Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis

FASEB Journal

Volumn 26, Issue 7, 2012, Pages 3065-3074

  Mutoh, Tatsuro ^a   Kawamura, Naoki ^a   Hirabayashi, Yoshio ^b   Shima, Sayuri ^a   Miyashita, Tadayuki ^a   Ito, Shinji ^a   Asakura, Kunihiko ^a   Araki, Wataru ^c   Cazzaniga, Emanuela ^d   Muto, Eri ^a   Masserini, Massimo ^d  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Alzheimer's disease; Gangliosides; Glucosylceramide; Glucosylceramide synthase

Indexed keywords

CERAMIDE GLUCOSYLTRANSFERASE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GANGLIOSIDE; GLUCOSYLCERAMIDE; GLYCOSPHINGOLIPID; MUTANT PROTEIN; PRESENILIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; DATA ANALYSIS; ENZYME INHIBITION; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; IN VIVO STUDY; LIPOGENESIS; MEDICAL RECORD; MOLECULAR INTERACTION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BASE SEQUENCE; BRAIN; CARBAMATES; CELL LINE; DIPEPTIDES; DNA PRIMERS; ENZYME INHIBITORS; GLUCOSYLTRANSFERASES; GLYCOSPHINGOLIPIDS; HUMANS; MICE; MICE, TRANSGENIC; MUTANT PROTEINS; MUTATION; PRESENILIN-1; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSFECTION;

ANIMALIA;

EID: 84863219371     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-198630     Document Type: Article

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