메뉴 건너뛰기




Volumn 172, Issue 11, 2004, Pages 7053-7059

Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EOTAXIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MACROGOL; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OVALBUMIN; UO 126; VASCULAR CELL ADHESION MOLECULE 1;

EID: 2442712697     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.11.7053     Document Type: Article
Times cited : (265)

References (46)
  • 2
    • 0038387445 scopus 로고    scopus 로고
    • To respond or not to respond: T cells in allergic asthma
    • Herrick, C. A., and K. Bottomly. 2003. To respond or not to respond: T cells in allergic asthma. Nat. Rev. Immunol. 3:1.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 1
    • Herrick, C.A.1    Bottomly, K.2
  • 3
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • Wynn, T. A. 2003. IL-13 effector functions. Annu. Rev. Immunol. 21:425.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 425
    • Wynn, T.A.1
  • 4
    • 0035523289 scopus 로고    scopus 로고
    • Role of chemokines in the pathogenesis of asthma
    • Lukacs, N. W. 2001. Role of chemokines in the pathogenesis of asthma. Nat. Rev. Immunol. 1:108.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 108
    • Lukacs, N.W.1
  • 5
    • 0032968706 scopus 로고    scopus 로고
    • Immunologic basis of antigen-induced airway hyperresponsiveness
    • Wills-Karp, M. 1999. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17:255.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 255
    • Wills-Karp, M.1
  • 6
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signaling cascades
    • Chang, L., and M. Karin. 2001. Mammalian MAP kinase signaling cascades. Nature 410:37.
    • (2001) Nature , vol.410 , pp. 37
    • Chang, L.1    Karin, M.2
  • 7
    • 0036247432 scopus 로고    scopus 로고
    • T-cell activation through the antigen receptor. 1. Signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse
    • Nel, A. E. 2002. T-cell activation through the antigen receptor. 1. Signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J. Allergy Clin. Immunol. 109:758.
    • (2002) J. Allergy Clin. Immunol. , vol.109 , pp. 758
    • Nel, A.E.1
  • 8
    • 0037189571 scopus 로고    scopus 로고
    • Convergence of signaling pathways on the activation of ERK in B cells
    • Jacob, A., D. Cooney, M. Pradhan, and K. M. Coggeshall. 2002. Convergence of signaling pathways on the activation of ERK in B cells. J. Biol. Chem. 277:23420.
    • (2002) J. Biol. Chem. , vol.277 , pp. 23420
    • Jacob, A.1    Cooney, D.2    Pradhan, M.3    Coggeshall, K.M.4
  • 9
    • 0037204949 scopus 로고    scopus 로고
    • B cell antigen receptor signaling: Roles in cell development and disease
    • Gauld, S. B., J. M. Dal Porto, and J. C. Cambier. 2002. B cell antigen receptor signaling: roles in cell development and disease. Science 296:1641.
    • (2002) Science , vol.296 , pp. 1641
    • Gauld, S.B.1    Dal Porto, J.M.2    Cambier, J.C.3
  • 10
    • 0033753014 scopus 로고    scopus 로고
    • Signal transduction by the high-affinity immunoglobulin E receptor FcεRI: Coupling form to function
    • Nadler, M. J., S. A. Matthews, H. Turner, and J. P. Kinet. 2000. Signal transduction by the high-affinity immunoglobulin E receptor FcεRI: coupling form to function. Adv. Immunol. 76:325.
    • (2000) Adv. Immunol. , vol.76 , pp. 325
    • Nadler, M.J.1    Matthews, S.A.2    Turner, H.3    Kinet, J.P.4
  • 11
    • 0032479926 scopus 로고    scopus 로고
    • Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation
    • Pazdrak, K., B. Olszewska-Pazdrak, S. Stafford, R. P. Garofalo, and R. Alam. 1998. Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation. J. Exp. Med. 188:421.
    • (1998) J. Exp. Med. , vol.188 , pp. 421
    • Pazdrak, K.1    Olszewska-Pazdrak, B.2    Stafford, S.3    Garofalo, R.P.4    Alam, R.5
  • 13
    • 0141445981 scopus 로고    scopus 로고
    • Mechanical stretch activates nuclear factor-κB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: Implications in asthma
    • Kumar, A., S. Lnu, R. Malya, D. Barron, J. Moore, D. B. Corry, and A. M. Boriek. 2003. Mechanical stretch activates nuclear factor-κB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma. FASEB J. 17:1800.
    • (2003) FASEB J. , vol.17 , pp. 1800
    • Kumar, A.1    Lnu, S.2    Malya, R.3    Barron, D.4    Moore, J.5    Corry, D.B.6    Boriek, A.M.7
  • 14
    • 0031656856 scopus 로고    scopus 로고
    • Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro
    • Tsang, F., A. H. M. Koh, W. L. Ting, P. T. H. Wong, and W. S. F. Wong. 1998. Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro. Br. J. Pharmacol. 125:61.
    • (1998) Br. J. Pharmacol. , vol.125 , pp. 61
    • Tsang, F.1    Koh, A.H.M.2    Ting, W.L.3    Wong, P.T.H.4    Wong, W.S.F.5
  • 17
    • 0344154290 scopus 로고    scopus 로고
    • Blockade of inflammation and airway hyper-responsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT
    • Myou, S., A. R. Leff, S. Myo, E. Boetticher, J. Tong, A. Y. Meliton, J. Liu, N. M. Munoz, and X. Zhu. 2003. Blockade of inflammation and airway hyper-responsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT. J. Exp. Med. 198:1573.
    • (2003) J. Exp. Med. , vol.198 , pp. 1573
    • Myou, S.1    Leff, A.R.2    Myo, S.3    Boetticher, E.4    Tong, J.5    Meliton, A.Y.6    Liu, J.7    Munoz, N.M.8    Zhu, X.9
  • 18
    • 0035661260 scopus 로고    scopus 로고
    • The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma
    • Tanaka, H., T. Masuda, S. Tokuoka, M. Komai, K. Nagao, Y. Takahashi, and H. Nagai. 2001. The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma. Inflamm. Res. 50:616.
    • (2001) Inflamm. Res. , vol.50 , pp. 616
    • Tanaka, H.1    Masuda, T.2    Tokuoka, S.3    Komai, M.4    Nagao, K.5    Takahashi, Y.6    Nagai, H.7
  • 20
    • 0037338904 scopus 로고    scopus 로고
    • The role of T lymphocytes in the pathogenesis of asthma
    • Larche, M., D. S. Robinson, and A. B. Kay. 2002. The role of T lymphocytes in the pathogenesis of asthma. J. Allergy Clin. Immunol. 111:450.
    • (2002) J. Allergy Clin. Immunol. , vol.111 , pp. 450
    • Larche, M.1    Robinson, D.S.2    Kay, A.B.3
  • 22
    • 0036251245 scopus 로고    scopus 로고
    • Regulation of IL-13 synthesis in human lymphocytes: Implications for asthma therapy
    • Pahl, A., M. Zhang, H. Kuss, I. Szelenyi, and K. Brune. 2002. Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy. Br. J. Pharmacol. 135:1915.
    • (2002) Br. J. Pharmacol. , vol.135 , pp. 1915
    • Pahl, A.1    Zhang, M.2    Kuss, H.3    Szelenyi, I.4    Brune, K.5
  • 23
    • 0035496927 scopus 로고    scopus 로고
    • Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells
    • Puig-Kroger, A., M. Relloso, O. Fernandez-Capetillo, A. Zubiaga, A. Silva, C. Bernabeu, and A. L. Corbi. 2001. Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 98:2175.
    • (2001) Blood , vol.98 , pp. 2175
    • Puig-Kroger, A.1    Relloso, M.2    Fernandez-Capetillo, O.3    Zubiaga, A.4    Silva, A.5    Bernabeu, C.6    Corbi, A.L.7
  • 24
    • 0036907405 scopus 로고    scopus 로고
    • Airway smooth muscle: An immunomodulatory cell
    • Reynold, A. A., Jr. 2002. Airway smooth muscle: an immunomodulatory cell. J. Allergy Clin. Immunol. 110:S269.
    • (2002) J. Allergy Clin. Immunol. , vol.110
    • Reynold Jr., A.A.1
  • 26
    • 0037090417 scopus 로고    scopus 로고
    • Selective induction of eotaxin release by interleukin-13 or interleukin-4 in human airway smooth muscle cells is synergistic with interleukin-1β and is mediated by the interleukin-4 receptor α-chain
    • Hirst, S. J., M. P. Hallsworth, Q. Peng, and T. H. Lee. 2002. Selective induction of eotaxin release by interleukin-13 or interleukin-4 in human airway smooth muscle cells is synergistic with interleukin-1β and is mediated by the interleukin-4 receptor α-chain. Am. J. Respir. Crit. Care Med. 165:1161.
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , pp. 1161
    • Hirst, S.J.1    Hallsworth, M.P.2    Peng, Q.3    Lee, T.H.4
  • 29
    • 0038404908 scopus 로고    scopus 로고
    • Role of activator protein 1, nuclear factor-κB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells
    • Lorentz, A., I. Klopp, T. Gebhardt, M. P. Manns, and S. C. Bischoff. 2003. Role of activator protein 1, nuclear factor-κB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells. J. Allergy Clin. Immunol. 111:1062.
    • (2003) J. Allergy Clin. Immunol. , vol.111 , pp. 1062
    • Lorentz, A.1    Klopp, I.2    Gebhardt, T.3    Manns, M.P.4    Bischoff, S.C.5
  • 30
    • 0037220903 scopus 로고    scopus 로고
    • Oncostatin M regulates eotaxin expression in fibroblasts and eosinophilic inflammation in C57BL/6 mice
    • Langdon, C., C. Kerr, L. Tong, and C. D. Richards. 2003. Oncostatin M regulates eotaxin expression in fibroblasts and eosinophilic inflammation in C57BL/6 mice. J. Immunol. 170:548.
    • (2003) J. Immunol. , vol.170 , pp. 548
    • Langdon, C.1    Kerr, C.2    Tong, L.3    Richards, C.D.4
  • 31
    • 0032929434 scopus 로고    scopus 로고
    • Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions
    • Jia, G.-Q., J. A. Gonzalo, A. Hidalgo, D. Wagner, M. Cybulsky, and J. C. Gutierrez-Ramos. 1999. Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions. Int. Immunol. 11:1.
    • (1999) Int. Immunol. , vol.11 , pp. 1
    • Jia, G.-Q.1    Gonzalo, J.A.2    Hidalgo, A.3    Wagner, D.4    Cybulsky, M.5    Gutierrez-Ramos, J.C.6
  • 32
    • 0033104696 scopus 로고    scopus 로고
    • Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells
    • Li, L., Y. Xia, A. Nguyen, Y. H. Lai, L. Feng, T. R. Mosmann, and D. Lo. 1999. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J. Immunol. 162:2477.
    • (1999) J. Immunol. , vol.162 , pp. 2477
    • Li, L.1    Xia, Y.2    Nguyen, A.3    Lai, Y.H.4    Feng, L.5    Mosmann, T.R.6    Lo, D.7
  • 33
    • 0034653460 scopus 로고    scopus 로고
    • Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases
    • Kampen, G. T., S. Stafford, T. Adachi, T. Jinquan, S. Quan, J. A. Grant, P. S. Skov, L. K. Poulsen, and R. Alam. 2000. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95:1911.
    • (2000) Blood , vol.95 , pp. 1911
    • Kampen, G.T.1    Stafford, S.2    Adachi, T.3    Jinquan, T.4    Quan, S.5    Grant, J.A.6    Skov, P.S.7    Poulsen, L.K.8    Alam, R.9
  • 35
    • 0030689729 scopus 로고    scopus 로고
    • Induction of airway mucus production by T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production
    • Cohn, L., R. J. Homer, A. Marinov, J. Rankin, and K. Bottomly. 1997. Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 186:1737.
    • (1997) J. Exp. Med. , vol.186 , pp. 1737
    • Cohn, L.1    Homer, R.J.2    Marinov, A.3    Rankin, J.4    Bottomly, K.5
  • 36
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu, Z., R. J. Homer, Z. Wang, Q. Chen, G. P. Geba, J. Wang, Y. Zhang, and J. A. Elias. 1999. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 103:779.
    • (1999) J. Clin. Invest. , vol.103 , pp. 779
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6    Zhang, Y.7    Elias, J.A.8
  • 37
    • 0043011579 scopus 로고    scopus 로고
    • IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation
    • Atherton, H. C., G. Jones, and H. Danahay. 2003. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am. J. Physiol. Lung Cell Mol. Physiol. 285:L730.
    • (2003) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.285
    • Atherton, H.C.1    Jones, G.2    Danahay, H.3
  • 38
    • 0035869267 scopus 로고    scopus 로고
    • Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen
    • Richards, J. D., S. H. Dave, C. H. G. Chou, A. A. Mamchak, and A. L. DeFranco. 2001. Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen. J. Immunol. 166:3855.
    • (2001) J. Immunol. , vol.166 , pp. 3855
    • Richards, J.D.1    Dave, S.H.2    Chou, C.H.G.3    Mamchak, A.A.4    DeFranco, A.L.5
  • 39
    • 0031852973 scopus 로고    scopus 로고
    • Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13
    • Emson, C. L., S. E. Bell, A. Jones, W. Wisden, and A. N. J. McKenzie. 1998. Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13. J. Exp. Med. 188:399.
    • (1998) J. Exp. Med. , vol.188 , pp. 399
    • Emson, C.L.1    Bell, S.E.2    Jones, A.3    Wisden, W.4    McKenzie, A.N.J.5
  • 40
    • 0036780841 scopus 로고    scopus 로고
    • Regulation of mast-cell and basophil function and survival by IgE
    • Kawakami, T., and S. J. Galli. 2002. Regulation of mast-cell and basophil function and survival by IgE. Nat. Rev. Immunol. 2:773.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 773
    • Kawakami, T.1    Galli, S.J.2
  • 41
    • 0041627689 scopus 로고    scopus 로고
    • Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma?
    • Fernandes, D. J., R. W. Mitchell, O. Lakser, M. Dowell, A. G. Stewart, and J. Solway. 2003. Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma? J. Appl. Physiol. 95:844.
    • (2003) J. Appl. Physiol. , vol.95 , pp. 844
    • Fernandes, D.J.1    Mitchell, R.W.2    Lakser, O.3    Dowell, M.4    Stewart, A.G.5    Solway, J.6
  • 42
    • 0034049677 scopus 로고    scopus 로고
    • Mechanisms of eosinophil-associate inflammation
    • Gleich, G. J. 2000. Mechanisms of eosinophil-associate inflammation. J. Allergy Clin. Immunol. 105:651.
    • (2000) J. Allergy Clin. Immunol. , vol.105 , pp. 651
    • Gleich, G.J.1
  • 43
    • 0030028768 scopus 로고    scopus 로고
    • Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    • Foster, P. S., S. P. Hogan, A. J. Ramsay, K. I. Matthaei, and I. G. Young. 1996. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183:195.
    • (1996) J. Exp. Med. , vol.183 , pp. 195
    • Foster, P.S.1    Hogan, S.P.2    Ramsay, A.J.3    Matthaei, K.I.4    Young, I.G.5
  • 44
    • 0037385864 scopus 로고    scopus 로고
    • Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13
    • Vargaftig, B. B., and M. Singer. 2003. Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am. J. Respir. Cell Mol. Biol. 28:410.
    • (2003) Am. J. Respir. Cell Mol. Biol. , vol.28 , pp. 410
    • Vargaftig, B.B.1    Singer, M.2
  • 45
    • 0034774796 scopus 로고    scopus 로고
    • Early interleukin 4-dependent response can induce airway hyperreactivity before development of airway inflammation in a mouse model of asthma
    • To, Y., M. Dohi, R. Tanaka, A. Sato, K. Nakagome, and K. Yamamoto. 2001. Early interleukin 4-dependent response can induce airway hyperreactivity before development of airway inflammation in a mouse model of asthma. Lab. Invest. 81:1385.
    • (2001) Lab. Invest. , vol.81 , pp. 1385
    • To, Y.1    Dohi, M.2    Tanaka, R.3    Sato, A.4    Nakagome, K.5    Yamamoto, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.