Cultured peripheral blood mast cells from chronic idiopathic urticaria patients spontaneously degranulate upon IgE sensitization: Relationship to expression of Syk and SHIP-2

Clinical Immunology

Volumn 132, Issue 3, 2009, Pages 342-348

  Saini, Sarbjit S ^a   Paterniti, Miya ^a   Vasagar, Kavitha ^a   Gibbons Jr , Scott P ^a   Sterba, Patricia M ^a   Vonakis, Becky M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD34+ stem cell; Fc RI; Mast cell; Signal transduction; Urticaria

Indexed keywords

HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN FC FRAGMENT; PROTEIN KINASE SYK; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2;

ADULT; ARTICLE; CD34 SELECTION; CONTROLLED STUDY; FEMALE; HISTAMINE RELEASE; HUMAN; IDIOPATHIC DISEASE; MALE; MAST CELL DEGRANULATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; SIGNAL TRANSDUCTION; URTICARIA;

ADULT; ANTIBODIES; CELL DEGRANULATION; FEMALE; HISTAMINE; HUMANS; IMMUNOGLOBULIN E; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAST CELLS; MIDDLE AGED; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, IGE; SIGNAL TRANSDUCTION; URTICARIA;

EID: 67651163434     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2009.05.003     Document Type: Article

References (38)

1. Jacques P., Lavoie A., Bedard P.M., Brunet C., and Hebert J. Chronic idiopathic urticaria: profiles of skin mast cell histamine release during active disease and remission. J. Allergy Clin. Immunol. 89 (1992) 1139-1143
2. Cohen R.W., and Rosenstreich D.L. Discrimination between urticaria-prone and other allergic patients by intradermal skin testing with codeine. J. Allergy Clin. Immunol. 77 (1986) 802-807
3. Gruber B.L., Baeza M.L., Marchese M.J., Agnello V., and Kaplan A.P. Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes. J. Invest. Dermatol. 90 (1988) 213-217
4. Hide M., Francis D.M., Grattan C.E., Hakimi J., Kochan J.P., and Greaves M.W. Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N. Engl. J. Med. 328 (1993) 1599-1604
5. Brodell L.A., Beck L.A., and Saini S.S. Pathophysiology of chronic urticaria. Ann. Allergy, Asthma, Immunol. 100 (2008) 291-297
6. Harris S.J., Parry R.V., Westwick J., and Ward S.G. Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. J. Biol. Chem. 283 (2008) 2465-2469
7. Kimura T., Sakamoto H., Appella E., and Siraganian R.P. The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor. J. Biol. Chem. 272 (1997) 13991-13996
8. Gimborn K., Lessmann E., Kuppig S., Krystal G., and Huber M. SHIP down-regulates FcepsilonR1-induced degranulation at supraoptimal IgE or antigen levels. J. Immunol. 174 (2005) 507-516
9. Huber M., Helgason C.D., Damen J.E., Liu L., Humphries R.K., and Krystal G. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 11330-11335
10. Vonakis B.M., Gibbons Jr. S., Sora R., Langdon J.M., and MacDonald S.M. Src homology 2 domain-containing inositol 5′ phosphatase is negatively associated with histamine release to human recombinant histamine-releasing factor in human basophils. J. Allergy Clin. Immunol. 108 (2001) 822-831
11. Gibbs B.F., Rathling A., Zillikens D., Huber M., and Haas H. Initial Fc epsilon RI-mediated signal strength plays a key role in regulating basophil signaling and deactivation. J. Allergy Clin. Immunol. 118 (2006) 1060-1067
12. Leung W.H., and Bolland S. The inositol 5′-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J. Immunol. 179 (2007) 95-102
13. Sabroe R.A., Francis D.M., Barr R.M., Black A.K., and Greaves M.W. Anti-Fc(episilon)RI auto antibodies and basophil histamine releasability in chronic idiopathic urticaria. J. Allergy Clin. Immunol. 102 (1998) 651-658
14. Vonakis B.M., Vasagar K., Gibbons J., C. S., Gober L., Sterba P., Chang H., and Saini S.S. Basophil FceRI histamine release parallels expression of Src-homology2-containing inositol phosphatases in chronic idiopathic urticaria. J. Allergy Clin. Immunol. 119 (2007) 441-448
15. Luquin E., Kaplan A.P., and Ferrer M. Increased responsiveness of basophils of patients with chronic urticaria to sera but hypo-responsiveness to other stimuli. Clin. Exp. Allergy 35 (2005) 456-460
16. Kern F., and Lichtenstein L.M. Defective histamine release in chronic urticaria. J. Clin. Invest. 57 (1976) 1369-1377
17. Langdon J.M., Schroeder J.T., Vonakis B.M., Bieneman A., Chichester K., and MacDonald S.M. Histamine Releasing Factor/Translationally Controlled Tumor Protein (HRF/TCTP) Induced Histamine Release is Enhanced with SHIP-1 Knockdown in Cultured Human Mast Cell and Basophil Models. J. Leukoc. Biol. 84 (2008) 1151-1158
18. Rossi A.B., Herlaar E., Braselmann S., Huynh S., Taylor V., Frances R., Issakani S.D., Argade A., Singh R., Payan D.G., and Masuda E.S. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J. Allergy Clin. Immunol. 118 (2006) 749-755
19. Zhang J., Berenstein E.H., Evans R.L., and Siraganian R.P. Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. J. Exp. Med. 184 (1996) 71-79
20. Macglashan Jr. D.W. Relationship between spleen tyrosine kinase and phosphatidylinositol 5′ phosphatase expression and secretion from human basophils in the general population. J. Allergy Clin. Immunol. 119 (2007) 626-633
21. Vonakis B.M., and Saini S.S. Syk-deficient basophils from donors with chronic idiopathic urticaria exhibit a spectrum of releasability. J. Allergy Clin. Immunol. 121 (2008) 262-264
22. Jiang Y., Kanaoka Y., Feng C., Nocka K., Rao S., and Boyce J.A. Cutting edge: interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling. J. Immunol. 177 (2006) 2755-2759
23. Eckman J., Hamilton R.G., Gober L.M., Sterba P.M., and Saini S.S. Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies. J. Invest. Dermatol. 128 (2008) 1956-1963
24. Baker R., Vasagar K., Ohameje N., Gober L., Chen S.C., Sterba P.M., and Saini S.S. Basophil histamine release activity and disease severity in chronic idiopahtic urticaria. Ann. Allergy, Asthma, Immunol, 100 (2008) 244-249
25. Kambe N., Kambe M., Kochan J.P., and Schwartz L.B. Human skin-derived mast cells can proliferate while retaining their characteristic functional and protease phenotypes. Blood 97 (2001) 2045-2052
26. Cruse G., Kaur D., Yang W., Duffy S.M., Brightling C.E., and Bradding P. Activation of human lung mast cells by monomeric immunoglobulin E. Eur. Respir. J. 25 (2005) 858-863
27. Matsuda K., Piliponsky A.M., Iikura M., Nakae S., Wang E.W., Dutta S.M., Kawakami T., Tsai M., and Galli S.J. Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response. J. Allergy Clin. Immunol. 116 (2005) 1357-1363
28. Schroeder J.T., Chichester K.L., and Bieneman A.P. Human basophils secrete IL-3: evidence of autocrine priming for phenotypic and functional responses in allergic disease. J. Immunol. 182 (2009) 2432-2438
29. Rauh M.J., and Krystal G. Of mice and men: elucidating the role of SH2-containing inositol 5-phosphatase (SHIP) in human disease. Clin. Invest. Med. 25 (2002) 68-70
30. Kepley C.L., Youssef L., Andrews R.P., Wilson B.S., and Oliver J.M. Multiple defects in Fc epsilon RI signaling in Syk-deficient nonreleaser basophils and IL-3-induced recovery of Syk expression and secretion. J. Immunol. 165 (2000) 5913-5920
31. Sly L.M., Rauh M.J., Kalesnikoff J., Buchse T., and Krystal G. SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide. Exp. Hematol. 31 (2003) 1170-1181
32. Pengal R.A., Ganesan L.P., Fang H., Marsh C.B., Anderson C.L., and Tridandapani S. SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling. J. Biol. Chem. 278 (2003) 22657-22663
33. Brauweiler A., Tamir I., Marschner S., Helgason C.D., and Cambier J.C. Partially distinct molecular mechanisms mediate inhibitory FcgammaRIIB signaling in resting and activated B cells. J. Immunol. 167 (2001) 204-211
34. Vonakis B.M., and Saini S.S. New concepts in chronic urticaria. Curr. Opin. Immunol. 20 (2008) 709-716
35. Meltzer E.O., Berkowitz R.B., and Grossbard E.B. An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment. J. Allergy Clin. Immunol. 115 (2005) 791-796
36. Guyer B.J., Shimamoto S.R., Bradhurst A.L., Grossbard E.B., Dreskin S.C., and Nelson H.S. Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis. Allergy Asthma Proc. 27 (2006) 208-213
37. Braselmann S., Taylor V., Zhao H., Wang S., Sylvain C., Baluom M., Qu K., Herlaar E., Lau A., Young C., Wong B.R., Lovell S., Sun T., Park G., Argade A., Jurcevic S., Pine P., Singh R., Grossbard E.B., Payan D.G., and Masuda E.S. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J. Pharmacol. Exp. Ther. 319 (2006) 998-1008
38. Gober L., Sterba P., Eckman J., and Saini S. Effect of anti-IgE (omalizumab) in chronic idiopathic urticaria patients. J. Allergy Clin. Immunol. 121 (2008) S147