Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells

Cancer Letters

Volumn 297, Issue 2, 2010, Pages 198-206

  Li, Haili ^a,b   Takai, Noriyuki ^a   Yuge, Akitoshi ^a   Furukawa, Yuichi ^a   Tsuno, Akitoshi ^a   Tsukamoto, Yoshiyuki ^a   Kong, Shigi ^a   Moriyama, Masatsugu ^a   Narahara, Hisashi ^a  

^a OITA UNIVERSITY   (Japan)

^b HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle; Gynecologic cancer; Microarray; Triptolide

Indexed keywords

CADHERIN; CADHERIN 4; CARBONATE DEHYDRATASE II; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 3; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; CD34 ANTIGEN; COLONY STIMULATING FACTOR 2; CONNEXIN 26; CYSTATIN; CYSTATIN S; FATTY ACID 2 HYDROXYLASE; GAP JUNCTION PROTEIN BETA 3; INTERLEUKIN 24; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESODERM SPECIFIC TRANSCRIPT HOMOLOG; ONCOPROTEIN; OXYTOCIN RECEPTOR; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN 11; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN 6; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN 8; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN 9; PROTEIN LRAP; SECRETED FRIZZLED RELATED PROTEIN 1; SERUM AMYLOID A; TENASCIN; THIOREDOXIN INTERACTING PROTEIN; TRIPTOLIDE; TROPONIN T; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL GROWTH INHIBITOR; DITERPENE; EPOXIDE; PHENANTHRENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; ENDOMETRIUM CANCER; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; OVARY CANCER; PRIORITY JOURNAL; UPREGULATION; WESTERN BLOTTING; CELL DEATH; CHEMISTRY; DRUG EFFECTS; ENDOMETRIAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OVARIAN NEOPLASMS; PATHOLOGY; TRIPTERYGIUM; TUMOR CELL LINE;

CELL CYCLE; CELL DEATH; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DITERPENES; DOWN-REGULATION; ENDOMETRIAL NEOPLASMS; EPOXY COMPOUNDS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARIAN NEOPLASMS; PHENANTHRENES; TRIPTERYGIUM;

TRIPTERYGIUM WILFORDII;

EID: 77956418436     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.05.012     Document Type: Article

References (36)

1. Reinhardt M.J. Gynecologic tumors. Recent Res. Cancer Res. 2008, 170:141-150.
2. Obel J.C., Friberg G., Fleming G.F. Chemotherapy in endometrial cancer. Clin. Adv. Hematol. Oncol. 2006, 4:459-468.
3. Winter 3rd W.E., Maxwell G.L., Tian C., Sundborg M.J., Rose G.S., Rose P.G., Rubin S.C., Muggia F., McGuire W.P. Tumor residual after surgical cytoreduction in prediction of clinical outcome in stage IV epithelial ovarian cancer: a gynecologic oncology group study. J. Clin. Oncol. 2008, 26:83-89.
4. Kupchan S.M., Court W.A., Dailey Jr R.G., Gilmore C.J., Bryan R.F. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J. Am. Chem. Soc. 1972, 94:7194-7195.
5. Qin W.Z., Zhu G.D., Yang S.M., Han K.Y., Wang J. Clinical observations on Tripterygium wilfordii in treatment of 26 cases of discoid lupus erythematosus. J. Tradit. Chin. Med. 1983, 3:131-132.
6. Tao X.L., Sun Y., Dong Y., Xiao Y.L., Hu D.W., Shi Y.P., Zhu Q.L., Dai H., Zhang N.Z. A prospective, controlled, double-blind, cross-over study of Tripterygium wilfodii Hook F in treatment of rheumatoid arthritis. Chin. Med. J. (Engl.) 1989, 102:327-332.
7. D. Qiu, P.N. Kao, Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook F, Drugs R.D. 4 (2003) 1-18..
8. Qiu D., Zhao G., Aoki Y., Shi L., Uyei A., Nazarian S., Ng J.C., Kao P.N. Immunosuppressant PG490 (triptolide) inhibits Tcell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J. Biol. Chem. 1999, 274:13443-13450.
9. Kiviharju T.M., Lecane P.S., Sellers R.G., Peehl D.M. Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin. Cancer Res. 2002, 8:2666-2674.
10. Yang S., Chen J., Guo Z Z., Xu X.M., Wang L., Pei X.F., Yang J., Underhill C.B., Zhang L. Triptolide inhibits the growth and metastasis of solid tumors. Mol. Cancer Ther. 2003, 2:65-72.
11. Carter B.Z., Mak D.H., Schober WD W.D., McQueen T., Harris D., Estrov Z., Evans R.L., Andreeff M. Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood 2006, 108:630-637.
12. Westfall S.D., Nilsson E.E., Skinner M.K. Role of triptolide as an adjunct chemotherapy for ovarian cancer. Chemotherapy 2008, 54:67-76.
13. Takai N., Ueda T., Nishida M., Nasu K., Narahara H. beta-Hydroxyisovalerylshikonin has a profound anti-growth activity in human endometrial and ovarian cancer cells. Gynecol. Oncol. 2008, 109:107-114.
14. Takai N., Desmond J.C., Kumagai T., Gui D., Said J.W., Whittaker S., Miyakawa I., Koeffler H.P. Histone deacetylase inhibitors have a profound anti-growth activity in endometrial cancer cells. Clin. Cancer Res. 2004, 10:1141-1149.
15. Rimon G., Bazenet C.E., Philpott K.L., Rubin L.L. Increased surface phosphatidylserine is an early marker of neuronal apoptosis. J. Neurosci. Res. 1997, 48:563-570.
16. Chen Y., Kramer D.L., Diegelman P., Vujcic S., Porter C.W. Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells. Cancer Res. 2001, 61:6437-6444.
17. Xu B., Guo X., Mathew S., Armesilla A.L., Cassidy J., Darling J.L., Wang W. Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines. Cancer Lett. 2010, 291:200-208.
18. Tanioka T., Hattori A., Masuda S., Nomura Y., Nakayama H., Mizutani S., Tsujimoto M. Human leukocyte-derived arginine aminopeptidase: the third member of the oxytocinase subfamily of aminopeptidases. J. Biol. Chem. 2003, 278:32275-32283.
19. Fruci D., Ferracuti S., Limongi M.Z., Cunsolo V., Giorda E., Fraioli R., Sibilio L., Carroll O., Hattori A., van Endert P.M., Giacomini P. Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines. J. Immunol. 2006, 176:4869-4879.
20. Sjodin A., Dahl U., Semb H. Mouse R-cadherin: expression during the organogenesis of pancreas and gastrointestinal tract. Exp. Cell Res. 1995, 221:413-425.
21. Miotto E., Sabbioni S., Veronese A., Calin G.A., Gullini S., Liboni A., Gramantieri L., Bolondi L., Ferrazzi E., Gafà R., Lanza G., Negrini M. Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer. Cancer Res. 2004, 64:8156-8159.
22. Agiostratidou G., Li M., Suyama K., Badano I., Keren R., Chung S., Anzovino A., Hulit J., Qian B., Bouzahzah B., Eugenin E., Loudig O., Phillips G.R., Locker J., Hazan B.B. Loss of retinal cadherin facilitates mammary tumor progression and metastasis. Cancer Res. 2009, 69:5030-5038.
23. Kucharczak J., Charrasse S., Comunale F., Zappulla J., Robert B., Teulon-Navarro I., Pèlegrin A., Gauthier-Rouvière C. R-cadherin expression inhibits myogenesis and induces myoblast transformation via Rac1 GTPase. Cancer Res. 2008, 68:6559-6568.
24. Gupta G.P., Nguyen D.X., Chiang A.C., Bos P.D., Kim J.Y., Nadal C., Gomis R.R., Manova-Todorova K., Massagué J. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 2007, 446:765-770.
25. Melkonyan H.S., Chang W.C., Shapiro J.P., Mahadevappa M., Fitzpatrick P.A., Kiefer M.C., Tomei L.D., Umansky S.R. SARPs: a family of secreted apoptosis-related proteins. Proc. Natl. Acad. Sci. USA 1997, 94:13636-13641.
26. Bafico A., Gazit A., Pramila T., Finch P.W., Yaniv A., Aaronson S.A. Interaction of frizzled related protein (FRP) with WNT ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of WNT signaling. J. Biol. Chem. 1999, 274:16180-16187.
27. Suzuki H., Watkins D.N., Jair K.W., Schuebel K.E., Markowitz S.D., Chen W.D., Pretlow T.P., Yang B., Akiyama Y., van Engeland M., Toyota M., Tokino T., Hinoda Y., Imai K., Herman J.G., Baylin S.B. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat. Genet. 2004, 36:417-422.
28. Chung M.T., Lai H.C., Sytwu H.K., Yan M.D., Shih Y.L., Chang C.C., Yu M.H., Liu H.S., Chu D.W., Lin Y.W. SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol. Oncol. 2009, 112:646-653.
29. Barrett A.J. The cystatins: a diverse superfamily of cysteine peptidase inhibitors. Biomed. Biochim. Acta 1986, 45:1363-1374.
30. Choi E.H., Kim J.T., Kim J.H., Kim S.Y., Song E.Y., Kim J.W., Kim S.Y., Yeom Y.I., Kim I.H., Lee H.G. Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer. Clin. Chim. Acta 2009, 406:45-51.
31. Wang Q., Reiter R.S., Huang Q.Q., Jin J.P., Lin J.J. Comparative studies on the expression patterns of three troponin T genes during mouse development. Anat. Rec. 2001, 263:72-84.
32. Ashida S., Nakagawa H., Katagiri T., Furihata M., Iiizumi M., Anazawa Y., Tsunoda T., Takata R., Kasahara K., Miki T., Fujioka T., Shuin T., Nakamura Y. Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs. Cancer Res. 2004, 64:5963-5972.
33. Basso D., Millino C., Greco E., Romualdi C., Fogar P., Valerio A., Bellin M., Zambon C.F., Navaglia F., Dussini N., Avogaro A., Pedrazzoli S., Lanfranchi G., Plebani M. Altered glucose metabolism and proteolysis in pancreatic cancer cell conditioned myoblasts: searching for a gene expression pattern with a microarray analysis of 5000 skeletal muscle genes. Gut 2004, 53:1159-1166.
34. Lim S.S., Hering G.E., Borisy G.G. Widespread occurrence of anti-troponin T crossreactive components in non-muscle cells. J. Cell Sci. 1986, 85:1-19.
35. Mechtersheimer S., Gutwein P., Agmon-Levin N., Stoeck A., Oleszewski M., Riedle S., Postina R., Fahrenholz F., Fogel M., Lemmon V., Altevogt P. Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins. J. Cell Biol. 2001, 155:661-673.
36. Gavert N., Conacci-Sorrell M., Gast D., Schneider A., Altevogt P., Brabletz T., Ben-Ze'ev A. L1 a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J. Cell Biol. 2005, 168:633-642.