Nanoencapsulation of usnic acid: An attempt to improve antitumour activity and reduce hepatotoxicity

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 64, Issue 2, 2006, Pages 154-160

  da Silva Santos, Noemia Pereira ^a   Nascimento, Silene Carneiro ^a   Wanderley, Marcela Silvestre Outtes ^a   Pontes Filho, Nicodemos Teles ^a   da Silva, José Figueiredo ^a   de Castro, Célia Maria Machado Barbosa ^a   Pereira, Eugênia Cristina ^a   da Silva, Nicácio Henrique ^a   Honda, Neli Kika ^b   Santos Magalhães, Nereide Stela ^a  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b FEDERAL UNIVERSITY OF MATO GROSSO DO SUL   (Brazil)

Author keywords

Antitumour activity; Cladonia substellata; Nanocapsules; Toxicity; Usnic acid

Indexed keywords

NANOPARTICLE; POLYGLYCOLIC ACID; USNIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASCITES TUMOR; BLOOD SAMPLING; CANCER GRAFT; CANCER INHIBITION; CONTROLLED STUDY; DRUG COATING; ENCAPSULATION; HISTOPATHOLOGY; KIDNEY; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; MOUSE STRAIN; NANOENCAPSULATION; NEPHROTOXICITY; NONHUMAN; PORTAL VEIN BLOOD FLOW; SARCOMA 180; SPLEEN; TISSUE SECTION;

ANIMALS; BENZOFURANS; CELL LINE, TUMOR; DISEASE PROGRESSION; DRUG COMPOUNDING; DRUG-INDUCED LIVER INJURY; HEPATITIS, TOXIC; INJECTIONS, INTRAPERITONEAL; LACTIC ACID; LIVER; MALE; MICE; NANOSTRUCTURES; POLYGLYCOLIC ACID; POLYMERS; SARCOMA 180; SURVIVAL ANALYSIS;

EID: 33747892833     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.05.018     Document Type: Article

References (13)

1. Takai M., Uehara Y., and Beisler J.A. Usnic acid derivatives as potential antineoplastic agents. J. Med. Chem. 22 (1979) 1380-1384
2. Yanmamoto Y., Miura Y., Kinoshita Y., Higuchi M., Yamada Y., Murakami A., Ohigashi H., and Koshimuzi K. Screening of tissue cultures and thalli and some of their active constituents for inhibition of tumor promoter-induced Epstein-Barr virus activation. Chem. Pharm. Bull. 43 (1995) 1388-1390
3. Mayer M., O'Neill M.A., Murray K.E., Santos-Magalhães N.S., Carneiro-Leão A.M.A., Thompson A.M., and Appleyard M.V.C.L. Usnic acid increases p53 protein expression in MCF7 cancer cells without increasing p53 transcriptional activity. Anticancer Drugs 16 (2005) 805-809
4. Erba E., Procar D., and Rossi L.M. New esters of R-(+)-usnic acid. Farmaco 53 (1998) 718-720
5. Han D., Matsumaru K., Rettori D., and Kaplowitz N. Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. Biochem. Pharm. 67 (2004) 439-445
6. Pramyothin P., Janthasoot W., Pongnimitprasert N., Phrukudom S., and Ruangrungsi N. Hepatotoxic effect of (+) usnic acid from Usnea siamensis Wainio in rats, isolated rat hepatocytes and isolated rat liver mitochondria. J. Ethnopharmacol. 90 (2004) 381-387
7. Fraveau J.-T., Ruy M.L., Braunstein G., Orshansky G., Park S.S., Coody G.L., Love L.A., and Fong T.L. Severe hepatotoxicity associated with the dietary supplement LipoKinetix. Ann. Intern. Med. 136 (2002) 590-595
8. Brigger I., Dubernet C., and Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv. Drug Deliv. Rev. 54 (2002) 351-631
9. Santos N.P., Nascimento S.C., Pereira E.C.G., Silva N.H., Honda N.K., and Santos-Magalhães N.S. Usnic acid-loaded nanocapsules: an evaluation of cytotoxicity. J. Drug Deliv. Sci. Tech. 15 (2005) 355-361
10. Pereira E.C., Nascimento S.C., Lima R.C., Silva N.H., Oliveira A.F., Bandeira E., Boitard M., Beriel H., Vicente C., and Legaz M.E. Analysis of Usnea fasciata crude extracts with antineoplastic activity. Tokai J. Exp. Clin. Med. 19 (1994) 47-52
11. Andrade C.A.S., Correia M.T.S., Nascimento S.C., Coelho L.C.B.B., and Santos-Magalhães N.S. Antitumor activity of Cratylia mollis lectin encapsulated into liposomes. Int. J. Pharm. 278 (2004) 435-445
12. Geran R.-I., Greenberg N.H., MacDonald M.M., Schumacher A.M., and Abbott B.J. Protocols for screening chemical agents and natural products against animal and other biological systems. Cancer Chemother. Rep. 3 (1972) 112
13. Ribeiro-Costa R.M., Alves A.J., Santos N.P., Nascimento S.C., Pereira E.C., Silva N.H., Honda N.K., and Santos-Magalhães N.S. In vitro and in vivo properties of usnic acid encapsulated into PLGA-microspheres. J. Microencapsul. 21 (2004) 371-384