Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay

Cancer Discovery

Volumn 1, Issue 4, 2011, Pages 312-325

  Herman, Ariel G ^a   Hayano, Miki ^a   Poyurovsky, Masha V ^a   Shimada, Kenichi ^a   Skouta, Rachid ^a   Prives, Carol ^a   Stockwell, Brent R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN ANTIBODY; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CAMPTOTHECIN; DOXORUBICIN; ETOPOSIDE; HYBRID PROTEIN; LIGASE INHIBITOR; LUCIFERASE; MESSENGER RNA; MURINE DOUBLE MINUTE 2 PROTEIN E3 LIGASE INHIBITOR 23; MURINE DOUBLE MINUTE 2 PROTEIN E3 LIGASE INHIBITOR 24; PROTEIN MDM2; PROTEIN P53; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; CANCER CELL CULTURE; CELL DEATH; CELL SCREENING; CELL STRAIN MCF 7; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA SEQUENCE; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NICK END LABELING; NONHUMAN; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PROTEIN FUNCTION; PROTEIN STABILITY; REAL TIME POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; UBIQUITINATION; WESTERN BLOTTING;

APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; ENZYME INHIBITORS; HCT116 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NUCLEAR PROTEINS; ONCOGENES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84865149674     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-11-0104     Document Type: Article

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