Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 23, 2008, Pages 10022-10028

  Clement, Jason A ^a   Kitagaki, Jirouta ^a   Yang, Yili ^a   Saucedo, Carrie J ^a   O'Keefe, Barry R ^a   Weissman, Allan M ^a   McKee, Tawnya C ^a   McMahon, James B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Ascidian; Hdm2; Lissoclinum; Marine natural product; Mdm2; Pyridoacridine

Indexed keywords

ALKALOID DERIVATIVE; ANTINEOPLASTIC AGENT; DIPLAMINE B; ISOLISSOCLINOTOXIN B; LISSOCLINIDINE B; PROTEIN MDM2; PROTEIN P53; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASCIDIACEA; CANCER INHIBITION; CELL CYCLE ARREST; CELL KILLING; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LISSOCLINUM BADIUM; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; UBIQUITINATION; WESTERN BLOTTING; WILD TYPE;

ACRIDINES; ALKALOIDS; ANIMALS; CELL LINE, TRANSFORMED; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; PHENANTHROLINES; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN; UROCHORDATA;

ASCIDIA; LISSOCLINUM;

EID: 55749113669     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.024     Document Type: Article

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