Presenilin 1 modifies lipid raft composition of neuronal membranes

Biochemical and Biophysical Research Communications

Volumn 382, Issue 4, 2009, Pages 673-677

  Eckert, Gunter P ^a   Müller, Walter E ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Secretase; Alzheimer; Amyloid precursor protein; Cholesterol; Fluidity; Lipid raft; Membrane; Membrane micro domain; Presenilin

Indexed keywords

AMYLOID BETA PROTEIN; CHOLESTEROL; GAMMA SECRETASE; MEMBRANE PROTEIN; PRESENILIN 1; SPHINGOMYELIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN MEMBRANE; CELL MEMBRANE FLUIDITY; CONTROLLED STUDY; LIPID COMPOSITION; LIPID RAFT; MOUSE; NERVE CELL MEMBRANE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN MODIFICATION; TRANSGENE;

ANIMALS; BRAIN; HUMANS; MEMBRANE MICRODOMAINS; MICE; MICE, TRANSGENIC; NEURONS; PRESENILIN-1;

MUS;

EID: 64749094500     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.03.070     Document Type: Article

References (31)

1. Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 430 (2004) 631-639
2. Takashima A., Shimojo M., and Wolozin B. The players on the gamma-secretase team. Nat. Med. 12 (2006) 766-767
3. Steiner H., Fluhrer R., and Haass C. Intramembrane proteolysis by gamma-secretase. J. Biol. Chem. 283 (2008) 29627-29631
4. Gamerdinger M., Clement A.B., and Behl C. Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase. Neuropharmacology 54 (2008) 998-1005
5. Sawamura N., Ko M., Yu W., Zou K., Hanada K., Suzuki T., Gong J.S., Yanagisawa K., and Michikawa M. Modulation of amyloid precursor protein cleavage by cellular sphingolipids. J. Biol. Chem. 279 (2004) 11984-11991
6. Wada S., Morishima-Kawashima M., Qi Y., Misono H., Shimada Y., Ohno-Iwashita Y., and Ihara Y. Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry 42 (2003) 13977-13986
7. Wahrle S., Das P., Nyborg A.C., McLendon C., Shoji M., Kawarabayashi T., Younkin L.H., Younkin S.G., and Golde T.E. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol. Dis. 9 (2002) 11-23
8. Ehehalt R., Keller P., Haass C., Thiele C., and Simons K. Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J. Cell Biol. 160 (2003) 113-123
9. Cordy J.M., Hooper N.M., and Turner A.J. The involvement of lipid rafts in Alzheimer's disease. Mol. Membr. Biol. 23 (2006) 111-122
10. Korade Z., and Kenworthy A.K. Lipid rafts, cholesterol, and the brain. Neuropharmacology 55 (2008) 1265-1273
11. Vereb G., Szollosi J., Matko J., Nagy P., Farkas T., Vigh L., Matyus L., Waldmann T.A., and Damjanovich S. Dynamic, yet structured: the cell membrane three decades after the Singer-Nicolson model. Proc. Nat. Acad. Sci. USA 100 (2003) 8053-8058
12. Grimm M.O.W., Tschape J.A., Grimm H.S., Zinser E.G., and Hartmann T. Altered membrane fluidity and lipid raft composition in presenilin-deficient cells. Acta Neurol. Scand. 114 (2006) 27-32
13. I. Peters, U. Igbabvoa, T. Schütt, S. Haidari, U. Hartig, S. Böttner, E. Copanaki, T. Deller, D. Kögel, W.G. Wood, W.E. Müller, G.P. Eckert, The interaction of beta amyloid peptide with cellular membranes stimulates its own production, BBA-Biomembranes, in press, doi:10.1016/j.bbamem.2009.01.012.
14. Schuessel K., Frey C., Jourdan C., Keil U., Weber C.C., Müller-Spahn F., Müller W.E., and Eckert A. Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice. Free Radic. Biol. Med. 40 (2006) 850-862
15. Eckert G.P., Wood W.G., and Müller W.E. Effects of aging and beta-amyloid on the properties of brain synaptic and mitochondrial membranes. J. Neural. Transm. 108 (2001) 1051-1064
16. Eckert G.P., Igbavboa U., Müller W.E., and Wood W.G. Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains. Brain Res. 962 (2003) 144-150
17. Mattson M.P., Cutler R.G., and Jo D.G. Alzheimer peptides perturb lipid-regulating enzymes. Nat. Cell Biol. 7 (2005) 1045-1047
18. Suzuki H., Park S.J., Tamura M., and Ando S. Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: a comparison of sardine oil diet with palm oil diet. Mech. Ageing Dev. 101 (1998) 119-128
19. Green K.N., Martinez-Coria H., Khashwji H., Hall E.B., Yurko-Mauro K.A., Ellis L., and LaFerla F.M. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J. Neurosci. 27 (2007) 4385-4395
20. Runz H., Rietdorf J., Tomic I., de Bernard M., Beyreuther K., Pepperkok R., and Hartmann T. Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J. Neurosci. 22 (2002) 1679-1689
21. Grimm M.O., Grimm H.S., Patzold A.J., Zinser E.G., Halonen R., Duering M., Tschape J.A., De Strooper B., Muller U., Shen J., and Hartmann T. Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat. Cell Biol. 7 (2005) 1118-1123
22. Burns M., Gaynor K., Olm V., Mercken M., LaFrancois J., Wang L., Mathews P.M., Noble W., Matsuoka Y., and Duff K. Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. J. Neurosci. 23 (2003) 5645-5649
23. Cutler R.G., Kelly J., Storie K., Pedersen W.A., Tammara A., Hatanpaa K., Troncoso J.C., and Mattson M.P. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc. Natl. Acad. Sci. USA 101 (2004) 2070-2075
24. Adams J.U. Lipid rafts' failure to launch. Scientist 20 (2006) 67
25. Douglass A.D., and Vale R.D. Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell 121 (2005) 937-950
26. Hur J.Y., Welander H., Behbahani H., Aoki M., Franberg J., Winblad B., Frykman S., and Tjernberg L.O. Active gamma-secretase is localized to detergent-resistant membranes in human brain. FEBS J. 275 (2008) 1174-1187
27. Chen T.Y., Liu P.H., Ruan C.T., Chiu L., and Kung F.L. The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein. Biochem. Biophys. Res. Commun. 342 (2006) 266-272
28. Nizzari M., Venezia V., Bianchini P., Caorsi V., Diaspro A., Repetto E., Thellung S., Corsaro A., Carlo P., Schettini G., Florio T., and Russo C. Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells. Ann. N.Y. Acad. Sci. 1096 (2007) 249-257
29. Schneider A., Rajendran L., Honsho M., Gralle M., Donnert G., Wouters F., Hell S.W., and Simons M. Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons. J. Neurosci. 28 (2008) 2874-2882
30. Vetrivel K.S., Cheng H., Kim S.H., Chen Y., Barnes N.Y., Parent A.T., Sisodia S.S., and Thinakaran G. Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 (2005) 25892-25900
31. Berezovska O., Lleo A., Herl L.D., Frosch M.P., Stern E.A., Bacskai B.J., and Hyman B.T. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J. Neurosci. 25 (2005) 3009-3017