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Volumn 47, Issue 6, 2012, Pages 689-695

Advances in the study of inhibitors of kinases and nuclear factors for treating allergic asthma

Author keywords

Airway hyperresponsiveness; Asthma; Nuclear transcription factor; Serine threonine kinase; Tyrosine kinase

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; IMMUNOSUPPRESSIVE AGENT; NUCLEAR FACTOR; NUCLEAR FACTOR INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84865339547     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1)

References (38)
  • 1
    • 40049092917 scopus 로고    scopus 로고
    • Treatment strategies for allergy and asthma
    • J
    • Holgate ST, Polosa R. Treatment strategies for allergy and asthma [J]. Nature, 2008, 8: 218-230.
    • (2008) Nature , vol.8 , pp. 218-230
    • Holgate, S.T.1    Polosa, R.2
  • 2
    • 52049113214 scopus 로고    scopus 로고
    • New targets for drug development in asthma
    • J
    • Adcock IM, Caramori G, Chung KF. New targets for drug development in asthma [J]. Lancet, 2008, 372: 1073-1087.
    • (2008) Lancet , vol.372 , pp. 1073-1087
    • Adcock, I.M.1    Caramori, G.2    Chung, K.F.3
  • 3
    • 0034662968 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu+ MMTV/TGF-α bigenic mice
    • J
    • Lenferink AE, Simpson JF, Shawver LK, et al. Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu+ MMTV/TGF-α bigenic mice [J]. Proc Natl Acad Sci USA, 2000, 97: 9609-9614.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9609-9614
    • Lenferink, A.E.1    Simpson, J.F.2    Shawver, L.K.3
  • 4
    • 79953646222 scopus 로고    scopus 로고
    • Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways
    • J
    • Cortijo J, Mata M, Milara J, et al. Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways [J]. Eur Respir J, 2011, 37: 244-254.
    • (2011) Eur Respir J , vol.37 , pp. 244-254
    • Cortijo, J.1    Mata, M.2    Milara, J.3
  • 5
    • 61849128182 scopus 로고    scopus 로고
    • T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance
    • J
    • Salmond RJ, Filby A, Qureshi I, et al. T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance [J]. Immunol Rev, 2009, 228: 9-22.
    • (2009) Immunol Rev , vol.228 , pp. 9-22
    • Salmond, R.J.1    Filby, A.2    Qureshi, I.3
  • 6
    • 70350135638 scopus 로고    scopus 로고
    • ITK inhibitors in inflammation and immune-mediated disorders
    • J
    • Sahu N, August A. ITK inhibitors in inflammation and immune-mediated disorders [J]. Curr Top Med Chem, 2009, 9: 690-703.
    • (2009) Curr Top Med Chem , vol.9 , pp. 690-703
    • Sahu, N.1    August, A.2
  • 7
  • 8
    • 30344435280 scopus 로고    scopus 로고
    • Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness
    • J
    • Matsubara S, Li G, Takeda K, et al. Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness [J]. Am J Respir Crit Care Med, 2006, 173: 56-63.
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 56-63
    • Matsubara, S.1    Li, G.2    Takeda, K.3
  • 9
    • 67651163434 scopus 로고    scopus 로고
    • Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: Relationship to expression of Syk and SHIP-2
    • J
    • Saini SS, Paterniti M, Vasagar K. Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: relationship to expression of Syk and SHIP-2 [J]. Clin Immunol, 2009, 132: 342-348.
    • (2009) Clin Immunol , vol.132 , pp. 342-348
    • Saini, S.S.1    Paterniti, M.2    Vasagar, K.3
  • 10
    • 0033712415 scopus 로고    scopus 로고
    • Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′, 5′-dibromo-4′- hydroxyphenyl) amino-6, 7-dimethoxyquinazoline (WHI-P97)
    • J
    • Malaviya R, Chen CL, Navara C, et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′, 5′-dibromo-4′-hydroxyphenyl) amino-6, 7-dimethoxyquinazoline (WHI-P97) [J]. J Pharmacol Exp Ther, 2000, 295: 912-926.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 912-926
    • Malaviya, R.1    Chen, C.L.2    Navara, C.3
  • 11
    • 0033578618 scopus 로고    scopus 로고
    • Targeting janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis
    • J
    • Malaviya R, Zhu D, Dibirdik I, et al. Targeting janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis [J]. J Biol Chem, 1999, 274: 27028-27038.
    • (1999) J Biol Chem , vol.274 , pp. 27028-27038
    • Malaviya, R.1    Zhu, D.2    Dibirdik, I.3
  • 12
    • 40349112980 scopus 로고    scopus 로고
    • Influence of the tyrosine kinase inhibitors STI571 (Glivec®), lavendustin A and genistein on human mast cell line (HMC-1560) activation
    • J
    • Löber K, Alfonso A, Escribano L, et al. Influence of the tyrosine kinase inhibitors STI571 (Glivec®), lavendustin A and genistein on human mast cell line (HMC-1560) activation [J]. J Cell Biochem, 2008, 103: 1076-1088.
    • (2008) J Cell Biochem , vol.103 , pp. 1076-1088
    • Löber, K.1    Alfonso, A.2    Escribano, L.3
  • 13
    • 77955085786 scopus 로고    scopus 로고
    • Genistein, a competitive PDE1-4 inhibitor, may bind on high-affinity rolipram binding sites of brain cell membranes and then induce gastrointestinal adverse effects
    • J
    • Shih CH, Lin LH, Lai YH, et al. Genistein, a competitive PDE1-4 inhibitor, may bind on high-affinity rolipram binding sites of brain cell membranes and then induce gastrointestinal adverse effects [J]. Eur J Pharmacol, 2010, 643: 113-120.
    • (2010) Eur J Pharmacol , vol.643 , pp. 113-120
    • Shih, C.H.1    Lin, L.H.2    Lai, Y.H.3
  • 14
    • 70349918769 scopus 로고    scopus 로고
    • Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells
    • J
    • Heo HJ, Lee SY, Lee MN, et al. Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells [J]. Phytother Res, 2009, 23: 1458-1461.
    • (2009) Phytother Res , vol.23 , pp. 1458-1461
    • Heo, H.J.1    Lee, S.Y.2    Lee, M.N.3
  • 15
    • 0033868558 scopus 로고    scopus 로고
    • Inhibition of basophil histamine release by tyrosine kinase and phosphatidylinositol 3-kinase inhibitors
    • J
    • Tedeschi A, Lorini M, Galbiati S, et al. Inhibition of basophil histamine release by tyrosine kinase and phosphatidylinositol 3-kinase inhibitors [J]. Int J Immunopharmacol, 2000, 22: 797-808.
    • (2000) Int J Immunopharmacol , vol.22 , pp. 797-808
    • Tedeschi, A.1    Lorini, M.2    Galbiati, S.3
  • 16
    • 0036290485 scopus 로고    scopus 로고
    • Inhibitors of the tyrosine kinase signaling cascade attenuated thrombin-induced guinea pig airway smooth muscle cell proliferation
    • J
    • Tsang F, Choo HH, Dawe GA, et al. Inhibitors of the tyrosine kinase signaling cascade attenuated thrombin-induced guinea pig airway smooth muscle cell proliferation [J]. Biochem Biophys Res Commun, 2002, 293: 72-78.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 72-78
    • Tsang, F.1    Choo, H.H.2    Dawe, G.A.3
  • 17
    • 0035102237 scopus 로고    scopus 로고
    • Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes
    • J
    • Haeryfar SMM, Hoskin DW. Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes [J]. Int Immunopharmacol, 2001, 1: 689-698.
    • (2001) Int Immunopharmacol , vol.1 , pp. 689-698
    • Haeryfar, S.M.M.1    Hoskin, D.W.2
  • 18
    • 0030445507 scopus 로고    scopus 로고
    • Factors affecting the cytokine production of human T cells stimulated by different modes of activation
    • J
    • Harada Y, Watanabe S, Yssel H, et al. Factors affecting the cytokine production of human T cells stimulated by different modes of activation [J]. J Allergy Clin Immunol, 1996, 98: 161-173.
    • (1996) J Allergy Clin Immunol , vol.98 , pp. 161-173
    • Harada, Y.1    Watanabe, S.2    Yssel, H.3
  • 19
    • 62349086231 scopus 로고    scopus 로고
    • Therapeutic surfactants modulate the viability of eosinophils and induce inflammatory mediator release
    • J
    • Erpenbeck VJ, Fischera I, Wiese K, et al. Therapeutic surfactants modulate the viability of eosinophils and induce inflammatory mediator release [J]. Int Arch Allergy Immunol, 2009, 149: 333-342.
    • (2009) Int Arch Allergy Immunol , vol.149 , pp. 333-342
    • Erpenbeck, V.J.1    Fischera, I.2    Wiese, K.3
  • 20
    • 15944425792 scopus 로고    scopus 로고
    • An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model
    • J
    • Duan W, Aguinaldo D, Leung BP, et al. An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model [J]. Int Immunopharmacol, 2005, 5: 495-502.
    • (2005) Int Immunopharmacol , vol.5 , pp. 495-502
    • Duan, W.1    Aguinaldo, D.2    Leung, B.P.3
  • 21
    • 77958173826 scopus 로고    scopus 로고
    • Targeting phosphoinositide-3-kinase-δ with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease
    • J
    • To Y, Ito K, Kizawa Y, et al. Targeting phosphoinositide-3-kinase-δ with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease [J]. Am J Respir Crit Care Med, 2010, 182: 897-904.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 897-904
    • To, Y.1    Ito, K.2    Kizawa, Y.3
  • 22
    • 77954342685 scopus 로고    scopus 로고
    • Emerging molecular targets for the treatment of asthma
    • J
    • Sharma P, Halayko AJ. Emerging molecular targets for the treatment of asthma [J]. Indian J Biochem Biophys, 2009, 46: 447-460.
    • (2009) Indian J Biochem Biophys , vol.46 , pp. 447-460
    • Sharma, P.1    Halayko, A.J.2
  • 23
    • 77952319119 scopus 로고    scopus 로고
    • Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle
    • J
    • Munoz L, Ramsay EE, Manetsch M, et al. Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle [J]. Eur J Pharmacol, 2010, 635: 212-218.
    • (2010) Eur J Pharmacol , vol.635 , pp. 212-218
    • Munoz, L.1    Ramsay, E.E.2    Manetsch, M.3
  • 24
    • 77951196142 scopus 로고    scopus 로고
    • Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma
    • J
    • Bhavsar P, Khorasani N, Hew M, et al. Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma [J]. Eur Respir J, 2010, 35: 4750-4756.
    • (2010) Eur Respir J , vol.35 , pp. 4750-4756
    • Bhavsar, P.1    Khorasani, N.2    Hew, M.3
  • 25
    • 40049100163 scopus 로고    scopus 로고
    • Role of GATA-3 in allergic diseases
    • J
    • Barnes PJ. Role of GATA-3 in allergic diseases [J]. Curr Mol Med, 2008, 8: 330-334.
    • (2008) Curr Mol Med , vol.8 , pp. 330-334
    • Barnes, P.J.1
  • 26
    • 3042752921 scopus 로고    scopus 로고
    • Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats
    • J
    • Eynott PR, Xu L, Bennett BL, et al. Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats [J]. Immunology, 2004, 112: 446-453.
    • (2004) Immunology , vol.112 , pp. 446-453
    • Eynott, P.R.1    Xu, L.2    Bennett, B.L.3
  • 27
    • 48749118638 scopus 로고    scopus 로고
    • Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: Differences in asthma
    • J
    • Burgess JK, Heelee J, Ge Q, et al. Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: differences in asthma [J]. J Cell Physiol, 2008, 216: 673-679.
    • (2008) J Cell Physiol , vol.216 , pp. 673-679
    • Burgess, J.K.1    Heelee, J.2    Ge, Q.3
  • 28
    • 2442712697 scopus 로고    scopus 로고
    • Anti-inflammatory effects of mitogen-activated protein kinase inhibitor U0126 in an asthma mouse model
    • J
    • Duan W, Chan JH, Wong CH, et al. Anti-inflammatory effects of mitogen-activated protein kinase inhibitor U0126 in an asthma mouse model [J]. J Immunol, 2004, 172: 7053-7059.
    • (2004) J Immunol , vol.172 , pp. 7053-7059
    • Duan, W.1    Chan, J.H.2    Wong, C.H.3
  • 29
    • 65349153165 scopus 로고    scopus 로고
    • Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 MAP kinase-dependent induction of Socs-3
    • J
    • Caruso R, Stolfi C, Sarra M, et al. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 MAP kinase-dependent induction of Socs-3 [J]. Blood, 2009, 113: 3512-3519.
    • (2009) Blood , vol.113 , pp. 3512-3519
    • Caruso, R.1    Stolfi, C.2    Sarra, M.3
  • 30
    • 18544406054 scopus 로고    scopus 로고
    • SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence
    • J
    • Underwood DC, Osborn RR, Kotzer CJ, et al. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence [J]. J Pharmacol Exp Ther, 2000, 293: 281-288.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 281-288
    • Underwood, D.C.1    Osborn, R.R.2    Kotzer, C.J.3
  • 31
    • 6344269852 scopus 로고    scopus 로고
    • Selective blockade of NF-κB activity in airway immune cells inhibits the effector phase of experimental asthma
    • J
    • Desmet C, Gosset P, Pajak B, et al. Selective blockade of NF-κB activity in airway immune cells inhibits the effector phase of experimental asthma [J]. J Immunol, 2004, 173: 5766-5775.
    • (2004) J Immunol , vol.173 , pp. 5766-5775
    • Desmet, C.1    Gosset, P.2    Pajak, B.3
  • 32
    • 0035163864 scopus 로고    scopus 로고
    • A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat
    • J
    • Huang TJ, Adcock IM, Chung KF. A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat [J]. Br J Pharmacol, 2001, 134: 1029-1036.
    • (2001) Br J Pharmacol , vol.134 , pp. 1029-1036
    • Huang, T.J.1    Adcock, I.M.2    Chung, K.F.3
  • 33
    • 0036839618 scopus 로고    scopus 로고
    • A small molecule inhibitor of redox-regulated NF-kappaB and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model
    • J
    • Henderson WR, Chi EC, Teo JL, et al. A small molecule inhibitor of redox-regulated NF-kappaB and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model [J]. J Immunol, 2002, 169: 5294-5299.
    • (2002) J Immunol , vol.169 , pp. 5294-5299
    • Henderson, W.R.1    Chi, E.C.2    Teo, J.L.3
  • 34
    • 37849022679 scopus 로고    scopus 로고
    • Marine natural products as targeted modulators of the transcription factor NF-κB
    • J
    • Folmer F, Jaspars M, Dicato M, et al. Marine natural products as targeted modulators of the transcription factor NF-κB [J]. Biochem Pharmacol, 2008, 75: 603-617.
    • (2008) Biochem Pharmacol , vol.75 , pp. 603-617
    • Folmer, F.1    Jaspars, M.2    Dicato, M.3
  • 35
    • 80052644840 scopus 로고    scopus 로고
    • SOCS3: A potential therapeutic target for many human disease
    • J
    • Xu WP, Li WD. SOCS3: a potential therapeutic target for many human disease [J]. Acta Pharm Sin, 2011, 46: 747-752.
    • (2011) Acta Pharm Sin , vol.46 , pp. 747-752
    • Xu, W.P.1    Li, W.D.2
  • 36
    • 4344627594 scopus 로고    scopus 로고
    • Inhibition of signal transducer and activator of transcription 1 attenuates allergen-induced airway inflammation and hyperreactivity
    • J
    • Quarcoo D, Weixler S, Groneberg D, et al. Inhibition of signal transducer and activator of transcription 1 attenuates allergen-induced airway inflammation and hyperreactivity [J]. J Allergy Clin Immunol, 2004, 114: 288-295.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 288-295
    • Quarcoo, D.1    Weixler, S.2    Groneberg, D.3
  • 37
    • 70349870911 scopus 로고    scopus 로고
    • A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice
    • J
    • Chiba Y, Todoroki M, Nishida Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice [J]. Am J Respir Cell Mol Biol, 2009, 41: 516-524.
    • (2009) Am J Respir Cell Mol Biol , vol.41 , pp. 516-524
    • Chiba, Y.1    Todoroki, M.2    Nishida, Y.3
  • 38
    • 33645354026 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 (SOCS3) in Th2 cells evokes Th2 cytokines, IgE, and eosinophilia
    • J
    • Kubo M, Inoue H. Suppressor of cytokine signaling 3 (SOCS3) in Th2 cells evokes Th2 cytokines, IgE, and eosinophilia [J]. Curr Allergy Asthma Rep, 2006, 6: 32-39.
    • (2006) Curr Allergy Asthma Rep , vol.6 , pp. 32-39
    • Kubo, M.1    Inoue, H.2


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