TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 29114-29124

  Maruyama, Kenta ^a   Kawagoe, Tatsukata ^a   Kondo, Takeshi ^a,b   Akira, Shizuo ^a,b   Takeuchi, Osamu ^a,c  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE FORMATION; BONE MARROW CELLS; BONE NODULES; BONE REMODELING; CORTICAL BONE; EXPRESSION LEVELS; IN-VITRO; MRNA EXPRESSION; NEGATIVE REGULATORS; OSTEOBLAST DIFFERENTIATION; OSTEOCLAST DIFFERENTIATION; OSTEOCLAST FORMATION; OSTEOCLASTOGENESIS; OVER-EXPRESSION; TOLL-LIKE RECEPTORS; TRABECULAR BONES; UBIQUITINATION; WILD TYPES; WILD-TYPE CONTROLS;

BONE; CELL MEMBRANES; CHEMICAL ACTIVATION; MAMMALS; OSTEOBLASTS;

TANKS (CONTAINERS);

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 11; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; REGULATOR PROTEIN; TRAF FAMILY MEMBER ASSOCIATED NF KAPPA B ACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DENSITY; BONE EROSION; BONE REMODELING; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HEMATOPOIETIC CELL; IN VITRO STUDY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BONE DENSITY; CELL DIFFERENTIATION; INTERLEUKIN-11; INTERLEUKIN-6; MICE; MICE, KNOCKOUT; NF-KAPPA B; OSTEOCLASTS; OSTEOGENESIS; RANK LIGAND; RNA, MESSENGER; TNF RECEPTOR-ASSOCIATED FACTOR 6; UBIQUITINATION;

EID: 84865268664     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.347799     Document Type: Article

References (33)

1. Karsenty, G., and Wagner, E. F. (2002) Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2, 389-406 (Pubitemid 34436569)
2. Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J., Wagner, E. F., Mak, T. W., Kodama, T., and Taniguchi, T. (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889-901 (Pubitemid 35460788)
3. Grigoriadis, A. E., Wang, Z. Q., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., and Wagner, E. F. (1994) c-Fos: a key regulator of osteoclastmacrophage lineage determination and bone remodeling. Science 266, 443-448
4. Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F., and Siebenlist, U. (1997) Requirement for NF-κB in osteoclast and B-cell development. Genes Dev. 11, 3482-3496 (Pubitemid 28023969)
5. Yamashita, T., Yao, Z., Li, F., Zhang, Q., Badell, I. R., Schwarz, E. M., Takeshita, S., Wagner, E. F., Noda, M., Matsuo, K., Xing, L., and Boyce, B. F. (2007) NF-κB p50 and p52 regulate receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J. Biol. Chem. 282, 18245-18253 (Pubitemid 47100255)
6. Yagi, M., Miyamoto, T., Sawatani, Y., Iwamoto, K., Hosogane, N., Fujita, N., Morita, K., Ninomiya, K., Suzuki, T., Miyamoto, K., Oike, Y., Takeya, M., Toyama, Y., and Suda, T. (2005) DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J. Exp. Med. 202, 345-351 (Pubitemid 41126951)
7. Yagi, M., Ninomiya, K., Fujita, N., Suzuki, T., Iwasaki, R., Morita, K., Hosogane, N., Matsuo, K., Toyama, Y., Suda, T., and Miyamoto, T. (2007) Induction of DC-STAMP by alternative activation and downstream signaling mechanisms. J. Bone Miner Res. 22, 992-1001 (Pubitemid 351339721)
8. Iotsova, V., Caamaño, J., Loy, J., Yang, Y., Lewin, A., and Bravo, R. (1997) Osteopetrosis in mice lacking NF-κB1 and NF-κB2. Nat. Med. 3, 1285-1289
9. Leibbrandt, A., and Penninger, J. M. (2008) RANK/RANKL: regulators of immune responses and bone physiology. Ann. N.Y. Acad. Sci. 1143, 123-150
10. Naito, A., Azuma, S., Tanaka, S., Miyazaki, T., Takaki, S., Takatsu, K., Nakao, K., Nakamura, K., Katsuki, M., Yamamoto, T., and Inoue, J. (1999) Severe osteopetrosis, defective interleukin-1 signaling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4, 353-362 (Pubitemid 29359450)
11. Lomaga, M. A., Yeh, W. C., Sarosi, I., Duncan, G. S., Furlonger, C., Ho, A., Morony, S., Capparelli, C., Van, G., Kaufman, S., van der Heiden, A., Itie, A., Wakeham, A., Khoo, W., Sasaki, T., Cao, Z., Penninger, J. M., Paige, C. J., Lacey, D. L., Dunstan, C. R., Boyle, W. J., Goeddel, D. V., and Mak, T. W. (1999) TRAF6 deficiency results in osteopetrosis and defective in-terleukin- 1, CD40, and LPS signaling. Genes Dev. 13, 1015-1024 (Pubitemid 29200984)
12. Kobayashi, T., Walsh, P. T., Walsh, M. C., Speirs, K. M., Chiffoleau, E., King, C. G., Hancock, W. W., Caamano, J. H., Hunter, C. A., Scott, P., Turka, L. A., and Choi, Y. (2003) TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19, 353-363 (Pubitemid 37153412)
13. Akira, S., Uematsu, S., and Takeuchi, O. (2006) Pathogen recognition and innate immunity. Cell 124, 783-801 (Pubitemid 43261452)
14. Takeuchi, O., and Akira, S. (2010) Cell 140, 805-820
15. Cheng, G., and Baltimore, D. (1996) TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation. Genes Dev. 10, 963-973
16. Rothe, M., Xiong, J., Shu, H. B., Williamson, K., Goddard, A., and Goeddel, D. V. (1996) I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc. Natl. Acad. Sci. U.S.A. 93, 8241-8246 (Pubitemid 26269541)
17. Chin, A. I., Shu, J., Shan Shi, C., Yao, Z., Kehrl, J. H., and Cheng, G. (1999) TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway. Mol. Cell Biol. 19, 6665-6672 (Pubitemid 29441850)
18. Pomerantz, J. L., and Baltimore, D. (1999) NF-κB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase. EMBO J. 18, 6694-6704
19. Kawagoe, T., Takeuchi, O., Takabatake, Y., Kato, H., Isaka, Y., Tsujimura, T., and Akira, S. (2009) TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat. Immunol. 10, 965-972
20. Guo, B., and Cheng, G. (2007) Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. J. Biol. Chem. 282, 11817-11826 (Pubitemid 47100710)
21. Satoh, T., Kato, H., Kumagai, Y., Yoneyama, M., Sato, S., Matsushita, K., Tsujimura, T., Fujita, T., Akira, S., and Takeuchi, O. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 1512-1517
22. Taguchi, Y., Yamamoto, M., Yamate, T., Lin, S. C., Mocharla, H., DeTogni, P., Nakayama, N., Boyce, B. F., Abe, E., and Manolagas, S. C. (1998) Interleukin- 6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage. Proc. Assoc. Am. Physicians 110, 559-574 (Pubitemid 28516131)
23. Shinkura, R., Kitada, K., Matsuda, F., Tashiro, K., Ikuta, K., Suzuki, M., Kogishi, K., Serikawa, T., and Honjo, T. (1999) Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κB-inducing kinase. Nat. Genet. 22, 74-77 (Pubitemid 29214808)
24. Maruyama, T., Fukushima, H., Nakao, K., Shin, M., Yasuda, H., Weih, F., Doi, T., Aoki, K., Alles, N., Ohya, K., Hosokawa, R., and Jimi, E. (2010) J. Bone Miner Res. 25, 1058-1067
25. Li, H., Cuartas, E., Cui, W., Choi, Y., Crawford, T. D., Ke, H. Z., Kobayashi, K. S., Flavell, R. A., and Vignery, A. (2005) IL-1 receptor-associated kinase Mis a central regulator of osteoclast differentiation and activation. J. Exp. Med. 201, 1169-1177 (Pubitemid 40524683)
26. Takeshita, S., Namba, N., Zhao, J. J., Jiang, Y., Genant, H. K., Silva, M. J., Brodt, M. D., Helgason, C. D., Kalesnikoff, J., Rauh, M. J., Humphries, R. K., Krystal, G., Teitelbaum, S. L., and Ross, F. P. (2002) SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat. Med. 8, 943-949 (Pubitemid 35033697)
27. Jin, W., Chang, M., Paul, E. M., Babu, G., Lee, A. J., Reiley, W., Wright, A., Zhang, M., You, J., and Sun, S. C. (2008) Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J. Clin. Invest. 118, 1858-1866 (Pubitemid 351632388)
28. Harris, E. D., Jr. (1990) Rheumatoid arthritis. Pathophysiology and implications for therapy. N. Engl. J. Med. 322, 1277-1289
29. Roodman, G. D., and Windle, J. J. (2005) Paget disease of bone. J. Clin. Invest. 115, 200-208 (Pubitemid 40385458)
30. de Koning, H. D., Bodar, E. J., van der Meer, J. W., Simon, A., and Schnitzler Syndrome Study, G. (2007) Schnitzler syndrome: beyond the case reports: review and follow-up of 94 patients with an emphasis on prognosis and treatment. Semin. Arthritis Rheum. 37, 137-148 (Pubitemid 350151505)
31. Almerigogna, F., Giudizi, M. G., Cappelli, F., and Romagnani, S. (2002) Schnitzler's syndrome: what's new? J. Eur. Acad. Dermatol. Venereol 16, 214-219 (Pubitemid 34785316)
32. Feng, X., and McDonald, J. M. (2011) Annu. Rev. Pathol. 6, 121-145
33. Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y. H., Inada, M., Sato, M., Okamoto, R., Kitamura, Y., Yoshiki, S., and Kishimoto, T. (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764 (Pubitemid 27516178)