The histamine H 4 receptor is functionally expressed on neurons in the mammalian CNS

British Journal of Pharmacology

Volumn 157, Issue 1, 2009, Pages 55-63

  Connelly, W M ^a   Shenton, F C ^b   Lethbridge, N ^b   Leurs, R ^c   Waldvogel, H J ^d   Faull, R L M ^d   Lees, G ^a   Chazot, P L ^b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b DURHAM UNIVERSITY   (United Kingdom)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Brain; Histamine h 4 receptor; Human; Hyperpolarization; JNJ 10191584; Mouse; Neurons

Indexed keywords

4 METHYLHISTAMINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; HISTAMINE H4 RECEPTOR; G PROTEIN COUPLED RECEPTOR; HISTAMINE RECEPTOR; HRH4 PROTEIN, HUMAN; HRH4 PROTEIN, MOUSE;

ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; HEMATOPOIETIC CELL; HIPPOCAMPUS; HUMAN; IMMUNOLOGICAL TECHNIQUE; MOUSE; NERVE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMATOSENSORY CORTEX; THALAMOCORTICAL TRACT; THALAMUS; ANIMAL; BIOSYNTHESIS; C3H MOUSE; CELL MEMBRANE POTENTIAL; HISTOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; PHYSIOLOGY;

ANIMALS; BRAIN; EXCITATORY POSTSYNAPTIC POTENTIALS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C3H; NEURONS; PATCH-CLAMP TECHNIQUES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE;

EID: 67149133756     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00227.x     Document Type: Article

References (49)

1. Agmon A, Connors BW (1991). Thalamocortical responses of mouse somatosensory (barrel) cortex in vitro. Neuroscience 41: 365-379.
2. Bakker RA, Lozada AF, van Marie A, Shenton FC, Drutel G, Karlstedt K et al. (2006). MoI Pharmacol 69: 1194-1206.
3. 4 receptors modulate dendritic cell migration through skin - immunomodulatory role of histamine. Allergy 63: 1387-1394.
4. Booth RG, Moniri NH, Bakker RA, Choksi NY, Nix WB, Timmerman H et al. (2002). A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(I) receptors. J Pharmacol Exp Ther 302: 328-336. (Pubitemid 34680455)
5. Breunig E, Michel K, Zeller F, Seidl S, Weyhern CW, Schemann M (2007). Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors. J. Physiol 583: 731-742.
6. Brown RE, Stevens DR, Haas H (2001). The physiology of brain histamine. Prog Neurobiol 63: 637-672.
7. Cannon KE, Chazot PL, Hann V, Shenton FC, Hough LB, Rice FL (2006). Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: potential antinociceptive targets. Pain 129: 76-92. (Pubitemid 46551373)
8. Chazot PL, Hann V, Wilson C, Lees G, Thompson CL (2001). Immunological identification of the mammalian H3 histamine receptor in the mouse brain. NeuroReport 12: 259-262. (Pubitemid 32114361)
9. Chu M, Huang ZL, Qu WM, Eguchi N, Yao MH, Urade Y (2004). Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats. Neurosci Res 49: 417-420. (Pubitemid 38953859)
10. Cianchi F, Cortesini C, Schiavone N, Perna F, Magnelli L, Fanti E et al. (2005). The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. Clin Cancer Res 11: 6807-6815. (Pubitemid 41428735)
11. Coge S-P, Guenin SP, Audinot V, Renouard-Try A, Beauverger P, Macia C et al. (2001a). Genomic organization and characterization of splice variants of the human histamine H3 receptor. Biochem J 355: 279-288. (Pubitemid 32397785)
12. 4-receptor gene. Biochem Biophys Res Commun 284: 301-309.
13. Cowart MD, Altenbach RJ, Liu H, Hsieh GC, Drizin I, Milicic I et al. (2008). Rotatlonally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J Med Chem 51: 6547-6557.
14. Dijkstra D, Leurs R, Chazot PL, Shenton FC, Stark H, Werfel T et al. (2007). Histamine downregulates monocyte CCL2 production through the histamine H(4) receptor. J Allergy Clin Immunol 120: 300-307.
15. Dijkstra D, Stark H, Chazot PL, Shenton FC, Leurs R, Werfel T et al. (2008). Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor. J Invest Dermatol 128:1696-1703. (Pubitemid 351847377)
16. + T cells. J Immunol 176: 7062-7070.
17. de Esch IJ, Thurmond RL, Jongejan A, Leurs R (2005). The histamine H4 receptor as a new therapeutic target for inflammation. Trends Pharmacol Sei 26: 462-469. (Pubitemid 41207878)
18. Grandi D, Shenton FC, Chazot PL, Morini G (2008). Immunolocalization of histamine H3 receptors on endocrine cells in the rat gastrointestinal tract. Histol Histopathol 23: 789-798.
19. Haas HL, Sergeeva OA, Selbach O (2008). Histamine in the nervous system. Physiol Rev 88: 1183-1241.
20. Herkenham M (1980). Laminar organization of thalamic projections to the Rat Neocortex. Science 44: 532-535. (Pubitemid 10139800)
21. 4 receptor mediates Chemotaxis and calcium mobilization of mast cells. J Pharmacol Exp Ther 305: 1212-1221.
22. Ikawa Y, Suzuki M, Shiono S, Ohki E, Moriya H, Negishi E et al. (2005). Histamine H4 receptor expression in human synovial cells obtained from patients suffering from rheumatoid arthritis. Biol Pharm Bull 28: 2016-2018. (Pubitemid 41437104)
23. Jablonowski JA, Grice CA, Chai W, Dvorak CA, Venable JD, Kwok AK et al. (2003). The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem 46: 3957-3960. (Pubitemid 37122442)
24. Kawaguchi Y, Kubota Y (1993). Correlation of physiological subgroupings of nonpyramidal cells with parvalbumin- and calbindinD28kimmunoreactive neurons in layer V of rat frontal cortex. J Neurophysiol 70: 387-396. (Pubitemid 23220322)
25. Lim HD, van Rijn RM, Ling P, Bakker RA, Thurmond RL, Leurs R (2005). Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J Pharmacol Exp Ther 314: 1310-1321.
26. Liu C, Ma X, Jiang X, Wilson SJ, Hofstra CL, Blevitt J et al. (2001). Cloning and pharmacological characterization of a fourth histamine receptor [H(4)] expressed in bone marrow. MoI Pharmacol 59: 420-426. (Pubitemid 32179918)
27. Lees G, Stöhr T, Errington AC (2006). Stereoselective effects of the novel anticonvulsant Lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro. Neuropharmacology 50: 98-110. (Pubitemid 43069776)
28. 4 receptors on mammary epithelial cells of the human breast with different types of carcinoma. Inflamm Res 55 (Suppl): S77-S78.
29. Morini G, Becchi G, Shenton FC, Chazot PL, Grandi D (2008). Histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosa. Inflamm Res 57 (Suppl: )S57-S58.
30. Morse KL, Behan J, Laz TM, West REJr, Greenfeder, SA, Anthes JC et al. (2001). Cloning and characterization of a novel human histamine receptor. J Pharmacol Exp Ther 296: 1058-1066. (Pubitemid 32187382)
31. Nakamura T, Itadani H, Hidaka Y, Ohta M, Tanaka K (2000). Molecular cloning and characterization of a new human histamine receptor, HH4R. Biochem Biophys Res Commun 279: 615-620. (Pubitemid 32016763)
32. Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R et al. (2001). Discovery of a novel member of the histamine receptor family. MoI Pharmacol 59: 427-433. (Pubitemid 32179919)
33. 4 receptor on human eosinophils - role in eosinophil Chemotaxis. J Recept Signal Transduct Res 22: 431-448.
34. Oda T, Morikawa N, Salto Y, Masuho Y, Matsumoto S (2000). Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes. J Biol Chem 275: 36781-36786. (Pubitemid 32002087)
35. Payne HL, Donoghue PS, Connelly WM, Hinterreiter S, Tiwari P, Ives JH et al. (2006). Aberrant GABAA receptor expression in the dentate gyrus of the epileptic mutant mouse, stargazer. J Neurosci 26: 8600-8608. (Pubitemid 44316189)
36. Pillot C, Heron A, Cochois V, Tardivel-Lacombe J, Ligneau X, Schwartz JC et al. (2002). A detailed mapping of the histamine H(3) receptor and its gene transcripts in rat brain. Neurostience 114: 173-193. (Pubitemid 35247499)
37. Povysheva NV, Gonzalez-Burgos G, Zaitsev AV, Kröner S, Barrionuevo G, Lewis DA et al. (2006). Properties of excitatory synaptic responses in fast-spiking intemeurons and pyramidal cells from monkey and rat prefrontal cortex. Cereb Cortex 16: 541-552.
38. van Rijn RM, Chazot PL, Shenton FC, Sansuk K, Bakker RA, Leurs R (2006). Oligomerization of recombinant and endogenously expressed human histamine H(4) receptors. MoI Pharmacol 70: 604-615. (Pubitemid 44092321)
39. van Rijn RM, van Marie A, Chazot PL, Langemeijer E, Qin Y, Shenton FC et al. (2008). Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor. Biochem J 414: 121-131.
40. Reiner PB, Kamondi A (1994). Mechanisms of antihistamine-induced sedation in the human brain: H1 receptor activation reduces a background leakage potassium current. Neuroscience 59: 579-588.
41. Seifert R, Wenzel-Seifert K, Burckstummer T, Pertz HH, Schunack W, Dove S et al. (2003). Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther 305: 1104-1115. (Pubitemid 36617989)
42. Strakhova MI, Nikkel AL, Manelli AM, Hsieh GC, Esbenshade TA, Brioni JD et al. (2009). Localization of histamine H4 receptors in the central nervous system of human and rat. Brain Res 1250: 41-48.
43. Strecker RE, Nalwalk J, Dauphin LJ, Thakkar MM, Chen Y, Ramesh V et al. (2002). Extracellular histamine levels in the feline preoptic/ anterior hypothalamic area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study. Neuroscience 113: 663-670. (Pubitemid 34874690)
44. Terzioglu N, van Rijn RM, Bakker RA, De Esch IJ, Leurs R (2004). Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists. Bioorg Med Chem Lett 14: 5251-5256. (Pubitemid 39348908)
45. 4 receptor antagonists on experimental colitis in the rat. Eur f Pharmacol 522: 130-138.
46. Venable JD, Cai H, Chai W, Dvorak CA, Grice CA, Jablonowski JA et al. (2005). Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine H4 antagonists. J Med Chem 48: 8289-8298. (Pubitemid 43032536)
47. Waldvogel HJ, Billinton A, White JH, Emson PC, Faull RL (2004). Comparative cellular distribution of GABAA and GABAB receptors In the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABRl and GABABR2 receptor subunits. J Comp Neurol 470: 339-356.
48. Waldvogel HJ, Curtis MA, Baer K, Rees MI, Faull RLM (2006). Immunohistochemical staining of post-mortem adult human brain sections. Nature Protocols 1: 2719-2732.
49. Zhu Y, Michalovich D, Wu H, Tan KB, Dytko GM, Mannan IJ et al. (2001). Cloning, expression, and pharmacological characterization of a novel human histamine receptor. MoI Pharmacol 59: 434-441. (Pubitemid 32179920)