A designer bleomycin with significantly improved DNA cleavage activity

Journal of the American Chemical Society

Volumn 134, Issue 32, 2012, Pages 13501-13509

  Huang, Sheng Xiong ^a,d   Feng, Zhiyang ^c   Wang, Liyan ^c   Galm, Ute ^c   Wendt Pienkowski, Evelyn ^c   Yang, Dong ^a   Tao, Meifeng ^c   Coughlin, Jane M ^c   Duan, Yanwen ^d   Shen, Ben ^a,b,c  

^a Department of Chemistry ^*  (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER ACTIVITIES; ANTICANCER DRUG; BIOSYNTHETIC GENE CLUSTER; BLEOMYCINS; CANCER PATIENTS; CIS-PLATIN; CLINICAL DRUGS; CLINICAL EFFICACY; COMPARATIVE ANALYSIS; DNA CLEAVAGE; ETOPOSIDE; LUNG FIBROSIS; MICROBIAL FERMENTATION; MOLECULAR BASIS; PATIENT POPULATION; PRECLINICAL STUDIES; SIDE EFFECT;

BACTERIA; BIOLOGICAL ORGANS; CHEMOTHERAPY; CLONING; DNA; ENZYME INHIBITION; MACHINERY; PLATINUM COMPOUNDS;

PATIENT TREATMENT;

6' DEOXY BLEOMYCIN Z; 6' HYDROXY ZORBAMYCIN; BLEOMYCIN; BLEOMYCIN Z; DISACCHARIDE; DNA; UNCLASSIFIED DRUG; ZORBAMYCIN;

ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DRUG ACTIVITY; DRUG POTENCY; FERMENTATION; FOLLOW UP; NONHUMAN;

ANTINEOPLASTIC AGENTS; BLEOMYCIN; DNA CLEAVAGE; GLYCOPEPTIDES; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; STREPTOMYCES;

EID: 84865124449     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3056535     Document Type: Article

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