Surface charge-modification prevents sequestration and enhances tumor-cell specificity of a recombinant granzyme B-TGFα fusion protein

Bioconjugate Chemistry

Volumn 23, Issue 8, 2012, Pages 1567-1576

  Jabulowsky, Robert A ^a   Oberoi, Pranav ^a   Bähr Mahmud, Hayat ^a   Dälken, Benjamin ^a   Wels, Winfried S ^a  

^a INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELL MEMBRANES; CYTOTOXICITY; ENZYME ACTIVITY; LIGANDS; MACROPHAGES; RECOMBINANT PROTEINS; SURFACE CHARGE; TUMORS; YEAST;

APOPTOTIC PROTEINS; CHARGE MODIFICATION; CYTOTOXIC; FUSION PROTEINS; GRANZYME B; IMMUNE DEFENSE; SERINE PROTEASE; TUMOR-TARGETING; TUMOUR CELLS; WILD TYPES;

ELECTROSTATICS;

ANTINEOPLASTIC AGENT; GRANZYME B; HYBRID PROTEIN; RECOMBINANT GRANZYME B TRANSFORMING GROWTH FACTOR ALPHA FUSION PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CELL SPECIFICITY; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PICHIA PASTORIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; STATIC ELECTRICITY; SURFACE CHARGE; TUMOR CELL; UTERINE CERVIX CARCINOMA; WILD TYPE;

EID: 84865113009     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc3000657     Document Type: Article

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