Inhibition of NF-κB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO

Protein Science

Volumn 16, Issue 9, 2007, Pages 2013-2022

  Wyler, Emanuel ^a,b   Kaminska, Monika ^a   Coïc, Yves Marie ^a   Baleux, Françoise ^a   Véron, Michel ^a   Agou, Fabrice ^a  

^a CNRS   (France)

^b ETH ZURICH   (Switzerland)

Author keywords

IKK complex; NEMO; NF B pathway; Protein evolution; Ribosome display

Indexed keywords

ANKYRIN; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; POLYPEPTIDE; POLYUBIQUITIN; PROTEIN INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN; BETA GALACTOSIDASE; COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; I KAPPA B KINASE; IKBKG PROTEIN, HUMAN; LUCIFERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOTINYLATION; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TARGETING; RIBOSOME; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; ESCHERICHIA COLI; GENETIC TRANSFECTION; GENETICS; HUMAN; KIDNEY; METABOLISM; PLASMID; PROTEIN TERTIARY STRUCTURE; REPORTER GENE;

ANKYRIN REPEAT; BETA-GALACTOSIDASE; CELL LINE; DNA, COMPLEMENTARY; ESCHERICHIA COLI; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; I-KAPPA B KINASE; KIDNEY; LUCIFERASES; MODELS, MOLECULAR; NF-KAPPA B; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN;

EID: 34548445097     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.072924907     Document Type: Article

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