Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence

Breast Cancer Research and Treatment

Volumn 121, Issue 2, 2010, Pages 293-300

  Rhodes, Lyndsay V ^a   Muir, Shannon E ^a   Elliott, Steven ^a   Guillot, Lori M ^a   Antoon, James W ^c   Penfornis, Patrice ^a   Tilghman, Syreeta L ^a   Salvo, Virgilio A ^a   Fonseca, Juan P ^a   Lacey, Michelle R ^b   Beckman, Barbara S ^c   McLachlan, John A ^c   Rowan, Brian G ^c   Pochampally, Radhika ^a   Burow, Matthew E ^c  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Tulane University   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast carcinoma; Mesenchymal stem cells; Progesterone receptor; Stromal derived factor 1; Tumor microenvironment

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

ADULT STEM CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CELL HOMING; CELL INTERACTION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; SIGNAL TRANSDUCTION; STROMA CELL; TUMOR CELL; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CELL LINE, TUMOR; DISEASE PROGRESSION; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MAMMARY NEOPLASMS, EXPERIMENTAL; MESENCHYMAL STEM CELLS; MICE; MICE, SCID; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77953023138     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-009-0458-2     Document Type: Article

References (29)

1. Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276: 71-74
2. Horwitz EM, Prockop DJ, Fitzpatrick LA et al (1999) Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 5: 309-313
3. Fox JM, Chamberlain G, Ashton BA et al (2007) Recent advances into the understanding of mesenchymal stem cell trafficking. Br J Haematol 137: 491-502
4. Studeny M, Marini FC, Dembinski JL et al. (2004) Mesenchymal stem cells: potential precursors for tumor stroma and targeteddelivery vehicles for anticancer agents. J Natl Cancer Inst 96: 1593-1603
5. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57-70
6. Hasebe T, Sasaki S, Sugitoh M et al (2001) Highly proliferative intratumoral fibroblasts and a high proliferative microvessel index, are significant predictors of tumor metastasis in T3 ulcerative-type colorectal cancer. Hum Pathol 32: 401-409
7. Kuniyasu H, Abbruzzese JL, Cleary KR et al (2001) Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. Int J Oncol 19: 681-685
8. Dvorak HF (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315: 1650-1659
9. Studeny M, Marini FC, Champlin RE et al (2002) Bone marrowderived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 62: 3603-3608
10. Hall B, Andreeff M, Marini F (2007) The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles. Handb Exp Pharmacol 180: 263-283
11. Djouad F, Bony C, Apparailly F et al (2006) Earlier onset of syngeneic tumors in the presence of mesenchymal stem cells. Transplantation 82: 1060-1066
12. Karnoub AE, Dash AB, Vo AP et al (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449: 557-563
13. Sekiya I, Larson BL, Smith JR et al (2002) Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 20: 530-541
14. Petz LN, Ziegler YS, Schultz JR et al (2004) Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site. Mol Endocrinol 18: 521-532
15. Salvo VA, Boue SM, Fonseca JP et al (2006) Antiestrogenic glyceollins suppress human breast and ovarian carcinoma tumorigenesis. Clin Cancer Res 12: 7159-7164
16. Team RDC (ed) (2008) A language and environment for statistical computing. Foundation for statistical computing, Vienna, Austria
17. Pinheiro J, Bates DM (2000) Mixed-effects models in S and SPLUS. Springer Verlag, New York
18. Kagiwada H, Yashiki T, Ohshima A et al (2008) Human mesenchymal stem cells as a stable source of VEGF-producing cells. J Tissue Eng Regen Med 2: 184-189
19. Hill RP (2006) Identifying cancer stem cells in solid tumors: case not proven. Cancer Res 66: 1891-1895 (discussion 1890)
20. Li Z, Carrier L, Belame A et al. (2008) Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts in nude mice through elevated apoptosis and reduced angiogenesis. Breast Cancer Res Treat, doi: 10.1007/s10549-008-0216-x
21. White AC, Levy JA, McGrath CM (1982) Site-selective growth of a hormone-responsive human breast carcinoma in athymic mice. Cancer Res 42: 906-912
22. Levy JA, White AC, McGrath CM (1982) Growth and histology of a human mammary-carcinoma cell line at different sites in the athymic mouse. Br J Cancer 45: 375-383
23. Fiedler J, Leucht F, Waltenberger J et al (2005) VEGF-A and PlGF-1 stimulate chemotactic migration of human mesenchymal progenitor cells. Biochem Biophys Res Commun 334: 561-568
24. Fierro FA, Sierralta WD, Epunan MJ et al (2004) Marrowderived mesenchymal stem cells: role in epithelial tumor cell determination. Clin. Exp Metastasis 21: 313-319
25. Hombauer H, Minguell JJ (2000) Selective interactions between epithelial tumour cells and bone marrow mesenchymal stem cells. Br J Cancer 82: 1290-1296
26. Müller A, Homey B, Soto H et al (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56
27. Sasser AK, Mundy BL, Smith KM et al (2007) Human bone marrow stromal cells enhance breast cancer cell growth rates in a cell line-dependent manner when evaluated in 3D tumor environments. Cancer Lett 254: 255-264
28. Yang SH, Wu CC, Shih TT et al (2008) In vitro study on interaction between human nucleus pulposus cells and mesenchymal stem cells through paracrine stimulation. Spine 33: 1951-1957
29. Nicola MH, Bizon R, Machado JJ et al (2003) Breast cancer micrometastases: different interactions of carcinoma cells with normal and cancer patients' bone marrow stromata. Clin Exp Metastasis 20: 471-479