Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes

EMBO Journal

Volumn 28, Issue 9, 2009, Pages 1319-1331

  Katagiri, Koko ^a   Katakai, Tomoya ^a   Ebisuno, Yukihiko ^a   Ueda, Yoshihiro ^a   Okada, Takaharu ^b,c   Kinashi, Tatsuo ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c RIKEN Center for Integrative Medical Sciences   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; L SELECTIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MST1 PROTEIN; PROTEIN KINASE; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1; TALIN; UNCLASSIFIED DRUG; MACROPHAGE STIMULATING PROTEIN; ONCOPROTEIN; SCATTER FACTOR;

ADOPTIVE TRANSFER; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; GENE TARGETING; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOSURVEILLANCE; LEUKOCYTE ADHERENCE; LYMPH NODE; LYMPHOCYTE HOMING; LYMPHOCYTE MIGRATION; LYMPHOID ORGAN; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; THYMOCYTE; THYMUS; ANIMAL; C57BL MOUSE; CELL ADHESION; CELL CULTURE; CELL LINE; CELL MOTION; CYTOLOGY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IN VITRO STUDY; LYMPHOCYTE; LYMPHOID TISSUE; METABOLISM; PHYSIOLOGY; STROMA CELL; T LYMPHOCYTE;

MUS;

ANIMALS; B-LYMPHOCYTES; CELL ADHESION; CELL LINE; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINE CCL21; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HEPATOCYTE GROWTH FACTOR; IMMUNOBLOTTING; LYMPH NODES; LYMPHOCYTES; LYMPHOID TISSUE; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS; SPLEEN; STROMAL CELLS; T-LYMPHOCYTES;

EID: 65649126736     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2009.82     Document Type: Article

References (58)

1. Alon R, Feigelson S (2002) From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts. Semin Immunol 14: 93-104
2. Bajenoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N, Germain RN (2006) Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25: 989-1001
3. Bergmeier W, Goerge T, Wang HW, Crittenden JR, Baldwin AC, Cifuni SM, Housman DE, Graybiel AM, Wagner DD (2007) Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J Clin Invest 117: 1699-1707
4. Bos JL, de Rooij J, Reedquist KA (2001) Rap1 signaling: adhering to new models. Nat Rev 2: 369-377
5. Bousso P, Robey E (2003) Dynamics of CD8 + T cell priming by dendritic cells in intact lymph nodes. Nat Immunol 4: 579-585
6. Butcher EC, Williams M, Youngman K, Rott L, Briskin M (1999) Lymphocyte trafficking and regional immunity. Advan Immunol 72: 209-253
7. Carman CV, Springer TA (2003) Integrin avidity regulation: are changes in affinity and conformation underemphasized? Curr Opin Cell Biol 15: 547-556
8. Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA, Beeser A, Etkin LD, Chernoff J, Earnshaw WC, Allis CD (2003) Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113: 507-517
9. Creasy CL, Chernoff J (1995) Cloning and characterization of a human protein kinase with homology to Ste20. J Biol Chem 270: 21695-21700
10. Crittenden JR, Bergmeier W, Zhang Y, Piffath CL, Liang Y, Wagner DD, Housman DE, Graybiel AM (2004) CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med 10: 982-986
11. De Smedt T, Pajak B, Muraille E, Lespagnard L, Heinen E, De Baetselier P, Urbain J, Leo O, Moser M (1996) Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J Exp Med 184: 1413-1424
12. Finger EB, Puri KD, Alon R, Lawrence MB, von Andrian UH, Springer TA (1996) Adhesion through L-selectin requires a threshold hydrodynamic shear. Nature 379: 266-269
13. Foger N, Rangell L, Danilenko DM, Chan AC (2006) Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science 313: 839-842
14. Fukui Y, Hashimoto O, Sanui T, Oono T, Koga H, Abe M, Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T (2001) Haematopoietic
15. cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 412: 826-831
16. Gerard A, Mertens AE, van der Kammen RA, Collard JG (2007) The Par polarity complex regulates Rap1- and chemokine-induced Tcell polarization. J Cell Biol 176: 863-875
17. Ghandour H, Cullere X, Alvarez A, Luscinskas FW, Mayadas TN (2007) Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood 110: 3682-3690
18. Han SB, Moratz C, Huang NN, Kelsall B, Cho H, Shi CS, Schwartz O, Kehrl JH (2005) Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles. Immunity 22: 343-354
19. Kanemitsu N, Ebisuno Y, Tanaka T, Otani K, Hayasaka H, Kaisho T, Akira S, Katagiri K, Kinashi T, Fujita N, Tsuruo T, Miyasaka M (2005) CXCL13 is an arrest chemokine for B cells in high endothelial venules. Blood 106: 2613-2618
20. Katagiri K, Hattori M, Minato N, Irie S, Takatsu K, Kinashi T (2000) Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidy-linositol-3-kinase. Mol Cell Biol 20: 1956-1969
21. Katagiri K, Imamura M, Kinashi T (2006) Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion. Nat Immunol 7: 919-928
22. Katagiri K, Maeda A, Shimonaka M, Kinashi T (2003) RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol 4: 741-748
23. Katagiri K, Ohnishi N, Kabashima K, Iyoda T, Takeda N, Shinkai Y, Inaba K, Kinashi T (2004) Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol 5: 1045-1051
24. Katakai T, Hara T, Sugai M, Gonda H, Shimizu A (2004) Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med 200: 783-795
25. Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Suematsu S, Ebisuno Y Katagiri K, Kinashi T, Shimizu A (2008) Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol 181: 6189-6200
26. Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J (2002) Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol 12: 253-265
27. Kim M, Carman CV, Springer TA (2003) Bidirectional transmem-brane signaling by cytoplasmic domain separation in integrins. Science 301: 1720-1725
28. Kimura N, Mitsuoka C, Kanamori A, Hiraiwa N, Uchimura K, Muramatsu T, Tamatani T, Kansas GS, Kannagi R (1999) Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotrans-ferase cDNA. Proc Natl Acad Sci USA 96: 4530-4535
29. Kinashi T (2005) Intracellular signalling controlling integrin activation in lymphocytes. Nat Rev Immunol 5: 546-559
30. Lammermann T, Bader BL, Monkley SJ, Worbs T, Wedlich-Soldner R, Hirsch K, Keller M, Forster R, Critchley DR, Fassler R, Sixt M (2008) Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 453: 51-55
31. Laudanna C, Kim JY, Constantin G, Butcher E (2002) Rapid leukocyte integrin activation by chemokines. Immunol Rev 186: 37-46
32. Lauffenburger DA, Horwitz AF (1996) Cell migration: a physically integrated molecular process. Cell 84: 359-369
33. Lo CG, Lu TT, Cyster JG (2003) Integrin-dependence of lymphocyte entry into the splenic white pulp. J Exp Med 197: 353-361
34. Lu TT, Cyster JG (2002) Integrin-mediated long-term B cell retention in the splenic marginal zone. Science 297: 409-412
35. Macatonia SE, Knight SC, Edwards AJ, Griffiths S, Fryer P (1987) Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies. J Exp Med 166: 1654-1667
36. Martin F, Kearney JF (2002) Marginal-zone B cells. Nat Rev Immunol 2: 323-335
37. Mempel TR, Henrickson SE, Von Andrian UH (2004) T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427: 154-159
38. Metlay JP, Witmer-Pack MD, Agger R, Crowley MT, Lawless D, Steinman RM (1990) The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med 171: 1753-1771
39. Miller MJ, Wei SH, Parker I, Cahalan MD (2002) Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296: 1869-1873
40. Morin NA, Oakes PW, Hyun YM, Lee D, Chin YE, King MR, Springer TA, Shimaoka M, Tang JX, Reichner JS, Kim M (2008) Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. J Exp Med 205: 195-205
41. Nombela-Arrieta C, Lacalle RA, Montoya MC, Kunisaki Y, Megias D, Marques M, Carrera AC, Manes S, Fukui Y, Martinez AC, Stein JV (2004) Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing. Immunity 21: 429-441
42. Nombela-Arrieta C, Mempel TR, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martinez AC, Fukui Y, von Andrian UH, Stein JV (2007) A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med 204: 497-510
43. Okada T, Cyster JG (2007) CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J Immunol 178: 2973-2978
44. Pasvolsky R, Feigelson SW, Kilic SS, Simon AJ, Tal-Lapidot G, Grabovsky V, Crittenden JR, Amariglio N, Safran M, Graybiel AM, Rechavi G, Ben-Dor S, Etzioni A, Alon R (2007) A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets. J Exp Med 204: 1571-1582
45. Pribila JT, Itano AA, Mueller KL, Shimizu Y (2004) The alpha 1 beta 1 and alpha E beta 7 integrins define a subset of dendritic cells in peripheral lymph nodes with unique adhesive and antigen uptake properties. J Immunol 172: 282-291
46. Sakata D, Taniguchi H, Yasuda S, Adachi-Morishima A, Hamazaki Y, Nakayama R, Miki T, Minato N, Narumiya S (2007) Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. J Exp Med 204: 2031-2038
47. Sanchez-Madrid F, del Pozo MA (1999) Leukocyte polarization in cell migration and immune interactions. Eur Mol Biol Org J 18: 501-511
48. Schmits R, Kundig TM, Baker DM, Shumaker G, Simard JJ, Duncan G, Wakeham A, Shahinian A, van der Heiden A, Bachmann MF, Ohashi PS, Mak TW, Hickstein DD (1996) LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J Exp Med 183: 1415-1426
49. Shamri R, Grabovsky V, Gauguet JM, Feigelson S, Manevich E, Kolanus W, Robinson MK, Staunton DE, von Andrian UH, Alon R (2005) Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. Nat Immunol 6: 497-506
50. Shimonaka M, Katagiri K, Nakayama T, Fujita N, Tsuruo T, Yoshie O, Kinashi T (2003) Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. J Cell Biol 161: 417-427
51. Smith A, Bracke M, Leitinger B, Porter JC, Hogg N (2003) LFA-1-induced Tcell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment. J Cell Sci 116: 3123-3133
52. Stachowiak AN, Wang Y, Huang YC, Irvine DJ (2006) Homeostatic lymphoid chemokines synergize with adhesion ligands to trigger T and B lymphocyte chemokinesis. J Immunol 177: 2340-2348
53. Stoll S, Delon J, Brotz TM, Germain RN (2002) Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296: 1873-1876
54. Sumen C, Mempel TR, Mazo IB, von Andrian UH (2004) Intravital microscopy: visualizing immunity in context. Immunity 21: 315-329
55. Tadokoro S, Shattil SJ, Eto K, Tai V Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA (2003) Talin binding to integrin beta tails: a final common step in integrin activation. Science 302: 103-106
56. von Andrian UH, Mempel TR (2003) Homing and cellular traffic in lymph nodes. Nat Rev Immunol 3: 867-878
57. Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson SW, Shulman Z, Hartmann T, Sixt M, Cyster JG, Alon R (2007) Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol 8: 1076-1085
58. Zeng Q, Hong W (2008) The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell 13: 188-192