Gas chromatography time-of-flight mass spectrometry based metabolomic approach to evaluating toxicity of triptolide

Metabolomics

Volumn 7, Issue 2, 2011, Pages 217-225

  Aa, Jiye ^a   Shao, Feng ^b   Wang, Guangji ^a   Huang, Qing ^a   Zha, Weibin ^a   Yan, Bei ^a   Zheng, Tian ^a   Liu, Linsheng ^a   Cao, Bei ^a   Shi, Jian ^a   Li, Mengjie ^a   Zhao, Chunyan ^a   Wang, Xinwen ^a   Wu, Zimei ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Simcere Pharmaceutical Research Institute   (China)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Metabolomics; Projection to latent structure discriminant analysis; Relative distance method; Toxicity; Triptolide

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALANINE AMINOTRANSFERASE; AMINO ACID; ASPARTATE AMINOTRANSFERASE; CREATININE; FATTY ACID; TAURINE; TRICARBOXYLIC ACID; TRIPTOLIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD ANALYSIS; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; DOSE TIME EFFECT RELATION; FATTY ACID OXIDATION; GAS CHROMATOGRAPHY TIME OF FLIGHT MASS SPECTROMETRY; HISTOPATHOLOGY; LATENT STRUCTURE ANALYSIS; LEUKOCYTE; LIVER TOXICITY; MALE; MASS FRAGMENTOGRAPHY; MATHEMATICAL MODEL; METABOLOME; METABOLOMICS; MITOCHONDRION; NEUTROPHIL; NONHUMAN; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; TOXICITY TESTING;

RATTUS;

EID: 79957460486     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-010-0241-8     Document Type: Article

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