Targeted induction of apoptosis by chimeric granzyme B fusion proteins carrying antibody and growth factor domains for cell recognition

Cell Death and Differentiation

Volumn 13, Issue 4, 2006, Pages 576-585

  Dalken B ^a   Giesubel U ^a   Knauer, S K ^a   Wels, W S ^a  

^a INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

Author keywords

Apoptosis; EGF receptor; ErbB2; Granzyme B; HER2

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CHIMERIC PROTEIN; CHLOROQUINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GRANZYME B; HYBRID PROTEIN; PROCASPASE 3; RECOMBINANT ENZYME; SERINE PROTEINASE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL TRANSPORT; CELL VACUOLE; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; CYTOTOXIC LYMPHOCYTE; CYTOTOXICITY; ENDOSOME; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INDUCTION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MOLECULAR RECOGNITION; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ANTIBODIES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL MEMBRANE; CELL SURVIVAL; CHLOROQUINE; CYTOPLASMIC VESICLES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; ENZYME ACTIVATION; GRANZYMES; HUMANS; INHIBITORY CONCENTRATION 50; PICHIA; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECOMBINANT FUSION PROTEINS; SERINE ENDOPEPTIDASES; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMALIA; PICHIA PASTORIS;

EID: 33644955934     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401773     Document Type: Article

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