Histamine H 4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system

Journal of Immunology

Volumn 188, Issue 2, 2012, Pages 541-547

  Del Rio, Roxana ^a   Noubade, Rajkumar ^a,f   Saligrama, Naresha ^a   Wall, Emma H ^a   Krementsov, Dimitry N ^a   Poynter, Matthew E ^a   Zachary, James F ^b   Thurmond, Robin L ^c   Teuscher, Cory ^a,d,e  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^d UNIVERSITY OF VERMONT   (United States)

^e University of Houston   (United States)

^f GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE H4 RECEPTOR; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN; HISTAMINE RECEPTOR; HRH4 PROTEIN, MOUSE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35 55); MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); PEPTIDE FRAGMENT;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FLOW CYTOMETRY; INTERMETHOD COMPARISON; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; LYMPHOID TISSUE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TH17 CELL; WILD TYPE; 129 MOUSE; ANIMAL; BLOOD BRAIN BARRIER; C57BL MOUSE; CD4 LYMPHOCYTE COUNT; CELL CULTURE; CELL MEMBRANE PERMEABILITY; GENETICS; HOSPITALIZATION; IMMUNOLOGY; INFLAMMATION; METABOLISM; MOUSE MUTANT; NERVE CELL; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; BLOOD-BRAIN BARRIER; CD4 LYMPHOCYTE COUNT; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GLYCOPROTEINS; INFLAMMATION; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURONS; PEPTIDE FRAGMENTS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES, REGULATORY;

EID: 84856010850     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101498     Document Type: Article

References (43)

1. Akdis, C. A., and F. E. Simons. 2006. Histamine receptors are hot in immunopharmacology. Eur. J. Pharmacol. 533: 69-76. (Pubitemid 43340005)
2. Jutel, M., K. Blaser, and C. A. Akdis. 2006. Histamine receptors in immune regulation and allergen-specific immunotherapy. Immunol. Allergy Clin. North Am. 26: 245-259, vii.
3. Abbott, N. J. 2000. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell. Mol. Neurobiol. 20: 131-147. (Pubitemid 30091452)
4. Bebo, B. F., Jr., T. Yong, E. L. Orr, and D. S. Linthicum. 1996. Hypothesis: a possible role for mast cells and their inflammatory mediators in the pathogenesis of autoimmune encephalomyelitis. J. Neurosci. Res. 45: 340-348. (Pubitemid 26299589)
5. Tuomisto, L., H. Kilpeläinen, and P. Riekkinen. 1983. Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis. Agents Actions 13: 255-257.
6. Orr, E. L., and N. C. Stanley. 1989. Brain and spinal cord levels of histamine in Lewis rats with acute experimental autoimmune encephalomyelitis. J. Neurochem. 53: 111-118. (Pubitemid 19158116)
7. Lock, C., G. Hermans, R. Pedotti, A. Brendolan, E. Schadt, H. Garren, A. Langer-Gould, S. Strober, B. Cannella, J. Allard, et al. 2002. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 8: 500-508. (Pubitemid 34546753)
8. Alonso, A., S. S. Jick, and M. A. Hernán. 2006. Allergy, histamine 1 receptor blockers, and the risk of multiple sclerosis. Neurology 66: 572-575. (Pubitemid 43739890)
9. Logothetis, L., I. A. Mylonas, S. Baloyannis, M. Pashalidou, A. Orologas, A. Zafeiropoulos, V. Kosta, and T. C. Theoharides. 2005. A pilot, open label, clinical trial using hydroxyzine in multiple sclerosis. Int. J. Immunopathol. Pharmacol. 18: 771-778.
10. Pedotti, R., J. J. DeVoss, S. Youssef, D. Mitchell, J. Wedemeyer, R. Madanat, H. Garren, P. Fontoura, M. Tsai, S. J. Galli, et al. 2003. Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination. Proc. Natl. Acad. Sci. USA 100: 1867-1872. (Pubitemid 36254540)
11. Ma, R. Z., J. Gao, N. D. Meeker, P. D. Fillmore, K. S. Tung, T. Watanabe, J. F. Zachary, H. Offner, E. P. Blankenhorn, and C. Teuscher. 2002. Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. Science 297: 620-623. (Pubitemid 34815349)
12. Teuscher, C., M. E. Poynter, H. Offner, A. Zamora, T. Watanabe, P. D. Fillmore, J. F. Zachary, and E. P. Blankenhorn. 2004. Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells. Am. J. Pathol. 164: 883-892. (Pubitemid 38235470)
13. Musio, S., B. Gallo, S. Scabeni, M. Lapilla, P. L. Poliani, G. Matarese, H. Ohtsu, S. J. Galli, R. Mantegazza, L. Steinman, and R. Pedotti. 2006. A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice. J. Immunol. 176: 17-26. (Pubitemid 43023244)
14. Noubade, R., G. Milligan, J. F. Zachary, E. P. Blankenhorn, R. del Rio, M. Rincon, and C. Teuscher. 2007. Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice. J. Clin. Invest. 117: 3507-3518. (Pubitemid 350097006)
15. Zampeli, E., and E. Tiligada. 2009. The role of histamine H4 receptor in immune and inflammatory disorders. Br. J. Pharmacol. 157: 24-33.
16. Liu, C., X. Ma, X. Jiang, S. J. Wilson, C. L. Hofstra, J. Blevitt, J. Pyati, X. Li, W. Chai, N. Carruthers, and T. W. Lovenberg. 2001. Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol. Pharmacol. 59: 420-426. (Pubitemid 32179918)
17. Rosethorne, E. M., and S. J. Charlton. 2011. Agonist-biased signalling at the histamine H4 receptor: JNJ7777120 recruits β-arrestin without activating G proteins. Mol. Pharmacol. 79: 749-757.
18. Desai, P., and R. L. Thurmond. 2011. Histamine H4 receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation. Eur. J. Immunol. 41: 1764-1773.
19. Schneider, E., M. Rolli-Derkinderen, M. Arock, and M. Dy. 2002. Trends in histamine research: new functions during immune responses and hematopoiesis. Trends Immunol. 23: 255-263. (Pubitemid 34499563)
20. Hofstra, C. L., P. J. Desai, R. L. Thurmond, and W. P. Fung-Leung. 2003. Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. J. Pharmacol. Exp. Ther. 305: 1212-1221. (Pubitemid 36618001)
21. Thurmond, R. L., E. W. Gelfand, and P. J. Dunford. 2008. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat. Rev. Drug Discov. 7: 41-53.
22. Gschwandtner, M., K. Rossbach, D. Dijkstra, W. Bäumer, M. Kietzmann, H. Stark, T. Werfel, and R. Gutzmer. 2010. Murine and human Langerhans cells express a functional histamine H4 receptor: modulation of cell migration and function. Allergy 65: 840-849.
23. Morgan, R. K., B. McAllister, L. Cross, D. S. Green, H. Kornfeld, D. M. Center, and W. W. Cruikshank. 2007. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J. Immunol. 178: 8081-8089. (Pubitemid 46898080)
24. Yu, B., Y. Shao, J. Zhang, X. L. Dong, W. L. Liu, H. Yang, L. Liu, M. H. Li, C. F. Yue, Z. Y. Fang, et al. 2010. Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis. Br. J. Dermatol. 162: 1038-1043.
25. Yu, B., Y. Shao, P. Li, J. Zhang, Q. Zhong, H. Yang, X. Hu, B. Chen, X. Peng, Q. Wu, et al. 2010. Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus. Br. J. Dermatol. 163: 935-940.
26. Goverman, J. 2009. Autoimmune T cell responses in the central nervous system. Nat. Rev. Immunol. 9: 393-407.
27. O'Connor, R. A., and S. M. Anderton. 2008. Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease. J. Neuroimmunol. 193: 1-11.
28. Sakaguchi, S., T. Yamaguchi, T. Nomura, and M. Ono. 2008. Regulatory T cells and immune tolerance. Cell 133: 775-787. (Pubitemid 351707693)
29. Forward, N. A., S. J. Furlong, Y. Yang, T. J. Lin, and D. W. Hoskin. 2009. Mast cells down-regulate CD4+CD25+ T regulatory cell suppressor function via histamine H1 receptor interaction. J. Immunol. 183: 3014-3022.
30. Lu, L. F., E. F. Lind, D. C. Gondek, K. A. Bennett, M.W. Gleeson, K. Pino-Lagos, Z. A. Scott, A. J. Coyle, J. L. Reed, J. Van Snick, et al. 2006. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442: 997-1002. (Pubitemid 44330250)
31. Ueha, S., H. Yoneyama, S. Hontsu, M. Kurachi, M. Kitabatake, J. Abe, O. Yoshie, S. Shibayama, T. Sugiyama, and K. Matsushima. 2007. CCR7 mediates the migration of Foxp3+ regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules. J. Leukoc. Biol. 82: 1230-1238. (Pubitemid 350133521)
32. Lapilla, M., B. Gallo, M. Martinello, C. Procaccini, M. Costanza, S. Musio, B. Rossi, S. Angiari, C. Farina, L. Steinman, et al. 2011. Histamine regulates autoreactive T cell activation and adhesiveness in inflamed brain microcirculation. J. Leukoc. Biol. 89: 259-267.
33. Kohm, A. P., and S. D. Miller. 2003. Role of ICAM-1 and P-selectin expression in the development and effector function of CD4+CD25+ regulatory T cells. J. Autoimmun. 21: 261-271. (Pubitemid 37410114)
34. Huehn, J., and A. Hamann. 2005. Homing to suppress: address codes for Treg migration. Trends Immunol. 26: 632-636. (Pubitemid 41628195)
35. Jadidi-Niaragh, F., and A. Mirshafiey. 2010. Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis. Neuropharmacology 59: 180-189.
36. Teuscher, C., M. Subramanian, R. Noubade, J. F. Gao, H. Offner, J. F. Zachary, and E. P. Blankenhorn. 2007. Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS. Proc. Natl. Acad. Sci. USA 104: 10146-10151. (Pubitemid 47175277)
37. Venken, K., N. Hellings, R. Liblau, and P. Stinissen. 2010. Disturbed regulatory T cell homeostasis in multiple sclerosis. Trends Mol. Med. 16: 58-68.
38. del Rio, R., Y. Sun, P. Alard, K. S. Tung, and C. Teuscher. 2011. H2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune disease. J. Immunol. 186: 382-389.
39. Wheeler, K. M., E. T. Samy, and K. S. Tung. 2009. Cutting edge: normal regional lymph node enrichment of antigen-specific regulatory T cells with autoimmune disease-suppressive capacity. J. Immunol. 183: 7635-7638.
40. Schneider, M. A., J. G. Meingassner, M. Lipp, H. D. Moore, and A. Rot. 2007. CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells. J. Exp. Med. 204: 735-745. (Pubitemid 46631604)
41. Szanya, V., J. Ermann, C. Taylor, C. Holness, and C. G. Fathman. 2002. The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J. Immunol. 169: 2461-2465. (Pubitemid 34920990)
42. Connelly, W. M., F. C. Shenton, N. Lethbridge, R. Leurs, H. J. Waldvogel, R. L. Faull, G. Lees, and P. L. Chazot. 2009. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br. J. Pharmacol. 157: 55-63.
43. Strakhova, M. I., A. L. Nikkel, A. M. Manelli, G. C. Hsieh, T. A. Esbenshade, J. D. Brioni, and R. S. Bitner. 2009. Localization of histamine H4 receptors in the central nervous system of human and rat. Brain Res. 1250: 41-48.