Prediction of the pharmacokinetic parameters of triptolide in rats based on endogenous molecules in pre-dose baseline serum

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Liu, Linsheng ^a   Cao, Bei ^a   Aa, Jiye ^a   Zheng, Tian ^a   Shi, Jian ^a   Li, Mengjie ^a   Wang, Xinwen ^a   Zhao, Chunyan ^a   Xiao, Wenjing ^a   Yu, Xiaoyi ^a   Sun, Runbin ^a   Gu, Rongrong ^a   Zhou, Jun ^a   Wu, Liang ^a   Hao, Gang ^a   Zhu, Xuanxuan ^b   Wang, Guangji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b AFFILIATED HOSPITAL OF NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; GLUTAMIC ACID; TRIPTOLIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; LIPID DIET; LOW DRUG DOSE; MALE; MASS FRAGMENTOGRAPHY; MAXIMUM PLASMA CONCENTRATION; METABOLOMICS; NONHUMAN; PHARMACOKINETICS; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BILE; CALORIC RESTRICTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CREATININE; DIET, HIGH-FAT; DITERPENES; EPOXY COMPOUNDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTAMIC ACID; LINEAR MODELS; LIVER; MALE; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; MULTIVARIATE ANALYSIS; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 84865089299     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043389     Document Type: Article

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