메뉴 건너뛰기




Volumn 400, Issue 7, 2011, Pages 1853-1863

Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria

Author keywords

Capillary electrophoresis; Hepatic steatosis; Methylation; NanoESI MS; Neutral loss scanning; Precursor ion scanning

Indexed keywords

ANIMAL MODEL; CELLULAR SIGNALING; FATTY LIVER; HEPATIC STEATOSIS; MOLECULAR BASIS; MOLECULAR SPECIES; NANO-ESI; NANOESI-MS; NEUTRAL LOSS SCANNING; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PRECURSOR ION SCANNING; QUANTITATIVE DETECTION; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; SYNTHASES; TRIACYLGLYCEROLS; WILD TYPES;

EID: 79956290239     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-4703-2     Document Type: Article
Times cited : (19)

References (28)
  • 1
    • 0034075997 scopus 로고    scopus 로고
    • Homocysteine, B vitamins, and risk of cardiovascular disease
    • K Robinson 2000 Homocysteine, B vitamins, and risk of cardiovascular disease Heart 83 127 130 10.1136/heart.83.2.127 1:STN:280:DC%2BD3c7hsF2rsQ%3D%3D (Pubitemid 30305534)
    • (2000) Heart , vol.83 , Issue.2 , pp. 127-130
    • Robinson, K.1
  • 3
    • 0036398629 scopus 로고    scopus 로고
    • Hyperhomocysteinemia: A new risk factor for degenerative diseases
    • W Herrmann JP Knapp 2002 Hyperhomocysteinemia: a new risk factor for degenerative diseases Clin Lab 48 471 481 1:CAS:528:DC%2BD38XosVSmsLY%3D (Pubitemid 35174963)
    • (2002) Clinical Laboratory , vol.48 , Issue.9-10 , pp. 471-481
    • Herrmann, W.1    Knapp, J.-P.2
  • 5
    • 4344575903 scopus 로고    scopus 로고
    • Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease
    • DOI 10.1038/sj.cdd.4401451
    • RC Austin SR Lentz GH Werstuck 2004 Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease Cell Death Differ 11 Suppl 1 S56 S64 10.1038/sj.cdd.4401451 1:CAS:528:DC%2BD2cXlsFelu7w%3D (Pubitemid 39136799)
    • (2004) Cell Death and Differentiation , vol.11 , Issue.SUPPL. 1
    • Austin, R.C.1    Lentz, S.R.2    Werstuck, G.H.3
  • 7
    • 0000971574 scopus 로고
    • Pathological findings in homocystinuria
    • 10.1136/jcp.17.4.427
    • JB Gibson NA Carson DW Neill 1964 Pathological findings in homocystinuria J Clin Pathol 17 427 437 10.1136/jcp.17.4.427
    • (1964) J Clin Pathol , vol.17 , pp. 427-437
    • Gibson, J.B.1    Carson, N.A.2    Neill, D.W.3
  • 8
    • 0028937163 scopus 로고
    • Mice deficient in cystathionine beta-synthase: Animal models for mild and severe homocyst(e)inemia
    • 10.1073/pnas.92.5.1585 1:CAS:528:DyaK2MXktFWku78%3D
    • M Watanabe J Osada Y Aratani K Kluckman R Reddick MR Malinow N Maeda 1995 Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia Proc Natl Acad Sci USA 92 1585 1589 10.1073/pnas.92.5.1585 1:CAS:528:DyaK2MXktFWku78%3D
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1585-1589
    • Watanabe, M.1    Osada, J.2    Aratani, Y.3    Kluckman, K.4    Reddick, R.5    Malinow, M.R.6    Maeda, N.7
  • 9
    • 0037926903 scopus 로고    scopus 로고
    • Hyperhomocysteinemia accelerates atherosclerosis in cystathionine β-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation
    • DOI 10.1182/blood-2002-08-2606
    • H Wang X Jiang F Yang JW Gaubatz L Ma MJ Magera X Yang PB Berger W Durante HJ Pownall AI Schafer 2003 Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation Blood 101 3901 3907 10.1182/blood-2002-08-2606 1:CAS:528:DC%2BD3sXktVGntb8%3D (Pubitemid 36857865)
    • (2003) Blood , vol.101 , Issue.10 , pp. 3901-3907
    • Wang, H.1    Jiang, X.2    Yang, F.3    Gaubatz, J.W.4    Ma, L.5    Magera, M.J.6    Yang, X.7    Berger, P.B.8    Durante, W.9    Pownall, H.J.10    Schafer, A.I.11
  • 10
    • 11144230938 scopus 로고    scopus 로고
    • Abnormal lipid metabolism in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia
    • DOI 10.1074/jbc.M406820200
    • K Namekata Y Enokido I Ishii Y Nagai T Harada H Kimura 2004 Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia J Biol Chem 279 52961 52969 10.1074/jbc.M406820200 1:CAS:528:DC%2BD2cXhtVKqurrF (Pubitemid 40051794)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.51 , pp. 52961-52969
    • Namekata, K.1    Enokido, Y.2    Ishii, I.3    Nagai, Y.4    Harada, T.5    Kimura, H.6
  • 11
    • 45749150751 scopus 로고    scopus 로고
    • Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia
    • DOI 10.1093/hmg/ddn097
    • N Akahoshi C Kobayashi Y Ishizaki T Izumi T Himi M Suematsu I Ishii 2008 Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia Hum Mol Genet 17 1994 2005 10.1093/hmg/ddn097 1:CAS:528:DC%2BD1cXntFOkt70%3D (Pubitemid 351865848)
    • (2008) Human Molecular Genetics , vol.17 , Issue.13 , pp. 1994-2005
    • Akahoshi, N.1    Kobayashi, C.2    Ishizaki, Y.3    Izumi, T.4    Himi, T.5    Suematsu, M.6    Ishii, I.7
  • 12
    • 77956194462 scopus 로고    scopus 로고
    • Cystathionine gamma-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury
    • 10.1074/jbc.M110.147439 1:CAS:528:DC%2BC3cXhtVahtbnK
    • I Ishii N Akahoshi H Yamada S Nakano T Izumi M Suematsu 2010 Cystathionine gamma-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury J Biol Chem 285 26358 26368 10.1074/jbc.M110.147439 1:CAS:528:DC%2BC3cXhtVahtbnK
    • (2010) J Biol Chem , vol.285 , pp. 26358-26368
    • Ishii, I.1    Akahoshi, N.2    Yamada, H.3    Nakano, S.4    Izumi, T.5    Suematsu, M.6
  • 13
    • 78650217752 scopus 로고    scopus 로고
    • Increase of oxidant-related triglycerides and phosphatidylcholines in serum and small intestinal mucosa during development of intestinal polyp formation in Min mice
    • 10.1111/j.1349-7006.2010.01754.x 1:CAS:528:DC%2BC3MXhslKns7Y%3D
    • K Ikeda M Mutoh N Teraoka H Nakanishi K Wakabayashi R Taguchi 2011 Increase of oxidant-related triglycerides and phosphatidylcholines in serum and small intestinal mucosa during development of intestinal polyp formation in Min mice Cancer Sci 102 79 87 10.1111/j.1349-7006.2010.01754.x 1:CAS:528: DC%2BC3MXhslKns7Y%3D
    • (2011) Cancer Sci , vol.102 , pp. 79-87
    • Ikeda, K.1    Mutoh, M.2    Teraoka, N.3    Nakanishi, H.4    Wakabayashi, K.5    Taguchi, R.6
  • 18
    • 19044385595 scopus 로고    scopus 로고
    • Cystathionine β synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver
    • DOI 10.1053/j.gastro.2005.02.034, PII S0016508505003252
    • K Robert J Nehme E Bourdon G Pivert B Friguet C Delcayre JM Delabar N Janel 2005 Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver Gastroenterology 128 1405 1415 10.1053/j.gastro.2005.02.034 1:CAS:528:DC%2BD2MXlt1CisL4%3D (Pubitemid 40712189)
    • (2005) Gastroenterology , vol.128 , Issue.5 , pp. 1405-1415
    • Robert, K.1    Nehme, J.2    Bourdon, E.3    Pivert, G.4    Friguet, B.5    Delcayre, C.6    Delabar, J.7    Janel, N.8
  • 20
    • 77954575279 scopus 로고    scopus 로고
    • Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
    • 10.1074/jbc.M110.108514 1:CAS:528:DC%2BC3cXos1Wnt74%3D
    • RL Jacobs Y Zhao DP Koonen T Sletten B Su S Lingrell G Cao DA Peake MS Kuo SD Proctor BP Kennedy JR Dyck DE Vance 2010 Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity J Biol Chem 285 22403 22413 10.1074/jbc.M110.108514 1:CAS:528:DC%2BC3cXos1Wnt74%3D
    • (2010) J Biol Chem , vol.285 , pp. 22403-22413
    • Jacobs, R.L.1    Zhao, Y.2    Koonen, D.P.3    Sletten, T.4    Su, B.5    Lingrell, S.6    Cao, G.7    Peake, D.A.8    Kuo, M.S.9    Proctor, S.D.10    Kennedy, B.P.11    Dyck, J.R.12    Vance, D.E.13
  • 21
    • 67651162183 scopus 로고    scopus 로고
    • Global analysis of triacylglycerols including oxidized molecular species by reverse-phase high resolution LC/ESI-QTOF MS/MS
    • 10.1016/j.jchromb.2009.03.047 1:CAS:528:DC%2BD1MXpt1Kis7s%3D
    • K Ikeda Y Oike T Shimizu R Taguchi 2009 Global analysis of triacylglycerols including oxidized molecular species by reverse-phase high resolution LC/ESI-QTOF MS/MS J Chromatogr B Analyt Technol Biomed Life Sci 877 2639 2647 10.1016/j.jchromb.2009.03.047 1:CAS:528:DC%2BD1MXpt1Kis7s%3D
    • (2009) J Chromatogr B Analyt Technol Biomed Life Sci , vol.877 , pp. 2639-2647
    • Ikeda, K.1    Oike, Y.2    Shimizu, T.3    Taguchi, R.4
  • 22
    • 77953361129 scopus 로고    scopus 로고
    • Precise and global identification of phospholipid molecular species by an Orbitrap mass spectrometer and automated search engine Lipid Search
    • 10.1016/j.chroma.2010.04.034 1:CAS:528:DC%2BC3cXmvVWisrs%3D
    • R Taguchi M Ishikawa 2010 Precise and global identification of phospholipid molecular species by an Orbitrap mass spectrometer and automated search engine Lipid Search J Chromatogr A 1217 4229 4239 10.1016/j.chroma.2010. 04.034 1:CAS:528:DC%2BC3cXmvVWisrs%3D
    • (2010) J Chromatogr A , vol.1217 , pp. 4229-4239
    • Taguchi, R.1    Ishikawa, M.2
  • 23
    • 3142729014 scopus 로고    scopus 로고
    • Sulfur amino acid metabolism: Pathways for production and removal of homocysteine and cysteine
    • DOI 10.1146/annurev.nutr.24.012003.132418
    • MH Stipanuk 2004 Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine Annu Rev Nutr 24 539 577 10.1146/annurev.nutr.24.012003.132418 1:CAS:528:DC%2BD2cXlvFKksLo%3D (Pubitemid 38938803)
    • (2004) Annual Review of Nutrition , vol.24 , pp. 539-577
    • Stipanuk, M.H.1
  • 24
    • 33745209659 scopus 로고    scopus 로고
    • Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption
    • 10.1074/jbc.M601876200 1:CAS:528:DC%2BD28XlsV2ltLo%3D
    • T Soga R Baran M Suematsu Y Ueno S Ikeda T Sakurakawa Y Kakazu T Ishikawa M Robert T Nishioka M Tomita 2006 Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption J Biol Chem 281 16768 16776 10.1074/jbc.M601876200 1:CAS:528: DC%2BD28XlsV2ltLo%3D
    • (2006) J Biol Chem , vol.281 , pp. 16768-16776
    • Soga, T.1    Baran, R.2    Suematsu, M.3    Ueno, Y.4    Ikeda, S.5    Sakurakawa, T.6    Kakazu, Y.7    Ishikawa, T.8    Robert, M.9    Nishioka, T.10    Tomita, M.11
  • 26
    • 0036322745 scopus 로고    scopus 로고
    • In the cystathionine β-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific
    • SF Choumenkovitch J Selhub PJ Bagley N Maeda MR Nadeau DE Smith SW Choi 2002 In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific J Nutr 132 2157 2160 1:CAS:528:DC%2BD38XmtF2qsLc%3D (Pubitemid 34851643)
    • (2002) Journal of Nutrition , vol.132 , Issue.8 , pp. 2157-2160
    • Choumenkovitch, S.F.1    Selhub, J.2    Bagley, P.J.3    Maeda, N.4    Nadeau, M.R.5    Smith, D.E.6    Choi, S.-W.7
  • 27
    • 0033569752 scopus 로고    scopus 로고
    • Molecular distinction of phosphatidylcholine synthesis between the CDP- choline pathway and phosphatidylethanolamine methylation pathway
    • DOI 10.1074/jbc.274.42.29683
    • CJ DeLong YJ Shen MJ Thomas Z Cui 1999 Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway J Biol Chem 274 29683 29688 10.1074/jbc.274.42.29683 1:CAS:528:DyaK1MXmvVajsro%3D (Pubitemid 29483336)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.42 , pp. 29683-29688
    • DeLong, C.J.1    Shen, Y.-J.2    Thomas, M.J.3    Cui, Z.4
  • 28
    • 2142851264 scopus 로고    scopus 로고
    • Lysophospholipid receptors: Signaling and biology
    • DOI 10.1146/annurev.biochem.73.011303.073731
    • I Ishii N Fukushima X Ye J Chun 2004 Lysophospholipid receptors: signaling and biology Annu Rev Biochem 73 321 354 10.1146/annurev.biochem.73. 011303.073731 1:CAS:528:DC%2BD2cXmslags7g%3D (Pubitemid 39050372)
    • (2004) Annual Review of Biochemistry , vol.73 , pp. 321-354
    • Ishii, I.1    Fukushima, N.2    Ye, X.3    Chun, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.