An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003

FEMS Microbiology Letters

Volumn 189, Issue 2, 2000, Pages 171-175

  Du, Liangcheng ^a   Chen, Mei ^a   Sánchez, César ^a   Shen, Ben ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biosynthesis; Bleomycin; Non ribosomal peptide synthetase; Oxidation domain; Streptomyces verticillus; Thiazole

Indexed keywords

BLEOMYCIN; OXIDOREDUCTASE; PEPTIDE SYNTHASE; THIAZOLE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CATALYSIS; DRUG OXIDATION; DRUG STRUCTURE; DRUG SYNTHESIS; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STREPTOMYCES; STREPTOMYCES VERTICILLUS;

AMINO ACID SEQUENCE; BLEOMYCIN; CATALYSIS; MOLECULAR SEQUENCE DATA; PEPTIDE SYNTHASES; SEQUENCE ALIGNMENT; STREPTOMYCES; SUBSTRATE SPECIFICITY; THIAZOLES;

ACTINOBACTERIA (CLASS); ESCHERICHIA COLI; STREPTOMYCES; STREPTOMYCES VERTICILLUS; UNCULTURED ACTINOMYCETE;

EID: 0034663771     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(00)00274-3     Document Type: Article

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