Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways

Angiogenesis

Volumn 15, Issue 3, 2012, Pages 421-432

  Song, Yajuan ^a   Dai, Fujun ^a   Zhai, Dong ^a   Dong, Yanmin ^a   Zhang, Jing ^a   Lu, Binbin ^a   Luo, Jian ^a   Liu, Mingyao ^a,b   Yi, Zhengfang ^a  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

AKT ERK; Angiogenesis; Tumor growth; Usnic acid; VEGFR2

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; S6 KINASE; USNIC ACID; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; BREAST TUMOR; CANCER INHIBITION; CELL STRUCTURE; CHICK EMBRYO; CHORIOALLANTOIS; CONTROLLED STUDY; CORNEA VASCULARIZATION; DRUG MECHANISM; EMBRYO; ENDOTHELIUM CELL; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MIGRATION INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BENZOFURANS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL PROLIFERATION; CELLS, CULTURED; CHICK EMBRYO; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MAP KINASE SIGNALING SYSTEM; MICE; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

MUS;

EID: 84865113022     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-012-9270-4     Document Type: Article

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