-
1
-
-
40049092917
-
Treatment strategies for allergy and asthma
-
J
-
Holgate ST, Polosa R. Treatment strategies for allergy and asthma [J]. Nature, 2008, 8: 218-230.
-
(2008)
Nature
, vol.8
, pp. 218-230
-
-
Holgate, S.T.1
Polosa, R.2
-
2
-
-
52049113214
-
New targets for drug development in asthma
-
J
-
Adcock IM, Caramori G, Chung KF. New targets for drug development in asthma [J]. Lancet, 2008, 372: 1073-1087.
-
(2008)
Lancet
, vol.372
, pp. 1073-1087
-
-
Adcock, I.M.1
Caramori, G.2
Chung, K.F.3
-
3
-
-
0034662968
-
Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu+ MMTV/TGF-α bigenic mice
-
J
-
Lenferink AE, Simpson JF, Shawver LK, et al. Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu+ MMTV/TGF-α bigenic mice [J]. Proc Natl Acad Sci USA, 2000, 97: 9609-9614.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9609-9614
-
-
Lenferink, A.E.1
Simpson, J.F.2
Shawver, L.K.3
-
4
-
-
79953646222
-
Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways
-
J
-
Cortijo J, Mata M, Milara J, et al. Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways [J]. Eur Respir J, 2011, 37: 244-254.
-
(2011)
Eur Respir J
, vol.37
, pp. 244-254
-
-
Cortijo, J.1
Mata, M.2
Milara, J.3
-
5
-
-
61849128182
-
T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance
-
J
-
Salmond RJ, Filby A, Qureshi I, et al. T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance [J]. Immunol Rev, 2009, 228: 9-22.
-
(2009)
Immunol Rev
, vol.228
, pp. 9-22
-
-
Salmond, R.J.1
Filby, A.2
Qureshi, I.3
-
6
-
-
70350135638
-
ITK inhibitors in inflammation and immune-mediated disorders
-
J
-
Sahu N, August A. ITK inhibitors in inflammation and immune-mediated disorders [J]. Curr Top Med Chem, 2009, 9: 690-703.
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 690-703
-
-
Sahu, N.1
August, A.2
-
8
-
-
30344435280
-
Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness
-
J
-
Matsubara S, Li G, Takeda K, et al. Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness [J]. Am J Respir Crit Care Med, 2006, 173: 56-63.
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 56-63
-
-
Matsubara, S.1
Li, G.2
Takeda, K.3
-
9
-
-
67651163434
-
Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: Relationship to expression of Syk and SHIP-2
-
J
-
Saini SS, Paterniti M, Vasagar K. Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: relationship to expression of Syk and SHIP-2 [J]. Clin Immunol, 2009, 132: 342-348.
-
(2009)
Clin Immunol
, vol.132
, pp. 342-348
-
-
Saini, S.S.1
Paterniti, M.2
Vasagar, K.3
-
10
-
-
0033712415
-
Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′, 5′-dibromo-4′- hydroxyphenyl) amino-6, 7-dimethoxyquinazoline (WHI-P97)
-
J
-
Malaviya R, Chen CL, Navara C, et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′, 5′-dibromo-4′-hydroxyphenyl) amino-6, 7-dimethoxyquinazoline (WHI-P97) [J]. J Pharmacol Exp Ther, 2000, 295: 912-926.
-
(2000)
J Pharmacol Exp Ther
, vol.295
, pp. 912-926
-
-
Malaviya, R.1
Chen, C.L.2
Navara, C.3
-
11
-
-
0033578618
-
Targeting janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis
-
J
-
Malaviya R, Zhu D, Dibirdik I, et al. Targeting janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis [J]. J Biol Chem, 1999, 274: 27028-27038.
-
(1999)
J Biol Chem
, vol.274
, pp. 27028-27038
-
-
Malaviya, R.1
Zhu, D.2
Dibirdik, I.3
-
12
-
-
40349112980
-
Influence of the tyrosine kinase inhibitors STI571 (Glivec®), lavendustin A and genistein on human mast cell line (HMC-1560) activation
-
J
-
Löber K, Alfonso A, Escribano L, et al. Influence of the tyrosine kinase inhibitors STI571 (Glivec®), lavendustin A and genistein on human mast cell line (HMC-1560) activation [J]. J Cell Biochem, 2008, 103: 1076-1088.
-
(2008)
J Cell Biochem
, vol.103
, pp. 1076-1088
-
-
Löber, K.1
Alfonso, A.2
Escribano, L.3
-
13
-
-
77955085786
-
Genistein, a competitive PDE1-4 inhibitor, may bind on high-affinity rolipram binding sites of brain cell membranes and then induce gastrointestinal adverse effects
-
J
-
Shih CH, Lin LH, Lai YH, et al. Genistein, a competitive PDE1-4 inhibitor, may bind on high-affinity rolipram binding sites of brain cell membranes and then induce gastrointestinal adverse effects [J]. Eur J Pharmacol, 2010, 643: 113-120.
-
(2010)
Eur J Pharmacol
, vol.643
, pp. 113-120
-
-
Shih, C.H.1
Lin, L.H.2
Lai, Y.H.3
-
14
-
-
70349918769
-
Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells
-
J
-
Heo HJ, Lee SY, Lee MN, et al. Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells [J]. Phytother Res, 2009, 23: 1458-1461.
-
(2009)
Phytother Res
, vol.23
, pp. 1458-1461
-
-
Heo, H.J.1
Lee, S.Y.2
Lee, M.N.3
-
15
-
-
0033868558
-
Inhibition of basophil histamine release by tyrosine kinase and phosphatidylinositol 3-kinase inhibitors
-
J
-
Tedeschi A, Lorini M, Galbiati S, et al. Inhibition of basophil histamine release by tyrosine kinase and phosphatidylinositol 3-kinase inhibitors [J]. Int J Immunopharmacol, 2000, 22: 797-808.
-
(2000)
Int J Immunopharmacol
, vol.22
, pp. 797-808
-
-
Tedeschi, A.1
Lorini, M.2
Galbiati, S.3
-
16
-
-
0036290485
-
Inhibitors of the tyrosine kinase signaling cascade attenuated thrombin-induced guinea pig airway smooth muscle cell proliferation
-
J
-
Tsang F, Choo HH, Dawe GA, et al. Inhibitors of the tyrosine kinase signaling cascade attenuated thrombin-induced guinea pig airway smooth muscle cell proliferation [J]. Biochem Biophys Res Commun, 2002, 293: 72-78.
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 72-78
-
-
Tsang, F.1
Choo, H.H.2
Dawe, G.A.3
-
17
-
-
0035102237
-
Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes
-
J
-
Haeryfar SMM, Hoskin DW. Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes [J]. Int Immunopharmacol, 2001, 1: 689-698.
-
(2001)
Int Immunopharmacol
, vol.1
, pp. 689-698
-
-
Haeryfar, S.M.M.1
Hoskin, D.W.2
-
18
-
-
0030445507
-
Factors affecting the cytokine production of human T cells stimulated by different modes of activation
-
J
-
Harada Y, Watanabe S, Yssel H, et al. Factors affecting the cytokine production of human T cells stimulated by different modes of activation [J]. J Allergy Clin Immunol, 1996, 98: 161-173.
-
(1996)
J Allergy Clin Immunol
, vol.98
, pp. 161-173
-
-
Harada, Y.1
Watanabe, S.2
Yssel, H.3
-
19
-
-
62349086231
-
Therapeutic surfactants modulate the viability of eosinophils and induce inflammatory mediator release
-
J
-
Erpenbeck VJ, Fischera I, Wiese K, et al. Therapeutic surfactants modulate the viability of eosinophils and induce inflammatory mediator release [J]. Int Arch Allergy Immunol, 2009, 149: 333-342.
-
(2009)
Int Arch Allergy Immunol
, vol.149
, pp. 333-342
-
-
Erpenbeck, V.J.1
Fischera, I.2
Wiese, K.3
-
20
-
-
15944425792
-
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model
-
J
-
Duan W, Aguinaldo D, Leung BP, et al. An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model [J]. Int Immunopharmacol, 2005, 5: 495-502.
-
(2005)
Int Immunopharmacol
, vol.5
, pp. 495-502
-
-
Duan, W.1
Aguinaldo, D.2
Leung, B.P.3
-
21
-
-
77958173826
-
Targeting phosphoinositide-3-kinase-δ with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease
-
J
-
To Y, Ito K, Kizawa Y, et al. Targeting phosphoinositide-3-kinase-δ with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease [J]. Am J Respir Crit Care Med, 2010, 182: 897-904.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 897-904
-
-
To, Y.1
Ito, K.2
Kizawa, Y.3
-
22
-
-
77954342685
-
Emerging molecular targets for the treatment of asthma
-
J
-
Sharma P, Halayko AJ. Emerging molecular targets for the treatment of asthma [J]. Indian J Biochem Biophys, 2009, 46: 447-460.
-
(2009)
Indian J Biochem Biophys
, vol.46
, pp. 447-460
-
-
Sharma, P.1
Halayko, A.J.2
-
23
-
-
77952319119
-
Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle
-
J
-
Munoz L, Ramsay EE, Manetsch M, et al. Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle [J]. Eur J Pharmacol, 2010, 635: 212-218.
-
(2010)
Eur J Pharmacol
, vol.635
, pp. 212-218
-
-
Munoz, L.1
Ramsay, E.E.2
Manetsch, M.3
-
24
-
-
77951196142
-
Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma
-
J
-
Bhavsar P, Khorasani N, Hew M, et al. Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma [J]. Eur Respir J, 2010, 35: 4750-4756.
-
(2010)
Eur Respir J
, vol.35
, pp. 4750-4756
-
-
Bhavsar, P.1
Khorasani, N.2
Hew, M.3
-
25
-
-
40049100163
-
Role of GATA-3 in allergic diseases
-
J
-
Barnes PJ. Role of GATA-3 in allergic diseases [J]. Curr Mol Med, 2008, 8: 330-334.
-
(2008)
Curr Mol Med
, vol.8
, pp. 330-334
-
-
Barnes, P.J.1
-
26
-
-
3042752921
-
Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats
-
J
-
Eynott PR, Xu L, Bennett BL, et al. Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats [J]. Immunology, 2004, 112: 446-453.
-
(2004)
Immunology
, vol.112
, pp. 446-453
-
-
Eynott, P.R.1
Xu, L.2
Bennett, B.L.3
-
27
-
-
48749118638
-
Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: Differences in asthma
-
J
-
Burgess JK, Heelee J, Ge Q, et al. Dual ERK and phosphatidylinositol 3-kinase pathways control airway smooth muscle proliferation: differences in asthma [J]. J Cell Physiol, 2008, 216: 673-679.
-
(2008)
J Cell Physiol
, vol.216
, pp. 673-679
-
-
Burgess, J.K.1
Heelee, J.2
Ge, Q.3
-
28
-
-
2442712697
-
Anti-inflammatory effects of mitogen-activated protein kinase inhibitor U0126 in an asthma mouse model
-
J
-
Duan W, Chan JH, Wong CH, et al. Anti-inflammatory effects of mitogen-activated protein kinase inhibitor U0126 in an asthma mouse model [J]. J Immunol, 2004, 172: 7053-7059.
-
(2004)
J Immunol
, vol.172
, pp. 7053-7059
-
-
Duan, W.1
Chan, J.H.2
Wong, C.H.3
-
29
-
-
65349153165
-
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 MAP kinase-dependent induction of Socs-3
-
J
-
Caruso R, Stolfi C, Sarra M, et al. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 MAP kinase-dependent induction of Socs-3 [J]. Blood, 2009, 113: 3512-3519.
-
(2009)
Blood
, vol.113
, pp. 3512-3519
-
-
Caruso, R.1
Stolfi, C.2
Sarra, M.3
-
30
-
-
18544406054
-
SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence
-
J
-
Underwood DC, Osborn RR, Kotzer CJ, et al. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence [J]. J Pharmacol Exp Ther, 2000, 293: 281-288.
-
(2000)
J Pharmacol Exp Ther
, vol.293
, pp. 281-288
-
-
Underwood, D.C.1
Osborn, R.R.2
Kotzer, C.J.3
-
31
-
-
6344269852
-
Selective blockade of NF-κB activity in airway immune cells inhibits the effector phase of experimental asthma
-
J
-
Desmet C, Gosset P, Pajak B, et al. Selective blockade of NF-κB activity in airway immune cells inhibits the effector phase of experimental asthma [J]. J Immunol, 2004, 173: 5766-5775.
-
(2004)
J Immunol
, vol.173
, pp. 5766-5775
-
-
Desmet, C.1
Gosset, P.2
Pajak, B.3
-
32
-
-
0035163864
-
A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat
-
J
-
Huang TJ, Adcock IM, Chung KF. A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat [J]. Br J Pharmacol, 2001, 134: 1029-1036.
-
(2001)
Br J Pharmacol
, vol.134
, pp. 1029-1036
-
-
Huang, T.J.1
Adcock, I.M.2
Chung, K.F.3
-
33
-
-
0036839618
-
A small molecule inhibitor of redox-regulated NF-kappaB and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model
-
J
-
Henderson WR, Chi EC, Teo JL, et al. A small molecule inhibitor of redox-regulated NF-kappaB and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model [J]. J Immunol, 2002, 169: 5294-5299.
-
(2002)
J Immunol
, vol.169
, pp. 5294-5299
-
-
Henderson, W.R.1
Chi, E.C.2
Teo, J.L.3
-
34
-
-
37849022679
-
Marine natural products as targeted modulators of the transcription factor NF-κB
-
J
-
Folmer F, Jaspars M, Dicato M, et al. Marine natural products as targeted modulators of the transcription factor NF-κB [J]. Biochem Pharmacol, 2008, 75: 603-617.
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 603-617
-
-
Folmer, F.1
Jaspars, M.2
Dicato, M.3
-
35
-
-
80052644840
-
SOCS3: A potential therapeutic target for many human disease
-
J
-
Xu WP, Li WD. SOCS3: a potential therapeutic target for many human disease [J]. Acta Pharm Sin, 2011, 46: 747-752.
-
(2011)
Acta Pharm Sin
, vol.46
, pp. 747-752
-
-
Xu, W.P.1
Li, W.D.2
-
36
-
-
4344627594
-
Inhibition of signal transducer and activator of transcription 1 attenuates allergen-induced airway inflammation and hyperreactivity
-
J
-
Quarcoo D, Weixler S, Groneberg D, et al. Inhibition of signal transducer and activator of transcription 1 attenuates allergen-induced airway inflammation and hyperreactivity [J]. J Allergy Clin Immunol, 2004, 114: 288-295.
-
(2004)
J Allergy Clin Immunol
, vol.114
, pp. 288-295
-
-
Quarcoo, D.1
Weixler, S.2
Groneberg, D.3
-
37
-
-
70349870911
-
A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice
-
J
-
Chiba Y, Todoroki M, Nishida Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice [J]. Am J Respir Cell Mol Biol, 2009, 41: 516-524.
-
(2009)
Am J Respir Cell Mol Biol
, vol.41
, pp. 516-524
-
-
Chiba, Y.1
Todoroki, M.2
Nishida, Y.3
-
38
-
-
33645354026
-
Suppressor of cytokine signaling 3 (SOCS3) in Th2 cells evokes Th2 cytokines, IgE, and eosinophilia
-
J
-
Kubo M, Inoue H. Suppressor of cytokine signaling 3 (SOCS3) in Th2 cells evokes Th2 cytokines, IgE, and eosinophilia [J]. Curr Allergy Asthma Rep, 2006, 6: 32-39.
-
(2006)
Curr Allergy Asthma Rep
, vol.6
, pp. 32-39
-
-
Kubo, M.1
Inoue, H.2
|