Histamine-induced actin polymerization in human eosinophils: An imaging approach for histamine H4 receptor

Cytometry Part A

Volumn 73, Issue 4, 2008, Pages 299-304

  Barnard, Ruth ^a   Barnard, Adrian ^a   Salmon, Gary ^a   Liu, Wai ^a   Sreckovic, Sasha ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Actin; Cellomics ArrayScan; Eosinophils; H4R; Histamine; Phalloidin

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; A 331440; A 631972; ANTIHISTAMINIC AGENT; CYTOSKELETON PROTEIN; DIPHENHYDRAMINE; F ACTIN; FAMOTIDINE; G ACTIN; HISTAMINE; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR ANTAGONIST; MEPYRAMINE; PEPTIDE; PHALLOIDIN; RANITIDINE; THIOPERAMIDE; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ASTHMA; CELL MIGRATION; CONFERENCE PAPER; CYTOSKELETON; DRUG DETERMINATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG TARGETING; EOSINOPHIL; FLOW CYTOMETRY; IMAGING SYSTEM; IMMUNOCOMPETENT CELL; INFLAMMATORY DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; TISSUE BLOOD FLOW;

ACTINS; CYTOSKELETON; EOSINOPHILS; FLOW CYTOMETRY; HISTAMINE; HUMANS; INFLAMMATION; INHIBITORY CONCENTRATION 50; MODELS, BIOLOGICAL; PHALLOIDINE; POLYMERS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; SENSITIVITY AND SPECIFICITY;

EID: 42049099229     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.20514     Document Type: Conference Paper

References (21)

1. de Esch IJ, Thurmond RL, Jongejan A, Leurs R. The histamine H4 receptor as a new therapeutic target for inflammation. Trends Pharmacol Sci 2005;26:462-469.
2. Lim HD, Smits RA, Leurs R, de Esch IJ. The emerging role of the histamine H4 receptor in anti-inflammatory therapy. Curr Top Med Chem 2006;6:1365-1373.
3. Parsons ME, Ganellin CR. Histamine and its receptors. Br J Pharmacol 2006;147 (Suppl 1):S127-S135.
4. Nakamura T, Itadani H, Hidaka Y, Ohta M, Tanaka K. Molecular cloning and characterization of a new human histamine receptor HH4R. Biochem Biophys Res Commun 2000;279:615-620.
5. Oda T, Morikawa N, Saito Y, Masuho Y, Matsumoto S. Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes. J Biol Chem 2000;275:36871-36786.
6. Liu C, Ma X, Jiang X, Wilson SJ, Hofstra CL, Blevitt J, Pyati J, Li X, Chai W, Carruthers N, Lovenberg TW. Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol 2001;59:420-426.
7. Morse KL, Behan J, Laz TM, West RE Jr., Greenfeder SA, Anthes JC. Cloning and characterization of a novel human histamine receptor. J Pharmacol Exp Ther 2001;296:1058-1066.
8. Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O'Dowd BF. Discovery of a novel member of the histamine receptor family. Mol Pharmacol 2001;59:427-433.
9. Zhu Y, Michalovich D, Wu H, Tan KB, Dytko GM, Mannan IJ, Zhu Y, Michalovich D, Wu H, Tan KB, Dytko GM, Mannan IJ, Boyce R, Alston J, Tierney LA, Li X, Herrity NC, Vawter L, Sarau HM, Ames RS, Davenport CM, Hieble JP, Wilson S, Bergsma DJ. Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Mol Pharmacol 2001;59:434-441.
10. O'Reilly M, Alpert R, Jenkinson S, Gladue RP, Foo S, Trim S, et al. Identification of a histamine H4 receptor on human eosinophils-role in eosinophil chemotaxis. J Recept Signal Transduct Res 2002;22:431-448.
11. Buckland KF, Williams TJ, Conroy DM. Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. Br J Pharmacol 2003;140:1117-1127.
12. Ling P, Ngo K, Nguyen S, Thurmond RL, Edwards JP, Karlsson L, Fung-Leung WP. Histamine H4 receptor mediates eosinophils chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol 2004;142:161-171.
13. Giembycz MA, Lindsay MA. Pharmacology of the eosinophil. Pharmacol Rev 1999;51:213-340.
14. Wieland T. The toxic peptides from Amanita mushrooms. Int J Pept Protein Res 1983;22:257-276.
15. Hancock AA, Bitner RS, Krueger KM, Otte S, Nikkei AL, Fey TA, Bush EN, Dickinson RW, Shapiro R, Knourek-Segel V, Droz BA, Brune ME, Jacobson PB, Cowart ND. Distinctions and contradistinctions between antiobesity histamine H3 receptor (H3R) antagonists compared to cognition-enhancing H3 receptor antagonists. Inflam Res 2006;55(Suppl 1):S1-S3.
16. Jablonowski JA, Grice CA, Chai W, Dvorak CA, Venable JD, Kwok AK, Ly KS, Wei J, Baker SM, Desai PJ, Jiang W, Wilson SJ, Thurmond RL, Karlsson L, Edwards JP, Lovenberg TW, Carruthers NI. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem 2003;46:3957-3960.
17. Nakayama T, Kato Y, Hieshma K, Nagakubo D, Kunori Y, Fujisawa T, Yoshie O. Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor. J Immunol 2004;173:2078-2083.
18. Brightling CE, Bradding P. The re-emergence of the mast cell as a pivotal cell in asthma pathogenesis. Curr Allergy Asthma Rep 2005;5:130-135.
19. Holgate ST, Finnerty JP. Antihistamines in asthma. J Allergy Clin Immunol 1989;83:537-547.
20. Walsh GM. Novel therapies for asthma-advances and problems. Curr Pharm Des 2005;11:3027-3038.
21. Lukacs NW. Role of chemokines in the pathogenesis of asthma. Nat Rev Immunol 2001;1:108-116.