The γ-secretase inhibitor DAPT increases the levels of gangliosides at neuritic terminals of differentiating PC12 cells

Neuroscience Letters

Volumn 525, Issue 1, 2012, Pages 49-53

  Oikawa, Naoto ^a   Goto, Miho ^b   Ikeda, Kazutaka ^c   Taguchi, Ryo ^b   Yanagisawa, Katsuhiko ^a  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b CHUBU UNIVERSITY   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Secretase; Alzheimer disease; Amyloid protein; Ganglioside; Lipidomics; Liquid chromatography electrospray ionization tandem mass spectrometry

Indexed keywords

AMYLOID BETA PROTEIN; CHOLESTEROL; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GANGLIOSIDE; PHOSPHATIDYLCHOLINE; PRESENILIN; SPHINGOMYELIN; SYNAPTOPHYSIN;

ANALYTIC METHOD; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DISEASE EXACERBATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FLOW RATE; LIQUID CHROMATOGRAPHY; LOSS OF FUNCTION MUTATION; MULTIPLE REACTION MONITORING; NERVE CELL DIFFERENTIATION; NERVE CELL MEMBRANE; NERVE ENDING; NEUROMODULATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING;

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL DIFFERENTIATION; CHOLESTEROL; DIPEPTIDES; GANGLIOSIDES; NEURITES; PC12 CELLS; PHOSPHATIDYLCHOLINES; RATS; SPHINGOMYELINS;

EID: 84865311604     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.07.027     Document Type: Article

References (35)

1. Ando K., Oishi M., Takeda S., Iijima K., Isohara T., Nairn A.C., Kirino Y., Greengard P., Suzuki T. Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. Journal of Neuroscience 1999, 19:4421-4427.
2. Barthet G., Shioi J., Shao Z., Ren Y., Georgakopoulos A., Robakis N.K. Inhibitors of {gamma}-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates. FASEB Journal 2011, 25:2937-2946.
3. Chan R.B., Oliveira T.G., Cortes E.P., Honig L.S., Duff K.E., Small S.A., Wenk M.R., Shui G., Di Paolo G. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. Journal of Biological Chemistry 2012, 287:2678-2688.
4. De Strooper B. Loss-of-function presenilin mutations in Alzheimer disease. Talking point on the role of presenilin mutations in Alzheimer disease. EMBO Reports 2007, 8:141-146.
5. Eckert G.P., Müller W.E. Presenilin 1 modifies lipid raft composition of neuronal membranes. Biochemical and Biophysical Research Communications 2009, 382:673-677.
6. Grimm M.O., Grimm H.S., Pätzold A.J., Zinser E.G., Halonen R., Duering M., Tschäpe J.A., De Strooper B., Müller U., Shen J., Hartmann T. Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nature Cell Biology 2005, 7:1118-1123.
7. Grimm M.O., Tschäpe J.A., Grimm H.S., Zinser E.G., Hartmann T. Altered membrane fluidity and lipid raft composition in presenilin-deficient cells. Acta Neurologica Scandinavica. Supplementum 2006, 185:27-32.
8. Grimm M.O., Zinser E.G., Grösgen S., Hundsdörfer B., Rothhaar T.L., Burg V.K., Kaestner L., Bayer T.A., Lipp P., Müller U., Grimm H.S., Hartmann T. Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism. PLoS One 2012, 7:e34095.
9. Gylys K.H., Fein J.A., Yang F., Miller C.A., Cole G.M. Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex. Neurobiology of Aging 2007, 28:8-17.
10. Heilig E.A., Xia W., Shen J., Kelleher R.J. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. Journal of Biological Chemistry 2010, 285:22350-22359.
11. Holmes O., Paturi S., Ye W., Wolfe M.S., Selkoe D.J. Effects of membrane lipids on the activity and processivity of purified γ-secretase. Biochemistry 2012, 51:3565-3575.
12. Houjou T., Yamatani K., Imagawa M., Shimizu T., Taguchi R. A shotgun tandem mass spectrometric analysis of phospholipids with normal-phase and/or reverse-phase liquid chromatography/electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry 2005, 19:654-666.
13. Ikeda K., Kubo A., Akahoshi N., Yamada H., Miura N., Hishiki T., Nagahata Y., Matsuura T., Suematsu M., Taguchi R., Ishii I. Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria. Analytical and Bioanalytical Chemistry 2011, 400:1853-1863.
14. Ikeda K., Taguchi R. Highly sensitive localization analysis of gangliosides and sulfatides including structural isomers in mouse cerebellum sections by combination of laser microdissection and hydrophilic interaction liquid chromatography/electrospray ionization mass spectrometry with theoretically expanded multiple reaction monitoring. Rapid Communications in Mass Spectrometry 2010, 24:2957-2965.
15. Kumar-Singh S., Theuns J., Van Broeck B., Pirici D., Vennekens K., Corsmit E., Cruts M., Dermaut B., Wang R., Van Broeckhoven C. Mean age-of-onset of familial Alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40. Human Mutation 2006, 27:686-695.
16. Molander-Melin M., Blennow K., Bogdanovic N., Dellheden B., Månsson J.E., Fredman P. Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains. Journal of Neurochemistry 2005, 92:171-182.
17. Morfini G., Quiroga S., Rosa A., Kosik K., Cáceres A. Suppression of KIF2 in PC12 cells alters the distribution of a growth cone nonsynaptic membrane receptor and inhibits neurite extension. Journal of Cell Biology 1997, 138:657-669.
18. Mutoh T., Kawamura N., Hirabayashi Y., Shima S., Miyashita T., Ito S., Asakura K., Araki W., Cazzaniga E., Muto E., Masserini M. Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis. FASEB Journal 2012, 26:3065-3074.
19. Parent A.T., Barnes N.Y., Taniguchi Y., Thinakaran G., Sisodia S.S. Presenilin attenuates receptor-mediated signaling and synaptic function. Journal of Neuroscience 2005, 25:1540-1549.
20. Probst A., Langui D., Ipsen S., Robakis N., Ulrich J. Deposition of beta/A4 protein along neuronal plasma membranes in diffuse senile plaques. Acta Neuropathologica 1991, 83:21-29.
21. Rüder C., Reimer T., Delgado-Martinez I., Hermosilla R., Engelsberg A., Nehring R., Dörken B., Rehm A. EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin. Molecular Biology of the Cell 2005, 16:1245-1257.
22. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Medicine 1996, 2:864-870.
23. Shen J., Kelleher R.J. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:403-409.
24. Song W., Nadeau P., Yuan M., Yang X., Shen J., Yankner B.A. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:6959-6963.
25. Tischler A.S., Greene L.A. Morphologic and cytochemical properties of a clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Laboratory Investigation 1978, 39:77-89.
26. van S.C., Jzendoorn I., Hoekstra D. Polarized sphingolipid transport from the subapical compartment changes during cell polarity development. Molecular Biology of the Cell 2000, 11:1093-1101.
27. van S.C., Jzendoorn I., Zegers M.M., Kok J.W., Hoekstra D. Segregation of glucosylceramide and sphingomyelin occurs in the apical to basolateral transcytotic route in HepG2 cells. Journal of Cell Biology 1997, 137:347-357.
28. Weihofen A., Lemberg M.K., Friedmann E., Rueeger H., Schmitz A., Paganetti P., Rovelli G., Martoglio B. Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors. Journal of Biological Chemistry 2003, 278:16528-16533.
29. Wiley J.C., Hudson M., Kanning K.C., Schecterson L.C., Bothwell M. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment. Journal of Neurochemistry 2005, 94:1189-1201.
30. Yamamoto N., Fukata Y., Fukata M., Yanagisawa K. GM1-ganglioside-induced Abeta assembly on synaptic membranes of cultured neurons. Biochimica et Biophysica Acta 2007, 1768:1128-1137.
31. Yamamoto N., Matsubara T., Sato T., Yanagisawa K. Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis. Biochimica et Biophysica Acta 2008, 1778:2717-2726.
32. Yanagisawa K. Role of gangliosides in Alzheimer's disease. Biochimica et Biophysica Acta 2007, 1768:1943-1951.
33. Yuyama K., Yamamoto N., Yanagisawa K. Chloroquine-induced endocytic pathway abnormalities: cellular model of GM1 ganglioside-induced Abeta fibrillogenesis in Alzheimer's disease. FEBS Letters 2006, 580:6972-6976.
34. Zhang L., Song L., Terracina G., Liu Y., Pramanik B., Parker E. Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides. Biochemistry 2001, 40:5049-5055.
35. Zhang M., Haapasalo A., Kim D.Y., Ingano L.A., Pettingell W.H., Kovacs D.M. Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment. FASEB Journal 2006, 20:1176-1178.