
    • Li, Y.J.1    Scott, W.K.2    Zhang, L.3
  • 53
    • 63249106838 scopus 로고    scopus 로고
    • Association of SORL 1 gene variants with Alzheimer's disease
    • Kolsch H, Jessen F, Wiltfang J, et al. Association of SORL 1 gene variants with Alzheimer's disease. Brain Res 2009;1264:1e6.
    • (2009) Brain Res , vol.1264 , pp. 1-6
    • Kolsch, H.1    Jessen, F.2    Wiltfang, J.3
  • 54
    • 79953752763 scopus 로고    scopus 로고
    • Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease
    • Belbin O, Carrasquillo MM, Crump M, et al. Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease. Hum Genet 2011;129:273e82.
    • (2011) Hum Genet , vol.129 , pp. 273-282
    • Belbin, O.1    Carrasquillo, M.M.2    Crump, M.3
  • 55
    • 33645742063 scopus 로고    scopus 로고
    • APOE alleles predict the rate of cognitive decline in Alzheimer's disease: A nonlinear model
    • Martins CA, Oulhaj A, de Jager CA, et al. APOE alleles predict the rate of cognitive decline in Alzheimer's disease: a nonlinear model. Neurology 2005;65:1888e93.
    • (2005) Neurology , vol.65 , pp. 1888-1893
    • Martins, C.A.1    Oulhaj, A.2    de Jager, C.A.3
  • 56
    • 17644438751 scopus 로고    scopus 로고
    • Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism
    • Grimaldi LM, Casadei VM, Ferri C, et al. Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism. Ann Neurol 2000;47:361e5.
    • (2000) Ann Neurol , vol.47 , pp. 361-365
    • Grimaldi, L.M.1    Casadei, V.M.2    Ferri, C.3
  • 57
    • 2942741011 scopus 로고    scopus 로고
    • A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro pathological hall marks of Alzheimer's disease
    • Licastro F, Veglia M, Chiappelli LM, et al. A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro pathological hall marks of Alzheimer's disease. Neurobiol Aging 2004;25:1017e22.
    • (2004) Neurobiol Aging , vol.25 , pp. 1017-1022
    • Licastro, F.1    Veglia, M.2    Chiappelli, L.M.3
  • 58
    • 3042675764 scopus 로고    scopus 로고
    • Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease
    • Blomqvist ME, Silburn PA, Buchanan DD, et al. Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease. Neurogenetics 2004;5:115e19.
    • (2004) Neurogenetics , vol.5 , pp. 115-119
    • Blomqvist, M.E.1    Silburn, P.A.2    Buchanan, D.D.3
  • 59
    • 0242321663 scopus 로고    scopus 로고
    • Genetic variation in a haplotype block spanning IDE influences Alzheimer's disease
    • Prince JA, Feuk L, Gu HF, et al. Genetic variation in a haplotype block spanning IDE influences Alzheimer's disease. Hum Mutat 2003;22:363e71.
    • (2003) Hum Mutat , vol.22 , pp. 363-371
    • Prince, J.A.1    Feuk, L.2    Gu, H.F.3
  • 60
    • 0035212797 scopus 로고    scopus 로고
    • Psychosis and aggression in Alzheimer's disease: The effect of dopamine receptor gene variation
    • Holmes C, Smith H, Ganderton R, et al. Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation. J Neurol Neurosurg Psychiatry 2001;71:777e9.
    • (2001) J Neurol Neurosurg Psychiatry , vol.71 , pp. 777-779
    • Holmes, C.1    Smith, H.2    Ganderton, R.3
  • 61
    • 80053563231 scopus 로고    scopus 로고
    • Using Alzheimer's disease as a model for genetic risk disclosure: Implications for personal genomics
    • Roberts JS, Christensen KD, Green RC. Using Alzheimer's disease as a model for genetic risk disclosure: implications for personal genomics. Clin Genet 2011;80:407e14.
    • (2011) Clin Genet , vol.80 , pp. 407-414
    • Roberts, J.S.1    Christensen, K.D.2    Green, R.C.3
  • 62
    • 34247509796 scopus 로고    scopus 로고
    • Epigenetic regulation in psychiatric disorders
    • Tsankova N, Renthal W, Kumar A, et al. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 2007;8:355e67.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 355-367
    • Tsankova, N.1    Renthal, W.2    Kumar, A.3
  • 63
    • 44649134044 scopus 로고    scopus 로고
    • Epigenetic codes in cognition and behaviour
    • Graff J, Mansuy IM. Epigenetic codes in cognition and behaviour. Behav Brain Res 2008;192:70e87.
    • (2008) Behav Brain Res , vol.192 , pp. 70-87
    • Graff, J.1    Mansuy, I.M.2
  • 64
    • 0033021455 scopus 로고    scopus 로고
    • Alzheimer's disease in 22 twin pairs-13-years follow-up: Hormonal, infectious and traumatic factors
    • Nee LE, Lippa CF. Alzheimer's disease in 22 twin pairs-13-years follow-up: hormonal, infectious and traumatic factors. Demen Geriatr Cogn Disord 1999;10:148e51.
    • (1999) Demen Geriatr Cogn Disord , vol.10 , pp. 148-151
    • Nee, L.E.1    Lippa, C.F.2
  • 65
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga MF, Ballestar E, Paz MF, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 2005;102:10604e9.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10604-10609
    • Fraga, M.F.1    Ballestar, E.2    Paz, M.F.3
  • 66
    • 77950866465 scopus 로고    scopus 로고
    • Epigenetic regulation in the pathophysiology of Alzheimer's disease
    • Chouliaras L, Rutten BP, Kenis G, et al. Epigenetic regulation in the pathophysiology of Alzheimer's disease. Prog Neurobiol 2010;90:498e510.
    • (2010) Prog Neurobiol , vol.90 , pp. 498-510
    • Chouliaras, L.1    Rutten, B.P.2    Kenis, G.3
  • 67
    • 70449725209 scopus 로고    scopus 로고
    • Epigenetic mechanisms in neurological diseases: Genes, syndromes and therapies
    • Urdinquio RG, Sanchez-Mut JV, Esteller M. Epigenetic mechanisms in neurological diseases: genes, syndromes and therapies. Lancet Neurol 2009;8:1056e72.
    • (2009) Lancet Neurol , vol.8 , pp. 1056-1072
    • Urdinquio, R.G.1    Sanchez-Mut, J.V.2    Esteller, M.3
  • 68
    • 44849107824 scopus 로고    scopus 로고
    • Promoter methylation analysis of SHRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease
    • Silva PN, Gigek CO, Leal MF, et al. Promoter methylation analysis of SHRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease. J Alzheimers Dis 2008;13:173e6.
    • (2008) J Alzheimers Dis , vol.13 , pp. 173-176
    • Silva, P.N.1    Gigek, C.O.2    Leal, M.F.3
  • 69
    • 50949132079 scopus 로고    scopus 로고
    • Dietary manipulation of histone structure and function
    • Delage B, Dashwood RH. Dietary manipulation of histone structure and function. Annu Rev Nutr 2008;28:347e66.
    • (2008) Annu Rev Nutr , vol.28 , pp. 347-366
    • Delage, B.1    Dashwood, R.H.2
  • 70
    • 0029799427 scopus 로고    scopus 로고
    • Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease
    • Morrison LD, Smith DD, Kish SJ. Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease. J Neurochem 1996;67:1328e31.
    • (1996) J Neurochem , vol.67 , pp. 1328-1331
    • Morrison, L.D.1    Smith, D.D.2    Kish, S.J.3
  • 71
    • 56949102195 scopus 로고    scopus 로고
    • The epigenetic effects of amyloid-beta (1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells
    • Chen KL, Wang SS, Yang YY, et al. The epigenetic effects of amyloid-beta (1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells. Biochem Biophys Res Commun 2009;378:57e61.
    • (2009) Biochem Biophys Res Commun , vol.378 , pp. 57-61
    • Chen, K.L.1    Wang, S.S.2    Yang, Y.Y.3
  • 72
    • 58049089518 scopus 로고    scopus 로고
    • Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: Implications for Alzheimer's disease
    • Belyaev ND, Nalivaeva NN, Makova NZ, et al. Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer's disease. EMBO Rep 2009;10:94e100.
    • (2009) EMBO Rep , vol.10 , pp. 94-100
    • Belyaev, N.D.1    Nalivaeva, N.N.2    Makova, N.Z.3
  • 73
    • 65549123471 scopus 로고    scopus 로고
    • HDAC 2 negatively regulates memory formation and synaptic plasticity
    • Guan JS, Haggarty SJ, Giacometti E, et al. HDAC 2 negatively regulates memory formation and synaptic plasticity. Nature 2009;459:55e60.
    • (2009) Nature , vol.459 , pp. 55-60
    • Guan, J.S.1    Haggarty, S.J.2    Giacometti, E.3
  • 74
    • 52949126723 scopus 로고    scopus 로고
    • Transgenerational epigenetic inheritance in health and disease
    • Whitelaw NC, Whitelaw E. Transgenerational epigenetic inheritance in health and disease. Curr Opin Genet Dev 2008;18:273e9.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 273-279
    • Whitelaw, N.C.1    Whitelaw, E.2
  • 76
    • 62449242294 scopus 로고    scopus 로고
    • Contribution of vascular risk factors to the progression in Alzheimer's disease
    • Helznep PE, Luchsinger JA, Scarmeas N, et al. Contribution of vascular risk factors to the progression in Alzheimer's disease. Arch Neurol 2009;66:343e8.
    • (2009) Arch Neurol , vol.66 , pp. 343-348
    • Helznep, P.E.1    Luchsinger, J.A.2    Scarmeas, N.3
  • 77
    • 0031853666 scopus 로고    scopus 로고
    • Gene-environment interaction in Alzheimer's disease: A potential role for cholesterol
    • Chandra V, Pandav R. Gene-environment interaction in Alzheimer's disease: a potential role for cholesterol. Neuroepidemiology 1998;17:225e32.
    • (1998) Neuroepidemiology , vol.17 , pp. 225-232
    • Chandra, V.1    Pandav, R.2
  • 78
    • 80052827558 scopus 로고    scopus 로고
    • Interaction between vascular factors and the APOE 34 allele in predicting rate of progression in Alzheimer's disease
    • Mielke MM, Leoutsakos JM, Tschanz JT, et al. Interaction between vascular factors and the APOE 34 allele in predicting rate of progression in Alzheimer's disease. J Alzheimers Dis 2011;26:127e34.
    • (2011) J Alzheimers Dis , vol.26 , pp. 127-134
    • Mielke, M.M.1    Leoutsakos, J.M.2    Tschanz, J.T.3
  • 79
    • 67649185049 scopus 로고    scopus 로고
    • Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases
    • Migliore L, Coppede F. Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases. Mutat Res 2009;667:82e97.
    • (2009) Mutat Res , vol.667 , pp. 82-97
    • Migliore, L.1    Coppede, F.2
  • 80
    • 34248523169 scopus 로고    scopus 로고
    • Recovery of learning and memory is associated with chromatin remodelling
    • Fischer A, Sananbenesi F, Wang X, et al. Recovery of learning and memory is associated with chromatin remodelling. Nature 2007;447:178e82.
    • (2007) Nature , vol.447 , pp. 178-182
    • Fischer, A.1    Sananbenesi, F.2    Wang, X.3
  • 81
    • 8044235632 scopus 로고    scopus 로고
    • Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease
    • Tang MX, Maestre G, Tsai WY, et al. Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease. Ann NY Acad Sci 1996;802:6e15.
    • (1996) Ann NY Acad Sci , vol.802 , pp. 6-15
    • Tang, M.X.1    Maestre, G.2    Tsai, W.Y.3
  • 82
    • 61449117869 scopus 로고    scopus 로고
    • Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease
    • T Cuenco KT, Lunetta K, Baldwin CT, et al. Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol 2008;65:1640e8.
    • (2008) Arch Neurol , vol.65 , pp. 1640-1648
    • Cuenco, T.K.T.1    Lunetta, K.2    Baldwin, C.T.3
  • 83
    • 33749053656 scopus 로고    scopus 로고
    • Increased brain activation during working memory in cognitively intact adults with APOE epsilon 4 allele
    • Wishart HA, Saykin AJ, Rabin LA, et al. Increased brain activation during working memory in cognitively intact adults with APOE epsilon 4 allele. Am J Psychiatry 2006;163:1603e10.
    • (2006) Am J Psychiatry , vol.163 , pp. 1603-1610
    • Wishart, H.A.1    Saykin, A.J.2    Rabin, L.A.3
  • 84
    • 45249114641 scopus 로고    scopus 로고
    • Influence of SORL1 gene variants: Association with CSF amyloid-beta products in probable Alzheimer's disease
    • Kolsch H, Jessen F, Wiltfang J, et al. Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease. Neurosci Lett 2008;440:68e71.
    • (2008) Neurosci Lett , vol.440 , pp. 68-71
    • Kolsch, H.1    Jessen, F.2    Wiltfang, J.3
  • 85
    • 27744539497 scopus 로고    scopus 로고
    • Pharmacogenomics and therapeutic prospects in Alzheimer's disease
    • Cacabelos R. Pharmacogenomics and therapeutic prospects in Alzheimer's disease. Expert Opin Pharmacother 2005;6:1967e87.
    • (2005) Expert Opin Pharmacother , vol.6 , pp. 1967-1987
    • Cacabelos, R.1
  • 86
    • 40449089537 scopus 로고    scopus 로고
    • Influence of pharmacogenetic factors on Alzheimer's disease therapeutics
    • Cacabelos R. Influence of pharmacogenetic factors on Alzheimer's disease therapeutics. Neurodegener Dis 2008;5:176e8.
    • (2008) Neurodegener Dis , vol.5 , pp. 176-178
    • Cacabelos, R.1
  • 87
    • 1242264290 scopus 로고    scopus 로고
    • The pharmacogenomics of Alzheimer's disease
    • Crentsil V. The pharmacogenomics of Alzheimer's disease. Ageing Res Rev 2004;3:153e69.
    • (2004) Ageing Res Rev , vol.3 , pp. 153-169
    • Crentsil, V.1
  • 88
    • 0036484691 scopus 로고    scopus 로고
    • Pharmacogenomics in Alzheimer's disease
    • Cacabelos R. Pharmacogenomics in Alzheimer's disease. Mini Rev Med Chem 2002;2:59e84.
    • (2002) Mini Rev Med Chem , vol.2 , pp. 59-84
    • Cacabelos, R.1
  • 89
    • 19544392168 scopus 로고    scopus 로고
    • Responsiveness to cholinesterase inhibitors in Alzheimer's disease: A possible role for the 192 Q/R polymorphism of the PON-1 gene
    • Pola R, Flex A, Ciaburri M, et al. Responsiveness to cholinesterase inhibitors in Alzheimer's disease: a possible role for the 192 Q/R polymorphism of the PON-1 gene. Neurosci Lett 2005;382:338e41.
    • (2005) Neurosci Lett , vol.382 , pp. 338-341
    • Pola, R.1    Flex, A.2    Ciaburri, M.3
  • 90
    • 0038408676 scopus 로고    scopus 로고
    • Regulation of attention and response to therapy in dementia by butyrylcholinesterase
    • O'Brien KK, Saxby BK, Ballard CG, et al. Regulation of attention and response to therapy in dementia by butyrylcholinesterase. Pharmacogenetics 2003;13:231e9.
    • (2003) Pharmacogenetics , vol.13 , pp. 231-239
    • O'Brien, K.K.1    Saxby, B.K.2    Ballard, C.G.3
  • 91
    • 43049165571 scopus 로고    scopus 로고
    • Current approaches in the treatment of Alzheimer's disease
    • Shah RS, Lee HG, Xiongwei Z, et al. Current approaches in the treatment of Alzheimer's disease. Biomed Pharmacother 2008;62:199e207.
    • (2008) Biomed Pharmacother , vol.62 , pp. 199-207
    • Shah, R.S.1    Lee, H.G.2    Xiongwei, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.