Synthesis and evaluation of small libraries of triazolylmethoxy chalcones, flavanones and 2-aminopyrimidines as inhibitors of mycobacterial FAS-II and PknG

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 17, 2012, Pages 5150-5163

  Anand, Namrata ^a   Singh, Priyanka ^a,b   Sharma, Anindra ^a   Tiwari, Sameer ^a   Singh, Vandana ^a   Singh, Diwakar K ^a   Srivastava, Kishore K ^a   Singh, B N ^a   Tripathi, Rama Pati ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b National Institute of Pharmaceutical Education and Research (NIPER)   (India)

Author keywords

2 Aminopyrimidines; FAS II; Mycobacterium tuberculosis; PknG; Triazolylmethoxy chalcones; Triazolylmethoxy flavanones

Indexed keywords

1 [2 HYDROXY 4 (PRO 2 YNYLOXY)PHENYL] 3 PHENYL PROP EN 1 ONE; 1 [4 [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL] 3 (2 CHLORO 6 FLUOROPHENYL)PROP 2 EN 1 ONE; 1 [4 [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL] 3 (4 CHLOROPHENYL)PROP 2 EN 1 ONE; 1 [4 [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL] 3 (4 ISOPROPYLPHENYL)PROP 2 EN 1 ONE; 1 [4 [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL] 3 PHENYL PROP 2 EN 1 ONE; 1 [4 [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL]ETHANONE; 1 [4 [(1 BROMOBENZYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL]ETHANONE; 1 [4 [(1 HEXYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL] 3 (4 ISOPROPYLPHENYL)PROP 2 EN 1 ONE; 1 [4 [(1 HEXYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 [(1 HEXYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL] 3 (NAPHTHALENE 1 YL)PROP 2 EN 1 ONE; 1 [4 [(1 HEXYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL] 3 [4 (PROPY 2 YNYLOXY) PHENYL]PROP 2 EN 1 ONE; 1 [4 [(1 HEXYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL] 3 PHENYL PROP 2 EN 1 ONE; 1 [4 [(1 HEXYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL]ETHANONE; 3 (2 CHLORO 6 FLUOROPHENYL) 1 [4 [(1 HEXYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL]PROP 2 EN 1 ONE; 3 (4 BROMOPHENYL) 1 [2 HYDROXY 4 (PROP 2 YNYLOXY)PHENYL]PROP 2 EN 1 ONE; 3 (4 BROMOPHENYL) 1 [4 [(1 HEXYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL]PROP 2 EN 1 ONE; 3 (4 CHLOROPHENYL) 1 [4 [(1 HEXYL 1H 1,2,3 TRIAZOL 4 YL)METHOXY] 2 HYDROXYPHENYL]PROP 2 EN 1 ONE; 4 PROPARGYLOXY 2 HYDROXY ACETOPHENONE; 4 PROPARGYLOXY 2 HYDROXYACETOPHENONE; ACETOPHENONE; AX 20017; CHALCONE DERIVATIVE; CYCLIC GMP DEPENDENT PROTEIN KINASE; FAS ANTIGEN; FLAVANONE DERIVATIVE; PROTEIN FAS II; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; TRIAZOLYLMETHOXY AMINOPYRIMIDINE DERIVATIVE; TRIAZOLYLMETHOXY CHALCONE DERIVATIVE; TRIAZOLYLMETHOXY FLAVANONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MYCOBACTERIUM; MYCOBACTERIUM AURUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; REPORTER GENE;

CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX, TYPE II; FLAVANONES; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 84865047716     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.009     Document Type: Article

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