Induction of DC-STAMP by alternative activation and downstream signaling mechanisms

Journal of Bone and Mineral Research

Volumn 22, Issue 7, 2007, Pages 992-1001

  Yagi, Mitsuru ^a   Ninomiya, Ken ^a   Fujita, Nobuyuki ^a   Suzuki, Toru ^a   Iwasaki, Ryotaro ^a   Morita, Kozo ^a   Hosogane, Naobumi ^a   Matsuo, Koichi ^a   Toyama, Yoshiaki ^a   Suda, Toshio ^a   Miyamoto, Takeshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell cell fusion; DC STAMP; Macrophage giant cells; Osteoclasts; Transcriptional regulation

Indexed keywords

DENDRITIC CELL SPECIFIC TRANSMEMBRANE PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; MEMBRANE PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; TACROLIMUS; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG; DC STAMP PROTEIN, MOUSE; DC-STAMP PROTEIN, MOUSE; LIGAND; MESSENGER RNA; NERVE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CELL FUSION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DC STAMP GENE; GENE; GENE EXPRESSION REGULATION; GIANT CELL; MACROPHAGE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; OSTEOCLAST; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; TRANSCRIPTION REGULATION; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL FUSION; GENE EXPRESSION REGULATION; GIANT CELLS; HUMANS; INTERLEUKIN-4; LIGANDS; MACROPHAGES; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; PROTO-ONCOGENE PROTEINS C-FOS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 34548248999     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070401     Document Type: Article

References (31)

1. 1 Vignery A 2000 Osteoclasts and giant cells: Macrophage‐macrophage fusion mechanism. Int J Exp Pathol 81: 291–304.
2. 2 Anderson JM 2000 Multinucleated giant cells. Curr Opin Hematol 7: 40–47.
3. 3 Yagi M, Miyamoto T, Sawatani Y, Iwamoto K, Hosogane N, Fujita N, Morita K, Ninomiya K, Suzuki T, Miyamoto K, Oike Y, Takeya M, Toyama Y, Suda T 2005 DC‐STAMP is essential for cell‐cell fusion in osteoclasts and foreign body giant cells. J Exp Med 202: 345–351.
4. 4 Miyamoto T, Ohneda O, Arai F, Iwamoto K, Okada S, Takagi K, Anderson DM, Suda T 2001 Bifurcation of osteoclasts and dendritic cells from common progenitors. Blood 98: 2544–2554.
5. 5 Gohda J, Akiyama T, Koga T, Takayanagi H, Tanaka S, Inoue J 2005 RANK‐mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis. EMBO J 24: 790–799.
6. 6 Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T 2002 Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3: 889–901.
7. 7 Matsuo K, Galson DL, Zhao C, Peng L, Laplace C, Wang KZ, Bachler MA, Amano H, Aburatani H, Ishikawa H, Wagner EF 2004 Nuclear factor of activated T‐cells (NFAT) rescues osteoclastogenesis in precursors lacking c‐Fos. J Biol Chem 279: 26475–26480.
8. 8 Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, Brasel K, Miyata T, Anderson DM, Suda T 1999 Commitment and differentiation of osteoclast precursor cells by the sequential expression of c‐Fms and receptor activator of nuclear factor kappaB (RANK) receptors. J Exp Med 190: 1741–1754.
9. 9 Miyamoto T, Arai F, Ohneda O, Takagi K, Anderson DM, Suda T 2000 An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony‐stimulating factor and receptor activator of nuclear factor kappa B ligand. Blood 96: 4335–4343.
10. 10 Kao WJ, McNally AK, Hiltner A, Anderson JM 1995 Role for interleukin‐4 in foreign‐body giant cell formation on a poly(etherurethane urea) in vivo. J Biomed Mater Res 29: 1267–1275.
11. 11 McNally AK, Anderson JM 1995 Interleukin‐4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells. Am J Pathol 147: 1487–1499.
12. 12 Abu‐Amer Y 2001 IL‐4 abrogates osteoclastogenesis through STAT6‐dependent inhibition of NF‐kappaB. J Clin Invest 107: 1375–1385.
13. 13 Moreno JL, Kaczmarek M, Keegan AD, Tondravi M 2003 IL‐4 suppresses osteoclast development and mature osteoclast function by a STAT6‐dependent mechanism: Irreversible inhibition of the differentiation program activated by RANKL. Blood 102: 1078–1086.
14. 14 Kamel Mohamed SG, Sugiyama E, Shinoda K, Hounoki H, Taki H, Maruyama M, Miyahara T, Kobayashi M 2005 Interleukin‐4 inhibits RANKL‐induced expression of NFATc1 and c‐Fos: A possible mechanism for downregulation of osteoclastogenesis. Biochem Biophys Res Commun 329: 839–845.
15. 15 Dominguez‐Soto A, Puig‐Kroger A, Vega MA, Corbi AL 2005 PU.1 regulates the tissue‐specific expression of dendritic cell‐specific intercellular adhesion molecule (ICAM)‐3‐grabbing nonintegrin. J Biol Chem 280: 33123–33131.
16. 16 Monaco C, Paleolog E 2004 Nuclear factor kappaB: A potential therapeutic target in atherosclerosis and thrombosis. Cardiovasc Res 61: 671–682.
17. 17 Iwamoto K, Miyamoto T, Sawatani Y, Hosogane N, Hamaguchi I, Takami M, Nomiyama K, Takagi K, Suda T 2004 Dimer formation of receptor activator of nuclear factor kappaB induces incomplete osteoclast formation. Biochem Biophys Res Commun 325: 229–234.
18. 18 Chen L, Glover JN, Hogan PG, Rao A, Harrison SC 1998 Structure of the DNA‐binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature 392: 42–48.
19. 19 Staege H, Brauchlin A, Schoedon G, Schaffner A 2001 Two novel genes FIND and LIND differentially expressed in deactivated and Listeria‐infected human macrophages. Immunogenetics 53: 105–113.
20. 20 Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF 1994 c‐Fos: A key regulator of osteoclast‐macrophage lineage determination and bone remodeling. Science 266: 443–448.
21. 21 Koga T, Inui M, Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T 2004 Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428: 758–763.
22. 22 Asagiri M, Sato K, Usami T, Ochi S, Nishina H, Yoshida H, Morita I, Wagner EF, Mak TW, Serfling E, Takayanagi H 2005 Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med 202: 1261–1269.
23. 23 Cui W, Ke JZ, Zhang Q, Ke HZ, Chalouni C, Vignery A 2006 The intracellular domain of CD44 promotes the fusion of macrophages. Blood 107: 796–805.
24. 24 Vignery A 2005 Macrophage fusion: The making of osteoclasts and giant cells. J Exp Med 202: 337–340.
25. 25 Namba K, Nishio M, Mori K, Miyamoto N, Tsurudome M, Ito M, Kawano M, Uchida A, Ito Y 2001 Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes. Cell Immunol 213: 104–113.
26. 26 Takeda Y, Tachibana I, Miyado K, Kobayashi M, Miyazaki T, Funakoshi T, Kimura H, Yamane H, Saito Y, Goto H, Yoneda T, Yoshida M, Kumagai T, Osaki T, Hayashi S, Kawase I, Mekada E 2003 Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J Cell Biol 161: 945–956.
27. 27 Kyriakides TR, Foster MJ, Keeney GE, Tsai A, Giachelli CM, Clark‐Lewis I, Rollins BJ, Bornstein P 2004 The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. Am J Pathol 165: 2157–2166.
28. 28 Low QE, Drugea IA, Duffner LA, Quinn DG, Cook DN, Rollins BJ, Kovacs EJ, DiPietro LA 2001 Wound healing in MIP‐1alpha(−/−) and MCP‐1(−/−) mice. Am J Pathol 159: 457–463.
29. 29 Kim MS, Day CJ, Morrison NA 2005 MCP‐1 is induced by receptor activator of nuclear factor‐(kappa)B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony‐stimulating factor suppression of osteoclast formation. J Biol Chem 280: 16163–16169.
30. 30 Horsley V, Jansen KM, Mills ST, Pavlath GK 2003 IL‐4 acts as a myoblast recruitment factor during mammalian muscle growth. Cell 113: 483–494.
31. 31 Charge S, Rudnicki MA 2003 Fusion with the fused: A new role for interleukin‐4 in the building of muscle. Cell 113: 422–423.