Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 34, 2012, Pages 13632-13637

  Artemenko, Yulia ^a   Batsios, Petros ^b   Borleis, Jane ^a   Gagnon, Zachary ^a   Lee, Josephine ^a   Rohlfs, Meino ^b   Sanséau, Doriane ^a   Willard, Stacey S ^a   Schleicher, Michael ^b   Devreotes, Peter N ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; HIPPO PROTEIN; MEMBRANE PROTEIN; MST1 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KRSA; PROTEIN KRSB; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL AGGREGATION; CELL GROWTH; CELL MIGRATION; CELL MOTION; CELL SPREADING; CELL STRUCTURE; CHEMOTAXIS; DICTYOSTELIUM DISCOIDEUM; ENZYME ACTIVATION; ENZYME SUBSTRATE; IMMUNOBLOTTING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SOUTHERN BLOTTING;

ANIMALS; CELL ADHESION; CELL MOVEMENT; CHEMOTAXIS; DICTYOSTELIUM; DIMERIZATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GREEN FLUORESCENT PROTEINS; HEPATOCYTE GROWTH FACTOR; HUMANS; NERVE TISSUE PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTOZOAN PROTEINS; THREONINE;

EID: 84865302970     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1211304109     Document Type: Article

References (36)

1. Funamoto S, Meili R, Lee S, Parry L, Firtel RA (2002) Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109:611-623.
2. Iijima M, Devreotes PN (2002) Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109:599-610.
3. Huang YE, et al. (2003) Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell 14:1913-1922.
4. Parent CA, Blacklock BJ, Froehlich WM, Murphy DB, Devreotes PN (1998) G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95:81-91.
5. Meili R, et al. (1999) Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J 18:2092-2105.
6. Funamoto S, Milan K, Meili R, Firtel RA (2001) Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium. J Cell Biol 153:795-810.
7. Lee S, et al. (2005) TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell 16:4572-4583.
8. Kamimura Y, et al. (2008) PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol 18:1034-1043.
9. Bosgraaf L, et al. (2002) A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium. EMBO J 21:4560-4570.
10. Gebbie L, et al. (2004) Phg2, a kinase involved in adhesion and focal site modeling in Dictyostelium. Mol Biol Cell 15:3915-3925.
11. Jeon TJ, Lee D-J, Merlot S, Weeks G, Firtel RA (2007) Rap1 controls cell adhesion and cell motility through the regulation of myosin II. J Cell Biol 176:1021-1033.
12. Swaney KF, Huang CH, Devreotes PN (2010) Eukaryotic chemotaxis: A network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys 39:265-289.
13. Wu S, Huang J, Dong J, Pan D (2003) hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114:445-456.
14. Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G (2003) Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 5: 914-920.
15. Harvey KF, Pfleger CM, Hariharan IK (2003) The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114:457-467.
16. Jia J, Zhang W, Wang B, Trinko R, Jiang J (2003) The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev 17:2514-2519.
17. Pantalacci S, Tapon N, Léopold P (2003) The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol 5:921-927.
18. Zhou D, et al. (2009) Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16:425-438.
19. Lu L, et al. (2010) Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci USA 107:1437-1442.
20. Song H, et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci USA 107:1431-1436.
21. Dan I, Watanabe NM, Kusumi A (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol 11:220-230.
22. Huang J, Wu S, Barrera J, Matthews K, Pan D (2005) The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122:421-434.
23. Dong J, et al. (2007) Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130:1120-1133.
24. Katagiri K, ImamuraM, Kinashi T (2006) Spatiotemporal regulation of the kinaseMst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat Immunol 7:919-928.
25. Dong Y, et al. (2009) A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol 183:3865-3872.
26. Katagiri K, et al. (2009) Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J 28:1319-1331.
27. Lee K-K, Ohyama T, Yajima N, Tsubuki S, Yonehara S (2001) MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J Biol Chem 276:19276-19285.
28. Glantschnig H, Rodan GA, Reszka AA (2002) Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation. J Biol Chem 277:42987-42996.
29. Parent CA, Devreotes PN (1996) Molecular genetics of signal transduction in Dictyostelium. Annu Rev Biochem 65:411-440.
30. Kortholt A, et al. (2011) Dictyostelium chemotaxis: Essential Ras activation and accessory signalling pathways for amplification. EMBO Rep 12:1273-1279.
31. Arasada R, et al. (2006) Characterization of the Ste20-like kinase Krs1 of Dictyostelium discoideum. Eur J Cell Biol 85:1059-1068.
32. Muramoto T, Kuwayama H, Kobayashi K, Urushihara H (2007) A stress response kinase, KrsA, controls cAMP relay during the early development of Dictyostelium discoideum. Dev Biol 305:77-89.
33. Fey P, Stephens S, Titus MA, Chisholm RL (2002) SadA, a novel adhesion receptor in Dictyostelium. J Cell Biol 159:1109-1119.
34. Cornillon S, et al. (2006) An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features. EMBO Rep 7:617-621.
35. Koenderman L, van der Linden JA, Honing H, Ulfman LH (2010) Integrins on neutrophils are dispensable for migration into three-dimensional fibrin gels. Thromb Haemost 104:599-608.
36. Jannat RA, Robbins GP, Ricart BG, Dembo M, Hammer DA (2010) Neutrophil adhesion and chemotaxis depend on substrate mechanics. J Phys Condens Matter 22:194117.